-
1
-
-
33846605587
-
Activation of the unfolded protein response in Parkinson's disease
-
Hoozemans, J. J. et al. Activation of the unfolded protein response in Parkinson's disease. Biochem. Biophys. Res. Commun. 354, 707-711 (2007).
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.354
, pp. 707-711
-
-
Hoozemans, J.J.1
-
2
-
-
65349093893
-
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus
-
Hoozemans, J. J. et al. The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus. Am. J. Pathol. 174, 1241-1251 (2009).
-
(2009)
Am. J. Pathol.
, vol.174
, pp. 1241-1251
-
-
Hoozemans, J.J.1
-
3
-
-
24344489466
-
The unfolded protein response is activated in Alzheimer's disease
-
Hoozemans, J. J. et al. The unfolded protein response is activated in Alzheimer's disease. Acta Neuropathol. 110, 165-172 (2005).
-
(2005)
Acta Neuropathol.
, vol.110
, pp. 165-172
-
-
Hoozemans, J.J.1
-
4
-
-
33744985455
-
Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo
-
Unterberger, U. et al. Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo. J. Neuropathol. Exp. Neurol. 65, 348-357 (2006).
-
(2006)
J. Neuropathol. Exp. Neurol.
, vol.65
, pp. 348-357
-
-
Unterberger, U.1
-
5
-
-
13644256191
-
A selective inhibitor of eIF2a dephosphorylation protects cells from ER stress
-
Boyce, M. et al. A selective inhibitor of eIF2a dephosphorylation protects cells from ER stress. Science 307, 935-939 (2005).
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
-
6
-
-
0025910229
-
Molecular biology of prion diseases
-
Prusiner, S. B. Molecular biology of prion diseases. Science 252, 1515-1522 (1991).
-
(1991)
Science
, vol.252
, pp. 1515-1522
-
-
Prusiner, S.B.1
-
7
-
-
0242363656
-
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis
-
Mallucci, G. et al. Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis. Science 302, 871-874 (2003).
-
(2003)
Science
, vol.302
, pp. 871-874
-
-
Mallucci, G.1
-
8
-
-
33846538022
-
Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice
-
Mallucci, G. R. et al. Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice. Neuron 53, 325-335 (2007).
-
(2007)
Neuron
, vol.53
, pp. 325-335
-
-
Mallucci, G.R.1
-
9
-
-
48249108696
-
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease
-
White, M. D. et al. Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease. Proc. Natl Acad. Sci. USA 105, 10238-10243 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 10238-10243
-
-
White, M.D.1
-
10
-
-
0036470471
-
Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration
-
Mallucci, G. R. et al. Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration. EMBO J. 21, 202-210 (2002).
-
(2002)
EMBO J
, vol.21
, pp. 202-210
-
-
Mallucci, G.R.1
-
11
-
-
34247185404
-
Disease-associated prion protein oligomers inhibit the 26S proteasome
-
Kristiansen, M. et al. Disease-associated prion protein oligomers inhibit the 26S proteasome. Mol. Cell 26, 175-188 (2007).
-
(2007)
Mol. Cell
, vol.26
, pp. 175-188
-
-
Kristiansen, M.1
-
12
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron, D. & Walter, P. Signal integration in the endoplasmic reticulum unfolded protein response. Nature Rev. Mol. Cell Biol. 8, 519-529 (2007).
-
(2007)
Nature Rev. Mol. Cell Biol.
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
13
-
-
0142105406
-
And endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein
-
Hetz, C., Russelakis-Carneiro, M., Maundrell, K., Castilla, J. & Soto, C. Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J. 22, 5435-5445 (2003).
-
(2003)
EMBO J
, vol.22
, pp. 5435-5445
-
-
Hetz, C.1
Russelakis-Carneiro, M.2
Maundrell, K.3
Castilla, J.4
Soto, C.5
-
14
-
-
0037121618
-
Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease
-
Yoo, B. C. et al.Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease. Neurosci. Lett. 334, 196-200 (2002).
-
(2002)
Neurosci. Lett.
, vol.334
, pp. 196-200
-
-
Yoo, B.C.1
-
15
-
-
36348958583
-
Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo
-
Steele, A. D. et al. Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. J. Neurosci. 27, 13022-13027 (2007).
-
(2007)
J. Neurosci.
, vol.27
, pp. 13022-13027
-
-
Steele, A.D.1
-
16
-
-
51649103992
-
Prion pathogenesis is independent of caspase-12
-
Steele, A. D. et al. Prion pathogenesis is independent of caspase-12. Prion 1, 243-247 (2007).
-
(2007)
Prion
, vol.1
, pp. 243-247
-
-
Steele, A.D.1
-
17
-
-
0033634654
-
Regulated translation initiation controls stress-induced gene expression in mammalian cells
-
Harding, H. P. et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 6, 1099-1108 (2000)
-
(2000)
Mol. Cell
, vol.6
, pp. 1099-1108
-
-
Harding, H.P.1
-
18
-
-
78649375395
-
Translational regulation of gene expression during conditions of cell stress
-
Spriggs, K. A., Bushell, M. & Willis, A. E. Translational regulation of gene expression during conditions of cell stress. Mol. Cell 40, 228-237 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 228-237
-
-
Spriggs, K.A.1
Bushell, M.2
Willis, A.E.3
-
19
-
-
0027319326
-
Mice devoid of PrP are resistant to scrapie
-
Bueler, H. et al. Mice devoid of PrP are resistant to scrapie. Cell 73, 1339-1347 (1993).
-
(1993)
Cell
, vol.73
, pp. 1339-1347
-
-
Bueler, H.1
-
20
-
-
0028703452
-
PrP gene dosage determines the timingbut not the final intensity or distribution of lesions in scrapie pathology
-
Manson, J. C., Clarke, A. R., McBride, P. A., McConnell, I.& Hope, J. PrP gene dosage determines the timingbut not the final intensity or distribution of lesions in scrapie pathology. Neurodegeneration 3, 331-340 (1994).
-
(1994)
Neurodegeneration
, vol.3
, pp. 331-340
-
-
Manson, J.C.1
Clarke, A.R.2
McBride, P.A.3
McConnell, I.4
Hope, J.5
-
21
-
-
79952167224
-
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
-
Sandberg, M. K., Al-Doujaily, H., Sharps, B., Clarke, A. R. & Collinge, J. Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. Nature 470, 540-542 (2011).
-
(2011)
Nature
, vol.470
, pp. 540-542
-
-
Sandberg, M.K.1
Al-Doujaily, H.2
Sharps, B.3
Clarke, A.R.4
Collinge, J.5
-
22
-
-
79953288480
-
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
-
Tsaytler, P.,Harding, H. P., Ron, D.&Bertolotti, A. Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science 332, 91-94 (2011).
-
(2011)
Science
, vol.332
, pp. 91-94
-
-
Tsaytler, P.1
Harding, H.P.2
Ron, D.3
Bertolotti, A.4
-
23
-
-
35848951621
-
Ab1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner
-
Chafekar, S. M., Hoozemans, J. J., Zwart, R., Baas, F. & Scheper, W. Ab1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner. Antioxid. Redox Signal. 9, 2245-2254 (2007).
-
(2007)
Antioxid. Redox Signal.
, vol.9
, pp. 2245-2254
-
-
Chafekar, S.M.1
Hoozemans, J.J.2
Zwart, R.3
Baas, F.4
Scheper, W.5
-
24
-
-
77950887221
-
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1
-
Wiseman, R. L. et al. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol. Cell 38, 291-304 (2010).
-
(2010)
Mol. Cell
, vol.38
, pp. 291-304
-
-
Wiseman, R.L.1
-
25
-
-
33846577831
-
Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain
-
Sokka, A. L. et al. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. J. Neurosci. 27, 901-908 (2007).
-
(2007)
J. Neurosci.
, vol.27
, pp. 901-908
-
-
Sokka, A.L.1
-
26
-
-
67349164383
-
Arole formotoneuron subtype-selectiveERstress in disease manifestations of FALS mice
-
Saxena, S., Cabuy, E.&Caroni, P.Arole formotoneuron subtype-selectiveERstress in disease manifestations of FALS mice. Nature Neurosci. 12, 627-636 (2009).
-
(2009)
Nature Neurosci.
, vol.12
, pp. 627-636
-
-
Saxena, S.1
Cabuy, E.2
Caroni, P.3
-
27
-
-
39849090073
-
Eif-2a protects brainstem motoneurons in a murine model of sleep apnea
-
Zhu, Y. et al. Eif-2a protects brainstem motoneurons in a murine model of sleep apnea. J. Neurosci. 28, 2168-2178 (2008).
-
(2008)
J. Neurosci.
, vol.28
, pp. 2168-2178
-
-
Zhu, Y.1
-
28
-
-
39349083915
-
Adapting proteostasis for disease intervention
-
Balch, W. E., Morimoto, R. I., Dillin, A.&Kelly, J. W. Adapting proteostasis for disease intervention. Science 319, 916-919 (2008).
-
(2008)
Science
, vol.319
, pp. 916-919
-
-
Balch, W.E.1
Morimoto, R.I.2
Dillin, A.3
Kelly, J.W.4
-
29
-
-
84858170830
-
A molecular toolbox for rapid generation of viral vectors to up-or down-regulate neuronal gene expression in vivo
-
White, M. D., Milne, R. V. & Nolan, M. F. A molecular toolbox for rapid generation of viral vectors to up-or down-regulate neuronal gene expression in vivo. Front. Mol. Neurosci. 4, 8 (2011).
-
(2011)
Front. Mol. Neurosci.
, vol.4
, pp. 8
-
-
White, M.D.1
Milne, R.V.2
Nolan, M.F.3
-
30
-
-
78649702914
-
Acute hyperbilirubinaemia induces presynaptic neurodegeneration at a central glutamatergic synapse
-
Haustein, M. D. et al. Acute hyperbilirubinaemia induces presynaptic neurodegeneration at a central glutamatergic synapse. J. Physiol. (Lond.) 588, 4683-4693 (2011).
-
(2011)
J. Physiol. (Lond.)
, vol.588
, pp. 4683-4693
-
-
Haustein, M.D.1
-
31
-
-
79960642998
-
Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability
-
Steinert, J. R. et al. Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability. Neuron 71, 291-305 (2011).
-
(2011)
Neuron
, vol.71
, pp. 291-305
-
-
Steinert, J.R.1
-
32
-
-
0031790633
-
Cap-independent polysomal association of natural mRNAs encoding c-myc BiP, and eIF4G conferred by internal ribosome entry sites
-
Johannes, G. & Sarnow, P. Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites. RNA 4, 1500-1513 (1998).
-
(1998)
RNA
, vol.4
, pp. 1500-1513
-
-
Johannes, G.1
Sarnow, P.2
-
33
-
-
4444354577
-
High Ca21-phosphate transfection efficiency enables single neuron gene analysis
-
Jiang, M., Deng, L. & Chen, G. High Ca21-phosphate transfection efficiency enables single neuron gene analysis. Gene Ther. 11, 1303-1311 (2004).
-
(2004)
Gene Ther.
, vol.11
, pp. 1303-1311
-
-
Jiang, M.1
Deng, L.2
Chen, G.3
-
34
-
-
0038809966
-
Synaptic changes characterize early behavioural signs in the ME7 model ofmurine prion disease
-
Cunningham, C. et al. Synaptic changes characterize early behavioural signs in the ME7 model ofmurine prion disease. Eur. J. Neurosci. 17, 2147-2155 (2003).
-
(2003)
Eur. J. Neurosci.
, vol.17
, pp. 2147-2155
-
-
Cunningham, C.1
|