Heme-regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

EMBO Journal

Volumn 20, Issue 23, 2001, Pages 6909-6918

  Han, An Ping ^a   Yu, Channing ^b   Lu, Linrong ^a   Fujiwara, Yuko ^b   Browne, Carol ^b   Chin, Gregory ^a   Fleming, Mark ^b   Leboulch, Philippe ^a,c   Orkin, Stuart H ^b,d   Chen, Jane Jane ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Apoptosis; Erythropoiesis; Heme regulated eIF2 kinase; Iron deficiency; Translation

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; HEME; PROTEIN SERINE THREONINE KINASE; COMPLEMENTARY DNA; EIF 2 KINASE; INITIATION FACTOR 2; IRON; PROTOPORPHYRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROCYTE COUNT; ERYTHROID PRECURSOR CELL; GENE DISRUPTION; GENE EXPRESSION REGULATION; IRON DEFICIENCY; MEGALOBLASTIC ANEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN SYNTHESIS; TRANSLATION REGULATION; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL LINEAGE; CELL SEPARATION; CYTOLOGY; DOSE RESPONSE; ELECTRON MICROSCOPY; ENZYMOLOGY; FLOW CYTOMETRY; GENE LIBRARY; GENOTYPE; METABOLISM; MOLECULAR CLONING; NORTHERN BLOTTING; NUTRITIONAL DEFICIENCY; PHOSPHORYLATION; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYSOME; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; RETICULOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION; STRESS; TIME; WESTERN BLOTTING;

ANIMAL; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINEAGE; CELL SEPARATION; CELL SURVIVAL; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; EIF-2 KINASE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ERYTHROCYTES; EUKARYOTIC INITIATION FACTOR-2; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE LIBRARY; GENOTYPE; HEME; IRON; MICE; MICROSCOPY, ELECTRON; MODELS, BIOLOGICAL; PHOSPHORYLATION; POLYRIBOSOMES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTOPORPHYRINS; RETICULOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STRESS; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; TRANSLATION, GENETIC;

EID: 17944362905     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.23.6909     Document Type: Article

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