The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells

PLoS Biology

Volumn 13, Issue 10, 2015, Pages 1-22

  Hassler, Justin R ^a,b   Scheuner, Donalyn L ^b,c   Wang, Shiyu ^a   Han, Jaeseok ^a   Kodali, Vamsi K ^a   Li, Philip ^a   Nguyen, Julie ^a   George, Jenny S ^b   Davis, Cory ^b   Wu, Shengyang P ^d   Bai, Yongsheng ^b,e   Sartor, Maureen ^b   Cavalcoli, James ^b   Malhi, Harmeet ^b,g   Baudouin, Gregory ^a   Zhang, Yaoyang ^f   Yates III, John R ^f   Itkin Ansari, Pamela ^a   Volkmann, Niels ^a   Kaufman, Randal J ^a,b,d  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e INDIANA STATE UNIVERSITY   (United States)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

^g MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; IRE1 ALPHA PROTEIN; MESSENGER RNA; PROINSULIN; PROTEIN IRE1; SIGNAL RECOGNITION PARTICLE; TRANSLOCON; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; DNA BINDING PROTEIN; ERN1 PROTEIN, HUMAN; INSULIN; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; REGULATORY FACTOR X TRANSCRIPTION FACTOR; RIBONUCLEASE; TRANSCRIPTION FACTOR; XBP1 PROTEIN, HUMAN; XBP1 PROTEIN, MOUSE;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DISEASE EXACERBATION; FEMALE; GENE; GENE DELETION; GLUCOSE INTOLERANCE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPOINSULINEMIA; INSULIN SYNTHESIS; IRE1 ALPHA GENE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN SECRETION; RNA SEQUENCE; RNA SPLICING; RNA TRANSLATION; UNFOLDED PROTEIN RESPONSE; ALTERNATIVE RNA SPLICING; ANIMAL; BLOOD; CELL CULTURE; CROSS BREEDING; DONOR; GENETICS; KNOCKOUT MOUSE; METABOLISM; MIDDLE AGED; PATHOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ULTRASTRUCTURE; YOUNG ADULT;

ADOLESCENT; ADULT; ALTERNATIVE SPLICING; ANIMALS; CELLS, CULTURED; CROSSES, GENETIC; DNA-BINDING PROTEINS; ENDORIBONUCLEASES; FEMALE; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE, KNOCKOUT; MICE, TRANSGENIC; MIDDLE AGED; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; REGULATORY FACTOR X TRANSCRIPTION FACTORS; SIGNAL TRANSDUCTION; TISSUE DONORS; TRANSCRIPTION FACTORS; X-BOX BINDING PROTEIN 1; YOUNG ADULT;

EID: 84946083953     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1002277     Document Type: Article

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