Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications

Cell Cycle

Volumn 13, Issue 5, 2014, Pages 801-806

  Krishnamoorthy, Jothilatha ^a   Rajesh, Kamindla ^a   Mirzajani, Farzaneh ^a   Kesoglidou, Polixenia ^a   Papadakis, Andreas I ^a,c   Koromilas, Antonis E ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Endoplasmic reticulum stress; mRNA translation; PERK PEK kinase; Pharmacological inhibitors; Protein phosphorylation; Translation initiation factor eIF2; Tumorigenesis; Unfolded protein response

Indexed keywords

ENDOPLASMIC RETICULUM RESIDENT PROTEIN KINASE PERK; GSK 2656157; INITIATION FACTOR 2ALPHA; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; ADENINE; ANTINEOPLASTIC AGENT; GSK2656157; INDOLE DERIVATIVE; INITIATION FACTOR 2; PERK KINASE; PROTEIN KINASE R;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST CULTURE; FIBROSARCOMA; GENE INACTIVATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SARCOMA CELL; WILD TYPE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION;

ADENINE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; HUMANS; INDOLES; MICE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS;

EID: 84898009679     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.27726     Document Type: Article

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