Targeting signal transduction

Advances in Enzyme Regulation

Volumn 43, Issue 1, 2003, Pages 47-56

  Weber, George ^a,c   Shen, Fei ^a   Orbán, Tamás I ^b   Kökeny, Szabolcs ^b   Olah, Edith ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^c Lab IN Univ Sch Exp Oncol Med   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; HEPATITIS C VIRUS;

EID: 0038378433     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(03)00021-9     Document Type: Conference Paper

References (14)

1. Jackson RC, Morris HP, Weber G. Partial purification, properties and regulation of inosine 5′-phosphate dehydrogenase in normal and malignant rat tissues. Biochem J 1977;166:1-10.
2. Lui MS, Faderan MA, Liepnieks JJ, Natsumeda Y, Olah E, Jayaram HN, Weber G. Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-β-D-ribofuranosylthiazole-4-carboxamide). J Biol Chem 1984;259:5078-82.
3. Nagai M, Natsumeda Y, Konno Y, Hoffman R, Irino S, Weber G. Selective up-regulation of type II inosine 5′-monophosphate dehydrogenase messenger RNA expression in human leukemias. Cancer Res 1991;51:3886-90.
4. Natsumeda Y, Ohno S, Kawasaki H, Konno Y, Weber G, Suzuki K. Two distinct cDNAs for human IMP dehydrogenase. J Biol Chem 1990;265:5292-5.
5. Natsumeda Y, Yamada Y, Yamaji Y, Weber G. Synergistic cytotoxic effect of tiazofurin and ribavirin in hepatoma cells. Biochem Biophys Res Commun 1988;153:321-7.
6. Olah E, Natsumeda Y, Ikegami T, Kote Z, Horanyi M, Szelenyi J, Paulik E, Kremmer T, Hollan SR, Sugar J, Weber G. Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K562 leukemia cells. Proc Natl Acad Sci USA 1988;85:6533-7.
7. Orban T, Olah E, Weber G. Ribavirin (RIBA) is antiproliferative and oncolytic; it down-regulates c-myc expression and signal transduction, causes apoptosis and induced differentiation. Proc Am Assoc Cancer Res 2002;43:967.
8. Prajda N, Hata Y, Abonyi M, Singhal RL, Weber G. Sequential impact of tiazofurin and ribavirin on enzymic program of the bone marrow. Cancer Res 1993;53:5982-6.
9. Tricot G, Jayaram HN, Weber G, Hoffman R. Tiazofurin: biological effects and clinical uses. Int J Cell Cloning 1990;8:161-70.
10. Weber G. Biochemical strategy of cancer cells and the design of chemotherapy: G.H.A. Clowes memorial lecture. Cancer Res 1983;43:3466-92.
11. Weber G, Nagai M, Natsumeda Y, Eble JN, Jayaram HN, Paulik E, Zhen W, Hoffman R, Tricot G. Tiaozfurin down-regulates expression of c-Ki-ras oncogene in a leukemic patient. Cancer Commun 1991;3:61-6.
12. Weber G, Nakamura H, Natsumeda Y, Szekeres T, Nagai M. Regulation of GTP biosynthesis. Adv Enzyme Regul 1992;32:57-69.
13. Weber G, Shen F, Yang H, Prajda N, Li W. Amplification of signal transduction capacity and down-regulation by drugs. Adv Enzyme Regul 1999;39:51-66.
14. Yamada Y, Natsumeda Y, Weber G. Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase. Biochemistry 1988;27:2193-6.