-
1
-
-
84861559058
-
Transmissible proteins: Expanding the prion heresy
-
Soto C (2012) Transmissible proteins: Expanding the prion heresy. Cell 149(5):968-977.
-
(2012)
Cell
, vol.149
, Issue.5
, pp. 968-977
-
-
Soto, C.1
-
2
-
-
33745919520
-
Epidemiology of Parkinson's disease
-
de Lau LM, Breteler MM (2006) Epidemiology of Parkinson's disease. Lancet Neurol 5(6):525-535.
-
(2006)
Lancet Neurol
, vol.5
, Issue.6
, pp. 525-535
-
-
De Lau, L.M.1
Breteler, M.M.2
-
3
-
-
0141741347
-
Parkinson's disease: Mechanisms and models
-
Dauer W, Przedborski S (2003) Parkinson's disease: Mechanisms and models. Neuron 39(6):889-909.
-
(2003)
Neuron
, vol.39
, Issue.6
, pp. 889-909
-
-
Dauer, W.1
Przedborski, S.2
-
4
-
-
79952451427
-
Mitophagy: The latest problem for Parkinson's disease
-
Vives-Bauza C, Przedborski S (2011) Mitophagy: The latest problem for Parkinson's disease. Trends Mol Med 17(3):158-165.
-
(2011)
Trends Mol Med
, vol.17
, Issue.3
, pp. 158-165
-
-
Vives-Bauza, C.1
Przedborski, S.2
-
6
-
-
79959500244
-
Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease
-
Calì T, Ottolini D, Brini M (2011) Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease. Biofactors 37(3):228-240.
-
(2011)
Biofactors
, vol.37
, Issue.3
, pp. 228-240
-
-
Calì, T.1
Ottolini, D.2
Brini, M.3
-
7
-
-
84875259777
-
An ERcentric view of Parkinson's disease
-
Mercado G, Valdés P, Hetz C (2013) An ERcentric view of Parkinson's disease. Trends Mol Med 19(3):165-175.
-
(2013)
Trends Mol Med
, vol.19
, Issue.3
, pp. 165-175
-
-
Mercado, G.1
Valdés, P.2
Hetz, C.3
-
8
-
-
84856111924
-
The unfolded protein response: Controlling cell fate decisions under ER stress and beyond
-
Hetz C (2012) The unfolded protein response: Controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 13(2):89-102.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, Issue.2
, pp. 89-102
-
-
Hetz, C.1
-
9
-
-
82255173966
-
The unfolded protein response: From stress pathway to homeostatic regulation
-
Walter P, Ron D (2011) The unfolded protein response: From stress pathway to homeostatic regulation. Science 334(6059):1081-1086.
-
(2011)
Science
, vol.334
, Issue.6059
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
10
-
-
79952264011
-
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
-
Tabas I Ron D (2011 Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress Nat Cell Biol 13 3 184-190
-
(2011)
Nat Cell Biol
, vol.13
, Issue.3
, pp. 184-190
-
-
Tabas, I.1
Ron, D.2
-
11
-
-
84887620615
-
When ER stress reaches a dead end
-
Urra H, Dufey E, Lisbona F, Rojas-Rivera D, Hetz C (2013) When ER stress reaches a dead end. Biochim Biophys Acta 1833(12):3507-3517.
-
(2013)
Biochim Biophys Acta
, vol.1833
, Issue.12
, pp. 3507-3517
-
-
Urra, H.1
Dufey, E.2
Lisbona, F.3
Rojas-Rivera, D.4
Hetz, C.5
-
12
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon M, et al. (2002) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415(6867):92-96.
-
(2002)
Nature
, vol.415
, Issue.6867
, pp. 92-96
-
-
Calfon, M.1
-
13
-
-
0037083755
-
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein respon se
-
Lee K, et al. (2002) IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein respon se. Genes Dev 16(4):452-466.
-
(2002)
Genes Dev
, vol.16
, Issue.4
, pp. 452-466
-
-
Lee, K.1
-
14
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly act ive transcription factor
-
Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly act ive transcription factor. Cell 107(7):881-891.
-
(2001)
Cell
, vol.107
, Issue.7
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
15
-
-
80054722420
-
The unfolded protein response: Integrating stress signals through the stress sensor IRE1
-
Hetz C, Martinon F, Rodriguez D, Glimcher LH (2011) The unfolded protein response: Integrating stress signals through the stress sensor IRE1. Physiol Rev 91(4):1219-1243.
-
(2011)
Physiol Rev
, vol.91
, Issue.4
, pp. 1219-1243
-
-
Hetz, C.1
Martinon, F.2
Rodriguez, D.3
Glimcher, L.H.4
-
16
-
-
84863740827
-
The impact of the unfolded protein response on human disease
-
Wang S, Kaufman RJ (2012) The impact of the unfolded protein response on human disease. J Cell Biol 197(7):857-867.
-
(2012)
J Cell Biol
, vol.197
, Issue.7
, pp. 857-867
-
-
Wang, S.1
Kaufman, R.J.2
-
17
-
-
84891273860
-
Role of the unfolded protein response in organ physiology: Lessons from mouse models
-
Corn ejo VH, Pihán P, Vidal RL, Hetz C (2013) Role of the unfolded protein response in organ physiology: Lessons from mouse models. IUBMB Life 65(12):962-975.
-
(2013)
IUBMB Life
, vol.65
, Issue.12
, pp. 962-975
-
-
Corn Ejo, V.H.1
Pihán, P.2
Vidal, R.L.3
Hetz, C.4
-
18
-
-
84897094564
-
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
-
Hetz C, Mollereau B (2014) Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases. Nat Rev Neurosci 15(4):233-249.
-
(2014)
Nat Rev Neurosci
, vol.15
, Issue.4
, pp. 233-249
-
-
Hetz, C.1
Mollereau, B.2
-
19
-
-
84870838478
-
End oplasmic reticulum dysfunction in neurological disease
-
Roussel BD, et al. (2013) End oplasmic reticulum dysfunction in neurological disease. Lancet Neurol 12(1):105-118.
-
(2013)
Lancet Neurol
, vol.12
, Issue.1
, pp. 105-118
-
-
Roussel, B.D.1
-
20
-
-
4444237848
-
Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology
-
Conn KJ, et al. (2004) Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology. Brain Res 1022(1-2): 164-172.
-
(2004)
Brain Res
, vol.1022
, Issue.1-2
, pp. 164-172
-
-
Conn, K.J.1
-
21
-
-
70350043611
-
Homocysteine-induced endoplasmic reticulum protein (herp) is up-regulated in parkinson ian substantia nigra and present in the core of Lewy bodies
-
Slodzinski H, et al. (2009) Homocysteine-induced endoplasmic reticulum protein (herp) is up-regulated in parkinson ian substantia nigra and present in the core of Lewy bodies. Clin Neuropathol 28(5):333-343.
-
(2009)
Clin Neuropathol
, vol.28
, Issue.5
, pp. 333-343
-
-
Slodzinski, H.1
-
22
-
-
33846605587
-
Activation of the unfolded protein response in Parkinson's disease
-
Hoozemans JJ, et al. (2007) Activation of the unfolded protein response in Parkinson's disease. Biochem Biophys Res Commun 354(3):707-711.
-
(2007)
Biochem Biophys Res Commun
, vol.354
, Issue.3
, pp. 707-711
-
-
Hoozemans, J.J.1
-
23
-
-
84863230467
-
Endoplasmic reticulum stress is important for the manifestations of -synucleinopathy in vivo
-
Colla E, et al. (2012) Endoplasmic reticulum stress is important for the manifestations of -synucleinopathy in vivo. J Neurosci 32(10):3306-3320.
-
(2012)
J Neurosci
, vol.32
, Issue.10
, pp. 3306-3320
-
-
Colla, E.1
-
24
-
-
84863229691
-
Accumulation of toxic -synuclein oligomer within endoplasmic reticulum occurs in -synucleinopathy in vivo
-
Colla E, et al. (2012) Accumulation of toxic -synuclein oligomer within endoplasmic reticulum occurs in -synucleinopathy in vivo. J Neurosci 32(10):3301-3305.
-
(2012)
J Neurosci
, vol.32
, Issue.10
, pp. 3301-3305
-
-
Colla, E.1
-
25
-
-
84888070126
-
Identification and rescue of -synuclein toxicity in Parkinson patient-derived neurons
-
C hung CY, et al. (2013) Identification and rescue of -synuclein toxicity in Parkinson patient-derived neurons. Science 342(6161):983-987.
-
(2013)
Science
, vol.342
, Issue.6161
, pp. 983-987
-
-
Hung, C.Y.C.1
-
26
-
-
0038143287
-
Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons
-
Holtz WA, O'Malley KL (2003) Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. J Biol Chem 278(21):19367-19377.
-
(2003)
J Biol Chem
, vol.278
, Issue.21
, pp. 19367-19377
-
-
Holtz, W.A.1
O'Malley, K.L.2
-
27
-
-
0037114971
-
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease
-
Ryu EJ, et al. (2002) Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci 22(24):10690-10698.
-
(2002)
J Neurosci
, vol.22
, Issue.24
, pp. 10690-10698
-
-
Ryu, E.J.1
-
28
-
-
63349104307
-
Protective effect against Parkinson's disease-related insults through the activation of XBP1
-
Sado M, et al. (2009) Protective effect against Parkinson's disease-related insults through the activation of XBP1. Brain Res 1257:16-24.
-
(2009)
Brain Res
, vol.1257
, pp. 16-24
-
-
Sado, M.1
-
29
-
-
28244466782
-
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism
-
Silva RM, et al. (2005) CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem 95(4):974-986.
-
(2005)
J Neurochem
, vol.95
, Issue.4
, pp. 974-986
-
-
Silva, R.M.1
-
30
-
-
79953148080
-
The endoplasmic reticulum stress sensor, ATF6, protects against neurotoxin-induced dopaminergic neuronal death
-
Egawa N, et al. (2011) The endoplasmic reticulum stress sensor, ATF6, protects against neurotoxin-induced dopaminergic neuronal death. J Biol Chem 286(10): 7947-7957.
-
(2011)
J Biol Chem
, vol.286
, Issue.10
, pp. 7947-7957
-
-
Egawa, N.1
-
31
-
-
84859717205
-
Neurotoxin-induced ER stress in mouse dopaminergic neurons involves down-regulation of TRPC1 and inhibition of AKT/mTOR signaling
-
Selvaraj S, et al. (2012) Neurotoxin-induced ER stress in mouse dopaminergic neurons involves down-regulation of TRPC1 and inhibition of AKT/mTOR signaling. J Clin Invest 122(4):1354-1367.
-
(2012)
J Clin Invest
, vol.122
, Issue.4
, pp. 1354-1367
-
-
Selvaraj, S.1
-
32
-
-
38649108109
-
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
-
Hetz C, et al. (2008) Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc Natl Acad Sci USA 105(2):757-762.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.2
, pp. 757-762
-
-
Hetz, C.1
-
33
-
-
45849137877
-
Regulation of hepatic lipogenesis by the transcription factor XBP1
-
Lee AH , Scapa EF, Cohen DE, Glimcher LH (2008) Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320(5882):1492-1496.
-
(2008)
Science
, vol.320
, Issue.5882
, pp. 1492-1496
-
-
Lee, A.H.1
Scapa, E.F.2
Cabelli, D.E.3
Glimcher, L.H.4
-
34
-
-
50249086073
-
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser A, et al. (2008) XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134(5):743-756.
-
(2008)
Cell
, vol.134
, Issue.5
, pp. 743-756
-
-
Kaser, A.1
-
35
-
-
84860471873
-
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
-
Vidal RL, et al. (2012) Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. Hum Mol Genet 21(10):2245-2262.
-
(2012)
Hum Mol Genet
, vol.21
, Issue.10
, pp. 2245-2262
-
-
Vidal, R.L.1
-
36
-
-
84857852395
-
Activation of the unfolded protein response enhances motor recovery after spinal cord injury
-
Valenzuela V, et al. (2012) Activation of the unfolded protein response enhances motor recovery after spinal cord injury. Cell Death Dis 3:e272.
-
(2012)
Cell Death Dis
, vol.3
-
-
Valenzuela, V.1
-
37
-
-
70349627027
-
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
-
Hetz C, et al. (2009) XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev 23(19):2294-2306.
-
(2009)
Genes Dev
, vol.23
, Issue.19
, pp. 2294-2306
-
-
Hetz, C.1
-
38
-
-
78649338141
-
Autophagy and the integrated stress response
-
Kroemer G, Marino G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40(2):280-293.
-
(2010)
Mol Cell
, vol.40
, Issue.2
, pp. 280-293
-
-
Kroemer, G.1
Marino, G.2
Levine, B.3
-
39
-
-
0037118259
-
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
-
Giasson BI, et al. (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 34(4):521-533.
-
(2002)
Neuron
, vol.34
, Issue.4
, pp. 521-533
-
-
Giasson, B.I.1
-
40
-
-
84859577308
-
AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease
-
Zuleta A, Vida l RL, Armentano D, Parsons G, Hetz C (2012) AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease. Biochem Biophys Res Commun 420(3):558-563.
-
(2012)
Biochem Biophys Res Commun
, vol.420
, Issue.3
, pp. 558-563
-
-
Zuleta, A.1
Vida, L.R.L.2
Armentano, D.3
Parsons, G.4
Hetz, C.5
-
41
-
-
84868135034
-
ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease
-
Hashida K, et al. (2012) ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease. PLoS ONE 7(10):e47950.
-
(2012)
PLoS ONE
, vol.7
, Issue.10
-
-
Hashida, K.1
-
42
-
-
33751069967
-
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
-
Rutkowski DT, et al. (2006) Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol 4(11):e374.
-
(2006)
PLoS Biol
, vol.4
, Issue.11
-
-
Rutkowski, D.T.1
-
43
-
-
65649146419
-
ER stress protects from retinal degeneration
-
Mendes CS, et al. (2009) ER stress protects from retinal degeneration. EMBO J 28(9): 1296-1307.
-
(2009)
EMBO J
, vol.28
, Issue.9
, pp. 1296-1307
-
-
Mendes, C.S.1
-
44
-
-
77957826835
-
Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery
-
Mao XR, Crowder CM (2010) Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery. Mol Cell Biol 30(21):5033-5042.
-
(2010)
Mol Cell Biol
, vol.30
, Issue.21
, pp. 5033-5042
-
-
Mao, X.R.1
Crowder, C.M.2
-
45
-
-
79953001199
-
Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein
-
Li J, Wang JJ, Zhang SX (2011) Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein J Biol Chem 286(6):4912-4921.
-
(2011)
J Biol Chem
, vol.286
, Issue.6
, pp. 4912-4921
-
-
Li, J.1
Wang, J.J.2
Zhang, S.X.3
-
46
-
-
79955543079
-
Cardioprotection by endoplasmic reticulum stress-induced autophagy
-
Petrovski G, et al. (2011) Cardioprotection by endoplasmic reticulum stress-induced autophagy. Antioxid Redox Signal 14(11):2191-2200.
-
(2011)
Antioxid Redox Signal
, vol.14
, Issue.11
, pp. 2191-2200
-
-
Petrovski, G.1
-
47
-
-
84864866226
-
Hormesis: Protecting neurons against cellular stress in Parkinson disease
-
Matus S, Castillo K, Hetz C (2012) Hormesis: Protecting neurons against cellular stress in Parkinson disease. Autophagy 8(6):997-1001.
-
(2012)
Autophagy
, vol.8
, Issue.6
, pp. 997-1001
-
-
Matus, S.1
Castillo, K.2
Hetz, C.3
-
48
-
-
84862303631
-
ER stress inhibits neuronal death by promoting autophagy
-
Fouillet A, et al. (2012) ER stress inhibits neuronal death by promoting autophagy. Autophagy 8(6):915-926.
-
(2012)
Autophagy
, vol.8
, Issue.6
, pp. 915-926
-
-
Fouillet, A.1
-
49
-
-
84883387793
-
Targeting the unfolded protein response in disease
-
Hetz C, Chevet E, Harding HP (2013) Targeting the unfolded protein response in disease. Nat Rev Drug Discov 12(9):703-719.
-
(2013)
Nat Rev Drug Discov
, vol.12
, Issue.9
, pp. 703-719
-
-
Hetz, C.1
Chevet, E.2
Harding, H.P.3
-
51
-
-
0034328476
-
Scaleable chromatographic purification process for recombinant adeno-associated virus (rAAV
-
O'Riordan CR, Lachapelle AL, Vincent KA, Wadsworth SC (2000) Scaleable chromatographic purification process for recombinant adeno-associated virus (rAAV). J Gene Med 2(6):444-454.
-
(2000)
J Gene Med
, vol.2
, Issue.6
, pp. 444-454
-
-
O'Riordan, C.R.1
Lachapelle, A.L.2
Vincent, K.A.3
Wadsworth, S.C.4
-
52
-
-
84861188701
-
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1
-
Rodriguez DA, et al. (2012) BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1. EMBO J 31(10):2322-2335.
-
(2012)
EMBO J
, vol.31
, Issue.10
, pp. 2322-2335
-
-
Rodriguez, D.A.1
|