ATF4 regulates γ-secretase activity during amino acid imbalance

Biochemical and Biophysical Research Communications

Volumn 352, Issue 3, 2007, Pages 722-727

  Mitsuda, Teruhiko ^a   Hayakawa, Yoshika ^a   Itoh, Masanori ^a   Ohta, Kazunori ^a   Nakagawa, Toshiyuki ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Amino acid; Amyloid ; Endoplasmic reticulum stress; Signal transduction; Transcription

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID; AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE; MESSENGER RNA; PRESENILIN 1; PROTEIN KINASE R;

ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INDUCTION; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACIDS, ESSENTIAL; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; FEEDBACK; MALE; MICE; MICE, INBRED C57BL; PRESENILIN-1;

EUKARYOTA;

EID: 33845311194     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.11.075     Document Type: Article

References (25)

1. Holcik M., and Sonenberg N. Translational control in stress and apoptosis. Nat. Rev. Mol. Cell Biol. 6 (2005) 318-327
2. Schroder M., and Kaufman R.J. ER stress and the unfolded protein response. Mutat Res. 569 (2005) 29-63
3. Hao S., Sharp J.W., Ross-Inta C.M., McDaniel B.J., Anthony T.G., Wek R.C., Cavener D.R., McGrath B.C., Rudell J.B., Koehnle T.J., and Gietzen D.W. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science 307 (2005) 1776-1778
4. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., and Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403 (2000) 98-103
5. Harding H.P., Novoa I., Zhang Y., Zeng H., Wek R., Schapira M., and Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 6 (2000) 1099-1108
6. Harding H.P., Zhang Y., Zeng H., Novoa I., Lu P.D., Calfon M., Sadri N., Yun C., Popko B., Paules R., Stojdl D.F., Bell J.C., Hettmann T., Leiden J.M., and Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell 11 (2003) 619-633
7. Edbauer D., Winkler E., Regula J.T., Pesold B., Steiner H., and Haass C. Reconstitution of gamma-secretase activity. Nat. Cell Biol. 5 (2003) 486-488
8. Takasugi N., Tomita T., Hayashi I., Tsuruoka M., Niimura M., Takahashi Y., Thinakaran G., and Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature 422 (2003) 438-441
9. Wolfe M.S., Xia W., Ostaszewski B.L., Diehl T.S., Kimberly W.T., and Selkoe D.J. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398 (1999) 513-517
10. Tanzi R.E., and Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120 (2005) 545-555
11. Rogaev E.I., Sherrington R., Wu C., Levesque G., Liang Y., Rogaeva E.A., Ikeda M., Holman K., Lin C., Lukiw W.J., de Jong P.J., Fraser P.E., Rommens J.M., and St George-Hyslop P. Analysis of the 5′ sequence genomic structure and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease. Genomics 40 (1997) 415-424
12. Pastorcic M., and Das H.K. An upstream element containing an ETS binding site is crucial for transcription of the human presenilin-1 gene. J. Biol. Chem. 274 (1999) 24297-24307
13. Amson R., Lassalle J.M., Halley H., Prieur S., Lethrosne F., Roperch J.P., Israeli D., Gendron M.C., Duyckaerts C., Checler F., Dausset J., Cohen D., Oren M., and Telerman A. Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice. Proc. Natl. Acad. Sci. USA 97 (2000) 5346-5350
14. Mitsuda N., Ohkubo N., Tamatani M., Lee Y.D., Taniguchi M., Namikawa K., Kiyama H., Yamaguchi A., Sato N., Sakata K., Ogihara T., Vitek M.P., and Tohyama M. Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1. J. Biol. Chem. 276 (2001) 9688-9698
15. Gietzen D.W., Ross C.M., Hao S., and Sharp J.W. Phosphorylation of eIF2alpha is involved in the signaling of indispensable amino acid deficiency in the anterior piriform cortex of the brain in rats. J. Nutr. 134 (2004) 717-723
16. Sato H., Nomura S., Maebara K., Sato K., Tamba M., and Bannai S. Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation. Biochem. Biophys. Res. Commun. 325 (2004) 109-116
17. Zhang P., McGrath B.C., Reinert J., Olsen D.S., Lei L., Gill S., Wek S.A., Vattem K.M., Wek R.C., Kimball S.R., Jefferson L.S., and Cavener D.R. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol. Cell Biol. 22 (2002) 6681-6688
18. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., and Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19 (2000) 5720-5728
19. Fafournoux P., Bruhat A., and Jousse C. Amino acid regulation of gene expression. Biochem. J. 351 (2000) 1-12
20. Louvi A., and Artavanis-Tsakonas S. Notch signalling in vertebrate neural development. Nat. Rev. Neurosci. 7 (2006) 93-102
21. Selkoe D.J. Clearing the brain's amyloid cobwebs. Neuron 32 (2001) 177-180
22. Steiner H., Capell A., Pesold B., Citron M., Kloetzel P.M., Selkoe D.J., Romig H., Mendla K., and Haass C. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. J. Biol. Chem. 273 (1998) 32322-32331
23. Costa-Mattioli M., Gobert D., Harding H., Herdy B., Azzi M., Bruno M., Bidinosti M., Ben Mamou C., Marcinkiewicz E., Yoshida M., Imataka H., Cuello A.C., Seidah N., Sossin W., Lacaille J.C., Ron D., Nader K., and Sonenberg N. Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature 436 (2005) 1166-1173
24. Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., and Selkoe D.J. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416 (2002) 535-539
25. Lesne S., Koh M.T., Kotilinek L., Kayed R., Glabe C.G., Yang A., Gallagher M., and Ashe K.H. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440 (2006) 352-357