Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects

Clinical Nutrition

Volumn 22, Issue 6, 2003, Pages 561-568

  Jung, U J ^a   Kim, H J ^a   Lee, J S ^a   Lee, M K ^a   Kim, H O ^a   Park, E J ^a   Kim, H K ^a   Jeong, T S ^b   Choi, M S ^a  

^a Kyungpook National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Antioxidant enzymes; Hypercholesterolemia; Naringin; Plasma lipids

Indexed keywords

ANTILIPEMIC AGENT; ANTIOXIDANT; APIGENIN; APOLIPOPROTEIN A; APOLIPOPROTEIN B; AURANTIIN; CATALASE; DAIDZEIN; ERYTHROCYTE ENZYME; FLAVONE DERIVATIVE; FLAVONOID; GENISTEIN; GLUTATHIONE PEROXIDASE; HESPERETIN; HESPERIDIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOFLAVONE DERIVATIVE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NARINGENIN; QUERCETIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CARCINOGENESIS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG CAPSULE; DRUG EFFICACY; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ERYTHROCYTE; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIVER PROTECTION; MALE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0345256647     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0261-5614(03)00059-1     Document Type: Article

References (69)

1. Key A. Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease Cambridge: Harvard University Press, 1980
2. Wald N J, Law M R. Serum cholesterol and ischaemic heart disease. Atherosclerosis 1995; 118 (Suppl): S1-S5
3. Hertog M G L, Poppel G V, Verhoeven D. Potentially auticarcinogenic secondary metabolites from fruit and vegetables. In: Tomas-Barberan F A, Robins R J (eds). Phytochemistry of Fruit and Vegetables. Oxford, UK: Oxford Science Publications, 1997: 313-329
4. Leake D S. The possible role of antioxidants in fruit, vegetables in protecting against coronary heart disease. In: Tomas-Barberan F A, Robins R J (eds). Phytochemistry of Fruit and Vegetables. Oxford, UK: Oxford Science Publications, 1997: 287-311
5. Bors W, Heller W, Michel C, Saran M. Flavonoids as antioxidants: determination of radical scavenging efficiencies. Methods Enzymol 1990; 186: 343-355
6. Cook N C, Samman S. Flavonoids - chemistry, metabolism, cardioprotective effects, and dietary source. J Nutr Biochem 1996; 7: 66-76
7. Middleton R H. The flavonoids. Trends Pharmacol Sci 1984; 5: 335-338
8. Gammal A A, Mansour R M. Antimicrobial activities of some flavonoid compounds. Zentrabl Mikrobiol 1986; 141: 561-565
9. Ng T B, Ling J M, Wang Z T. Examination of coumarins, flavonoids and polysaccharopeptide for antibacterial activity. Gen Pharmacol 1996; 27: 1237-1240
10. Aboobaker V S, Balgi A D, Bhattacharya R K. In vivo effect of dietary factors on the molecular action of aflatoxin B1: Role of non-nutrient phenolic compounds on the catalytic activity of liver fraction. In Vivo 1994; 8: 1095-1098
11. Gordon P B, Holen I, Seglen P O. Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid. J Biol Chem 1995; 270: 5830-5838
12. Blankson H, Holen I, Seglen P O. Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid. Exp Cell Res 1995; 218: 522-530
13. Affany A, Salvayre R, Douste-Blazy L. Comparison of the protective effect of various flavonoids against lipid peroxidation of erythrocyte membranes (induced by cumene hydroperoxide). Fundam Clin Pharmacol 1987; 1: 451-457
14. Chen Y T, Zheng R L, Jia Z J. Flavonoids as superoxide scavengers and antioxidants. Free Radical Biol Med 1990; 9: 19-21
15. Gabor M, Antal A, Liptak K. Capillary resistance in the skin of rats fed flavone-free and atherogenic diets, and their response to hesperidin-methylchakone. Acta Physiol Acad Sci Hung 1970; 38: 71-75
16. Basarkar P W, Nath N. Cholesterol lowering action of vitamin P-like compounds in rats. Indian J Exp Biol 1981; 19: 787-789
17. Rathi A B, Nath N, Chari S N. Action of vitamin P like compounds on lysosomal status in hypercholesterolemic rats. Acta Vitaminol Enzymol 1983; 5: 255-261
18. Monforte M J, Trovato A, Kirjavainen S. Biological effects of hesperidin, a citrus flavonoid (note II): hypolipidemic activity on experimental hypercholesterolemia in rat. Pharmacology 1995; 50: 595-599
19. Bok S H, Shin Y W, Bae K H. Effects of naringin and lovastatin on plasma and hepatic lipids in high-fat and high-cholesterol fed rats. Nutr Res 2000; 20: 1007-1015
20. Sin Y W, Bok S H, Jeong T S et al. Hypocholesterolemic effect of naringin is associated with hepatic cholesterol regulating enzyme changes. Int J Vitam Nutr Res 1999; 69: 341-347
21. Choi M S, Do K M, Park Y B et al. Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. Ann Nutr Metab 2001; 45: 193-201
22. Jeon S M, Bok S H, Jan M K et al. Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits. Clin Chim Acta 2002; 317: 181-190
23. McCord J M, Fridovich I. Superoxide dismutase. An enzymatic function for erythrocuprein (Hemocuprein). J Biol Chem 1969; 244: 6049-6055
24. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974; 47: 469-474
25. Aebi H. Catalase in Method of Enzymatic Analysis, Vol 2. New York: Academic Press, 1974: 673-684
26. Paglia E D, Valentine W N. Studies on the quantitative and qualitative characterization of erythrocytes glutathione peroxidase. J Lab Clin Med 1967; 70: 158-169
27. Tarladgis B G, Pearson A M, Duran L R. Chemistry of the 2thio-barbituric acid test for determination of oxidative rancidity in foods. J Sci Food Agric 1979; 95: 351-358
28. Moor de Burgos A, Wartanowicz M, Ziemlanski S. Blood vitamin and lipid levels in overweight and obese women. Eur J Clin Nutr 1992; 46: 803-808
29. Gey K F, Brubacher G B, Stahelin H B. Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. Am J Clin Nutr 1987; 45(5 Suppl): 1368-1377
30. Gey K F, Stahelin H B, Eichholzer M. Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke: basel prospective study. Clin Invest 1993; 71: 3-6
31. Singh R B, Niaz M A, Bishnoi I. Diet, antioxidant vitamins. oxidative stress and risk of coronary artery disease: the Peerzada Prospective Study. Acta Cardiol 1994; 49: 453-467
32. Singh R B, Ghosh S, Niaz M A. Dietary intake, plasma levels of antioxidant vitamins, and oxidative stress in relation to coronary artery disease in elderly subjects. Am J Cardiol 1995; 76: 1233-1238
33. Adams A K, Wermuth E O, McBride P E. Antioxidant vitamins and the prevention of coronary heart disease. Am Fam Physician 1999; 60: 895-904
34. Kendall M J, Nuttall S L, Martin U. Antioxidant therapy - a new therapeutic option for reducing mortality from coronary artery disease. J Clin Pharm Ther 1998; 23: 323-325
35. Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) Lancet 1994; 344: 1383-1389
36. Shepherd J, Cobbe S M, Ford I. For the west of Scotland Coronary Prevention Study Group. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med 1995; 333: 1301-1307
37. Sacks F M, Pfeffer M A, Moye L A. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 1996; 335: 1001-1009
38. Downs J R, Clearfield M, Weis S. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. JAMA 1998; 279: 1615-1622
39. The Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID) Study Group. Prevention of cardiovasacular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357
40. Kuhnau J. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet 1976; 24: 117-191
41. Hertog M G, Hollman P C, Katan M B, Kromhout D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer 1993; 20: 21-29
42. Markham K R. Flavones, flavonols and their glycosides. Methods Plant Biochem 1989; 1: 197-235
43. Penny M, Kris-Etherton, Carl L. Keen. Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health. Curr Opin Lipidol 2002; 13: 41-49
44. Gugler R, Leschik M, Dengler H J. Disposition of quercetin in man after single oral and intravenous doses. Eur J Clin Pharmacol 1975; 9: 229-234
45. Shoskes D A. Zeitlin S I, Shahed A, Rajfer J. Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 1999; 54: 960-963
46. Choe S C, Kim H S, Jeong T S, Bok S H, Park Y B. Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits. J Cardiovasc Pharmacol 2001; 38: 947-955
47. Kurowska E M, Borradaile N M, Spence J D, Carroll K K. Hypocholesterolemic effects of dietary citrus juices in rabbits. Nutr Res 2000; 20: 121-129
48. Harats D, Chevion S, Nahir M, Norman Y, Sagee O, Berry E M. Citrus fruit supplementation reduces lipoprotein oxidation in young men ingesting a diet high in saturated fat: presumptive evidence for an interaction between vitamins C and E in vivo. Am J Clin Nutr 1998; 67: 240-245
49. Bellu R, Ortisi M T, Scaglioni S, Agostini C, Salanitri V S, Riva E, Giovannini M T. Lipid and apoprotein A-I and B levels in obese school age children. Results of a study in the Milan area. J Pediatr Gastroenterol Nutr 1993; 16: 446-450
50. Norum K R. Dietary fat, blood lipids. Nutr Rev 1992; 50: 30-37
51. Dennison B A, Kikuchi D A, Srinivasa S R, Webber L S, Berenson G S. Measurement of apolipoprotein B as a screening test for identifying children with elevated levels of low-density lipoprotein cholesterol. J Pediatr 1990; 117: 358-363
52. Kurowska E M, Hasegawa S, Manners G D. Regulation of apo B production in HepG2 cells by citrus limonoids. In: Berhow E M, Hasegawa S, Manners G D (eds). Citrus limonoids: functional chemicals in agriculture and foods. ACS Symposium Series, Vol. 758. Wahington, DC: American Chemical Society, 2000: 175-184
53. Anderson J W, Johnstone B M, Cook-Newell M E. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 1995; 332: 276-282
54. Raines E W, Ross R. Biology of atherosclerotic plaque formation: possible role of growth factors in lesion development and the potential impact of soy. J Nutr 1995; 125: 624S-630S
55. Anderson J J B, Anthony M, Messina M, Garner S C. Effects of phytoestrogens on tissues. Nutr Res Rev 1999; 12: 75-116
56. Miksicek R J. Estrogenic flavonoids: structural requirements for biological activity. Proc Soc Exp Biol Med 1995; 208: 44-50
57. Shorey R L, Bazan B, Lo G D, Steinke F H. Determinants of hypocholesterolemic response to soy and animal protein based diets. Am J Clin Nutr 1981; 34: 1769-1778
58. Breinholt V, Larsen J C. Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay. Chem Res Toxicol 1998; 11: 622-629
59. Kroyer G. The antioxidant activity of citrus fruit peels. Z Ernäbrungswiss 1986; 25: 63-69
60. Ueng Y F, Chang Y L, Oda Y, Park S S, Liao J F, Lin M F, Chen C F. In vitro and in vivo effects of naringin on cytochrone P450-dependent monoxygenase in mouse liver. Life Sci 65: 2591-2602
61. Ng T B, Liu F, Wang Z T. Antioxidative activity of natural products from plants. Life Sci 2000; 66: 709-723
62. Fukuda F, Ohta T, Yamazoe Y. Grapefruit component interacting with rat and human P450 CYP3A: possible involvement of non-flavonoid components in drug interaction. Biol Pharm Bull 1997; 20: 560-564
63. Guengerich F P, Kim D H. In vitro inhibition of dihydropyridine oxidation and alfatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. Carcinogenesis 1990; 11: 2275-2279
64. Dror H, Shlomit C, Menahem N. Yehudit N, Oded S, Elliot M B. Citrus fruit supplementation reduces lipoprotein oxidation in young men ingesting a diet high in saturated fat: presumptive evidence for an interaction between vitamins C and E in vivo. Am J Clin Nutr 1998; 67: 240-245
65. Chan T, Galati G, O'Brien P J. Oxygen activation during peroxidase catalyzed metabolism of lavones or flavanones. Chem Biol Interact 1999; 122: 15-25
66. Galati G, Chan T, Wu B, O'Brien P J. Glutathione-dependent generation of reactive oxygen species by the peroxidase-catalyzed redox cycling of flavonoids. Chem Res in Toxicol 1999; 12: 521-525
67. Ratty A K, Das N F. Effects of flavonoids on nonenzymatic lipid peroxidation: structure-activity relationship. Biochem Med Metab Biol 1988; 39: 69-79
68. Haron D. The aging: major risk factor for disease and death. Proc Natl Acad Sci USA 1991; 88: 5360-5364
69. Lee M K, Bok S H, Jeong T S, Moon S S, Lee S E, Park Y B, Choi M S. Supplementation of naringenin and its synthetic derivative alters antioxidant enzyme activities of erythrocyte and liver in high cholesterol-fed rat. Bioorg Med Chem 2002; 10: 2239-2244