Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction

Nature Medicine

Volumn 17, Issue 3, 2011, Pages 356-365

  Zhou, Yingjiang ^a   Lee, Justin ^a   Reno, Candace M ^b   Sun, Cheng ^a   Park, Sang Won ^a   Chung, Jason ^a   Lee, Jaemin ^a   Fisher, Simon J ^b   White, Morris F ^a   Biddinger, Sudha B ^a   Ozcan, Umut ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; DNA; GLUCOSE; GLUCOSE 6 PHOSPHATASE; HEAT SHOCK PROTEIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEASOME; PROTEIN DISULFIDE ISOMERASE; PROTEIN DNAJ; PROTEIN KINASE B; SOMATOMEDIN BINDING PROTEIN 1; TRANSCRIPTION FACTOR FKHR; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHO CELL; CONTROLLED STUDY; DISEASE MODEL; DNA BINDING; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG MEGADOSE; EMBRYO; ENDOPLASMIC RETICULUM; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLYCEMIC CONTROL; IN VIVO STUDY; INSULIN DEFICIENCY; INSULIN RESISTANCE; LOW DRUG DOSE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

ANIMALS; BLOOD GLUCOSE; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; HOMEOSTASIS; HYDROLYSIS; INSULIN RESISTANCE; LIVER; MICE; MUTATION; PHOSPHORYLATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 79952381078     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2293     Document Type: Article

References (46)

1. James, P.T., Rigby, N. & Leach, R. The obesity epidemic, metabolic syndrome and future prevention strategies. Eur. J. Cardiovasc. Prev. Rehabil. 11, 3-8 (2004). (Pubitemid 38388918)
2. Kitamura, Y. & Accili, D. New insights into the integrated physiology of insulin action. Rev. Endocr. Metab. Disord. 5, 143-149 (2004). (Pubitemid 39012112)
3. de Luca, C. & Olefsky, J.M. Stressed out about obesity and insulin resistance. Nat. Med. 12, 41-42 discussion 42 (2006). (Pubitemid 43050060)
4. Biddinger, S.B. & Kahn, C.R. From mice to men: insights into the insulin resistance syndromes. Annu. Rev. Physiol. 68, 123-158 (2006).
5. Saltiel, A.R. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104, 517-529 (2001). (Pubitemid 32201947)
6. Schröder, M. & Kaufman, R.J. The mammalian unfolded protein response. Annu. Rev. Biochem. 74, 739-789 (2005). (Pubitemid 40995523)
7. Marciniak, S.J. & Ron, D. Endoplasmic reticulum stress signaling in disease. Physiol. Rev. 86, 1133-1149 (2006). (Pubitemid 44521649)
8. Bernales, S., Papa, F.R. & Walter, P. Intracellular signaling by the unfolded protein response. Annu. Rev. Cell Dev. Biol. 22, 487-508 (2006).
9. Ron, D. & Walter, P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8, 519-529 (2007). (Pubitemid 46985379)
10. Zhang, K. & Kaufman, R.J. From endoplasmic-reticulum stress to the inflammatory response. Nature 454, 455-462 (2008).
11. Cox, J.S., Shamu, C.E. & Walter, P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73, 1197-1206 (1993). (Pubitemid 23180493)
12. Mori, K., Ma, W., Gething, M.J. & Sambrook, J. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell 74, 743-756 (1993). (Pubitemid 23259754)
13. Yoshida, H., Matsui, T., Yamamoto, A., Okada, T. & Mori, K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881-891 (2001). (Pubitemid 34084979)
14. Lee, K. et al. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 16, 452-466 (2002). (Pubitemid 34165102)
15. Calfon, M. et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415, 92-96 (2002). (Pubitemid 34062456)
16. Lee, A.H., Iwakoshi, N.N. & Glimcher, L.H. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol. Cell. Biol. 23, 7448-7459 (2003). (Pubitemid 37271447)
17. Sriburi, R., Jackowski, S., Mori, K. & Brewer, J.W. XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J. Cell Biol. 167, 35-41 (2004). (Pubitemid 39363412)
18. Ozcan, U. et al. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol. Cell 29, 541-551 (2008). (Pubitemid 351384644)
19. Ozcan, U. et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313, 1137-1140 (2006). (Pubitemid 44300242)
20. Ozcan, U. et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457-461 (2004). (Pubitemid 39372439)
21. Ozcan, L. et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 9, 35-51 (2009).
22. Park, S.W. et al. The regulatory subunits of PI3K, p85 and p85, interact with XBP-1 and increase its nuclear translocation. Nat. Med. 16, 429-437 (2010).
23. Gross, D.N., van den Heuvel, A.P. & Birnbaum, M.J. The role of FoxO in the regulation of metabolism. Oncogene 27, 2320-2336 (2008). (Pubitemid 351501783)
24. Accili, D. & Arden, K.C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117, 421-426 (2004). (Pubitemid 38610228)
25. Hedrick, S.M. The cunning little vixen: Foxo and the cycle of life and death. Nat. Immunol. 10, 1057-1063 (2009).
26. Puigserver, P. et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1 interaction. Nature 423, 550-555 (2003). (Pubitemid 36648580)
27. Matsumoto, M. & Accili, D. The tangled path to glucose production. Nat. Med. 12, 33-34 (2006). (Pubitemid 43050053)
28. Daitoku, H. et al. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc. Natl. Acad. Sci. USA 101, 10042-10047 (2004). (Pubitemid 38891191)
29. Motta, M.C. et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 116, 551-563 (2004). (Pubitemid 38264432)
30. Frescas, D., Valenti, L. & Accili, D. Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J. Biol. Chem. 280, 20589-20595 (2005). (Pubitemid 40776761)
31. Yamagata, K. et al. Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol. Cell 32, 221-231 (2008).
32. Huang, H. et al. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc. Natl. Acad. Sci. USA 102, 1649-1654 (2005). (Pubitemid 40209222)
33. Matsuzaki, H., Daitoku, H., Hatta, M., Tanaka, K. & Fukamizu, A. Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc. Natl. Acad. Sci. USA 100, 11285-11290 (2003). (Pubitemid 37205927)
34. Aoki, M., Jiang, H. & Vogt, P.K. Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins. Proc. Natl. Acad. Sci. USA 101, 13613-13617 (2004). (Pubitemid 39238451)
35. Nakae, J., Kitamura, T., Silver, D.L. & Accili, D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J. Clin. Invest. 108, 1359-1367 (2001). (Pubitemid 33107764)
36. Dong, X.C. et al. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 8, 65-76 (2008). (Pubitemid 351863393)
37. Michael, M.D. et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 6, 87-97 (2000).
38. Matsumoto, M., Pocai, A., Rossetti, L., Depinho, R.A. & Accili, D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab. 6, 208-216 (2007). (Pubitemid 47336849)
39. Ozawa, K. et al. The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes 54, 657-663 (2005). (Pubitemid 40322067)
40. Henis-Korenblit, S. et al. Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc. Natl. Acad. Sci. USA 107, 9730-9735 (2010).
41. Fan, W. et al. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J (2010).
42. Kenyon, C.J. The genetics of ageing. Nature 464, 504-512 (2010).
43. Russell, S.J. & Kahn, C.R. Endocrine regulation of ageing. Nat. Rev. Mol. Cell Biol. 8, 681-691 (2007). (Pubitemid 47312823)
44. Blüher, M., Kahn, B.B. & Kahn, C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574 (2003). (Pubitemid 36135156)
45. Taguchi, A., Wartschow, L.M. & White, M.F. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317, 369-372 (2007). (Pubitemid 47106376)
46. Altomonte, J. et al. Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. Am. J. Physiol. Endocrinol. Metab. 285, E718-E728 (2003). (Pubitemid 37176422)