Why fruits and vegetables are good for health

Environmentally Friendly Technologies for Agricultural Produce Quality

Volumn , Issue , 2005, Pages 333-396

  Ekman, Jenny H ^a   Patterson, Brian D ^b  

^a Department of Primary Industries   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84887207963     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (391)

1. Abramovitz, D., S. Gavri, D. Harats, H. Levkovitz, D. Mirelman, T. Miron, S. Eilat-Adar, A. Rabinkov, M. Wilchek, M. Eldar, and Z. Vered. 1999. Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet. Coron. Artery Dis. 10:515-519.
2. Ackermann, R.T., C.D. Mulrow, and C.D. Ramir. 2001. Garlic shows promise for improving some cardiovascular risk factors. Arch. Intern. Med. 161:813-824.
3. Ali, M., K.K. Al-Quattan, F. Al-Enezi, R.M.A. Khanafer, and R.M.A. Mus. 1999. Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet. Prostaglandins Leukot. Essent. Fatty Acids 62:253-259.
4. Ali, M., M. Thomson, and M. Afzal. 2000. Garlic and onions: their effect on eicosanoid metabolism and its clinical relevance. Prostaglandins Leukotrienes Essential Fatty Acids 62:55-65.
5. Ankri, S. and D. Mirelman. 1999. Antimicrobial properties of allicin from garlic. Microbes Infect. 1:125-129
6. Arai, Y., S. Watanabe, M. Kimira, K. Shimoi, R. Mochizuki, and N. Kinae. 2000. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J. Nutr. 130:2243-2250.
7. Ariazi, E.A., Y. Satomi, M.J. Ellis, J.D. Haag, W. Shi, C.A. Sattler, and M.N. Gould. 1999. Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. Cancer Res. 59:1917-1928.
8. Ashfield-Watt, P.A.L., S.J. Moat, S.N. Doshi, and I.F.W. McDowell. 2001. Folate, homocysteine, endothelial function and cardiovascular disease. What is the link? Biomed. Pharmacotherapy 55:425-433.
9. Atkinson, C., H.E. Skor, E.D. Fitzgibbons, D. Scholes, C. Chen, K. Wähälä, S.M. Schwartz, and J.W. Lampe. 2003. Urinary equol excretion in relation to 2-hydroxyestrone and 16-hydroxyestrone concentrations: an observational study of young to middle-aged women. J. Steroid Biochem. Mol. Biol. 86:71-77.
10. Avellone, G., V. Di Garbo, G. Abruzzese, M. Bono, G. Avellone, G. Raneli, R. De Simone, and G. Licata. 2003. Cross-over study on effects of Mediterranean diet in two randomly selected population samples. Nutr. Res. 23:1329-1339.
11. Awad, A.B., H. Williams, and C.S. Fink. 2003. Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. J. Nutrit. Biochem. 14:111-119.
12. Aydin, A., G. Ersöz, O. Tekesin, E. Akçiçek, and M. Tuncyürek. 2000. Garlic oil and Helicobacter pylori infection. Am. J. Gastroenterol. 95:563-564.
13. Bailey, H.H., D. Levy, L.S. Harris, J.C. Schink, F. Foss, P. Beatty, and S.A. Wadler. 2002. Phase II trial of daily perillyl alcohol in patients with advanced ovarian cancer: eastern cooperative oncology group study E2E96. Gynaecol. Oncol. 85:464-468.
14. Balachandran, B. and A.V. Rao. 2003. Time-dependent uptake and antiperoxidative potential of lycopene in multilamellar liposomes. Food Res. Internat. 36:611-616.
15. Balasenthil, S., C.R. Ramachandran, and S. Nagini. 2001. Prevention of 4-nitroquinoline 1- oxide-induced rat tongue carcinogenesis by garlic. Fitoterapia72:524-531.
16. Balasenthil, S., K.S. Rao, and S. Nagini. 2002. Garlic induces apoptosis during 7, 12-dimethylbenz [a ]anthracene-induced hamster buccal pouch carcinogenesis. Oral Oncol. 38: 431-436.
17. Baluchnejadmojarad, T. and S. Roghani. 2003. Garlic extract attenuates time-dependent changes in the reactivity of isolated aorta in streptozotocin-diabetic rats. Life Sci. 73:2281-2289.
18. Banerjee, S.K., M. Maulik, S.C. Mancahanda, A.K. Dinda, S.K. Gupta, and S.K. Maulik. 2002. Dose-dependent induction of endogenous antioxidants in rat heart by chronic administration of garlic. Life Sci. 70:1509-1518.
19. Barch, D.H., N.S. Pillay, and L.M. Rundhaugen. 1995. Ellagic acid induces transcription of the rat glutathione S-transferase Ya gene. Carcinogenesis 16:665-668.
20. Bardon, S., V. Foussard, S. Fournel, and A. Loubat. 2002. Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. Cancer Lett. 181:187-194.
21. Baritaux, O., M.J. Amiot, H. Richard, and J. Nicolas. 1991. Enzymatic browning of basil (Ocimum basilicum L.): studies on phenolic compounds and polyphenol oxidase. Sci. Aliments. 11:49-62.
22. Barja, G. 2002. Rate of generation of oxidative stress-related damage and animal longevity. Free Radic. Biol. Med. 33:1167-1172.
23. Barja, G. and A. Herrero. 2000. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J. 14:312-318.
24. Barter, P., J. Kastelein, A. Nunn, and R. Hobbs and Future Forum Editorial Board. 2003. High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions. Atherosclerosis 168:195-211.
25. Bazzano, L.A., J. He, L.G. Ogden, C.M. Loria, S. Vupputuri, L. Myers, and P.K. Whelton. 2002. Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Am. J. Clin. Nutr. 76:93-99.
26. Beatty, E.R., J.D. O’Reilly, T.G. England, G.T. McAnlis, I.S. Young, C.A. Geissler, T.A. Sanders, and H. Wiseman. 2000. Effect of dietary quercetin on oxidative DNA damage in healthy human subjects. Br. J. Nutr. 84:919-925.
27. Beatty, S., I.J. Murray, D.B. Henson, D. Carden, H. Koh, and M.E. Boulton. 2001. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest. Ophthalmol. Visual Sci. 42:439-446.
28. Belguendouz, L., L. Fremont, and M.T. Gozzelino. 1998. Interaction of transresveratrol with plasma lipoproteins. Biochem. Pharmacol. 55:811-816.
29. Bell, M.C., P. Crowley-Nowick, H.L. Bradlow, D.W. Sepkovic, D. Schmidt-Grimminger, P. Howell, E.J. Mayeaux, A. Tucker, E.A. Turbat-Herrera, and J.M. Mathis. 2000. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol. Oncol. 78:123-129.
30. Bell, S.J. and B. Sears. 2003. Low-glycemic-load diets: impact on obesity and chronic diseases. Crit. Rev. Food Sci. Nutr. 43:357-377.
31. Bernhard, D., W. Schwaiger, R. Crazzolara, I. Tinhofer, R. Kofler, and A. Csordas. 2003. Enhanced MTT-reducing activity under growth inhibition by resveratrol in CEMC7H2 lymphocytic leukemia cells. Cancer Lett. 195:193-199.
32. Bernstein, P.S., F. Khachik, L.S. Carvalho, G.J. Muir, D.Y. Zhao, and N.B. Katz. 2001. Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye. Exp. Eye Res. 72:215-223.
33. Bianchini, F. and N.B. Vainio. 2001. Allium vegetables and organosulfur compounds: do they help prevent cancer? Environ. Health Perspec. 109:893-902.
34. Biesalski, H.K. 2000. The role of antioxidants in nutritional support. Nutr. 16:593-596.
35. Block, E., M. Birringer, W. Jiang, T. Nakahodo, H.J. Thompson, P.J. Toscano, H. Uzar, X. Zhang, and Z. Zhu. 2001. Allium chemistry: synthesis, natural occurrence, biological activity and chemistry of Se-alk(en)ylselenocysteines and their gamma-glutamyl derivatives and oxidation products. J. Agric. Food Chem. 49:458-470.
36. Block, E., X.J. Cai, P.C. Uden, X. Zhang, B.D. Quimby, and J.J. Sullivan. 1996. Allium chemistry: natural abundance of organoselenium compounds from garlic, onion and related plants and in human garlic breath. Pure Appl. Chem. 68:937-944.
37. Bock, K.W. 2003. Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects. Biochem. Pharmacol. 66:691-696.
38. Böhm, V., K. Fröhlich, and R. Bitsch. 2003. Rosehip - a “new” source of lycopene? Mol. Aspects Med. 24:384-389.
39. Bonnesen, C., C. Eggleston, and J.D. Hayes. 2001. Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Res. 61:6120-6130.
40. Borek, C. 2001. Antioxidant health effects of aged garlic extract. J. Nutr. 131:1010S-1015S.
41. Boscher, J., J. Auger, N. Mandon, and S. Ferary. 1995. Qualitative and quantitative comparison of volatile sulphides and flavour precursors in different organs of some wild and cultivated garlics. Biochem. Syst. Ecol. 23:787-791.
42. Boyle, S.P., V.L. Dobson, S.J. Duthie, J.A. Kyle, and A.R. Collins. 2000. Absorption and DNA protective effects of flavonoid glycosides from an onion meal. Eur. J. Nutr. 39:213-223.
43. Bradbury, J. 2001. Lutein may help reduce atherosclerosis. Lancet 357:2030.
44. Bramley, P.M. 2000. Is lycopene beneficial to human health. Phytochem. 54:233-236.
45. Brandt, K., L.P. Christensen, J. Hansen-Møller, S.L. Hansen, J. Haraldsdottir, L. Jespersen, S. Purup, A. Kharazmi, V. Barkholt, H. Frøkiær, and M. Kobæk-Larsen. 2004. Health promoting compounds in vegetables and fruits: a systematic approach for identifying plant components with impact on human health. Trends Food Sci. Technol. 15:384-393.
46. Bravo, L. 1998. Polyphenols: chemistry, dietary sources, metabolism and nutritional significance. Nutr. Rev. 11:317.
47. Bray, F., R. Sankila, J. Ferlay, and D.M. Parkin. 2002. Estimates of cancer incidence and mortality in Europe in 1995. Eur. J. Cancer 38:99-166.
48. Breinholt, V.M., A-M. Mølck, G.W. Svendsen, B. Daneshvar, A.M. Vinggaard, M. Poulsen, and L.O. Dragste. 2003. Effects of dietary antioxidants and 2-amino-3-methylimidazo[ 4. 5-f]- quinoline (IQ) on preneoplastic lesions and on oxidative damage, hormonal status: and detoxification capacity in the rat. Food Chem. Toxicol. 41:1315-1323.
49. Breithaupt-Grogler, K., M. Ling, H. Boudoulas, and H. Belz. 1997. Protective effect of chronic garlic intake on elastic properties of aorta in the elderly. Circulation 96:2649-2655.
50. Briggs, W.H., J.D. Folts, H.E. Osman, and E.L. Goldman. 2001. Administration of raw onion inhibits platelet-mediated thrombosis in dogs. J. Nutr. 131:2619-2622.
51. Broitman, S.A., J. Wilkinson 4th, and Cerda, S. 1996. Effects of monoterpenes and mevinolin on murine colon tumour CT-26 in vitro and its hepatic ‘metastases’ in vivo. Adv. Exp. Med. Biol. 401:111-130.
52. Brooks, J.D., V.G. Paton, and G. Vidanes. 2001. Potent induction of Phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol. Biomarkers Prevention 10:949-955.
53. Brown, P.D., J.G. Tokuhisa, M. Reichelt, and J. Gershenzon. 2003. Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana. Phytochemistry 62:471-481.
54. Brownson, D.M., N.G. Azios, B.K. Fuqua, S.F. Dharmawardhane, and T.J. Mabry. 2002. Flavonoid effects relevant to cancer. J. Nutr. 132:3482S-3489S.
55. Bub, A., B. Watzl, M. Blockhaus, K. Briviba, U. Liegibel, H. Müller, B.L. Pool-Zobel, and G. Rechkemmer. 2003. Fruit juice consumption modulates antioxidative status, immune status and DNA damage. J. Nutr. Biochem. 14:90-98.
56. Burns, J., P.D. Fraser, and P.M. Bramley. 2003. Identification and quantification of carotenoids, tocopherols and chlorophylls in commonly consumed fruits and vegetables. Phytochemistry 62:939-947.
57. Buskov, S., J. Hasselstrøm, C.E. Olsen, H. Sørensen, J.C. Sørensen, and S. Sørensen. 2000. Supercritical fluid chromatography as a method of analysis for the determination of 4-hydroxybenzylglucosinolate degradation products. J. Biochem. Bioph. Meth. 43:157-174.
58. Butterfield, D.A., A. Castegna, C.B. Pocernich, J. Drake, G. Scapagnini, and V. Calabrese. 2002. Nutritional approaches to combat oxidative stress in Alzheimer’s disease. J. Nutr. Biochem. 13:444-461.
59. Cano, A., M. Acosta, and M.B. Arnao. 2003. Hydrophilic and lipophilic antioxidant activity changes during on-vine ripening of tomatoes (Lycopersicon esculentum Mill.). Postharvest Biol. Technol. 28:59-65.
60. Cao, Y., R. Cao, and E. Bråkenhielm. 2002. Antiangiogenic mechanisms of diet-derived polyphenols. J. Nutr. Biochem. 13:380-390.
61. Casagrande, F. and J.M. Darbon. 2001. Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem. Pharmacol. 61:1205-1215.
62. Chan, K., C. Hsu, and M. Yin. 2002. Protective effect of three diallyl sulphides against glucoseinduced erythrocyte and platelet oxidation and ADP-induced platelet aggregation. Thrombosis Res. 108:317-322.
63. Chandalia, M., A. Garg, D. Lutjohann, K. von Bergmann, S.M. Grundy, and L.J. Brinkley. 2000. Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. New Engl. J. Med. 342:1392-1398.
64. Chisolm, G.M. and D. Steinberg. 2000. The oxidative modification hypothesis of atherogenesis:an overview. Free Radic. Biol. Med. 28:1815-1826.
65. Choi, J.S., H.Y. Chung, S.S. Kang, M.J. Jung, J.W. Kim, J.K. No, and H.A. Jung. 2002. The structure-activity relationship of flavonoids as scavengers of peroxynitrite. Phytother. Res. 16:232-235.
66. Christen, Y. 2000. Oxidative stress and Alzheimer disease. Am. J. Clin. Nutr. 71:621S-629S.
67. Chu, Y.-H., D.A. Chang, and D.A. Hsu. 2000. Flavonoid content of several vegetables and their antioxidant activity. J. Sci. Food Agric. 80:561-566.
68. Chung, M.J., S.H. Lee, and N.J. Sung. 2002. Inhibitory effect of whole strawberries. garlic juice or kale juice on endogenous formation of N-nitrosodimethylamine in humans. Cancer Lett. 182:1-10.
69. Cipriani, F., E. Buiatti, and D. Palli. 1991. Gastric cancer in Italy. Ital. J. Gastroenterol. 23:429-435.
70. Clinton, S.K. 1998. Lycopene: chemistry, biology, and implications for human health and disease. Nutr. Rev. 56:35-51.
71. Combourieu, B., L.A.M. Elfoul, and S. Robot. 2000. Identification of new derivatives of sinigrin and glucotropaeolin produced by the human digestive microflora using H-1 NMR spectroscopy analysis of in vitro incubations. Drug Metab. Disposit. 29:1440-1445.
72. Commenges, D., V. Scotet, S. Renaud, H. Jacqmin-Gadda, P. Barberger-Gateau, and J.F. Dartigues. 2000. Intake of flavonoids and risk of dementia. Eur. J. Epidemiol. 16:357-363.
73. Conaway, C.C., J. Krzeminski, S. Amin, and F.-L. Chung. 2001. Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes. Chem. Res. Toxicol. 14:1170-1176.
74. Cordain, L., M.R. Eades, and M.D. Eades. 2003. Hyperinsulinemic diseases of civilization:more than just Syndrome X. Comp. Biochem. Physiol. A. 136:95-112.
75. Crowell, P.L., Z. Ren, S. Lin, E. Vedejs, and M.N. Gould. 1994. Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation. Biochem. Pharmacol. 47:1405-1415.
76. Crowell, P.L. 1999. Prevention and therapy of cancer by dietary monoterpenes. J. Nutr. 129:775S-778S.
77. Cummings, S.R., J.L. Kelsey, M.C. Nevitt, and K.J. O’Dowd. 1985. Epidemiology of osteoporosis and osteoporotic fractures. Epidem. Rev. 7:178-208.
78. Curran-Celentano, J., B.R. Hammond Jr., T.A. Ciulla, D.A. Cooper, L.M. Pratt, and R.B. Danis. 2001. Relation between dietary intake, serum concentrations, retinal concentrations of lutein and zeaxanthin in adults in a midwest population. Am. J. Clin. Nutr. 74:796-802.
79. Dabestani, R. and I.N. Ivanov. 1999. A compilation of physical and photophysical properties of polycyclic aromatic hydrocarbons. Photochem. Photobiol. 70:10-34.
80. Dashwood, R.H. and Xu, M. 2003. The disposition and metabolism of 2-amino-3-methylimidazo-[ 4. 5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol. Food Chem. Toxicol. 41:1185-1192.
81. Dashwood, R.H. 1998. Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables? Chem. Biol. Interact. 110:1-5.
82. Dashwood, R.H. 2002. Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity:an A-to-Z guide to chemopreventive agents, promoters, and transgenic models. Mutation Res. 511:89-112.
83. Davis, L.E., J. Shen, and R.E. Royer. 1994. In vitro synergism of concentrated Allium sativum extract and amphotericin B against Cryptococcus neoformans. Planta Med. 60:546-549
84. de Jong, A., J. Plat, and R.P. Mensink. 2003. Metabolic effects of plant sterols and stanols. J. Nutr. Biochem. 14:362-369.
85. Dekker, M., R. Verkerk, and W.M.F. Jongen. 2000. Predictive modelling of health aspects in the food production chain: a case study on glucosinolates in cabbage. Trends Food Sci. Technol. 11:174-181.
86. Deschamps, V., P. Barberger-Gateau, E. Peuchant, and J.M. Orgogozo. 2001. Nutritional factors in cerebral aging and dementia: epidemiological arguments for a role of oxidative stress. Neuroepidemiology 20:7-15.
87. Dillon, S.A., R.S. Burmi, G.M. Lowe, D. Billington, and K. Rahman. 2003. Antioxidant properties of aged garlic extract: an in vitro study incorporating human low density lipoprotein. Life Sci. 72:1583-1594.
88. Dirsch, V.M., A.K. Kiemer, H. Wagner, and A.M. vollmar. 1998. Effect of allicin and ajoene (two compounds of garlic) on inducible nitric oxide synthase. Atherosclerosis. 139:333-339.
89. Dirsch, V.M. and A.M. Vollmar. 2001. Ajoene. a natural product with non-steroidal antiinflammatory drug (NSAID)-like properties? Biochem. Pharmacol. 61:587-593.
90. Dirsch, V.M. 1998. Ajoene (a compound of garlic) induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kB. Mol. Pharmacol. 53:402-407.
91. Dong, Z. 2003. Molecular mechanism of the chemopreventive effect of resveratrol. Mutation Res./Fundamental and Molecular Mechanisms of Mutagenesis 523:145-150.
92. Drake, J., R. Petroze, A. Castegna, Q. Ding, J.N. Keller, W.R. Markesbery, M.A. Lovell, and D.A. Butterfield. 2004. 4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer’s disease. Neurosci. Lett. 356:155-158.
93. Drewnowski, A. and C. Gomez-Carneros. 2000. Bitter taste, Phytonutrients, and the consumer:a review. Am. J. Clin. Nutr. 72:1424-1435.
94. Duthie, G.G., S.J. Duthie, and J.A.M. Kyle. 2000. Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants. Nutr. Res. Rev. 13:79-106.
95. Dwyer, J.H., M. Navab, K.M. Dwyer, K. Hassan, P. Sun, A. Shircore, S. Hama-Levy, G. Hough, X. Wang, T. Drake, C.N. Merz, and A.M. Fogelman. 2001. Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study. Circulation 103:2922-2927.
96. Edenharder, R., H. Krieg, V. Köttgen, and K.L. Platt. 2003. Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7. 8-dihydrodiol in mice in vivo by fruits, vegetables and flavonoids. Envir. Mutagen. 537:169-181.
97. Egen-Schwind, C., R. Eckard, F.W. Jekat, and H. Winterhoff. 1992. Pharmacokinetics of vinyldithiins, transformation products of allicin. Planta Med. 58: 8-13.
98. Elegbede, J.A. and M.N. Gould. 2002. Monoterpenes reduced adducts formation in rats exposed to aflatoxin B1. Afr. J. Biotechnol. 1:46-50.
99. Elfoul, L., S. Rabot, N. Khelifa, A. Quinsac, and A. Rimbault. 2001. Formation of allyl isothiocyanate from sinigrin in the digestive tract of rats with a human colonic strain of Bacteroides thetaiotaomicron. FEMS Microbiol. Lett. 197:99-103.
100. Elkayam, A., D. Mirelman, E. Peleg, M. Wilchek, T. Miron, A. Rabinkov, S. Sadetzki, and T. Rosenthal. 2001. The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats. Am. J. Hypertension 14:377-381.
101. Elson, C.E. 1995. Suppression of mevalonate pathway activities by dietary isoprenoids:protective roles in cancer and cardiovascular disease. J. Nutr. 125:1666S-1672S.
102. Fahey, J.W. and P. Talalay. 1999. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxification enzymes. Food Chem. Toxicol. 37:973-879.
103. Fahey, J.W., A.T. Zalcmann, and P. Talalay. 2001. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry 56:5-51.
104. Fahey, J.W., Y. Zhang, and P. Talalay. 1997. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Nat. Acad. Sci. USA 94:10367-10372.
105. Fahey, J.W., K.L. Wade, K.K. Stephenson, and F.E. Chou. 2003. Separation and purification of glucosinolates from crude plant homogenates by high-speed counter-current chromatography. J. Chromatog. A. 996:85-93.
106. Fahey, J.W., X. Haristoy, P.M. Dolan, T.W. Kensler, I. Scholtus, K.K. Stephenson, A. Lozniewski, and P. Talalay. 2002. Sulforaphane inhibits extracellular, intracellular and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyreneinduced stomach tumors. Proc. Natl. Acad. Sci. USA 99:7610-7615.
107. Ferguson, L.R., M. Philpott, and N. Karunasinghe. 2004. Dietary cancer and prevention using antimutagens. Toxicology. 198:147-159.
108. Feskanich, D., R.G. Ziegler, and D.S. Michaud. 2000. Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women. J. Nat. Cancer Inst. 92:1812-1823.
109. Fleischauer, A.T. and L. Arab. 2001. Garlic and cancer - a critical review of the epidemiologic literature. J. Nutr. 131:1032S-1040S.
110. Fordham, I.M., B.A. Clevidence, E.R. Wiley, and R.H. Zimmerman. 2001. Fruit of autumn olive: a rich source of lycopene. HortScience 36:1136-2001.
111. Fragopoulou, E., S. Antonopoulou, T. Nomikos, and C.A. Demopoulos. 2003. Structure elucidation of phenolic compounds from red/white wine with antiatherogenic properties. Biochim. Biophys. Acta 1632:90-99.
112. Fraser, P.D. and P.M. Bramley. 2004. The biosynthesis and nutritional uses of carotenoids. Prog. Lipid. Res. 43:228-265.
113. Freedman, J.E., C. Parker, and L. Li. 2001. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation. 103:2792-2798.
114. Frei, B. 2003. To C or not to C. that is the question! J. Am. Coll. Cardiol. 42:253-255.
115. Fuhrman, B., A. Elis, and M. Aviram. 1997. Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages. Biochem. Biophys. Res. Comm. 233:658-662.
116. Galvano, F., L. La Fauci, G. Lazzarino, V. Fogliano, A. Ritieni, S. Ciappellano, N.C. Battistini, B. Tavazzi, and G. Galvano. 2004. Cyanidins: metabolism and biological properties. J. Nutr. Biochem. 15:2-11.
117. Gamet-Payrastre, L., P. Li, S. Lumeau, G. Cassar, M.-A. Dupont, S. Chevolleau, N. Gasc, J. Tulliez, and F. Terce. 2000. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. 60:1426-1433.
118. Gandini, S., H. Merzenich, C. Robertson, and P. Boyle. 2000. Meta-analysis of studies on breast cancer risk and diet: the role of fruit and vegetable consumption and the intake of associated micronutrients. Eur. J. Cancer 36:636-646.
119. Gao, C.M., T. Takezaki, and J.H. Ding. 1999. Protective effect of allium vegetables against both esophageal and stomach cancer: a simultaneous case-referent study of a highepidemic area in Jiangsu province, China. Jpn. J. Cancer Res. 90:614-625.
120. Gao, X., A.T. Dinkova-Kostova, and P. Talalay. 2001. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. Proc. Natl. Acad. Sci. USA 98:15221-15226.
121. Gao, Z., H. Xu, X. Chen, and H. Chen. 2003. Antioxidant status and mineral contents in tissues of rutin and baicalin fed rats. Life Sci. 73:1599-1610.
122. Gardner, C.D., L.M. Chatterjee, and J.J. Carlson. 2001. The effect of a garlic preparation on plasma lipid levels in moderately hypercholesterolemic adults. Atherosclerosis 154:213-220.
123. Gebhardt, R. and Beck, H. 1996. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Lipids 31:1269-1276.
124. Gebhardt, R. 2002. Inhibition of cholesterol biosynthesis in HepG2 cells by artichoke extracts is reinforced by glucosidase pretreatment. Phyto. Res. 16:368-372.
125. Gingras, D., M. Gendron, D. Boivin, A. Moghrabi, Y. Théorêt, and R. Béliveau. 2004. Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables. Cancer Lett. 203:35-43.
126. Giovannucci, E. 1999. Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiological literature. J. Natl. Cancer Inst. 91:317-325.
127. Grant, W.B. 2004. A multicountry ecologic study of risk and risk reduction factors for prostate cancer mortality. Eur. Urol. 45:271-279.
128. Greenacre, S.A.B. and R. Ischiropoulos. 2001. Tyrosine nitration: localisation, quantification, consequences for protein function and signal transduction. Free Rad. Res. 34:541-581.
129. Greenwald, P., C.K. Clifford, and J.A. Milner. 2001. Diet and cancer prevention. Eur. J. Cancer 37:948-965.
130. Grey, C.E. and P. Adlercreutz. 2003. Ability of antioxidants to prevent oxidative mutations in Salmonella typhimurium TA102. Mutat. Res. 527:27-36.
131. Griffiths G., L. Trueman, T. Crowther, B. Thomas, and B. Smith. 2002. Onions-a global benefit to health. Phytother. Res. 16:603-615.
132. Grönberg, H. 2003. Prostate cancer epidemiology. Lancet 361:859-864.
133. Gupta, S., F. Afaqa, and H. Mukhtara. 2002. Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells. Oncogene 21:3727-3738.
134. Gupta, S.K., D. Trivedi, S. Srivastava, S. Joshi, N. Halder, and S.D. Verma. 2003. Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study. Nutrition 19:794-799.
135. Guyonnet, D., C. Belloir, M. Suschetet, M.-H. Siess, and M.-H. Le Bon. 2001. Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction. Mutat. Res. 495:135-145.
136. Haag, J.D. and M.N. Gould. 1994. Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene. Cancer Chemother. Pharmacol. 34:477-483.
137. Harborne, J.B. and C.A. Williams. 2000. Advances in flavonoid research since 1992. Phytochemistry 55:481-504.
138. Hassan, H.T. 2004. Ajoene: a new anti-leukaemia agent for AML therapy. Leuk. Res. (in press).
139. Havsteen, B.H. 2002. The biochemistry and medical significance of the flavonoids. Pharmacol. Therapeut. 96:67-202.
140. Haw, N., G.W. Veijer, and L.S. Roe. 2001. Randomized controlled trial of use by hypercholesterolaemic patients of a vegetable oil sterol-enriched fat spread. Atherosclerosis 156:329-337.
141. Hecht, S.S. 2000. Inhibition of carcinogenesis by isothiocyanates. Drug Metab. Rev. 32:395-411.
142. Heck, A.M., B.A. DeWitt, and A.L. Lukes. 2000. Potential interactions between alternative therapies and warfarin. Am. J. Health Syst. Pharm. 57:1221-1227.
143. Heijnen, C.G., G.R. Haenen, F.A. van Acker, W.J. van der Vijgh, and A. Bast. 2001. Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. Toxicol. In Vitro. 15:3-6.
144. Heilbronn, L.K., M. Noakes, and P.M. Clifton. 2002. The effect of high and low-glycemic index energy restricted diets on plasma lipid and glucose profiles in type 2 diabetic subjects with varying glycemic control. J. Amer. College Nutr. 21:120-127.
145. Heim, K.E., A.R. Tagliaferro, and D.J. Bobilya. 2002. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J. Nutr. Biochem. 13: 572-584.
146. Heinonen, O.P., D. Albanes, J. Virtamo, P.R. Taylor, J.K. Huttunen, A.M. Harman, J. Hapakoski, N. Malila, S. Ratualahti, H. Maenpaa, L. Teerenhovi, L. Koss, M. Virolainen, and B.K. Edwards. 1998. Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J. Natl. Cancer Inst. 90:440-446.
147. Hintze, K.J., A.-S. Keck, J.W. Finley, and E.H. Jefferey. 2003. Induction of hepatic thioreductase activity by sulforaphane, both in Hepa1c1c7 cells and in male Fisher 344 rats. J. Nutr. Biochem. 14:173-179.
148. Hirsch, K. 2000. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr. Cancer 38:245-254.
149. Ho, P.I., D. Ashline, S. Dhitavat, D. Ortiz, S.C. Collins, T.B. Shea, and E. Rogers. 2003. Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol. Dis. 14:32-42.
150. Hohl, R.J. 1996. Monoterpenes as regulators of malignant cell proliferation, pp. 137-157, in Dietary Phytochemicals in Cancer Prevention and Treatment. Plenum Press, New York.
151. Hollman, P.C., J.M. van Trijp, M.N. Buysman, M.S. van der Gaag, M.J. Mengelers, J.H. de Vries, and M.B. Katan. 1997. Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett. 418:152-156.
152. Horner, N.K., A.R. Kristal, J. Prunty, H.E. Skor, J.D. Potter, and J.W. Lampe. 2002. Dietary determinants of plasma enterolactone. Cancer Epidemiol. Biomarkers Prev. 11:121-126.
153. Hsing, A.W., A.P. Chokkalingam, Y. Gao, N.P. Madigan, J. Deng, G. Gridley, and J.F. Fraumeni. 2002. Allium vegetables and risk of prostate cancer: a population-based study. J. Nat. Cancer Inst. 94:1648-1651.
154. Hsu J.-T., C. Ying, and C.-J. Chen. 2000. Regulation of inducible nitric oxide synthase by dietary phytoestrogen in MCF-7 human mammary cancer cells. Reprod. Nutr. Dev. 40:11-18.
155. Hubbard, G.P., S. Wolffram, J.A. Lovegrove, and J.M. Gibbins. 2003. The role of polyphenolic compounds in the diet as inhibitors of platelet function. Proc. Nutr. Soc. 62:469-475.
156. Hudson, T.S., P.S. Carlton, A. Gupta, G.D. Stoner, and M.A. Morse. 2001. Investigation of the enhancement of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis by 6-phenylhexyl isothiocyanate. Cancer Lett. 162:19-26.
157. Hulten, K., A. Winkvist, P. Lenner, R. Johansson, H. Adlercreutz, and G. Hallmans. 2002. An incident case-referent study on plasma enterolactone and breast cancer. Eur. J. Nutr. 41:168-176.
158. Ide, N., K. Ryu, K. Ogasawara, T. Sasaoka, H. Matsuura, S. Sumi, H. Sumiyoshi, and B.H.S. Laub. 2002. Antioxidants in processed garlic I. Fructosyl arginine identified in aged garlic extract. Int. Cong. Ser. 1245:447-448.
159. Ignatowicz, E., B. Balana, S.Vulimiri, H. Szaefer, and W. Baer-Dubowska. 2003. The effect of plant phenolics on the formation of 7, 12-dimethylbenz[a]anthracene-DNA adducts and TPA-stimulated polymorphonuclear neutrophils chemiluminescence in vitro. Toxicology 89:199-209.
160. Igura, K., T. Ohta, Y. Kuroda, and K. Kaji. 2001. Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 171:11-16.
161. Imai, S., N. Tsuge, M. Tomotake, Y. Nagatome, H. Sawada, T. Nagata, and H. Kumagai. 2002. An onion enzyme that makes the eyes water. Nature 419:85.
162. Ippoushi, K., H. Itou, K. Azuma, and H. Higashio. 2002. Effect of naturally occurring organosulfur compounds on nitric oxide production in lipopolysaccharide-activated macrophages. Life Sci. 71:411-419.
163. Ishige, K., D. Schubert, and S. Yataka. 2001. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Rad. Biol. Med. 30:433-446.
164. Ishikawa, T. 1992. The ATP-dependent glutathione S-conjugate export pump. Trends Biochem. Sci. 17:63-468.
165. Jakubowski, H. 2003. On the health benefits of Allium sp. Nutrition 19:167-168.
166. Jeffery, E.H., A.F. Brown, A.C. Kurilich, A.S. Keck, N. Matusheski, B.P. Klein, and J.A. Juvik. 2003. Variation in content of bioactive components in broccoli. J. Food Comp. Anal. 16:323-330.
167. Jeon, K.-I., J.-K. Rih, H.J. Kim, Y.J. Lee, C.-H. Cho, I.D. Goldberg, E.M. Rosen, and I. Bae. 2003. Pretreatment of indole-3-carbinol augments TRAIL-induced apoptosis in a prostate cancer cell line, LNCaP. FEBS Lett. 544:246-251.
168. Jiménez-Cruz, A., W.H. Turnbull, M. Bacardi-Gascón, and P. Rosales. 2004. A high-fiber, moderate-glycemic-index, Mexican style diet improves dyslipidemia in individuals with type 2 diabetes. Nutr. Res. 24:19-27.
169. Johnson, I.T. 2001. Glucosinolates: bioavailability and importance to health. Int. J. Vitam. Nutr. Res. 72:26-31.
170. Johnson, T. 2002. Anticarcinogenic effects of diet-related apoptosis in the colorectal mucosa. Food Chem. Toxicol. 40:1171-1178.
171. Jones, P.J.H. and V. Vuksan. 2003. The Garden of Eden? Plant based diets, the genetic drive to conserve cholesterol and its implications for heart disease in the 21st century. Comp. Biochem. Physiol. A. 136:141-151.
172. Joseph, J.A., B. Shukitt-Hale, N.A. Denisova, D. Bielinski, A. Martin, J.J. McEwen, and P.C. Bickford. 1999. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J. Neurosci. 19:8114-8121.
173. Joshipura, K.J., F.B. Hu, J.E. Manson, M.J. Stampfer, E.B. Rimm, F.E. Speizer, G. Colditz, A. Ascherio, B. Rosner, D. Spiegelman, and W.C. Willett. 2001. The effect of fruit and vegetable intake on risk for coronary heart disease. Ann. Intern. Med. 134:1106-1114.
174. Jung, U.J., H.J. Kim, J.S. Lee, M.K. Lee, H.O. Kim, E.J. Park, H.K. Kim, T.S. Jeong, and M.S. Choi. 2003. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. Clin. Nutr. 22:561-568.
175. Junghans, A., H. Sies, and W. Stahl. 2001. Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes. Arch. Biochem. Biophys. 391:160-164.
176. Jurado, J., E. Alejandre-Duran, A. Alonso-Moraga, and C. Pueyo. 1991. Study on the mutagenic activity of 13 bioflavonoids with the Salmonella Ara test. Mutagenesis 6:289-295.
177. Kafatos, A., A. Diacatou, G. Voukiklaris, N. Nikolakakis, J. Vlachonikolis, D. Kounali, G. Mamalakis, and A.S. Dontas. 1997. Heart disease risk-factor status and dietary changes in the Cretan population over the past 30 y: the Seven Countries Study. Am. J. Clin. Nutr. 65:1882-1886.
178. Kang, I.-H., H.-J. Kim, H. Oh, Y.I. Park, and M.-S. Dong. 2004. Biphasic effects of the flavonoids quercetin and naringenin on the metabolic activation of 2-amino-3. 5- dimethylimidazo[4. 5-f]quinoline by Salmonella typhimurium TA1538 co-expressing. human cytochrome P450 1A2:NADPH-cytochrome P450 reductase and cytochrome b5. Mutat. Res. 545:37-47.
179. Kang, N.S., E.Y. Moon, C.G. Cho, and S. Pyo. 2001. Immunomodulating effect of garlic component, allicin, on murine peritoneal macrophages. Nutr. Res. 21:617-626.
180. Kapahi, P., M.E. Boulton, and T.B.L. Kirkwood. 1999. Positive correlation between mammalian life span and cellular resistance to stress. Free Rad. Biol. Med. 26:495-500.
181. Kassie, F., B. Laky, E. Nobis, M. Kundi, and S. Knasmüller. 2001. Genotoxic effects of methyl isothiocyanate. Mutat. Res. 490:1-9.
182. Kassie, F., B. Laky, R. Gminski, V. Mersch-Sundermann, G. Scharf, E. Lhoste, and S. Kansmüller. 2003. Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage:a model study with the single cell gel electrophoresis/Hep G2 assay. Chemico-Biol. Interact. 142:285-296.
183. Katchamart, S. and D.E. Williams. 2001. Indole-3-carbinol modulation of hepatic monooxygenases CYP1A1, CYP1A2 and FMO1 in guinea pig, mouse and rabbit. Comp. Biochem. Physiol. C. 129:377-384.
184. Keaney, J.F. 2000. Atherosclerosis: from lesion formation to plaque activation and endothelial dysfunction. Mol. Asp. Med. 21:99-166.
185. Kelly, C., C. Jewell, and N.M. O’Brien. 2003. The effect of dietary supplementation with the citrus limonoids, limonin and nomilin on xenobiotic-metabolizing enzymes in the liver and small intestine of the rat. Nutr. Res. 23:681-690.
186. Key, T.J., N.E. Allen, E.A. Spencer, and R.C. Travis. 2002. The effect of diet on risk of cancer. Lancet 360:861-868.
187. Khaw, K.-T., S. Bingham, A. Welch, R. Luben, N. Wareham, S. Oakes, and N. Day. 2001. Relation between plasma ascorbic acid and mortality in men and women in EPICNorfolk prospective study: a prospective population study. Lancet 357:657-663.
188. Khokhar, S. and R.K.O. Apenten. 2003. Iron binding characteristics of phenolic compounds:some tentative structure-activity relations. Food Chem. 81:133-140.
189. Kik, C., R. Kahane, and R. Gebhardt. 2001. Garlic and health. Nutr. Metab. Cardiovasc. Dis. 11:57-65.
190. Kim, K., S. Chun, M. Koo, W. Choi, T. Kim, Y. Kwon, H. Chung, T.R.D. Billiar, and Y. Kim. 2001. Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine. Free Rad. Biol. Med. 30:747-756.
191. Kimura, Y. and H. Okuda. 2001. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J. Nutr. 131:1844-1849.
192. Knekt, P., J. Kumpulainen, R. Järvinen, H. Rissanen, M. Heliövaara, A. Reunanen, T. Hakulinen, and A. Aromaa. 2002. Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 76:560-568.
193. Knowler, W.C., P.H. Bennett, R.F. Hamman, and M. Miller. 1978. Diabetes incidence and prevalence in Pima Indians: a 19-fold greater incidence than in Rochester, Minnesota. Am. J. Epidemiol. 108: 497-505.
194. Kohlmeier, L. and L. Su. 1997. Cruciferous vegetable consumption and colorectal cancer risk: meta-analysis of the epidemiological evidence. FASEB J. 11:A369.
195. Kolonel, L.N., J.H. Hankin, and A.S. Whittemore. 2000. Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol. Biomark. Prev. 9:795.
196. Kostyuk, V.A., T. Kraemer, H. Sies, and T. Schewe. 2003. Myeloperoxidase/nitrite-mediated lipid peroxidation of low-density lipoprotein as modulated by flavonoids. FEBS Lett. 537:146-150.
197. Kowald, A. and T.B. Kirkwood. 2000. Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in ageing of postmitotic and dividing cells. J. Theor. Biol. 202:145-160.
198. Kozuki, Y., Y. Miura, and K. Yagasaki. 2001. Resveratrol suppresses hepatoma cell invasion independently of its anti-proliferative action. Cancer Lett. 167:151-156.
199. Krinsky, N.I. 2002. Possible biologic mechanisms for a protective role of xanthophylls. J. Nutr. 132:540S-542S.
200. Kris-Etherton, P.M., K.D. Hecker, A. Bonanome, S.M. Coval, A.E. Binkoski, K.F. Hilpert, A.E. Griel, and T.D. Etherton. 2002. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am. J. Med. 113:71-88.
201. Krul, C., C. Humblot, M. Vermeulen, M. van Nuenen, R. Havenaar, and S. Rabot. 2002. Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large intestinal model. Carcinogenesis 23:1009-1016.
202. Ku, D.D., T.T. Abdel-Razek, J. Dai, S. Kim-Park, M.B. Fallon, and G.A. Abrams. 2002. Garlic and its active metabolite allicin produce endothelium- and nitric oxide-dependent relaxation in rat pulmonary arteries. Clin. Exp. Pharmacol. Physiol. 29:84-91.
203. Kwon, K.B., S.J. Yoo, D.G. Ryu, J.Y. Yang, H.W. Rho, J.S. Kim, J.W. Park, H.R. Kim, and B.H. Park. 2002. Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells. Biochem. Pharmacol. 63:41-47.
204. Kwon, M.J., Y.S. Song, M.S. Choi, S.J. Park, K.S. Jeong, and Y.O. Song. 2003. Cholesteryl ester transfer protein activity and atherogenic parameters in rabbits supplemented with cholesterol and garlic powder. Life Sci. 72:2953-2964.
205. Lachmann, G., D. Lorenz, W. Radeck, and M. Steiper. 1994. The pharmacokinetics of the S35 labeled labeled garlic constituents alliin, allicin and vinyldithiine. Arzneim. Forsch. 44:734-737.
206. Laky, B., S. Knasmüller, R. Gminsky, V. Mersch-Sundermann, G. Scharf, R. Verkerk, C. Freywald, M. Uhl, and F. Kassie. 2002. Protective effect of Brussels sprouts towards B[a]P-induced DNA damage: a model study with the single-cell gel electrophoresis (SCGE) Hep/G2 assay. Food Chem. Toxicol. 40:1077-1083.
207. Lamm, D.L. and D.R. Riggs. 2001. Enhanced immunocompetence by garlic - role in bladder cancer and other malignancies. J. Nutr. 131:1067S-1070S.
208. Lancaster, J.E., M.L. Shaw, and E.F. Walton. 2000. S-Alk(en)yl-l-cysteine sulfoxides, alliinase and aroma in Leucocoryne. Phytochemistry 55:127-130.
209. Landrault, N., F. Larronde, J.-C. Delaunay, C. Castagnino, J. Vercauteren, J.-M. Merillon, F. Gasc, G. Cros, and P.-L. Teissedre. 2002. Levels of stilbene oligomers and astilbin in French varietal wines and in grapes during noble rot development. J. Agric. Food Chem. 50:2046-2052.
210. Landrum, J.T. and Bone, R.A. 2001. Lutein, zeaxanthin and the macular pigment. Arch. Biochem. Biophys. 385:28-40.
211. Launer, L.J. 2000. Is there epidemiologic evidence that anti-oxidants protect against disorders in cognitive function? J. Nutr. Health Aging 4:197-201.
212. Lautraite, S., A.C. Musonda, J. Doehmer, G.O. Edwards, and J.K. Chipman. 2002. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis 17:45-53.
213. Lawson, L.D., Z.J. Wang, and B.G. Hughes. 1991. Identification and HPLC quantitation of the sulfides and dialk(en)yl thiosulfinates in commercial garlic products. Planta Med. 57:363-367.
214. Le Bon, A.M. and M.H. Siess. 2000. Organosulfur compounds from allium and the chemoprevention of cancer. Drug Metabol. Drug Interact. 17:51-79.
215. Le Bourg, E. 2001. Oxidative stress, aging and longevity in Drosophila melanogaster. FEBS Lett. 498:183-186.
216. Le Marchand, L. 2002. Cancer preventive effects of flavonoids - a review. BioMed. Pharmacother. 56:296-301.
217. Lee, H.S. and J.G. Kim. 2003. Effects of debittering on red grapefruit juice concentrate. Food Chem. 82:177-181.
218. Leuck, M. and H. Kunz. 1998. Synthesis of active principles from the leaves of Moringa oleifera using S-pent-4-enyl thioglycosides. Carbohydr. Res. 312:33-37.
219. Levi, F., C. Pasche, C. La Vecchia, F. Lucchini, and S. Franceschi. 1999. Food groups and colorectal cancer risk. Br. J. Cancer 79:1283-1287.
220. Li, H., Y. Cheng, H. Wang, H. Sun, Y. Liu, K. Liu, and S. Peng. 2003. Inhibition of nitrobenzene- induced DNA and hemoglobin adductions by dietary constituents. Appl. Radiat. Isotopes 58:291-298.
221. Lin, M.T. and M.F. Beal. 2003. The oxidative damage theory of aging. Clin. NeuroSci. Res. 2:305-311.
222. Lin, X.Y., J.Z. Liu, and J.A. Milner. 1994. Dietary garlic suppresses DNA adducts caused by N- nitroso compounds. Carcinogenesis 15:349-352.
223. Liston, B.W., R. Nines, P.S. Carlton, A. Gupta, R. Aziz, W. Frankel, and G.D. Stoner. 2003. Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. Cancer Res. 15:2399-2403.
224. Liu, L. and Y.Y. Yeh. 2002. S-Alk(en)yl cysteines of garlic inhibit cholesterol synthesis by deactivating HMG-CoA reductase in cultured rat hepatocytes. J. Nutr. 132:1129-1134.
225. London, S.J., J.-M. Yuan, F.-L. Chung, Y.-T. Gao, G.A. Coetzee, R.K. Ross, and M.C. Yu. 2000. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung cancer risk: a prospective study of men in Shanghai, China. Lancet 356:724-729.
226. Loo, G. 2003. Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation. J. Nutr. Biochem. 14:64-73.
227. Lopaczynski, W. and S.H. Zeisel. 2001. Antioxidants, programmed cell death, and cancer. Nutr. Res. 21:295-307.
228. López, M., F. Martínez, C. Del Valle, M. Ferrit, and R. Luque. 2003. Study of phenolic compounds as natural antioxidants by a fluorescence method. Talanta 60:609-612.
229. Lugasi, A., L. Bíró, J. Hóvárie, K.V. Sági, S. Brandt, and É. Barna. 2003. Lycopene content of foods and lycopene intake in two groups of the Hungarian population. Nutr. Res. 23:1035-1039.
230. Maas, J.L., G.J. Galletta, and G.D. Stoner. 1991. Ellagic acid, an anticarcinogen in fruits, especially in strawberries. A review. HortSci. 26:10-14.
231. Maki, K.C., M.H. Davidson, D.M. Umporowicz, E.J. Schaefer, M.R. Dicklin, K.A. Ingram, S. Chen, J.R. McNamara, B.W. Gebhart, J.D. Ribaya-Mercado, G. Perrone, G. Robins, and W.C. Franke. 2001. Lipid responses to plant-sterol-enriched reduced-fat spreads incorporated into a National Cholesterol Education Program Step I diet. Am. J. Clin. Nutr. 74:33-43.
232. Maler, J.M., W. Seifert, G. Hüther, J. Wiltfang, E. Rüther, J. Kornhuber, and S. Bleich. 2003. Homocysteine induces cell death of rat astrocytes in vitro. NeuroSci. Lett. 347:85-88.
233. Malumbres, M. and M. Barbacid. 2001. To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer 1:222-231.
234. Mandlekar, S., R. Yu, T.H. Tan, and A.N. Kong. 2000. Activation of caspase-3 and c-jun NH2- terminal kinase-1 signalling pathways in tamoxifen-induced apoptosis in human breast cancer cells. Cancer Res. 60:5995-6000.
235. Manesh, C. and G. Kuttan. 2003. Effect of naturally occurring allyl and phenyl isothiocyanates in the inhibition of experimental pulmonary metastasis induced by B16F-10 melanoma cells. Fitoterapia 74:355-363.
236. Mann, J.I. 2002. Diet and risk of coronary heart disease and type 2 diabetes. Lancet 360:783-789.
237. Mansoor, G.A. 2001. Herbs and alternative therapies in the hypertension clinic. Am. J. Hypertension 14:971-975.
238. Marks, H.S., J.A. Hilson, H.C. Leichtweis, and G.S. Stoewsand. 1992. S-methylcysteine sulfoxide in Brassica vegetables and formation of methyl methanethiosulfinate from brussels sprouts. J. Agric. Food Chem. 40:2098-2104.
239. Mazur, W. and H. Adlercreutz. 2000. Overview of naturally occurring endocrine-active substances in the human diet in relation to human health. Nutrition 16:654-658.
240. Meng, Q., M. Qi, D.Z. Chen, R. Yuan, I.D. Goldberg, E.M. Rosen, K. Auborn, and S. Fan. 2000. Suppression of breast cancer invasion and migration by indole-3-carbinol:associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J. Mol. Med. 78:155-165.
241. Metodiewa, D., A.K. Jaiswal, N. Cenas, E. Dickancaité, and J. Segura-Aguilar. 1999. Quercetin may act as a cytotoxic prooxidant after its metabolic activation to emiquone and quinoidal product. Free Rad. Biol. Med. 26:107-116.
242. Michaelsson, K., H. Melhus, R. Bellocco, and A. Wolk. 2003. Dietary calcium and vitamin D intake in relation to osteoporotic fracture risk. Bone 32:694-703.
243. Michels, K.B., E. Giovannucci, K.J. Joshipura, B.A. Rosner, M.J. Stampfer, C.S. Fuchs, J.A. Colditz, F.E. Speizer, and W.C. Willett. 2000. Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. J. Nat. Cancer Inst. 92:1740-1752.
244. Mills, J.J., R.S. Chari, I.J. Boyer, M.N. Gould, and R.L. Jirtle. 1995. Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Res. 55:979-983.
245. Milner, J.A. 2001. A historical perspective on garlic and cancer. J. Nutr. 31:1027S-1031S.
246. Miodini, P., L. Fioravantio, G. Di Fronzo, and V. Cappelletti. 1999. The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function. Br. J. Cancer 80:1150-1155.
247. Mithen, R.F., M. Dekker, R. Verkerk, S. Rabot, and I.T. Johnson. 2000. The nutritional significance, biosynthesis and bioavailability of glucosinolates in human foods. J. Sci. Food Agric. 80:967-984.
248. Moat, S.J., D. Lang, I.F.W. McDowell, Z.L. Clarke, A.K. Madhavan, M.J. Lewis, and J. Goodfellow. 2004. Folate, homocysteine, endothelial function and cardiovascular disease. J. Nutr. Biochem. 15:64-79.
249. Moeller, S.M., P.F. Jacques, and J.B. Blumberg. 2000. The potential role of dietary xanthophylls in cataract and age-related macular degeneration. J. Am. Coll. Nutr. 19:522S-527S.
250. Mollerup, S., S. Ovrebo, and A. Haugen. 2001. Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells. Int. J. Cancer 92:18-25.
251. Mondy, N., D. Duplat, J.P. Christides, I. Arnault, and J. Auger. 2002. Aroma analysis of fresh and preserved onions and leek by dual solid-phase microextraction-liquid extraction and gas chromatography/mass spectrometry. J. Chromatogr. A. 963:89-93.
252. Moriguchi, T., J. Takasugi, and J. Itakura. 2001. The effects of aged garlic extract on lipid peroxidation and the deformability of erythrocytes. J. Nutr. 131:1016S-1019S.
253. Morihara, N., I. Sumioka, T. Moriguchi, N. Uda, and E. Kyo. 2002. Aged garlic extract enhances production of nitric oxide. Life Sci. 71:509-517.
254. Morris, M.C., D.A. Evans, J.L. Bienias, C.C. Tangney, D.A. Bennett, N. Aggarwal, R.S. Wilson, and P.A. Scherr. 2002. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. J. Am. Med. Assoc. 287:3230-3237.
255. Morris, M.M. 2003. Homocysteine and Alzheimer’s disease. Lancet Neurol. 2:425-428.
256. Mozaffarieh, M., S. Sacu, and A. Wedrich. 2003. The role of carotenoids, lutein and zeaxanthin in protecting against age-related macular degeneration: a review based on controversial evidence. Nutr. J. 2:20-28.
257. Mullen, W., T. Yokota, M.E.J. Lean, and A. Crozier. 2003. Analysis of ellagitannins and conjugates of ellagic acid and quercetin in raspberry fruits by LC-MS. Phytochemistry 64:617-624.
258. Munday, R. and C.M. Munday. 2001. Relative activities of organosulfur compounds derived from onions and garlic in increasing tissue activities of quinone reductase and glutathione transferase in rat tissues. Nutr. Cancer. 40:205-210.
259. Murillo, G. and R.G. Mehta. 2001. Cruciferous vegetables and cancer prevention. Nutr. Cancer 41:17-28.
260. Murota, K. and J. Terao. 2003. Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch. Biochem. Biophys. 417:12-17.
261. Mutoh, M., M. Takashi, K. Fukuda, H. Komatsu, T. Enya, Y. Masushima-Hibiya, H. Mutoh, T. Sugimura, and K. Wakabayashi. 2000. Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structureactivity relationship. Jpn. J. Cancer Res. 91:686-691.
262. Nakagawa, H., K. Tsuta, K. Kiuchi, K. Senzaki, K. Tanaka, K. Hioki, and K. Tsubura. 2001a. Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines. Carcinogenesis 22:891-897.
263. Nakagawa, H., Y. Kiyozuka, Y. Uemura, H. Senzaki, N. Shikata, K. Hioki, and A. Tsubura. 2001b. Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator. J. Cancer Res. Clin. Oncol. 127:258-264.
264. Nakamura, Y., H. Ohigashi, S. Masuda, A. Murakami, Y. Kawamoto, Y. Morimitsu, T. Osawa, M. Imagawa, and K. Uchida. 2000. A glutathione S-transferase inducer from papaya:rapid screening. identification and structure-activity relationship of isothiocyanates. Cancer Lett. 57:193-200.
265. Narayanan, B.A. and G.G. Re. 2001. IGF-2 down regulation associated cell cycle arrest in colon cancer cells exposed to phenolic antioxidant ellagic acid. AntiCancer Res. 21:359-364.
266. Netzel, M., G. Strass, I. Bitsch, R. Könitz, M. Christmann, and R. Bitsch. 2003. Effect of grape processing on selected antioxidant phenolics in red wine. J. Food Eng. 56:223-228.
267. New, S.A., S.P. Robins, M.K. Campbell, J.C. Martin, M.J. Garton, C. Bolton-Smith, D.A. Grubb, S.J. Lee, and D.M. Reid. 2000. Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am. J. Clin. Nutr. 71:142-151.
268. Niiveldt, R.J., E. Van Nood, D.E. Van Hoorn, P.G. Boelens, K. Van Norren, and P.A. Van Leeuwen. 2001. Flavonoids: a review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr. 74:418-425.
269. Niles, R.M., M. McFarland, M.B. Weimer, A. Redkar, Y.-M. Fu, and G.G. Meadows. 2003. Resveratrol is a potent inducer of apoptosis in human melanoma cells. Cancer Lett. 190:157-163.
270. Noda, Y., T. Kneyuki, K. Igarashi, A. Mori, and L. Packer. 2000. Antioxidant activity of nasunin, an anthocyanin in eggplant peels. Toxicology 148:119-123.
271. Nordin, B.E.C. 1997. Calcium and osteoporosis. Nutrition 13:664-686.
272. Norrish, A.E., R.T. Jackson, S.J. Sharpe, and C.M. Skeaff. 2000. Prostate cancer and dietary carotenoids. Am. J. Epidemiol. 151:119-123.
273. Nurmi, T., S. Heinonen, W. Mazur, T. Deyama, S. Nishibe, and H. Adlercreutz. 2003. Lignans in selected wines. Food Chem. 83:303-307.
274. Nuutila, A.M., R. Puupponen-Pimiä, M. Aarni, and K.-M. Oksman-Caldentey. 2003. Comparison of antioxidant activities of onion and garlic extracts by inhibition of lipid peroxidation and radical scavenging activity. Food Chem. 81:485-491.
275. Oganesian, A., J.D. Hendricks, and C.B. Pereira. 1999. Potency of dietary indole-3-carbinol as a promoter of aflatoxin B1-initiated hepatocarcinogenesis: results from a 9000 animal tumor study. Carcinogenesis 20:453-458.
276. Ojewole, J.A.O. and C.O. Adewunmi. 2001. Possible mechanisms of antihypertensive effect of garlic: evidence from mammalian experimental models. Am. J. Hypertension 14:A29-A35.
277. Olmedilla, B., F. Granado, I. Blanco, and M. Vaquero. 2003. Lutein, but not tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2- y double-blind, placebo-controlled pilot study. Nutrition 19:21-24.
278. Onyilagha, J., A. Bala, R. Hallett, M. Gruber, J. Soroka, and N. Westcott. 2003. Leaf flavonoids of the cruciferous species, Camelina sativa, Crambe spp., Thlaspi arvense and several other genera of the family Brassicaceae. Biochem. System Ecol. 31:1309-1313.
279. Oommen, S., R.J. Anto, G. Srinivas, and D. Karunagaran. 2004. Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. Eur. J. Pharmacol. 485:97-103.
280. O’Prey, J., J. Brown, J. Fleming, and P.R. Harrison. 2003. Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. Biochem. Pharmacol. 66:2075-2088.
281. Owuor, E.D. and A.N.-T. Kong. 2002. Anti-oxidants and oxidant regulated signal transduction pathways. Biochem. Pharmacol. 64:765-770.
282. Paolini, M., S.Z. Abdel-Rahman, A. Sapone, G.F. Pedulli, P. Perocco, and MS. Cantelli-Forti. 2003. Carotene: a cancer chemopreventive agent or a co-carcinogen? Rev. Mutat. Res. 543:195-200.
283. Paré, P.W. and J.H. Tumlinson. 1999. Plant volatiles as a defense against insect herbivores. Plant Physiol. 121:325-331.
284. Park, Y.K., E. Park, J.-S. Kim, and M.-H. Kang. 2003. Daily grape juice consumption reduces oxidative DNA damage and plasma free radical levels in healthy Koreans. Mutat. Res. 529:77-86.
285. Parvaiz, S. 2001. Resveratrol - from the bottle to the bedside? Leuk. Lymph. 40:5-11.
286. Passamonti, S., U. Vrhovsek, A. Vanzo, and F. Mattivi. 2003. The stomach as a site for anthocyanins absorption from food. FEBS Lett. 544:1210-1213.
287. Patterson, B.D. 1998. Fresh: Seeds from the Past and Food for Tomorrow, p. 63. Allen & Unwin, St. Leonards, Australia.
288. Peffley, D.M. and A.K. Gayen. 2003. Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. J. Nutr. 133:38-44.
289. Perkins-Veazie, P., J.K. Collins, S.D. Pair, and W. Roberts. 2001. Lycopene content differs among red-fleshed watermelon cultivars. J. Sci. Food Ag. 81:983-987.
290. Pietinen, P., K. Stumpf, S. Männistö, V. Kataja, M. Uusitupa, and H. Adlercreutz. 2001. Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiol. Biomark. Prev. 10: 339-344.
291. Pietta, P.G. 2000. Flavonoids as antioxidants. J. Nat. Prod. 63:1035-1042.
292. Pintao, A.M., M.S.S. Pais, H. Coley, L.R. Kelland, and I.R. Judson. 1995. In vitro and in vivo antitumor activity of benzyl isothiocyanate: a natural product from Tropaeolum majus. Planta Medica 61:233-236.
293. Pinto, J.T. and R.S. Rivlin. 2001. Antiprofilerative effects of allium derivatives from garlic. J. Nutr. 131:1058S-1060S.
294. Piver, B., F. Berthou, F. Dreano, and D. Lucas. 2003. Differential inhibition of human cytochrome P450 enzymes by viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. Life Sci. 73:1199-1213.
295. Podrez, E.A., H.M. Abu-Soud, and S.L. Hazen. 2000. Myeloperoxidase-generated oxidants and atherosclerosis. Free Rad. Biol. Med. 28:1717-1725.
296. Prättälä, R. 2003. Dietary changes in Finland; success stories and future challenges. Appetite 41:245-249.
297. Qi, R. and Z. Wang. 2003. Pharmacological effects of garlic extract. Trends Pharmacol. Sci. 24:62-63.
298. Qi, R. 2000. 5-Trisphosphophate (IP3) formation in activated platelets, inhibition by diallyl trisulfide, a garlic component, of intracellular Ca2+ mobilization without affecting inositol-1:4. Biochem. Pharmacol. 60:1475-1483.
299. Rabinkov, A., T. Miron, L. Konstantinovski, M. Wilchek, M. Mirelman, and L. Weiner. 1998. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochim. Biophys. Acta. 1379:233-244.
300. Rahman, K. and D. Billington. 2000. Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J. Nutr. 130:2662-2665.
301. Rahman, K. 2001. Historical perspective on garlic and cardiovascular disease. J. Nutr. 131:977S-979S.
302. Ranelletti, F.O., N. Maggiano, F.G. Serra, R. Ricci, L.M. Larocca, P. Lanza, G. Scambia, A. Fattorossi, A. Capelli, and M. Piantelli. 2000. Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors. Int. J. Cancer 85:438-445.
303. Raso, G.M., R. Meli, G. Di Carlo, M. Pacilio, and R. Di Carlo. 2001. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci. 68:921-931.
304. Reilly, M., N. Delanty, J.A. Lawson, and G.A. FitzGerald. 1996. Modulation of oxidant stress in vivo in chronic cigarette smokers. Circulation 94:19-25.
305. Ren, Z. and M.N. Gould. 1994. Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. Cancer Lett. 76:185-190.
306. Riboli, E. and T. Norat. 2001. Cancer prevention and diet: opportunities in Europe. Publ. Health Nutr. 4:475-484.
307. Riby, J.E., C. Chang, Y.C. Feng, C.M. Schaldach, G.L. Firestone, and L.F. Bjeldanes. 2000. The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway. Biochemistry 39:910-918.
308. Richer, S. 2000. Nutritional influences on eye health. Optometry 71:657-666.
309. Rinaldi, P., M.C. Polidori, A. Metastasio, E. Mariani, P. Mattioli, A. Cherubini, M. Catani, R. Cecchetti, U. Senin, and P. Mecocci. 2003. Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease. Neurobiol. Aging 24:915-919.
310. Rotelli, A.E., T. Guardia, A.O. Juárez, N.E. de la Rocha, and N.E. Pelzer. 2003. Comparative study of flavonoids in experimental models of inflammation. Pharmacol. Res. 48:601-606.
311. Rouzard, G., A.J. Duncan, S. Young, and B. Ratcliffe. 2001. Bioavailability of cancerprotective isothiocyanates following ingestion of cooked cabbage, coleslaw and mustard by healthy human subjects. Proc. Nutr. Soc. 60:34A.
312. Safari, M-R. and N. Sheikh. 2003. Effects of flavonoids on the susceptibility of low-density lipoprotein to oxidative modification. Prostaglandins Leukotrienes Essential Fatty Acids. 69:73-77.
313. Samman, S., G. Sivarajah, J.C. Man, Z.I. Ahmad, P. Petocz, and I.D. Caterson. 2003. A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers plasma homocysteine in men. Am. J. Nutr. 133:2188-2193.
314. Sans, S., H. Kesteloot, and D. Kromhaut. 1997. The burden of cardiovascular diseases mortality in Europe. Eur. Heart J. 18:1231-1248.
315. Schaur, R.J. 2003. Basic aspects of the biochemical reactivity of 4-hydroxynonenal. Mol. Aspects Med. 24:149-159.
316. Schmidt, E.B., H.A. Skou, J.H. Christensen, and J. Dyerberg. 2000. N-3 fatty acids from fish and coronary artery disease: implications for public health. Pub. Health Nutr. 31:91-98.
317. Schneider, Y., F. Vincent, B. Duranton, L. Badolo, F. Gossé, C. Bergmann, N. Seiler, and F. Raul. 2000. Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett. 158:85-91.
318. Schroeter, H., R.J. Williams, R. Matin, L. Iversen, and C. Rice-Evans. 2000. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein. Free Rad. Biol. Med. 29:1222-1233.
319. Semba, R.D. and G. Dagnelie. 2003. Are lutein and zeaxanthin conditionally essential nutrients for eye health? Med. Hypoth. 61:465-472.
320. Sengupta, A., S. Ghosh, and S. Das. 2002. Administration of garlic and tomato can protect from carcinogen induced clastogenicity. Nutr. Res. 22:859-864.
321. Sepkovic, D.W., H.L. Bradlow, and M. Bell. 2001. Quantitative determination of 3. 3-diindolylmethane in urine of individuals receiving indole-3-carbinol. Nutr. Cancer 41:57-63.
322. Serraino, I., L. Dugo, P. Dugo, L. Mondello, E. Mazzon, G. Dugo, A.P. Caputi, and S. Cuzzocrea. 2003. Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. Life Sci. 73:1097-1114.
323. Shapiro, T.A., J.W. Fahey, K.L. Wade, K.K. Stephenson, and P. Talalay. 2001. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol. Biomark. Prev. 10:501-508.
324. Sharifi, A.M., R. Darabi, and N. Akbarloo. 2003. Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat. J. Ethnopharmacol. 86:219-224.
325. Sharoni, Y., R. Agbaria, H. Amir, A. Ben-Dor, I. Bobilev, N. Doubi, Y. Giat, K. Hirsh, G. Izumchenko, M. Khanin, E. Kirilov, R. Krimer, A. Nahum, M. Steiner, Y. Walfisch, S. Walfisch, G. Zango, M. Danilenko, and J. Levy. 2003. Modulation of transcriptional activity by antioxidant carotenoids. Mol. Asp. Med. 24:371-384.
326. Sheen, L.-Y., C.-C. Wu, C.-K. Lii, and S.-J. Tsai. 2002. Effect of diallyl sulfide and diallyl disulfide, the active principles of garlic, on the aflatoxin-induced DNA damage in primary rat hepatocytes. Toxicol. Lett. 122:45-52.
327. Shimoi, K., H. Okada, M. Furugori, T. Goda, S. Takase, M. Suzuki, Y. Hara, and N. Kinae. 1998. Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. FEBS Lett. 438:220-224.
328. Shu, X.O., F. Jin, Q. Dai, W. Wen, J.D. Potter, L.H. Kushi, Z. Ruan, Y.T. Gao, and W. Zheng. 2001. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol. Biomark. Prev. 10:483-488.
329. Shukla, Y. and P. Taneja. 2002. Antimutagenic effects of garlic extract on chromosomal aberrations. Cancer Lett. 176:31-36.
330. Siegers, C.P., A. Robke, and R. Pentz. 1999a. Effects of garlic preparations on superoxide production by phorbol ester activated granulocytes. PhytoMedicine 6:13-16.
331. Siegers, C.P., B. Steffen, A. Robke, and R. Pentz. 1999b. The effects of garlic preparations against human tumor cell proliferation. Phytomedicine 6:7-11.
332. Solt, D.B., K. Chang, I. Helenowski, and A.W. Rademaker. 2003. Phenethyl isothiocyanate inhibits nitrosamine carcinogenesis in a model for study of oral cancer chemoprevention. Cancer Lett. 202:147-152.
333. Spencer, J.P.E., M.M.A. El Mohsen, and C. Rice-Evans. 2004. Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity. Arch. Biochem. Biophys. 423:148-161.
334. Stahl, W. and H. Sies. 2003. Antioxidant activity of carotenoids. Mol. Asp. Med. 24:345-351.
335. Stahl, W., H. van den Berg, J.A.A. Bast, J. Dainty, R.M. Faulks, C. Gärtner, G. Haenen, P. Hollman, and B. Holst. 2002. Bioavailability and metabolism. Mol. Asp. Med. 23:39-100.
336. Steiner, M. and W. Li. 2001. Aged garlic extract a modulator of cardiovascular risk factors:a dose-finding study on the effects of AGE on platelet functions. J. Nutr. 131:980S-984S.
337. Steinmetz, K.A. and L.H. Kushi. 1994. Vegetables, fruit and colon cancer in the Iowa women’s health study. Am. J. Epidemiol. 139:1-15.
338. Stevinson, C., M.H. Pittler, and E. Ernst. 2000. Garlic for treating hypercholesterolemia. Ann. Intern. Med. 133:420-429.
339. Stintzing, F.C. and R. Carle. 2004. Functional properties of anthocyanins and betalains in plants, food, and in human nutrition. Trends Food Sci. Technol. 15:19-38.
340. Stoewsand, G.S. 1995. Bioactive organosulfur phytochemicals in Brassica oleracea vegetables - a review. Food Chem. Toxicol. 33:537-543.
341. Sun, A.Y., A. Simonyi, and G.Y. Sun. 2002. The “French paradox” and beyond: neuroprotective effects of polyphenols. Free Rad. Biol. Med. 32:314-318.
342. Szaefer, H., J. Jodynis-Liebert, M. Cichocki, A. Matuszewska, and W. Baer-Dubowska. 2003. Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine. Toxicology 186:67-77.
343. Takeoka, G.R., L.T. Dao, S. Flessa, D.M. Gillespie, W.T. Jewell, B.H. Huebner, D. Bertow, and S.E. Ebeler. 2001. Processing effects on lycopene content and antioxidant activity of tomatoes. J. Agric. Food Chem. 49:3713-3717.
344. Talalay, P., A.T. Dinkova-Kostova, and W.D. Holtzclaw. 2003. Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis. Adv. Enz. Reg. 43:121-134.
345. Tate, P., A. Kuzmar, S.W. Smith, D.E. Wedge, and L.L. Larcom. 2003. Comparative effects of eight varieties of blackberry on mutagenesis. Nutr. Res. 23:971-974.
346. Tatman, D. and H. Mo. 2002. Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells. Cancer Lett. 175:129-139.
347. Temple, N.J. and K.K. Gladwin. 2003. Fruit, vegetables, and the prevention of cancer, research challenges. Nutrition 19:467-470.
348. Teranishi, K., R. Apitz-Castro, S.C. Robson, E. Romano, and D.K.C. Cooper. 2003. Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene. Xenotransplantation 10: 374-379.
349. Terman, A. and U.T. Brunk. 2004. Myocyte aging and mitochondrial turnover. Exp. Gerontol. 39:701-705.
350. Teyssier, C., L. Guenot, M. Suschetet, and M.H. Siess. 1999. Metabolism of diallyl disulfide by human liver microsomal cytochromes P-450 and flavin-containing monooxygenases. Drug Metab. Dispos. 27:835-841.
351. Teyssier, C., M.-J. Amiot, N. Mondy, J. Auger, R. Kahane, and M.-H. Siess. 2001. Effect of onion consumption by rats on hepatic drug-metabolizing enzymes. Food Chem. Toxicol. 39:981-987.
352. Thatte, U., S. Bagadey, and S. Dahanukar. 2000. Modulation of programmed cell death by medicinal plants. Cell Mol. Biol. 46:199-214.
353. Tirillini, B. 2000. Grapefruit: the last decade acquisitions. Fitoterapia 71:S29-S37.
354. Tombola, F., S. Campello, L. De Luca, P. Ruggiero, G. Del Giudice, E. Papini, and M. Zoratti. 2003. Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. FEBS Lett. 543:184-189.
355. Tsai, Y., K.A. McGlynn, Y. Hu, A.B. Cassidy, J. Arnold, P.F. Engstrom, and K.H. Buetow. 2003. Genetic susceptibility and dietary patterns in lung cancer. Lung Cancer 41:269-281.
356. Tucker, K.L., M.T. Hannan, H. Chen, L.A. Cupples, P.W.F. Wilson, and D.P. Kiel. 1999. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am. J. Clin. Nutr. 69:727-736.
357. Tuomilheto, J., J. Lindström, J.G. Eriksson, T.T. Valle, H. Hämäläinen, P. Ilanne-Parikka, and V. Keinänen-Kiukaanniemi. 2001. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New Engl. J. Med. 344:1343-1352.
358. Tyssandier, V., G. Choubert, P. Borel, and P. Grolier. 2003. Carotenoids, mostly the xanthophylls, exchange between plasma lipoproteins. Int. J. Vit. Nutr. Res. 72:300-308.
359. Uchida, K. and T. Kumagai. 2003. 4-Hydroxy-2-nonenal as a COX-2 inducer. Mol. Aspects Med. 24:213-218.
360. Uchida, K. 2003. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Progr. Lipid Res. 42:318-343.
361. Upston, J.M., L. Kritharides, and R. Stocker. 2003. The role of Vitamin E in atherosclerosis. Progr. Lipid Res. 42:405-422.
362. Van den Brandt, P., L. Voorrips, I. Hertz-Picciotto, D. Shuker, H. Boeing, G. Speijers, C. Guittard, J. Knowles, M. Kleiner, A. Wolk, and A. Goldbohm. 2002. The contribution of epidemiology. Food Chem. Toxicol. 40:387-424.
363. Van Exel, E., J. Gussekloo, P. Houx, A.J.M.P. de Craen, W. Macfarlane, A. Bootsma-van der Wiel, G.J. Blauw, and R.G.J. Westendorp. 2002. Atherosclerosis and cognitive impairment are linked in the elderly. The Leiden 85-plus Study. Atherosclerosis 165:353-359.
364. Vanharanta, M., S. Voutilainen, T. Kaikkonen, J. Nurmi, L.J. Roberts, J.D. Morrow, H. Adlercreutz, and J.T. Salonen. 2002. Association between low serum enterolactone and increased plasma isoprostanes. a measure of lipid peroxidation. Atherosclerosis 160:465-469.
365. Velísek, J., R. Kubec, and J. Davídek. 1997. Chemical composition and classification of culinary and pharmaceutical garlic-based products. Z. Lebensm. Unters. Forsch. A. 204:161-164.
366. Vigushin, D.M., G.K. Poon, A. Boddy, J. English, G.W. Halbert, C. Pagonis, M. Jarman, and R.C. Coombes. 1998. Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. Cancer Chemother. Pharmacol. 42:111-117.
367. Virgili, M. and A. Contestabile. 2000. Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats. Neurosci. Lett. 281:123-126.
368. Visioli, F., L. Borsani, and C. Galli. 2000. Diet and prevention of coronary heart disease: the potential role of phytochemicals. Cardiovasc. Res. 47:419-425.
369. Wakutani, Y., H. Kowa, M. Kusumi, K. Nakaso, K. Yasui, K. Isoe-Wada, H. Yano, K. Urakami, T. Takeshima, and K. Nakashima. 2004. A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer’s disease. Neurobiol. Aging 25:291-294.
370. Wattel, A., S. Kamel, R. Mentaverri, F. Lorget, C. Prouillet, J.-P. Petit, P. Fardelonne, and M. Brazier. 2003. Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption. Biochem. Pharmacol. 65:35-42.
371. Weber, G., F. Shen, T.I. Orbán, S. Kökeny, and E. Olah. 2003. Targeting signal transduction. Adv. Enz. Reg. 43:47-56.
372. Weisburger, J.H. 2002. Comments on the history and importance of aromatic and heterocyclic amines in public health. Mutat. Res. 506:9-20.
373. West, K.P. Jr., J. Katz, S.K. Khatry, S.C. LeClerq, E.K. Pradhan, S.R. Shrestha, P.B. Connor, S.M. Dali, P. Christian, R.P. Pokhrel, and A. Sommer. 1999. A double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. Brit. Med. J. 318:570-575.
374. Whalley, L.J., R.T. Staff, A.D. Murray, S.J. Duthie, A.R. Collins, H.A. Lemmon, J.M. Starr, and I.J. Deary. 2003. Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people. NeuroSci. Lett. 341:173-176.
375. Willcox, J.K., G.L. Catignani, and S. Lazarus. 2003. Tomatoes and cardiovascular health. Crit. Rev. Food Sci. Nutr. 43:1-18.
376. Willis, M.S. and F.H. Wians Jr. 2003. The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances. Clin. Chim. Acta. 330:57-83.
377. Witte, J.S., M.P. Longnecker, and C.L. Bird. 1996. Relation of vegetable, fruit and grain consumption to colorectal adenomatous polyps. Am. J. Epidemiol. 144:1015-1025.
378. Wittstock, U. and B.A. Halkier. 2002. Glucosinolate research in the Arabidopsis era. Trends Plant Sci. 7:263-270.
379. Wolford, J.K., P.B. Colligan, J.D. Gruber, and C. Bogardus. 2003. Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians. Mol. Genet. Metab. 80:338-343.
380. Xiao, H. and K.L. Parkin. 2002. Antioxidant functions of selected Allium thiosulphinates and S-alk (en)yl-cysteine sulphoxides. J. Agric. Food Chem. 50:2488-2493.
381. Yanagita, T., S. Han, Y. Wang, Y. Tsuruta, and T. Anno. 2003. Cycloalliin, a cyclic sulfur imino acid, reduces serum triacylglycerol in rats. Nutrition 19:140-143.
382. Yang, C.S., J.M. Landau, M.T. Huang, and H.L. Newmark. 2001. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 21:381-406.
383. Yoshida, H., H. Katsuzaki, R. Ohta, K. Ishikawa, H. Fukuda, T. Fujino, and A. Suzuki. 1999. Antimicrobial activity of the thiosulfinates isolated from oil-macerated garlic extract. Biosci. Biotechnol. Biochem. 63:591-594.
384. Youdim, K.A. and J.A. Joseph. 2001. A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects. Free Rad. Biol. Med. 30:583-594.
385. Yu, F.-L., W. Bender, Q. Fang, A. Ludeke, and B. Welch. 2003. Prevention of chemical carcinogen DNA binding and inhibition of nuclear RNA polymerase activity by organosulfur compounds as the possible mechanisms for their anticancer initiation and proliferation effects. Cancer Detection Prev. 27:370-379.
386. Yuan, F., D.Z. Chen, K. Liu, D.W. Sepkovic, H.L. Bradlow, and K. Auborn. 1999. Antiestrogenic activities of indole-3-carbinol in cervical cells: implication for prevention of cervical cancer. AntiCancer Res. 19:1673-1680.
387. Zanda, R.S.R., D.J.A. Jenkins, T.J. Brown, and E.P. Diamandis. 2002. Flavonoids can block PSA production by breast and prostate cancer cell lines. Clin. Chim. Acta 317:17-21.
388. Zhang, J., J. Dai, Y. Lu, Z. Yao, C.A. O’Brien, J.M. Murtha, W. Qi, D.E. Hall, S.C. Manolagas, W.B. Ershler, and E.T. Keller. 2004. In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging. Exp. Gerontol. 39:239-247.
389. Zhao, C., Y. Shi, W. Wang, Z. Jia, S. Yao, B. Fan, and R. Zheng. 2003a. Fast repair of deoxythymidine radical anions by two polyphenols: rutin and quercetin. Biochem. Pharmacol. 65:1967-1971.
390. Zhao, L., S.V. Kirkmeyer, and B.J. Tepper. 2003b. A paper screening test to assess genetic taste sensitivity to 6-n-propylthiouracil. Physiol. Behav. 78:625-633.
391. Zhu, C.-Y. and S. Loft. 2003. Effect of chemopreventive compounds from Brassica vegetables on NAD(P)H:quinone reductase and induction of DNA strand breaks in murine hepa1c1c7 cells. Food Chem. Toxicol. 41:455-462.