α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease

Neurobiology of Disease

Volumn 76, Issue , 2015, Pages 112-125

  Credle, Joel J ^a   Forcelli, Patrick A ^a   Delannoy, Michael ^b   Oaks, Adam W ^a   Permaul, Eva ^c   Berry, Deborah L ^c   Duka, Valeriy ^a   Wills, Jonathan ^a   Sidhu, Anita ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

ATF6; COPII; Endoplasmic reticulum associated degradation; Neurodegeneration; Parkinson's disease; Unfolded protein response; XBP1; Synuclein

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA SYNUCLEIN; COAT PROTEIN COMPLEX II; GLUCOSE REGULATED PROTEIN 78; ATF6 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DOPAMINERGIC NERVE CELL; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; UNFOLDED PROTEIN RESPONSE; COATED VESICLE; METABOLISM; NERVE CELL; TUMOR CELL LINE;

ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA-SYNUCLEIN; CELL LINE, TUMOR; CELL NUCLEUS; COP-COATED VESICLES; ENDOPLASMIC RETICULUM STRESS; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; HUMANS; NEURONS; PARKINSON DISEASE; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; UNFOLDED PROTEIN RESPONSE;

EID: 84923871028     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2015.02.005     Document Type: Article

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