The RtcB RNA ligase is an essential component of the metazoan unfolded protein response

EMBO Reports

Volumn 15, Issue 12, 2014, Pages 1278-1285

  Kosmaczewski, Sara Guckian ^a   Edwards, Tyson James ^a   Han, Sung Min ^a   Eckwahl, Matthew J ^a   Meyer, Benjamin Isaiah ^a   Peach, Sally ^b   Hesselberth, Jay R ^b   Wolin, Sandra L ^a   Hammarlund, Marc ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Caenorhabditis elegans; HSPC117; RtcB; tRNA; xbp 1

Indexed keywords

COMPLEMENTARY DNA; GENOMIC DNA; HEAT SHOCK PROTEIN; MESSENGER RNA PRECURSOR; PROTEIN IRE1; RNA; RNA LIGASE; RTCB RNA LIGASE; TRANSFER RNA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; CAENORHABDITIS ELEGANS PROTEIN; CARRIER PROTEIN; XBP-1 PROTEIN, C ELEGANS;

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENOME ANALYSIS; IN VIVO GENE TRANSFER; INTRON; LIFESPAN; LOSS OF FUNCTION MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEFECT; PROTEIN FUNCTION; PROTEIN PROCESSING; RNA CLEAVAGE; RNA EXTRACTION; RNA LIGATION; RNA PROCESSING; RNA SEQUENCE; RNA SPLICING; START CODON; UNFOLDED PROTEIN RESPONSE; ANIMAL; GENETICS; METABOLISM; PHYSIOLOGY;

CAENORHABDITIS ELEGANS; METAZOA;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CARRIER PROTEINS; RNA LIGASE (ATP); UNFOLDED PROTEIN RESPONSE;

EID: 84915814883     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201439531     Document Type: Article

References (33)

1. Filipowicz W, Konarska M, Gross HJ, Shatkin AJ, (1983) RNA 3′-terminal phosphate cyclase activity and RNA ligation in HeLa cell extract. Nucleic Acids Res 11: 1405-1418
2. Filipowicz W, Shatkin AJ, (1983) Origin of splice junction phosphate in tRNAs processed by HeLa cell extract. Cell 32: 547-557
3. Laski FA, Fire AZ, RajBhandary UL, Sharp PA, (1983) Characterization of tRNA precursor splicing in mammalian extracts. J Biol Chem 258: 11974-11980
4. Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR, (2004) Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3′ end formation. Cell 117: 311-321
5. Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, et al, (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107: 893-903
6. Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D, (2002) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415: 92-96
7. Silber R, Malathi VG, Hurwitz J, (1972) Purification and properties of bacteriophage T4-induced RNA ligase. Proc Natl Acad Sci USA 69: 3009-3013
8. Englert M, Beier H, (2005) Plant tRNA ligases are multifunctional enzymes that have diverged in sequence and substrate specificity from RNA ligases of other phylogenetic origins. Nucleic Acids Res 33: 388-399
9. Greer CL, Peebles CL, Gegenheimer P, Abelson J, (1983) Mechanism of action of a yeast RNA ligase in tRNA splicing. Cell 32: 537-546
10. Popow J, Englert M, Weitzer S, Schleiffer A, Mierzwa B, Mechtler K, Trowitzsch S, Will CL, Lührmann R, Söll D, et al, (2011) HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 331: 760-764
11. Popow J, Schleiffer A, Martinez J, (2012) Diversity and roles of (t)RNA ligases. Cell Mol Life Sci 69: 2657-2670
12. Knapp G, Beckmann JS, Johnson PF, Fuhrman SA, Abelson J, (1978) Transcription and processing of intervening sequences in yeast tRNA genes. Cell 14: 221-236
13. Kaine BP, Gupta R, Woese CR, (1983) Putative introns in tRNA genes of prokaryotes. Proc Natl Acad Sci USA 80: 3309-3312
14. Chan PP, Lowe TM, (2009) GtRNAdb: a database of transfer RNA genes detected in genomic sequence. Nucl Acids Res 37: D93-D97
15. Englert M, Sheppard K, Aslanian A, Yates JR III, Söll D, (2011) Archaeal 3′-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation. Proc Natl Acad Sci USA 108: 1290-1295
16. Emara MM, Ivanov P, Hickman T, Dawra N, Tisdale S, Kedersha N, Hu G-F, Anderson P, (2010) Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly. J Biol Chem 285: 10959-10968
17. Ivanov P, Emara MM, Villen J, Gygi SP, Anderson P, (2011) Angiogenin-induced tRNA fragments inhibit translation initiation. Mol Cell 43: 613-623
18. Nwagwu M, Nana M, (1980) Ribonucleic acid synthesis in embryonic chick muscle, rates of synthesis and half-lives of transfer and ribosomal RNA species. J Embryol Exp Morphol 56: 253-267
19. Cox JS, Walter P, (1996) A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87: 391-404
20. Tanaka N, Meineke B, Shuman S, (2011) RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo. J Biol Chem 286: 30253-30257
21. Yoshida H, (2007) Unconventional splicing of XBP-1 mRNA in the unfolded protein response. Antioxid Redox Signal 9: 2323-2334
22. Qabazard B, Ahmed S, Li L, Arlt VM, Moore PK, Stürzenbaum SR, (2013) Caenorhabditis elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2. PLoS ONE 8: e80135
23. Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P, (2007) Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6: 111-119
24. Lu Y, Liang F-X, Wang X, (2014) A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB. Mol Cell 55: 758-770
25. Saikia M, Krokowski D, Guan B-J, Ivanov P, Parisien M, Hu G, Anderson P, Pan T, Hatzoglou M, (2012) Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress. J Biol Chem 287: 42708-42725
26. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, et al, (2013) CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature 495: 474-480
27. Hamamichi S, Rivas RN, Knight AL, Cao S, Caldwell KA, Caldwell GA, (2008) Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proc Natl Acad Sci USA 105: 728-733
28. Gonzalez TN, Sidrauski C, Dörfler S, Walter P, (1999) Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J 18: 3119-3132
29. Kanai Y, Dohmae N, Hirokawa N, (2004) Kinesin transports RNA: isolation and characterization of an RNA-transporting granule. Neuron 43: 513-525
30. Frøkjaer-Jensen C, Davis MW, Hopkins CE, Newman BJ, Thummel JM, Olesen SP, Grunnet M, Jorgensen Jorgensen, (2008) Single-copy insertion of transgenes in Caenorhabditis elegans. Nat Genet 40: 1375-1383
31. Frøkjær-Jensen C, Davis MW, Ailion M, Jorgensen Jorgensen, (2012) Improved Mos1-mediated transgenesis in C. elegans. Nat Methods 9: 117-118
32. Tarn WY, Yario TA, Steitz JA, (1995) U12 snRNA in vertebrates: evolutionary conservation of 5′ sequences implicated in splicing of pre-mRNAs containing a minor class of introns. RNA 1: 644-656
33. Taylor RC, Dillin A, (2013) XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. Cell 153: 153-1447