Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase

Atherosclerosis

Volumn 139, Issue 2, 1998, Pages 333-339

  Dirsch, Verena M ^a   Kiemer, Alexandra K ^a   Wagner, Hildebert ^b   Vollmar, Angelika M ^a  

^a Inst Pharmacol Toxicol Pharm   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Ajoene; Allicin; Atherosclerosis; Garlic; Nitric oxide

Indexed keywords

AJOENE; ALLICIN; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CATALYSIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INDUCTION; GARLIC; IMMUNOMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SUPERNATANT;

CELL LINE; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; GARLIC; HOMEOSTASIS; LIPOPOLYSACCHARIDES; MACROPHAGES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PLANTS, MEDICINAL; RNA, MESSENGER; SULFINIC ACIDS;

EID: 0031830565     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(98)00094-X     Document Type: Article

References (29)

1. Agarwal K.C. Therapeutic actions of garlic constituents. Med Res Rev. 16:1996;111-124.
2. Reuter HD, Koch HP, Lawson LD. Therapeutic effects and applications of garlic and its preparations. In: Koch HP, Lawson LD, editors. Garlic. The Science and Therapeutic Application of Allium sativum L. and Related Species. Baltimore: Williams and Wilkins, 1996:135-212.
3. Radomski M.W., Salas E. Nitric oxide-biological mediator, modulator and factor of injury: its role in the pathogenesis of atherosclerosis. Atherosclerosis. 118(Suppl):1995;S69-S80.
4. Böger R.H., Bode-Böger S.M., Frölich J.C. The L-arginine-nitric oxide pathway: role in atherosclerosis and therapeutic implications. Atherosclerosis. 127:1996;1-11.
5. Bult H. Nitric oxide and atherosclerosis: possible implications for therapy. Mol Med Today. 2:1996;510-518.
6. Matthys K.E., Bult H. Nitric oxide function in atherosclerosis. Mediat Inflamm. 6:1997;3-21.
7. Buttery L.D.K., Springall D.R., Chester A.H.et al. Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite. Lab Invest. 75:1996;77-85.
8. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol 1996;271 (Cell Physiol 1996;40):C1424-C1437.
9. Stuehr D.J., Cho H.J., Kwon N.S., Weise M.F., Nathan C.F. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: a FAD- and FMN-containing flavoprotein. Proc Natl Acad Sci USA. 88:1991;7773-7777.
10. Nathan C., Xie Q.-W. Nitric oxide synthases: roles, tolls, and controls. Cell. 78:1994;915-918.
11. 15N]nitrate in biological fluids. Anal Biochem. 126:1982;131-138.
12. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 65:1983;55-63.
13. Thiemermann C., Wu C.C., Szabo C., Perretti M., Vane J.R. Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock. Br J Pharmacol. 110:1993;177-182.
14. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:1976;248-254.
15. Rothe H., Bosse G., Fischer H.G., Kolb H. Generation and characterization of inducible nitric oxide synthase deficient macrophage cell lines. Biol Chem Hoppe Seyler. 377:1996;227-231.
16. Vollmar A.M., Schulz R. Gene expression and secretion of atrial natriuretic peptide by murine macrophages. J Clin Invest. 94:1994;539-545.
17. Kleinert H., Euchenhofer C., Ihrig-Biedert I., Förstermann U. Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B. Mol Pharmacol. 49:1996;15-21.
18. Xie Q.-W., Kashiwabara Y., Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem. 269:1994;4705-4708.
19. Watanabe T., Haraoka S., Shimokama T. Inflammatory and immunological nature of atherosclerosis. Int J Cardiol. 54(Suppl):1996;S25-S34.
20. Ross R. The pathogenesis of atherosclerosis: a perspective of the 1990s. Nature. 362:1993;801-809.
21. Hansson GK. Immune responses in atherosclerosis. In: Hansson GK, Libby P, editors. Immune Functions of the Vessel Wall. Amsterdam: Harwood, 1996:143-159.
22. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 87:1990;1620-1624.
23. White C.R., Brock T.A., Chang L.-Y.et al. Superoxide and peroxynitrite in atherosclerosis. Proc Natl Acad Sci USA. 91:1994;1044-1048.
24. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 43:1991;109-142.
25. Das I., Khan N.S., Sooranna S.R. Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic application. Curr Med Res Opin. 13:1995;257-263.
26. Sooranna S.R., Hirani J., Das I. Garlic can induce both GTP cyclohydrolase and nitric oxide synthase activity in choriocarcinoma cells. Biochem Soc Trans. 23:1995;543S.
27. Myat-Thanda, Hitsumoto Y, Saheki S, Kitagawa H, Yano J, Matsuura S. Attenuation of human chorionic gonadotropin release by nitric oxide in choriocarcinoma cell lines. J Endocrinol 1996;150:243- 253.
28. Das I., Hirani J., Sooranna S. Arginine is not responsible for the activation of nitric oxide synthase by garlic. J Ethnopharmacol. 53:1996;5-9.
29. Koch HP. Biopharmaceutics of garlic's effective constituents. In: Koch HP, Lawson LD, editors. Garlic. The Science and Therapeutic Application of Allium sativum L. and Related Species. Baltimore: Williams and Wilkins, 1996:213-220.