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Volumn 9, Issue 12, 2013, Pages

The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153;

EID: 84892393658     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003937     Document Type: Article
Times cited : (59)

References (63)
  • 1
    • 81155126122 scopus 로고    scopus 로고
    • International trends in liver cancer incidence rates
    • Center MM, Jemal A, (2011) International trends in liver cancer incidence rates. Cancer Epidemiol Biomarkers Prev 20: 2362-2368.
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , pp. 2362-2368
    • Center, M.M.1    Jemal, A.2
  • 2
    • 63049133092 scopus 로고    scopus 로고
    • Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
    • Altekruse SF, McGlynn KA, Reichman ME, (2009) Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 27: 1485-1491.
    • (2009) J Clin Oncol , vol.27 , pp. 1485-1491
    • Altekruse, S.F.1    McGlynn, K.A.2    Reichman, M.E.3
  • 3
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL, (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 4
    • 84860277559 scopus 로고    scopus 로고
    • Obesity-related hepatocellular carcinoma: roles of risk factors altered in obesity
    • Shen C, Zhao CY, Zhang R, Qiao L, (2012) Obesity-related hepatocellular carcinoma: roles of risk factors altered in obesity. Front Biosci 17: 2356-2370.
    • (2012) Front Biosci , vol.17 , pp. 2356-2370
    • Shen, C.1    Zhao, C.Y.2    Zhang, R.3    Qiao, L.4
  • 5
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection
    • Starley BQ, Calcagno CJ, Harrison SA, (2010) Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology 51: 1820-1832.
    • (2010) Hepatology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 6
    • 77953153048 scopus 로고    scopus 로고
    • Regulation of basal cellular physiology by the homeostatic unfolded protein response
    • Rutkowski DT, Hegde RS, (2010) Regulation of basal cellular physiology by the homeostatic unfolded protein response. J Cell Biol 189: 783-794.
    • (2010) J Cell Biol , vol.189 , pp. 783-794
    • Rutkowski, D.T.1    Hegde, R.S.2
  • 7
    • 0033634654 scopus 로고    scopus 로고
    • Regulated translation initiation controls stress-induced gene expression in mammalian cells
    • Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, et al. (2000) Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6: 1099-1108.
    • (2000) Mol Cell , vol.6 , pp. 1099-1108
    • Harding, H.P.1    Novoa, I.2    Zhang, Y.3    Zeng, H.4    Wek, R.5
  • 8
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: from stress pathway to homeostatic regulation
    • Walter P, Ron D, (2011) The unfolded protein response: from stress pathway to homeostatic regulation. Science 334: 1081-1086.
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 9
    • 0037353039 scopus 로고    scopus 로고
    • An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
    • Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, et al. (2003) An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11: 619-633.
    • (2003) Mol Cell , vol.11 , pp. 619-633
    • Harding, H.P.1    Zhang, Y.2    Zeng, H.3    Novoa, I.4    Lu, P.D.5
  • 10
    • 39049160268 scopus 로고    scopus 로고
    • Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development
    • Dong D, Ni M, Li J, Xiong S, Ye W, et al. (2008) Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res 68: 498-505.
    • (2008) Cancer Res , vol.68 , pp. 498-505
    • Dong, D.1    Ni, M.2    Li, J.3    Xiong, S.4    Ye, W.5
  • 11
    • 84864054515 scopus 로고    scopus 로고
    • SEL1L, an UPR response protein, a potential marker of colonic cell transformation
    • Ashktorab H, Green W, Finzi G, Sessa F, Nouraie M, et al. (2012) SEL1L, an UPR response protein, a potential marker of colonic cell transformation. Dig Dis Sci 57: 905-912.
    • (2012) Dig Dis Sci , vol.57 , pp. 905-912
    • Ashktorab, H.1    Green, W.2    Finzi, G.3    Sessa, F.4    Nouraie, M.5
  • 13
    • 35448967382 scopus 로고    scopus 로고
    • The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
    • Pyrko P, Schonthal AH, Hofman FM, Chen TC, Lee AS, (2007) The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res 67: 9809-9816.
    • (2007) Cancer Res , vol.67 , pp. 9809-9816
    • Pyrko, P.1    Schonthal, A.H.2    Hofman, F.M.3    Chen, T.C.4    Lee, A.S.5
  • 14
    • 77954592806 scopus 로고    scopus 로고
    • Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients
    • Bartkowiak K, Effenberger KE, Harder S, Andreas A, Buck F, et al. (2010) Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients. J Proteome Res 9: 3158-3168.
    • (2010) J Proteome Res , vol.9 , pp. 3158-3168
    • Bartkowiak, K.1    Effenberger, K.E.2    Harder, S.3    Andreas, A.4    Buck, F.5
  • 15
    • 77954535031 scopus 로고    scopus 로고
    • PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage
    • Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, Zhang F, Ye J, et al. (2010) PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage. Oncogene 29: 3881-3895.
    • (2010) Oncogene , vol.29 , pp. 3881-3895
    • Bobrovnikova-Marjon, E.1    Grigoriadou, C.2    Pytel, D.3    Zhang, F.4    Ye, J.5
  • 16
    • 0038216621 scopus 로고    scopus 로고
    • Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis
    • Shuda M, Kondoh N, Imazeki N, Tanaka K, Okada T, et al. (2003) Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J Hepatol 38: 605-614.
    • (2003) J Hepatol , vol.38 , pp. 605-614
    • Shuda, M.1    Kondoh, N.2    Imazeki, N.3    Tanaka, K.4    Okada, T.5
  • 17
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • Oyadomari S, Mori M, (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11: 381-389.
    • (2004) Cell Death Differ , vol.11 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 18
    • 59349111783 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and autophagy as targets for cancer therapy
    • Schonthal AH, (2009) Endoplasmic reticulum stress and autophagy as targets for cancer therapy. Cancer Lett 275: 163-169.
    • (2009) Cancer Lett , vol.275 , pp. 163-169
    • Schonthal, A.H.1
  • 19
    • 80255123387 scopus 로고    scopus 로고
    • Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: involvement of ROS-dependent ER-stress
    • Moon DO, Park SY, Choi YH, Ahn JS, Kim GY, (2011) Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: involvement of ROS-dependent ER-stress. Biochem Pharmacol 82: 1641-1650.
    • (2011) Biochem Pharmacol , vol.82 , pp. 1641-1650
    • Moon, D.O.1    Park, S.Y.2    Choi, Y.H.3    Ahn, J.S.4    Kim, G.Y.5
  • 20
    • 0027227651 scopus 로고
    • Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
    • Crozat A, Aman P, Mandahl N, Ron D, (1993) Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 363: 640-644.
    • (1993) Nature , vol.363 , pp. 640-644
    • Crozat, A.1    Aman, P.2    Mandahl, N.3    Ron, D.4
  • 21
    • 0027276357 scopus 로고
    • Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
    • Rabbitts TH, Forster A, Larson R, Nathan P, (1993) Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. Nat Genet 4: 175-180.
    • (1993) Nat Genet , vol.4 , pp. 175-180
    • Rabbitts, T.H.1    Forster, A.2    Larson, R.3    Nathan, P.4
  • 23
    • 77956855726 scopus 로고    scopus 로고
    • Transposon-based screens for cancer gene discovery in mouse models
    • Dupuy AJ, (2010) Transposon-based screens for cancer gene discovery in mouse models. Semin Cancer Biol 20: 261-268.
    • (2010) Semin Cancer Biol , vol.20 , pp. 261-268
    • Dupuy, A.J.1
  • 24
    • 70350227239 scopus 로고    scopus 로고
    • A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice
    • Dupuy AJ, Rogers LM, Kim J, Nannapaneni K, Starr TK, et al. (2009) A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res 69: 8150-8156.
    • (2009) Cancer Res , vol.69 , pp. 8150-8156
    • Dupuy, A.J.1    Rogers, L.M.2    Kim, J.3    Nannapaneni, K.4    Starr, T.K.5
  • 25
    • 84876878661 scopus 로고    scopus 로고
    • Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis
    • Riordan JD, Keng VW, Tschida BR, Scheetz TE, Bell JB, et al. (2013) Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis. PLoS Genet 9: e1003441.
    • (2013) PLoS Genet , vol.9
    • Riordan, J.D.1    Keng, V.W.2    Tschida, B.R.3    Scheetz, T.E.4    Bell, J.B.5
  • 26
    • 10644233167 scopus 로고    scopus 로고
    • CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
    • Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, et al. (2004) CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 18: 3066-3077.
    • (2004) Genes Dev , vol.18 , pp. 3066-3077
    • Marciniak, S.J.1    Yun, C.Y.2    Oyadomari, S.3    Novoa, I.4    Zhang, Y.5
  • 27
    • 17144417669 scopus 로고    scopus 로고
    • TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
    • Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H, (2005) TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. Embo J 24: 1243-1255.
    • (2005) Embo J , vol.24 , pp. 1243-1255
    • Ohoka, N.1    Yoshii, S.2    Hattori, T.3    Onozaki, K.4    Hayashi, H.5
  • 28
    • 0142059951 scopus 로고    scopus 로고
    • XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    • Lee AH, Iwakoshi NN, Glimcher LH, (2003) XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23: 7448-7459.
    • (2003) Mol Cell Biol , vol.23 , pp. 7448-7459
    • Lee, A.H.1    Iwakoshi, N.N.2    Glimcher, L.H.3
  • 29
    • 34548189283 scopus 로고    scopus 로고
    • ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress
    • Wu J, Rutkowski DT, Dubois M, Swathirajan J, Saunders T, et al. (2007) ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev Cell 13: 351-364.
    • (2007) Dev Cell , vol.13 , pp. 351-364
    • Wu, J.1    Rutkowski, D.T.2    Dubois, M.3    Swathirajan, J.4    Saunders, T.5
  • 30
    • 0032054744 scopus 로고    scopus 로고
    • CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
    • Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, et al. (1998) CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12: 982-995.
    • (1998) Genes Dev , vol.12 , pp. 982-995
    • Zinszner, H.1    Kuroda, M.2    Wang, X.3    Batchvarova, N.4    Lightfoot, R.T.5
  • 32
    • 0020603511 scopus 로고
    • Kinetics of diethylnitrosamine hepatocarcinogenesis in the infant mouse
    • Vesselinovitch SD, Mihailovich N, (1983) Kinetics of diethylnitrosamine hepatocarcinogenesis in the infant mouse. Cancer Res 43: 4253-4259.
    • (1983) Cancer Res , vol.43 , pp. 4253-4259
    • Vesselinovitch, S.D.1    Mihailovich, N.2
  • 33
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M, (2005) IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121: 977-990.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 34
    • 84861197159 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace
    • Baffy G, Brunt EM, Caldwell SH, (2012) Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol 56: 1384-1391.
    • (2012) J Hepatol , vol.56 , pp. 1384-1391
    • Baffy, G.1    Brunt, E.M.2    Caldwell, S.H.3
  • 35
  • 36
    • 84879568119 scopus 로고    scopus 로고
    • C/EBP Homologous Protein-induced Macrophage Apoptosis Protects Mice from Steatohepatitis
    • Malhi H, Kropp EM, Clavo VF, Kobrossi CR, Han J, et al. (2013) C/EBP Homologous Protein-induced Macrophage Apoptosis Protects Mice from Steatohepatitis. J Biol Chem 288: 18624-18642.
    • (2013) J Biol Chem , vol.288 , pp. 18624-18642
    • Malhi, H.1    Kropp, E.M.2    Clavo, V.F.3    Kobrossi, C.R.4    Han, J.5
  • 37
    • 33746032571 scopus 로고    scopus 로고
    • Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
    • Sakurai T, Maeda S, Chang L, Karin M, (2006) Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 103: 10544-10551.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10544-10551
    • Sakurai, T.1    Maeda, S.2    Chang, L.3    Karin, M.4
  • 38
    • 84856429876 scopus 로고    scopus 로고
    • Obesity, inflammation, and liver cancer
    • Sun B, Karin M, (2012) Obesity, inflammation, and liver cancer. J Hepatol 56: 704-713.
    • (2012) J Hepatol , vol.56 , pp. 704-713
    • Sun, B.1    Karin, M.2
  • 39
    • 46049083964 scopus 로고    scopus 로고
    • Intra-portal transplantation of bone marrow stromal cells ameliorates liver fibrosis in mice
    • Zheng JF, Liang LJ, (2008) Intra-portal transplantation of bone marrow stromal cells ameliorates liver fibrosis in mice. Hepatobiliary Pancreat Dis Int 7: 264-270.
    • (2008) Hepatobiliary Pancreat Dis Int , vol.7 , pp. 264-270
    • Zheng, J.F.1    Liang, L.J.2
  • 40
    • 0033515099 scopus 로고    scopus 로고
    • Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat
    • Qi Z, Atsuchi N, Ooshima A, Takeshita A, Ueno H, (1999) Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc Natl Acad Sci U S A 96: 2345-2349.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 2345-2349
    • Qi, Z.1    Atsuchi, N.2    Ooshima, A.3    Takeshita, A.4    Ueno, H.5
  • 41
    • 19944432263 scopus 로고    scopus 로고
    • Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis
    • Schiffer E, Housset C, Cacheux W, Wendum D, Desbois-Mouthon C, et al. (2005) Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis. Hepatology 41: 307-314.
    • (2005) Hepatology , vol.41 , pp. 307-314
    • Schiffer, E.1    Housset, C.2    Cacheux, W.3    Wendum, D.4    Desbois-Mouthon, C.5
  • 42
    • 0021827737 scopus 로고
    • A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat
    • Jenkins SA, Grandison A, Baxter JN, Day DW, Taylor I, et al. (1985) A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat. J Hepatol 1: 489-499.
    • (1985) J Hepatol , vol.1 , pp. 489-499
    • Jenkins, S.A.1    Grandison, A.2    Baxter, J.N.3    Day, D.W.4    Taylor, I.5
  • 44
    • 84877578475 scopus 로고    scopus 로고
    • ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
    • Han J, Back SH, Hur J, Lin YH, Gildersleeve R, et al. (2013) ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol 15: 481-490.
    • (2013) Nat Cell Biol , vol.15 , pp. 481-490
    • Han, J.1    Back, S.H.2    Hur, J.3    Lin, Y.H.4    Gildersleeve, R.5
  • 45
    • 0035144493 scopus 로고    scopus 로고
    • Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
    • McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ, (2001) Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249-1259.
    • (2001) Mol Cell Biol , vol.21 , pp. 1249-1259
    • McCullough, K.D.1    Martindale, J.L.2    Klotz, L.O.3    Aw, T.Y.4    Holbrook, N.J.5
  • 46
    • 34250758642 scopus 로고    scopus 로고
    • ER stress triggers apoptosis by activating BH3-only protein Bim
    • Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, et al. (2007) ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 129: 1337-1349.
    • (2007) Cell , vol.129 , pp. 1337-1349
    • Puthalakath, H.1    O'Reilly, L.A.2    Gunn, P.3    Lee, L.4    Kelly, P.N.5
  • 47
    • 84861696528 scopus 로고    scopus 로고
    • 2-Deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines
    • Zagorodna O, Martin SM, Rutkowski DT, Kuwana T, Spitz DR, et al. (2011) 2-Deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines. Oncogene 31: 2738-2749.
    • (2011) Oncogene , vol.31 , pp. 2738-2749
    • Zagorodna, O.1    Martin, S.M.2    Rutkowski, D.T.3    Kuwana, T.4    Spitz, D.R.5
  • 48
    • 1242336980 scopus 로고    scopus 로고
    • Apoptosis: the nexus of liver injury and fibrosis
    • Canbay A, Friedman S, Gores GJ, (2004) Apoptosis: the nexus of liver injury and fibrosis. Hepatology 39: 273-278.
    • (2004) Hepatology , vol.39 , pp. 273-278
    • Canbay, A.1    Friedman, S.2    Gores, G.J.3
  • 49
    • 77953669860 scopus 로고    scopus 로고
    • Microarray-based gene expression analysis of hepatocellular carcinoma
    • Maass T, Sfakianakis I, Staib F, Krupp M, Galle PR, et al. (2010) Microarray-based gene expression analysis of hepatocellular carcinoma. Curr Genomics 11: 261-268.
    • (2010) Curr Genomics , vol.11 , pp. 261-268
    • Maass, T.1    Sfakianakis, I.2    Staib, F.3    Krupp, M.4    Galle, P.R.5
  • 51
    • 27144458505 scopus 로고    scopus 로고
    • ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
    • Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, et al. (2005) ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. Embo J 24: 3470-3481.
    • (2005) Embo J , vol.24 , pp. 3470-3481
    • Bi, M.1    Naczki, C.2    Koritzinsky, M.3    Fels, D.4    Blais, J.5
  • 52
    • 33845465578 scopus 로고    scopus 로고
    • Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress
    • Blais JD, Addison CL, Edge R, Falls T, Zhao H, et al. (2006) Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol Cell Biol 26: 9517-9532.
    • (2006) Mol Cell Biol , vol.26 , pp. 9517-9532
    • Blais, J.D.1    Addison, C.L.2    Edge, R.3    Falls, T.4    Zhao, H.5
  • 53
    • 84866905708 scopus 로고    scopus 로고
    • Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-p yrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)
    • Axten JM, Medina JR, Feng Y, Shu A, Romeril SP, et al. (2012) Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-p yrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem 55: 7193-7207.
    • (2012) J Med Chem , vol.55 , pp. 7193-7207
    • Axten, J.M.1    Medina, J.R.2    Feng, Y.3    Shu, A.4    Romeril, S.P.5
  • 54
    • 84871759394 scopus 로고    scopus 로고
    • Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK
    • Harding HP, Zyryanova AF, Ron D, (2012) Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK. J Biol Chem 287: 44338-44344.
    • (2012) J Biol Chem , vol.287 , pp. 44338-44344
    • Harding, H.P.1    Zyryanova, A.F.2    Ron, D.3
  • 55
    • 0032546811 scopus 로고    scopus 로고
    • Human translocation liposarcoma-CCAAT/enhancer binding protein (C/EBP) homologous protein (TLS-CHOP) oncoprotein prevents adipocyte differentiation by directly interfering with C/EBPbeta function
    • Adelmant G, Gilbert JD, Freytag SO, (1998) Human translocation liposarcoma-CCAAT/enhancer binding protein (C/EBP) homologous protein (TLS-CHOP) oncoprotein prevents adipocyte differentiation by directly interfering with C/EBPbeta function. J Biol Chem 273: 15574-15581.
    • (1998) J Biol Chem , vol.273 , pp. 15574-15581
    • Adelmant, G.1    Gilbert, J.D.2    Freytag, S.O.3
  • 56
    • 0031558772 scopus 로고    scopus 로고
    • CAAT/enhancer binding proteins directly modulate transcription from the peroxisome proliferator-activated receptor gamma 2 promoter
    • Clarke SL, Robinson CE, Gimble JM, (1997) CAAT/enhancer binding proteins directly modulate transcription from the peroxisome proliferator-activated receptor gamma 2 promoter. Biochem Biophys Res Commun 240: 99-103.
    • (1997) Biochem Biophys Res Commun , vol.240 , pp. 99-103
    • Clarke, S.L.1    Robinson, C.E.2    Gimble, J.M.3
  • 57
    • 0029130373 scopus 로고
    • Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153)
    • Batchvarova N, Wang XZ, Ron D, (1995) Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153). Embo J 14: 4654-4661.
    • (1995) Embo J , vol.14 , pp. 4654-4661
    • Batchvarova, N.1    Wang, X.Z.2    Ron, D.3
  • 58
    • 0027250370 scopus 로고
    • Fatty-acid metabolism and the pathogenesis of hepatocellular carcinoma: review and hypothesis
    • Ockner RK, Kaikaus RM, Bass NM, (1993) Fatty-acid metabolism and the pathogenesis of hepatocellular carcinoma: review and hypothesis. Hepatology 18: 669-676.
    • (1993) Hepatology , vol.18 , pp. 669-676
    • Ockner, R.K.1    Kaikaus, R.M.2    Bass, N.M.3
  • 59
    • 84873662942 scopus 로고    scopus 로고
    • C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver
    • Chikka MR, McCabe DD, Tyra HM, Rutkowski DT, (2013) C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver. J Biol Chem 288: 4405-4415.
    • (2013) J Biol Chem , vol.288 , pp. 4405-4415
    • Chikka, M.R.1    McCabe, D.D.2    Tyra, H.M.3    Rutkowski, D.T.4
  • 60
    • 0034181477 scopus 로고    scopus 로고
    • Increased expression of the transcription factors CCAAT-enhancer binding protein-beta (C/EBBeta) and C/EBzeta (CHOP) correlate with invasiveness of human colorectal cancer
    • Rask K, Thorn M, Ponten F, Kraaz W, Sundfeldt K, et al. (2000) Increased expression of the transcription factors CCAAT-enhancer binding protein-beta (C/EBBeta) and C/EBzeta (CHOP) correlate with invasiveness of human colorectal cancer. Int J Cancer 86: 337-343.
    • (2000) Int J Cancer , vol.86 , pp. 337-343
    • Rask, K.1    Thorn, M.2    Ponten, F.3    Kraaz, W.4    Sundfeldt, K.5
  • 61
    • 84876407251 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma
    • Dalton LE, Clarke HJ, Knight J, Lawson MH, Wason J, et al. (2013) The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma. Br J Cancer 108: 1340-1347.
    • (2013) Br J Cancer , vol.108 , pp. 1340-1347
    • Dalton, L.E.1    Clarke, H.J.2    Knight, J.3    Lawson, M.H.4    Wason, J.5
  • 62
    • 84891955443 scopus 로고    scopus 로고
    • CCAAT/Enhancer-Binding Protein omologous (CHOP) Protein Promotes Carcinogenesis in the DEN-Induced Hepatocellular Carcinoma Model
    • doi:10.1371/journal.pone.0081065
    • Scaiewicz V, Nahmias A, Chung RT, Mueller T, Tirosh B, et al. (2013) CCAAT/Enhancer-Binding Protein omologous (CHOP) Protein Promotes Carcinogenesis in the DEN-Induced Hepatocellular Carcinoma Model. PLoS ONE 8(12): e81065 doi:10.1371/journal.pone.0081065.
    • (2013) PLoS ONE , vol.8 , Issue.12
    • Scaiewicz, V.1    Nahmias, A.2    Chung, R.T.3    Mueller, T.4    Tirosh, B.5
  • 63
    • 33751069967 scopus 로고    scopus 로고
    • Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    • Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, et al. (2006) Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol 4: e374.
    • (2006) PLoS Biol , vol.4
    • Rutkowski, D.T.1    Arnold, S.M.2    Miller, C.N.3    Wu, J.4    Li, J.5


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