-
1
-
-
51349156218
-
Insulin sensitivity: Modulation by nutrients and inflammation
-
Schenk S, Saberi M, Olefsky JM. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 2008;118:2992-3002
-
(2008)
J Clin Invest
, vol.118
, pp. 2992-3002
-
-
Schenk, S.1
Saberi, M.2
Olefsky, J.M.3
-
2
-
-
80755168947
-
Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats
-
Knight CM, Gutierrez-Juarez R, Lam TK, et al. Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. Diabetes 2011;60:2691-2700
-
(2011)
Diabetes
, vol.60
, pp. 2691-2700
-
-
Knight, C.M.1
Gutierrez-Juarez, R.2
Lam, T.K.3
-
3
-
-
79952595599
-
Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress
-
Purkayastha S, Zhang H, Zhang G, Ahmed Z, Wang Y, Cai D. Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proc Natl Acad Sci USA 2011;108:2939-2944
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 2939-2944
-
-
Purkayastha, S.1
Zhang, H.2
Zhang, G.3
Ahmed, Z.4
Wang, Y.5
Cai, D.6
-
4
-
-
16244388931
-
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
-
Lam TK, Pocai A, Gutierrez-Juarez R, et al. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 2005;11: 320-327
-
(2005)
Nat Med
, vol.11
, pp. 320-327
-
-
Lam, T.K.1
Pocai, A.2
Gutierrez-Juarez, R.3
-
5
-
-
48749105887
-
Activation of hypothalamic S6 kinase mediates diet- induced hepatic insulin resistance in rats
-
Ono H, Pocai A, Wang Y, et al. Activation of hypothalamic S6 kinase mediates diet- induced hepatic insulin resistance in rats. J Clin Invest 2008; 118:2959-2968
-
(2008)
J Clin Invest
, vol.118
, pp. 2959-2968
-
-
Ono, H.1
Pocai, A.2
Wang, Y.3
-
7
-
-
17844379717
-
Hypothalamic K(ATP) channels control hepatic glucose production
-
Pocai A, Lam TK, Gutierrez-Juarez R, et al. Hypothalamic K(ATP) channels control hepatic glucose production. Nature 2005;434:1026-1031
-
(2005)
Nature
, vol.434
, pp. 1026-1031
-
-
Pocai, A.1
Lam, T.K.2
Gutierrez-Juarez, R.3
-
8
-
-
0035948624
-
The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: Activating transcription factor proteins and homeostasis
-
Hai T, Hartman MG. The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene 2001;273:1-11
-
(2001)
Gene
, vol.273
, pp. 1-11
-
-
Hai, T.1
Hartman, M.G.2
-
9
-
-
0036464604
-
Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice
-
Masuoka HC, Townes TM. Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood 2002; 99:736-745
-
(2002)
Blood
, vol.99
, pp. 736-745
-
-
Masuoka, H.C.1
Townes, T.M.2
-
10
-
-
0032452122
-
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres
-
Tanaka T, Tsujimura T, Takeda K, et al. Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Genes Cells 1998;3:801-810
-
(1998)
Genes Cells
, vol.3
, pp. 801-810
-
-
Tanaka, T.1
Tsujimura, T.2
Takeda, K.3
-
11
-
-
70350539531
-
Atf4 regulates obesity, glucose homeostasis, and energy expenditure
-
Seo J, Fortuno ES 3rd, Suh JM, et al. Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes 2009;58:2565-2573
-
(2009)
Diabetes
, vol.58
, pp. 2565-2573
-
-
Seo, J.1
Fortuno III, E.S.2
Suh, J.M.3
-
12
-
-
76449101799
-
ATF4 regulates lipid metabolism and thermogenesis
-
Wang C, Huang Z, Du Y, Cheng Y, Chen S, Guo F. ATF4 regulates lipid metabolism and thermogenesis. Cell Res 2010;20:174-184
-
(2010)
Cell Res
, vol.20
, pp. 174-184
-
-
Wang, C.1
Huang, Z.2
Du, Y.3
Cheng, Y.4
Chen, S.5
Guo, F.6
-
13
-
-
70349226800
-
The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts
-
Yoshizawa T, Hinoi E, Jung DY, et al. The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest 2009;119:2807- 2817
-
(2009)
J Clin Invest
, vol.119
, pp. 2807-2817
-
-
Yoshizawa, T.1
Hinoi, E.2
Jung, D.Y.3
-
14
-
-
80051686720
-
ATF4 deficiency protects mice from highcarbohydrate- diet-induced liver steatosis
-
Li H, Meng Q, Xiao F, et al. ATF4 deficiency protects mice from highcarbohydrate- diet-induced liver steatosis. Biochem J 2011;438:283-289
-
(2011)
Biochem J
, vol.438
, pp. 283-289
-
-
Li, H.1
Meng, Q.2
Xiao, F.3
-
15
-
-
52949096557
-
Hypothalamic IKKbeta/ NF- kappaB and ER stress link overnutrition to energy imbalance and obesity
-
Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. Hypothalamic IKKbeta/ NF- kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008;135:61-73
-
(2008)
Cell
, vol.135
, pp. 61-73
-
-
Zhang, X.1
Zhang, G.2
Zhang, H.3
Karin, M.4
Bai, H.5
Cai, D.6
-
16
-
-
10444226462
-
ER stress and the unfolded protein response
-
Schröder M, Kaufman RJ. ER stress and the unfolded protein response. Mutat Res 2005;569:29-63
-
(2005)
Mutat Res
, vol.569
, pp. 29-63
-
-
Schröder, M.1
Kaufman, R.J.2
-
17
-
-
34548032380
-
Clenbuterol inhibits SREBP-1c expression by activating CREB1
-
Zhou L, Li Y, Nie T, et al. Clenbuterol inhibits SREBP-1c expression by activating CREB1. J Biochem Mol Biol 2007;40:525-531
-
(2007)
J Biochem Mol Biol
, vol.40
, pp. 525-531
-
-
Zhou, L.1
Li, Y.2
Nie, T.3
-
18
-
-
0035877643
-
Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation
-
He CH, Gong P, Hu B, et al. Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. J Biol Chem 2001;276:20858-20865
-
(2001)
J Biol Chem
, vol.276
, pp. 20858-20865
-
-
He, C.H.1
Gong, P.2
Hu, B.3
-
19
-
-
30044447631
-
Leptin regulates insulin sensitivity via phosphatidylinositol- 3-OH kinase signaling in mediobasal hypothalamic neurons
-
Morton GJ, Gelling RW, Niswender KD, Morrison CD, Rhodes CJ, Schwartz MW. Leptin regulates insulin sensitivity via phosphatidylinositol- 3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab 2005;2:411-420
-
(2005)
Cell Metab
, vol.2
, pp. 411-420
-
-
Morton, G.J.1
Gelling, R.W.2
Niswender, K.D.3
Morrison, C.D.4
Rhodes, C.J.5
Schwartz, M.W.6
-
20
-
-
80052295292
-
Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system
-
Cheng Y, Zhang Q, Meng Q, et al. Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system. Mol Endocrinol 2011;25:1624-1635
-
(2011)
Mol Endocrinol
, vol.25
, pp. 1624-1635
-
-
Cheng, Y.1
Zhang, Q.2
Meng, Q.3
-
21
-
-
0033910854
-
Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse
-
Ueda H, Ikegami H, Kawaguchi Y, et al. Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse. Diabetologia 2000;43:932-938
-
(2000)
Diabetologia
, vol.43
, pp. 932-938
-
-
Ueda, H.1
Ikegami, H.2
Kawaguchi, Y.3
-
22
-
-
79952374033
-
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways
-
Xiao F, Huang Z, Li H, et al. Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes 2011;60: 746-756
-
(2011)
Diabetes
, vol.60
, pp. 746-756
-
-
Xiao, F.1
Huang, Z.2
Li, H.3
-
23
-
-
84866607486
-
S6K1 in the central nervous system regulates energy expenditure via MC4R/corticotropin-releasing hormone pathways in response to deprivation of an essential amino acid
-
Xia T, Cheng Y, Zhang Q, et al. S6K1 in the central nervous system regulates energy expenditure via MC4R/corticotropin-releasing hormone pathways in response to deprivation of an essential amino acid. Diabetes 2012;61:2461-2471
-
(2012)
Diabetes
, vol.61
, pp. 2461-2471
-
-
Xia, T.1
Cheng, Y.2
Zhang, Q.3
-
24
-
-
17144417669
-
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
-
Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J 2005;24:1243-1255
-
(2005)
EMBO J
, vol.24
, pp. 1243-1255
-
-
Ohoka, N.1
Yoshii, S.2
Hattori, T.3
Onozaki, K.4
Hayashi, H.5
-
25
-
-
52449086180
-
Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation
-
van den Hoek AM, van Heijningen C, Schröder-van der Elst JP, et al. Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation. Diabetes 2008;57: 2304-2310
-
(2008)
Diabetes
, vol.57
, pp. 2304-2310
-
-
Van Den Hoek, A.M.1
Van Heijningen, C.2
Schröder-Van Der Elst, J.P.3
-
26
-
-
0035408764
-
Intracerebroventricular glucocorticoid infusion in normal rats: Induction of parasympathetic-mediated obesity and insulin resistance
-
Cusin I, Rouru J, Rohner-Jeanrenaud F. Intracerebroventricular glucocorticoid infusion in normal rats: induction of parasympathetic-mediated obesity and insulin resistance. Obes Res 2001;9:401-406
-
(2001)
Obes Res
, vol.9
, pp. 401-406
-
-
Cusin, I.1
Rouru, J.2
Rohner-Jeanrenaud, F.3
-
27
-
-
70349337472
-
Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve
-
German J, Kim F, Schwartz GJ, et al. Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology 2009;150:4502-4511
-
(2009)
Endocrinology
, vol.150
, pp. 4502-4511
-
-
German, J.1
Kim, F.2
Schwartz, G.J.3
-
28
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 2002;8:1376-1382
-
(2002)
Nat Med
, vol.8
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
29
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-484
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
30
-
-
58149094542
-
S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
-
Zhang J, Gao Z, Yin J, Quon MJ, Ye J. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J Biol Chem 2008;283:35375-35382
-
(2008)
J Biol Chem
, vol.283
, pp. 35375-35382
-
-
Zhang, J.1
Gao, Z.2
Yin, J.3
Quon, M.J.4
Ye, J.5
-
31
-
-
14244252683
-
Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes
-
Tremblay F, Gagnon A, Veilleux A, Sorisky A, Marette A. Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. Endocrinology 2005;146:1328-1337
-
(2005)
Endocrinology
, vol.146
, pp. 1328-1337
-
-
Tremblay, F.1
Gagnon, A.2
Veilleux, A.3
Sorisky, A.4
Marette, A.5
-
32
-
-
33749342069
-
Molecular mechanisms of insulin resistance: Serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: The two sides of a coin
-
Draznin B. Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: The two sides of a coin. Diabetes 2006;55:2392-2397
-
(2006)
Diabetes
, vol.55
, pp. 2392-2397
-
-
Draznin, B.1
-
33
-
-
0035144307
-
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways
-
Rui L, Aguirre V, Kim JK, et al. Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest 2001;107:181-189
-
(2001)
J Clin Invest
, vol.107
, pp. 181-189
-
-
Rui, L.1
Aguirre, V.2
Kim, J.K.3
-
34
-
-
35348832340
-
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
-
Tremblay F, Brûlé S, Hee Um S, et al. Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc Natl Acad Sci USA 2007;104:14056-14061
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 14056-14061
-
-
Tremblay, F.1
Brûlé, S.2
Hee Um, S.3
-
35
-
-
0034700456
-
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice
-
Pende M, Kozma SC, Jaquet M, et al. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature 2000;408:994-997
-
(2000)
Nature
, vol.408
, pp. 994-997
-
-
Pende, M.1
Kozma, S.C.2
Jaquet, M.3
-
36
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um SH, Frigerio F, Watanabe M, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004;431:200-205
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
-
37
-
-
56449115916
-
Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis
-
Blouet C, Ono H, Schwartz GJ. Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. Cell Metab 2008;8:459- 467
-
(2008)
Cell Metab
, vol.8
, pp. 459-467
-
-
Blouet, C.1
Ono, H.2
Schwartz, G.J.3
-
38
-
-
21544471229
-
Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes
-
Kaneto H, Matsuoka TA, Nakatani Y, et al. Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes. J Mol Med (Berl) 2005;83:429-439
-
(2005)
J Mol Med (Berl)
, vol.83
, pp. 429-439
-
-
Kaneto, H.1
Matsuoka, T.A.2
Nakatani, Y.3
-
39
-
-
43549105167
-
The unfolded protein response: A pathway that links insulin demand with beta-cell failure and diabetes
-
Scheuner D, Kaufman RJ. The unfolded protein response: A pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev 2008; 29:317-333
-
(2008)
Endocr Rev
, vol.29
, pp. 317-333
-
-
Scheuner, D.1
Kaufman, R.J.2
-
40
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin ction, and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin ction, and type 2 diabetes. Science 2004;306:457-461
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
-
41
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U, Yilmaz E, Ozcan L, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006;313:1137-1140
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
-
42
-
-
57849115277
-
Endoplasmic reticulum stress plays a central role in development of leptin resistance
-
Ozcan L, Ergin AS, Lu A, et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 2009;9:35-51
-
(2009)
Cell Metab
, vol.9
, pp. 35-51
-
-
Ozcan, L.1
Ergin, A.S.2
Lu, A.3
-
43
-
-
0034610743
-
Caspase-12 mediates ndoplasmicreticulum- specific apoptosis and cytotoxicity by amyloid-beta
-
Nakagawa T, Zhu H, Morishima N, et al. Caspase-12 mediates ndoplasmicreticulum- specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000;403:98-103
-
(2000)
Nature
, vol.403
, pp. 98-103
-
-
Nakagawa, T.1
Zhu, H.2
Morishima, N.3
-
44
-
-
33748789479
-
Mediators of endoplasmic reticulum stress-induced apoptosis
-
Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006;7:880-885
-
(2006)
EMBO Rep
, vol.7
, pp. 880-885
-
-
Szegezdi, E.1
Logue, S.E.2
Gorman, A.M.3
Samali, A.4
-
45
-
-
50949092240
-
Regulation of food intake through hypothalamicj signaling networks involving mTOR
-
Woods SC, Seeley RJ, Cota D. Regulation of food intake through hypothalamicj signaling networks involving mTOR. Annu Rev Nutr 2008;28:295- 311
-
(2008)
Annu Rev Nutr
, vol.28
, pp. 295-311
-
-
Woods, S.C.1
Seeley, R.J.2
Cota, D.3
-
46
-
-
33846945033
-
Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits
-
Pang T, Xiong B, Li JY, et al. Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. J Biol Chem 2007;282:495-506
-
(2007)
J Biol Chem
, vol.282
, pp. 495-506
-
-
Pang, T.1
Xiong, B.2
Li, J.Y.3
-
47
-
-
2342652187
-
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
-
Dobrzyn P, Dobrzyn A, Miyazaki M, et al. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci USA 2004;101:6409-6414
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 6409-6414
-
-
Dobrzyn, P.1
Dobrzyn, A.2
Miyazaki, M.3
-
48
-
-
40449135787
-
Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats
-
Klieverik LP, Sauerwein HP, Ackermans MT, Boelen A, Kalsbeek A, Fliers E. Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. Am J Physiol Endocrinol Metab 2008;294:E513-E520
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
-
-
Klieverik, L.P.1
Sauerwein, H.P.2
Ackermans, M.T.3
Boelen, A.4
Kalsbeek, A.5
Fliers, E.6
-
49
-
-
70349128200
-
A major role for perifornical orexin neurons in the control of glucose metabolism in rats
-
Yi CX, Serlie MJ, Ackermans MT, et al. A major role for perifornical orexin neurons in the control of glucose metabolism in rats. Diabetes 2009;58: 1998-2005
-
(2009)
Diabetes
, vol.58
, pp. 1998-2005
-
-
Yi, C.X.1
Serlie, M.J.2
Ackermans, M.T.3
|