ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice

Diabetologia

Volumn 56, Issue 4, 2013, Pages 911-924

  Han, J ^a,d   Murthy, R ^d   Wood, B ^d   Song, B ^d   Wang, S ^a,d   Sun, B ^b   Malhi, H ^c,d   Kaufman, R J ^a,d,e  

^a BURNHAM INSTITUTE   (United States)

^b OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

^c MAYO CLINIC   (United States)

^d UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Adipocyte; C EBP homologous protein (CHOP); eIF2 phosphorylation; Endoplasmic reticulum; Unfolded protein response (UPR)

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; INOSITOL REQUIRING ENZYME 1 ALPHA; MESSENGER RNA; PROTEIN KINASE; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL SIZE; CELL STRAIN 3T3; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; FAT MASS; FIBROBLAST; GENETIC ENGINEERING; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA SPLICING; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; WEIGHT CHANGE; WILD TYPE;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; BODY COMPOSITION; CELL DIFFERENTIATION; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; EUKARYOTIC INITIATION FACTOR-2; FIBROBLASTS; GENE DELETION; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

EID: 84876485565     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2809-5     Document Type: Article

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