A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease

Neurobiology of Aging

Volumn 25, Issue 3, 2004, Pages 291-294

  Wakutani, Yosuke ^a   Kowa, Hisanori ^a   Kusumi, Masayoshi ^a   Nakaso, Kazuhiro ^a   Yasui, Ken Ichi ^a   Isoe Wada, Kenji ^a   Yano, Hidetaka ^a   Urakami, Katsuya ^a   Takeshima, Takao ^a   Nakashima, Kenji ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

A1298C; A1793G; Alzheimer; Association; C677T; Haplotype; MTHFR gene; Protective

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALANINE; APOLIPOPROTEIN E; APOLIPOPROTEIN E EPSILON 4; ARGININE; GLUTAMIC ACID; GLUTAMINE; UNCLASSIFIED DRUG; VALINE;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BRAIN PROTECTION; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; ETHNIC GROUP; FEMALE; GENE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; ONSET AGE; POPULATION RESEARCH; PRIORITY JOURNAL;

EID: 10744220005     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(03)00082-4     Document Type: Article

References (24)

1. Bailey L.B., Duhaney R.L., Maneval D.R., Kauwell G.P., Quinlivan E.P., Davis S.R.et al. Vitamin B-12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydrofolate reductase polymorphisms. J. Nutr. 132:2002;1872-1878.
2. Brunelli T., Bagnoli S., Giusti B., Nacmias B., Pepe G., Sorbi S.et al. The C677T methylenetetrahydrofolate reductase mutation is not associated with Alzheimer's disease. Neurosci. Lett. 315:2001;103-105.
3. Clarke R., Smith A.D., Jobst K.A., Refsum H., Sutton L., Ueland P.M. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 55:1998;1449-1455.
4. Colton C.A., Brown C.M., Cook D., Needham L.K., Xu Q., Czapiga M.et al. APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. Neurobiol. Aging. 23:2002;777-785.
5. Goyette P., Pai A., Milos R., Frosst P., Tran P., Chen Z.et al. Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm. Genome. 9:1998;652-656.
6. Hixson J.E., Vernier D.T. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J. Lipid Res. 31:1990;545-548.
7. Ji Y., Urakami K., Adachi Y., Maeda M., Isoe K., Nakashima K. Apolipoprotein E polymorphism in patients with Alzheimer's disease, vascular dementia and ischemic cerebrovascular disease. Dement. Geriatr. Cogn. Disord. 9:1998;243-245.
8. Kang S.S., Passen E.L., Ruggie N., Wong P.W., Sora H. Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease. Circulation. 88:1993;1463-1469.
9. Kehoe P., Wavrant-De Vrieze F., Crook R., Wu W.S., Holmans P., Fenton I.et al. A full genome scan for late onset Alzheimer's disease. Hum. Mol. Genet. 8:1999;237-245.
10. Meisel C., Cascorbi I., Gerloff T., Stangl V., Laule M., Muller J.M.et al. Identification of six methylenetetrahydrofolate reductase (MTHFR) genotypes resulting from common polymorphisms: impact on plasma homocysteine levels and development of coronary artery disease. Atherosclerosis. 154:2001;651-658.
11. Miyata M., Smith J.D. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nat. Genet. 14:1996;55-61.
12. Myers A., Wavrant De-Vrieze F., Holmans P., Hamshere M., Crook R., Compton D.et al. Full genome screen for Alzheimer disease: stage II analysis. Am. J. Med. Genet. 114:2002;235-244.
13. Nishiyama M., Kato Y., Hashimoto M., Yukawa S., Omori K. Apolipoprotein E methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia - an epidemiological study using the polymerase chain reaction (PCR) method. J. Epidemiol. 10:2000;163-172.
14. Pericak-Vance M.A., Bass M.P., Yamaoka L.H., Gaskell P.C., Scott W.K., Terwedow H.A.et al. Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. JAMA. 278:1997;1237-1241.
15. Prince J.A., Feuk L., Sawyer S.L., Gottfries J., Ricksten A., Nagga K.et al. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. Eur. J. Hum. Genet. 9:2001;437-444.
16. Rady P.L., Szucs S., Grady J., Hudnall S.D., Kellner L.H., Nitowsky H.et al. Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas; a report of a novel MTHFR polymorphic site, G1793A. Am. J. Med. Genet. 107:2002;162-168.
17. Reyes-Engel A., Munoz E., Gaitan M.J., Fabre E., Gallo M., Dieguez J.L. et al. Implications on human fertility of the 677C → T and 1298A → C polymorphisms of the MTHFR gene: consequences of a possible genetic selection. Mol. Hum. Reprod. 8:2002;952-957.
18. Rosenberg N., Murata M., Ikeda Y., Opare-Sem O., Zivelin A., Geffen E.et al. The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans. Am. J. Hum. Genet. 70:2002;758-762.
19. Seshadri S., Beiser A., Selhub J., Jacques P.F., Rosenberg I.H., D'Agostino R.B.et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. New Engl. J. Med. 346:2002;476-483.
20. Shea T.B., Rogers E. Folate quenches oxidative damage in brains of apolipoprotein E-deficient mice: augmentation by vitamin E. Brain Res. Mol. Brain Res. 108(1/2):2002;1-6.
21. Shea T.B., Rogers E., Ashline D., Ortiz D., Sheu M.S. Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue. Free Radic. Biol. Med. 33:2002;1115-1120.
22. Stegmann K., Ziegler A., Ngo E.T., Kohlschmidt N., Schroter B., Ermert A.et al. Linkage disequilibrium of MTHFR genotypes 677C/T-1298A/C in the German population and association studies in probands with neural tube defects (NTD). Am. J. Med. Genet. 87:1999;23-29.
23. Weisberg I.S., Jacques P.F., Selhub J., Bostom A.G., Chen Z., Curtis Ellison R.et al. The 1298A → C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis. 156:2001;409-415.
24. Yamada K., Chen Z., Rozen R., Matthew R.G. Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proc. Natl. Acad. Sci. U.S.A. 98:2001;14853-14858.