Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes

Science Translational Medicine

Volumn 5, Issue 211, 2013, Pages

  Engin, Feyza ^a   Yermalovich, Alena ^a   Ngyuen, Truc ^a   Hummasti, Sarah ^a   Fu, Wenxian ^b   Eizirik, Decio L ^c   Mathis, Diane ^b,d   Hotamisligil, Gökhan S ^a,d  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; INSULIN; TAUROURSODEOXYCHOLIC ACID; X BOX BINDING PROTEIN 1;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATF6 GENE; CELL SPECIFICITY; CELL STRUCTURE; CELL SURVIVAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETOGENESIS; DISEASE ACTIVITY; DISEASE COURSE; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE DELETION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMPAIRED GLUCOSE TOLERANCE; INCIDENCE; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; LYMPHOCYTE FUNCTION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; UNFOLDED PROTEIN RESPONSE;

ANIMALS; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED NOD; UNFOLDED PROTEIN RESPONSE;

EID: 84890076252     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3006534     Document Type: Article

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