Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: Structure-activity relationship

Japanese Journal of Cancer Research

Volumn 91, Issue 7, 2000, Pages 686-691

  Mutoh, Michihiro ^a,b   Takahashi, Mami ^b   Fukuda, Kazunori ^c   Komatsu, Hajime ^a   Enya, Takeji ^a   Matsushima Hibiya, Yuko ^a   Mutoh, Hiroshi ^b   Sugimura, Takashi ^a   Wakabayashi, Keiji ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Colon cancer; Cyclooxygenease 2; Electron density; Flavonoids; Reporter gene assay

Indexed keywords

ACETOPHENONE DERIVATIVE; CATECHIN; CYCLOOXYGENASE 2; EPICATECHIN; EPIGALLOCATECHIN; ERIODICTYOL; FISETIN; FLAVONOID; GENISTEIN; KAEMPFEROL; LUTEOLIN; MYRICETIN; PHLORETINE; QUERCETIN; RHAMNETIN; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; BROMINATION; CANCER CELL; CARCINOGENESIS; COLON CANCER; CONTROLLED STUDY; DENSITY; DRUG ACTIVITY; DRUG STRUCTURE; ELECTRON; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; STRUCTURE ACTIVITY RELATION;

ACETOPHENONES; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; ELECTRONS; FLAVONOIDS; GENES, REPORTER; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; MEMBRANE PROTEINS; OXYGEN; PROMOTER REGIONS (GENETICS); PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; QUERCETIN; RESORCINOLS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0033867003     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2000.tb01000.x     Document Type: Article

References (22)

1. Effect of flavonoids on immune and inflammatory cell functions
2. Inhibition of carcinogenesis by minor dietary constituents
3. Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships
4. Relationship between flavonoid structure and inhibition of phosphatidyl-inositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition
5. The isoforms of cyclooxygenase: Structure and function
6. Prostaglandin synthase 2
7. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
8. Expression of cyclooxygenase-1 and -2 in human colorectal cancer
9. COX-2 inhibitors for colorectal cancer
10. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis
11. Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice
12. Suppressive effect of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice
13. Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure
14. Reaction of benzanthrone (7H-benz[d, e]anthracen-7-one) with nitrogen dioxide alone or admixture with ozone. Implications for the atmospheric formation of genotoxic 3-nitrobenzanthrone
15. AM-1: A new general purpose quantum mechanical molecular model
16. Inhibitory effects of tea catechins, black tea extract and oolong tea extract on hepatocarcinogenesis in rat
17. Cancer chemoprevention agent development strategies for genistein
18. Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents
19. Estrone-induced cell proliferation and differentiation in the mammary gland of the female Noble rat
20. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia
21. The relative antioxidant activities of plant-derived polyphenolic flavonoids
22. The crystal molecular structure of quercetin: A biologically active and naturally occurring flavonoid