Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome

Cell Metabolism

Volumn 16, Issue 2, 2012, Pages 265-273

  Oslowski, Christine M ^b   Hara, Takashi ^a,b,c   O'Sullivan Murphy, Bryan ^b   Kanekura, Kohsuke ^a,b   Lu, Simin ^a,b   Hara, Mariko ^a,b   Ishigaki, Shinsuke ^d   Zhu, Lihua J ^b   Hayashi, Emiko ^b   Hui, Simon T ^e   Greiner, Dale ^b   Kaufman, Randal J ^f   Bortell, Rita ^b   Urano, Fumihiko ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c Cardiovascular Metabolics Research Laboratories   (Japan)

^d NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; INFLAMMASOME; INSULIN; INTERLEUKIN 1BETA; MESSENGER RNA; PERK PROTEIN; PROTEIN; PROTEIN IRE1; THIOREDOXIN INTERACTING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; WOLFRAM SYNDROME;

ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DIABETES MELLITUS; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; HUMANS; IMMUNOBLOTTING; INFLAMMASOMES; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; LUCIFERASES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; THIOREDOXINS;

EID: 84864693470     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2012.07.005     Document Type: Article

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