Regulation of hepatic lipogenesis by the transcription factor XBP1

Science

Volumn 320, Issue 5882, 2008, Pages 1492-1496

  Lee, Ann Hwee ^a   Scapa, Erez F ^b,c   Cohen, David E ^b,c   Glimcher, Laurie H ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

X BOX BINDING PROTEIN 1; CHOLESTEROL; DNA BINDING PROTEIN; FATTY ACID; FRUCTOSE; MESSENGER RNA; NUCLEAR PROTEIN; TRE BINDING PROTEIN; TRE-BINDING PROTEIN; TRIACYLGLYCEROL;

CARBOHYDRATE; ENZYME; FATTY ACID; PHENOTYPE; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY ACID SYNTHESIS; FATTY LIVER; HYPERCHOLESTEROLEMIA; LIPOGENESIS; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; REGULATORY MECHANISM; ANIMAL; BIOSYNTHESIS; BLOOD; CARBOHYDRATE DIET; DNA MICROARRAY; DOWN REGULATION; ENDOPLASMIC RETICULUM; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; GLYCOLYSIS; LIVER CELL; METABOLISM; PROTEIN FOLDING; ULTRASTRUCTURE;

MUS;

ANIMALS; CHOLESTEROL; DIETARY CARBOHYDRATES; DNA-BINDING PROTEINS; DOWN-REGULATION; ENDOPLASMIC RETICULUM; FATTY ACIDS; FRUCTOSE; GENE DELETION; GENE EXPRESSION REGULATION; GLYCOLYSIS; HEPATOCYTES; LIPOGENESIS; LIVER; MICE; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN FOLDING; RNA, MESSENGER; TRIGLYCERIDES;

EID: 45849137877     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1158042     Document Type: Article

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23. Supported by NIH grants AI32412 and P01 AI56296 (L.H.G.), NIH grants DK48873 and DK56626 (D.E.C.), and the Ellison Medical Foundation (L.H.G.). We thank K. Rajewsky for providing Mx1-cre mice, J. Goldstein and M. Brown for SREBP antibodies, R. Milne for apoB antibody, K. Mori for ATF6α antibody, E. Fisher for advice on pulse-chase experiments, M. Wu and J. Wei for help with FPLC analyses, D. Hu for histologic analyses, K. Heidtman for excellent technical assistance, and M. Wein and W. Garrett for critical reading of the manuscript. L.H.G. has equity in Bristol-Myers Squibb and has filed a patent regarding methods for regulating hepatic lipogenesis with XBP1.