Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress

Cancer Discovery

Volumn 4, Issue 6, 2014, Pages 702-715

  Feng, Yu Xiong ^a   Sokol, Ethan S ^a,b   Del Vecchio, Catherine A ^a   Sanduja, Sandhya ^a   Claessen, Jasper H L ^a   Proia, Theresa A ^a   Jin, Dexter X ^a,b   Reinhardt, Ferenc ^a   Ploegh, Hidde L ^a,b   Wang, Qiu ^f   Gupta, Piyush B ^a,b,c,d,e  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DITHIOTHREITOL; DOXORUBICIN; INITIATION FACTOR 2ALPHA; PACLITAXEL; PROTEIN KINASE; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; SCLEROPROTEIN; THAPSIGARGIN; TRANSCRIPTION FACTOR TWIST; TUNICAMYCIN; UNCLASSIFIED DRUG; UVOMORULIN; ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENT; ATF4 PROTEIN, HUMAN; EIF2AK3 PROTEIN, HUMAN; INITIATION FACTOR 2; PROTEIN KINASE R;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; CELL SURVIVAL; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG RESISTANCE; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; GEL ELECTROPHORESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; METASTASIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; SIGNAL TRANSDUCTION; TUMOR GROWTH; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WESTERN BLOTTING; ANIMAL; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; SCID MOUSE; TUMOR CELL LINE;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL-MESENCHYMAL TRANSITION; EUKARYOTIC INITIATION FACTOR-2; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE, SCID; UNFOLDED PROTEIN RESPONSE;

EID: 84904053401     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-13-0945     Document Type: Article

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