Effect of chemopreventive compounds from Brassica vegetables on NAD(P)H:quinone reductase and induction of DNA strand breaks in murine hepa1c1c7 cells

Food and Chemical Toxicology

Volumn 41, Issue 4, 2003, Pages 455-462

  Zhu, C Y ^a   Loft, S ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Brassica vegetables; Brussels sprouts; DNA strand breaks; Hydrogen peroxide; Murine hepa1c1c7 cells; NAD(P)H:quinone reductase

Indexed keywords

2,3 BIS(INDOL 3 YLMETHYL)INDOLE; 3 INDOLEMETHANOL; 3,3' DIINDOLYLMETHANE; BRUSSEL SPROUT EXTRACT; GLUCOSINOLATE; HYDROGEN PEROXIDE; INDOLE DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE; PLANT EXTRACT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SINIGRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRASSICA; BRUSSELS SPROUT; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INDUCTION; HYDROLYSIS; INCUBATION TIME; MOUSE; NONHUMAN; VEGETABLE;

ANIMALS; ANTICARCINOGENIC AGENTS; BRASSICA; CELL LINE; CELL SURVIVAL; COMET ASSAY; DNA DAMAGE; GLUCOSINOLATES; HYDROGEN PEROXIDE; MICE; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATION-REDUCTION;

BRASSICA; BRASSICA OLERACEA VAR. GEMMIFERA; MURINAE;

EID: 0037399899     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(02)00278-8     Document Type: Article

References (35)

1. Bonnesen C., Stephensen P.U., Andersen O., Sørensen H., Vang O. Modulation of cytochrome P-450 and glutathione S-transferase isoform expression in vivo by intact and degraded indolyl glucosinolates. Nutrition and Cancer. 33:1999;178-187.
2. Buskov S., Hansen L.B., Olsen C.E., Søresen J.C., Sørensen H., Sørensen S. Determination of ascorbigens in autolysates of various Brassica species using supercritical fluid chromatography. Journal of Agricultural and Food Chemistry. 48:2000;2693-2701.
3. Buskov S., Hasselstrøm J., Olsen C.E., Sørensen H., Sørensen J.C., Sørensen S. Supercritical-fluid chromatography as a method of analysis for the determination of 4-hydroxybenzylglucosinolate degradation products. Journal of Biochemical and Biophysical Methods. 43:2000;157-174.
4. Buskov S., Olsen C.E., Sørensen H., Sørensen S. Supercritical fluid chromatography as basis for identification and quantitative determination of indol-3-ylmethyl oligomers and ascorbigens. Journal of Biochemical and Biophysics Methods. 43:2000;175-195.
5. Deng X.S., Tuo J.S., Poulsen H.E., Loft S. Prevention of oxidative DNA damage in rats by Brussels sprouts. Free Radical Research. 28:1998;323-333.
6. Dinkova-Kostova A.T., Talalay P. Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen. Free Radicals Biology and Medicine. 29:2000;231-240.
7. Hansen M., Laustsen A.M., Olsen C.E., Poll L., Sørensen H. Chemistry and sensory quality of Broccoli (Brassica Oleracea L. var.). Journal of Food Quality. 20:1997;441-459.
8. Hansen M., Møller P., Sørensen H. Glucosinolates in Broccoli stored under controlled atmosphere. Journal of the American Society for Horticultural Science. 120:1995;1069-1074.
9. Jongen W.M.F. Glucosinolates in Brassica. occurrence and significance as cancer-modulating agents Proceedings of the Nutrition Society of the USA. 55:1996;433-446.
10. Kensler T.W. Chemoprevention by inducers of carcinogen detoxification enzymes. Environmental Health Perspectives. 105(Suppl. 4):1997;964-970.
11. Loft S., Otte J., Poulsen H.E., Sørensen H. Influence of intact and myrosinase-treated indolyl glucosinolates on the metabolism in vivo of metronidazole and antipyrine in the rat. Food and Chemical Toxicology. 30:1992;927-935.
12. London S.J., Yuan J.M., Chung F.C., Gao Y.T., Coetzee G.A., Ross R.K., Yu M.C. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphism, and lung-cancer risk. a prospective study of men in Shanghai, China Lancet. 356:2000;724-729.
13. McDanell R., McLean A.E., Hanley A.B., Heaney R.K., Fenwick G.R. The effect of feeding Brassica vegetables and intact glucosinolates on mixed-function oxidase activity in the livers and intestines of rats. Food and Chemical Toxicology. 27:1989;289-293.
14. Posner G.H., Cho C.G., Green J.V., Zhang Y., Talalay P. Design and synthesis of biofunctional isothiocyanate analogies of sulforaphane. correlation between structure and potency as inducers of anticarcinogenic detoxification enzymes Journal of Medicinal Chemistry. 37:1994;170-176.
15. Prestera T., Talalay P. Electrophile and antioxidant regulation of enzymes that detoxify carcinogens. Proceedings of the National Academy of Sciences of the USA. 92:1995;8965-8969.
16. Prochaska H.J., Talalay P. Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver. Cancer Research. 48:1988;4776-4782.
17. Sørensen M., Jensen B.R., Poulsen H.E., Deng X.S., Tygstrup N., Dalhoff K., Loft S. Brussels sprouts extract-induced oxidative DNA damage and metabolizing enzymes in rat liver. Food and Chemical Toxicology. 39:2001;533-540.
18. Stoewsand G.S., Anderson J.L., Munson L. Protective effect of dietary Brussels sprouts against mammary carcinogenesis in Sprague-Dawley rats. Cancer Letters. 39:1988;199-207.
19. Talalay P. The role of enzyme induction in protection against carcinogenesis. Wattenberg L., Lipkin M., Boone C.W., Kelloff G.J. Cancer Chemoprevention. 1992;469-478 CRC Press, Boca Raton, FL.
20. Tawfiq N., Heaney R.K., Plumb J.A., Fenwick G.R., Musk S.R.R., Williamson G. Dietary glucosinolates as blocking agents against carcinogenesis. glucosinolate breakdown products assessed by induction of quinone reductase activity in murine hepa1c1c7 cells Carcinogenesis. 16:1995;1191-1194.
21. Tawfiq N., Wanigatunga S., Heaney R.K., Musk S.R.R., Williamson G., Fenwick G.R. Induction of the anticarcinogenic enzyme quinone reductase by food extracts using murine hepatoma cells. European Journal of Cancer Prevention. 3:1994;285-292.
22. Tuo J.S., Loft S., Thomsen M.S., Poulsen H.E. Ex vivo time-dependent cell DNA-degradation shown by single cell gel electrophoresis. Pharmacology and Toxicology. 78:1996;55-57.
23. Vang O., Jensen M.B., Autrup H. Induction of cytochrome P450IA1 in rat colon and liver by indole-3-carbinol and 5,6-benzoflavone. Carcinogenesis. 11:1990;1259-1263.
24. Vang O., Jensen H., Autrup H. Induction of cytochrome P-450IA1, IA2, IIB1, IIB2 and IIE1 by broccoli in rat liver and colon. Chemico-Biological Interactions. 78:1991;85-96.
25. Vang O., Rasmussen B.F., Andersen O. Combined effects of complex mixtures of potentially anti-carcinogenic compounds on antioxidant enzymes and carcinogen metabolizing enzymes in the rat. Cancer Letters. 114:1997;283-286.
26. Verhagen H., de Vries A., Nijhoff W.A., Schouten A., van Poppel G., Peters W.H.M., van den Berg H. Effect of Brussels sprouts on oxidative DNA-damage in man. Cancer Letters. 114:1997;127-130.
27. Verhagen H., Poulsen H.E., Loft S., van Poppel G., Willems M.I., van Bladeren P.J. Reduction of oxidative DNA-damage in humans by Brussels sprouts. Carcinogenesis. 16:1995;969-970.
28. Verhoeven D.T.H., Goldbohm R.A., van Poppel G., Verhagen H., van den Brandt P.A. Epidemiological studies on Brassica vegetables and cancer risk. Cancer Epidemiology Biomarkers and Prevention. 5:1996;733-748.
29. Verhoeven D.T.H., Verhagen H., Goldbohm R.A., van den Brandt P.A., van Poppel G. A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chemico-Biological Interactions. 103:1997;79-129.
30. Williamson G., Faulkner K., Plumb G.W. Glucosinolates and phenolics as antioxidants from plant foods. European Journal of Cancer Prevention. 7:1998;17-21.
31. Wortelboer H.M., de Kruif C.A., van Iersel A.A., Noordhoek J., Blaauboer B.J., van Bladeren P.J., Falke H.E. Effects of cooked Brussels sprouts on cytochrome P-450 profile and phase II enzymes in liver and small intestinal mucosa of the rat. Food and Chemical Toxicology. 30:1992;17-27.
32. Zhang Y., Kensler T.W., Cho C.G., Posner G.H., Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proceedings of the National. Academy of Sciences of the USA. 91:1994;3147-3150.
33. Zhang Y., Talalay P., Cho C.G., Posner G.H. A major inducer of anticarcinogenic protective enzymes from broccoli. isolation and elucidation of structure Proceedings of the National Academy of Sciences of the USA. 89:1992;2399-2403.
34. Zhu C.-Y., Loft S. Effects of Brussels sprouts extracts on hydrogen peroxide-induced DNA strand breaks in human lymphocytes. Food and Chemical Toxicology. 39:2001;1191-1197.
35. Zhu C.-Y., Poulsen E., Loft S. Inhibition of oxidative DNA damage in vitro by extract of Brussels sprouts. Free Radical Research. 33:2000;187-196.