Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

Science Translational Medicine

Volumn 5, Issue 206, 2013, Pages

  Moreno, Julie A ^a   Halliday, Mark ^a   Molloy, Colin ^a   Radford, Helois ^a   Verity, Nicholas ^a   Axten, Jeffrey M ^b   Ortori, Catharine A ^c   Willis, Anne E ^a   Fischer, Peter M ^c   Barrett, David A ^c   Mallucci, Giovanna R ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GSK 2606414; NEUROPROTECTIVE AGENT; PHOSPHOTRANSFERASE; PRION PROTEIN; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN SPONGIOSIS; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG PENETRATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLIOSIS; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN TARGETING; UNFOLDED PROTEIN RESPONSE;

ADENINE; ADMINISTRATION, ORAL; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; INDOLES; MICE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PRION DISEASES; PRIONS; PROTEIN BIOSYNTHESIS; SYNAPSES; UNFOLDED PROTEIN RESPONSE;

EID: 84885463900     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3006767     Document Type: Article

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