Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis

Hepatology

Volumn 61, Issue 3, 2015, Pages 857-869

  Xu, Xu ^a   Park, Jong Gil ^a   So, Jae Seon ^a   Lee, Ann Hwee ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CIDEA PROTEIN; CIDEB PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN H; FAT DROPLET; FAT SPECIFIC PROTEIN 27; FAT SPECIFIC PROTEIN 27 ALPHA; FAT SPECIFIC PROTEIN 27 BETA; MESSENGER RNA; NUCLEIC ACID BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLIN1 PROTEIN; PLIN2 PROTEIN; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; CREB3L3 PROTEIN, MOUSE; FAT-SPECIFIC PROTEIN 27, MOUSE; PROTEIN; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DIET RESTRICTION; DNA SEQUENCE; EXON; FATTY LIVER; HALF LIFE TIME; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYDROLYSIS; LIPID STORAGE; LIPOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; START CODON; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; WHITE ADIPOSE TISSUE; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; GENETICS; LIVER; METABOLISM; PHYSIOLOGY;

ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FATTY LIVER; LIPID DROPLETS; LIVER; MICE; MICE, INBRED C57BL; ORGAN SPECIFICITY; PPAR GAMMA; PROTEINS; TRANSCRIPTIONAL ACTIVATION; TRIGLYCERIDES;

EID: 84923525246     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27371     Document Type: Article

References (39)

1. Walther TC, Farese RV Jr. The life of lipid droplets. Biochim Biophys Acta 2009;1791:459-466.
2. Farese RV Jr, Walther TC. Lipid droplets finally get a little R-E-S-P-E-C-T. Cell 2009;139:855-860.
3. Gong J, Sun Z, Li P. CIDE proteins and metabolic disorders. Curr Opin Lipidol 2009;20:121-126.
4. Martin S, Parton RG. Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 2006;7:373-378.
5. Yang H, Galea A, Sytnyk V, Crossley M. Controlling the size of lipid droplets: lipid and protein factors. Curr Opin Cell Biol 2012;24:509-516.
6. Matsusue K. A physiological role for fat specific protein 27/cell death-inducing DFF45-like effector C in adipose and liver. Biol Pharm Bull 2010;33:346-350.
7. Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, et al. Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell biol 2011;195:953-963.
8. Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, et al. Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes. Nat Commun 2013;4:1594.
9. Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, et al. FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest 2008;118:2808-2821.
10. Toh SY, Gong J, Du G, Li JZ, Yang S, Ye J, et al. Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS One 2008;3:e2890.
11. Aibara D, Matsusue K, Matsuo K, Takiguchi S, Gonzalez FJ, Yamano S. Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver. Biol Pharm Bull 2013;36:1766-1772.
12. Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Gao J, et al. Hepatic peroxisome proliferator-activated receptor-gamma-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals. Eur Heart J 2012;33:1279-1289.
13. Flach RJ, Qin H, Zhang L, Bennett AM. Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27. J Biol Chem 2011;286:22195-22202.
14. Yu S, Matsusue K, Kashireddy P, Cao WQ, Yeldandi V, Yeldandi AV, et al. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. J Biol Chem 2003;278:498-505.
15. Matsusue K, Kusakabe T, Noguchi T, Takiguchi S, Suzuki T, Yamano S, et al. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab 2008;7:302-311.
16. Puri V, Konda S, Ranjit S, Aouadi M, Chawla A, Chouinard M, et al. Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem 2007;282:34213-34218.
17. Jambunathan S, Yin J, Khan W, Tamori Y, Puri V. FSP27 promotes lipid droplet clustering and then fusion to regulate triglyceride accumulation. PLoS One 2011;6:e28614.
18. Liu K, Zhou S, Kim JY, Tillison K, Majors D, Rearick D, et al. Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA. Am J Physiol Endocrinol Metab 2009;297:E1395-1413.
19. Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, et al. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A 2008;105:7833-7838.
20. Kim YJ, Cho SY, Yun CH, Moon YS, Lee TR, Kim SH. Transcriptional activation of Cidec by PPARgamma2 in adipocyte. Biochem Biophys Res Commun 2008;377:297-302.
21. Vila-Brau A, De Sousa-Coelho AL, Goncalves JF, Haro D, Marrero PF. Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate. J Lipid Res 2013;54:592-601.
22. Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, et al. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology 2012;55:1070-1082.
23. Lee MW, Chanda D, Yang J, Oh H, Kim SS, Yoon YS, et al. Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. Cell Metab 2010;11:331-339.
24. Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, et al. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med 2011;17:812-815.
25. Lee AH. The role of CREB-H transcription factor in triglyceride metabolism. Curr Opin Lipidol 2012;23:141-146.
26. VerHague MA, Cheng D, Weinberg RB, Shelness GS. Apolipoprotein A-IV expression in mouse liver enhances triglyceride secretion and reduces hepatic lipid content by promoting very low density lipoprotein particle expansion. Arterioscler Thromb Vasc Biol 2013;33:2501-2508.
27. Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, et al. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology 2008;48:1242-1250.
28. Danesch U, Hoeck W, Ringold GM. Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C/EBP) and C/EBP-like proteins interact with sequences required for differentiation-dependent expression. J Biol Chem 1992;267:7185-7193.
29. Xu X, Park JG, So JS, Hur KY, Lee AH. Transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH. J Lipid Res 2014;55:850-859.
30. Ranjit S, Boutet E, Gandhi P, Prot M, Tamori Y, Chawla A, et al. Regulation of fat specific protein 27 by isoproterenol and TNF-alpha to control lipolysis in murine adipocytes. J Lipid Res 2011;52:221-236.
31. Nian ZQ, Sun ZQ, Yu LX, Toh SY, Sang JL, Li P. Fat-specific protein 27 undergoes ubiquitin-dependent degradation regulated by triacylglycerol synthesis and lipid droplet formation. J Biol Chem 2010;285:9604-9615.
32. Keller P, Petrie JT, De Rose P, Gerin I, Wright WS, Chiang SH, et al. Fat-specific protein 27 regulates storage of triacylglycerol. J Biol Chem 2008;283:14355-14365.
33. Grahn TH, Kaur R, Yin J, Schweiger M, Sharma VM, Lee MJ, et al. FSP27 interacts with ATGL to regulate lipolysis and insulin sensitivity in human adipocytes. J Biol Chem 2014;289:12029-12039.
34. Affo S, Dominguez M, Lozano JJ, Sancho-Bru P, Rodrigo-Torres D, Morales-Ibanez O, et al. Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis. Gut 2013;62:452-460.
35. Starmann J, Falth M, Spindelbock W, Lanz KL, Lackner C, Zatloukal K, et al. Gene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis. PLoS One 2012;7:e46584.
36. Kim H, Mendez R, Zheng Z, Chang L, Cai J, Zhang R, et al. Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor alpha to regulate metabolic hormone FGF21. Endocrinology 2014;155:769-782.
37. Gentile CL, Wang D, Pfaffenbach KT, Cox R, Wei Y, Pagliassotti MJ. Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin. Mol Cell Biochem 2010;344:99-107.
38. Danno H, Ishii KA, Nakagawa Y, Mikami M, Yamamoto T, Yabe S, et al. The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha. Biochem Biophys Res Commun 2010;391:1222-1227.
39. VerHague MA, Cheng D, Weinberg RB, Shelness GS. Apolipoprotein A-IV expression in mouse liver enhances triglyceride secretion and reduces hepatic lipid content by promoting very low density lipoprotein particle expansion. Arterioscler Thromb Vasc Biol 2013;33:2501-2508.