Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression

Cancer Letters

Volumn 181, Issue 2, 2002, Pages 187-194

  Bardon, Sylvie ^a   Foussard, Valérie ^b   Fournel, Sophie ^b   Loubat, Agnès ^c  

^a CEMAGREF   (France)

^b UFR de Medecine   (France)

^c INSERM   (France)

Author keywords

Colon cancer; Cyclin; HCT 116 cells; Monoterpene; P21Waf1 Cip1; Perillyl alcohol

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; DRUG METABOLITE; MONOTERPENE PERILLYL ALCOHOL; PERILLIC ACID; PROTEIN P21; TERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; CELL DIVISION; COLONIC NEOPLASMS; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; CYCLOHEXENES; DOSE-RESPONSE RELATIONSHIP, DRUG; G1 PHASE; GENE EXPRESSION; HUMANS; MONOTERPENES; RNA, MESSENGER; S PHASE; TERPENES; TUMOR CELLS, CULTURED;

RODENTIA;

EID: 0037178560     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00047-2     Document Type: Article

References (39)

1. Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene
2. Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation
3. Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J) F1 mouse lung
4. Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol
5. Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol
6. Chemoprevention of colon carcinogenesis by dietary perillyl alcohol
7. Phase I clinical trial of perillyl alcohol administered daily
8. Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day
9. Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies
10. Selective inhibition of isoprenylation of 21-26-Kda proteins by the anticarcinogen d-limonene and its metabolites
11. Growth inhibition of rat liver epithelial tumor cells by monoterpenes does not involve Ras plasma membrane association
12. Inhibition of tumor cell growth by monoterpenes in vitro: Evidence of a Ras-independent mechanism of action
13. Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies
14. Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol
15. Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation
16. cdc2 expression in colonic adenocarcinoma SW480 cells
17. The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the central nervous system
18. A fluorometric deoxyribonucleic acid assay for tridimensional lattice cultures of fibroblasts
19. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis
20. Induction of p21 mediated by reactive oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells
21. Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents
22. Monoterpenes inhibit cell growth, cell cycle progression and cyclin D1 gene expression in human breast cancer cell lines
23. G1 phase progression: Cycling on cue
24. Cell-cycle control and its watchman
25. CDK inhibitors: Positive and negative regulators of G1-phase progression
26. G1 control in mammalian cells
27. NA22598, a novel antitumor compound, reduces cyclin D1 levels, arrests cell cycle at G1 phase and inhibits anchorage-independent growth of human tumor cells
28. P21-dependent G(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228
29. Downregulation of the cyclin D1/cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines
30. Altered expression of cyclin D1 and cyclin-dependent kinase 4 in azoxymethane-induced mouse colon tumorigenesis
31. Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients
32. Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon
33. Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: Induction of cyclin D3 and p21expression
34. P21/WAF1 expression in human colorectal factor carcinoma: Association with p53, transcription factor AP-2 and prognosis
35. Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21(WAF1/CIP1) expression and correlates with patient survival
36. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase
37. P21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption
38. Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol
39. Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocarcinoma relative to untransformed ductal epithelial cells