Folate deprivation induces neurodegeneration: Roles of oxidative stress and increased homocysteine

Neurobiology of Disease

Volumn 14, Issue 1, 2003, Pages 32-42

  Ho, Pei I ^a   Ashline, David ^a   Dhitavat, Sirikarnt ^a   Ortiz, Daniela ^a   Collins, Scott C ^b   Shea, Thomas B ^a,b   Rogers, Eugene ^a  

^a UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

^b University of Massachusetts Lowell   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 DEAZAADENOSINE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; AMINO ACID; AMYLOID BETA PROTEIN; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; DIZOCILPINE; FOLIC ACID; GLUTATHIONE; HOMOCYSTEINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTOXIN; NIMOPRIDINE; PHOSPHORUS DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; CYTOSOL; DISEASE ASSOCIATION; EMBRYO; EMBRYO CELL; FOLIC ACID DEFICIENCY; HOMEOSTASIS; HUMAN; HUMAN CELL; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROBLASTOMA CELL; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRECURSOR; PRIORITY JOURNAL; PROTEIN DETERMINATION; QUANTITATIVE ANALYSIS; VITAMIN SUPPLEMENTATION;

EID: 0041833480     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-9961(03)00070-6     Document Type: Article

References (65)

1. Allen, R.H., Stabler, S.P., Lindenbaum, J., 1998. Eur. J. Pediatr. 157, S122-S126.
2. Araki A., Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 422:1987;43-52.
3. Bell I.R., Edman J.S., Selhub J., Morrow F.D., Marby D.W., Kayne H.L., Cole J.O. Plasma homocysteine in vascular disease and nonvascular dementia of depressed elderly people. Acta Psychiat. Scand. 86:1992;386-390.
4. Blom H.J. Consequences of homocysteine export and oxidation in the vascular system. Semin. Thromb. Hemost. 26:2000;227-232.
5. Christensen B., Refsum H., Vintermyr O., Ueland P.M. Homocysteine export from cells cultured in the presence of physiological or superfluous levels of methionine methionine loading or non-transformed, transformed, proliferating, and quiescent cells in culture . J. Cell Physiol. 146:1991;52-62.
6. Clarke R., Smith A.D., Jobst K.A., Refsum H., Sutton L., Ueland P.M. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 55:1998;1449-1455.
7. Collins J.A., Schandi C.A., Young K.K., Vesely J., Willingham M.C. Major DNA fragmentation is a late event in apoptosis. J. Histochem. Cytochem. 45:1997;923-934.
8. Dhitavant S., Rogers E., Shea T.B. Differential efficacy of lipophilic and cytosolic antioxidants on generation of reactive oxygen species by amyloid-beta. J. Alz. Dis. 3:2001;525-529.
9. Dringen, R., Hamprecht, 1999. N-Acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain. Neurosci. Lett. 259, 79-82.
10. Duan W., Ladenheim B., Cutler R.G., Kruman I.I., Cadet J.L., Mattson M.P. Dietary folate defeciency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J. Neurochem. 80:2002;101-110.
11. Ekinci F.J., Shea T.B. Hyperphosphorylation of tau does not correlate with neurodegeneration in cortical neurons in culture. J. Alz. Dis. 2:2000;7-12.
12. Ekinci F.J., Linsley M.-D., Shea T.B. Beta-Amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation. Mol. Brain Res. 76:2000;389-395.
13. Ekinci F.J., Malik K.M., Shea T.B. Beta-Amyloid induces calcium influx and neurodegeneration by MAP kinase-mediated activation of the L voltage-sensitive calcium channel. J. Biol. Chem. 274:1999;30322-30327.
14. Fiskerstrand T., Ueland P.M., Refsum H. Folate depletion induced by methotrexate affects methionine synthase activity and its susceptibility to inactivation by nitrous oxide. J. Pharmacol. Exp. Ther. 282:1997;1305-1311.
15. Gray G.E. Nutrition and dementia. J. Am. Diet Assoc. 89:1989;1795-1802.
16. Gray C.W., Patel A.J. Neurodegeneration mediated by glutamate and beta-amyloid peptide a comparison and possible interaction . Brain Res. 691:1995;169-179.
17. Growdon J. Incorporating biomarkers into clinical drug trials in Alzheimer's disease. J. Alz. Dis. 3:2001;287-292.
18. Hassing L., Wahlin A., Winblad B., Backman L. Further evidence on the effects of vitamin B12 and folate levels on episodic memory functioning a population-based study of healthy very old adults . Biol. Psychiatry. 45:1999;1472-1480.
19. Hatanaka Y., Suzuki K., Kawasaki Y., Endo Y., Taniguchi N., Takei N. A role of peroxides in Ca ionophore-induced apoptosis in cultured rat cortical neurons. Biochem. Biophys. Res. Commun. 227:1996;513-518.
20. Ho P., Collins S.C., Dhitavat S., Ortiz D., Ashline D., Rogers E., Shea T.B. Homocysteine potentiates beta-amyloid neurotoxicity role of oxidative stress . J. Neurochem. 78:2001;249-253.
21. Ho P., Ashline D., Dhitavat S., Ortiz D., Collins S.C., Rogers E., Shea T.B. Folate deprivation induces neurodegeneration roles of oxidative stress and increased homocysteine . Mol. Biol. Cell. 12:2001;120a.
22. Ho, P.I., Ortiz, D., Rogers E., Shea, T.B., 2002. Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. J. Neurosci. Res., in press.
23. Huang H.M., Ou H.C., Hsieh S.J. Antioxidants prevent amyloid peptide-induced apoptosis and alteration of calcium homeostasis in cultured cortical neurons. Life Sci. 66:2000;1879-1892.
24. Huang R.F., Huang H.M., Lin B.S., Hung C.Y., Lu H.T. N-Acetylcysteine, vitamin C and vitamin E diminish homocysteine thiolactone-induced apoptosis in human promyeloid HL-60 cells. J. Nutr. 132:2002;2151-2156.
25. Hultberg B., Andersson A., Isaksson A. Metabolism of homocysteine, its relation to the other cellular thiols and its mechanism of cell damage in a cell culture line (human histiocytic cell line U-937). Biochim. Biophys. Acta. 1269:1995;6-12.
26. Jakubowski H. Metabolism of homocysteine thiolactone in human cell cultures. Possible mechanism for pathological consequences of elevated homocysteine levels. J. Biol. Chem. 272:1997;1935-1942.
27. Jeong S.-Y., Ahn S.-G., Lee J.-H., Kim H.-S., Kim J.-W., Rhim H., Jeong S.-W., Kim I.-K. 3-Deazaadenosine, S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kB regulation. J. Biol. Chem. 274:1999;18981-18988.
28. Kreis, W., Goodenow, M., 1987. Methionine requirement and replacement by homocysteine in tissue cultures of selected rodent and human malignant and normal cells. Cancer Res. 2259-2262.
29. Kruman I.I., Culmsee C., Chan S., Kruman Y., Guo Z., Penix L., Mattson M.P. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J. Neurosci. 20:2000;6920-6926.
30. Kruman I.I., Kumaravel T.S., Lohani A., Pedersen W.A., Cutler R.G., Kruman Y., Haughey N., Lee J., Evans M., Mattson M.P. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J. Neurosci. 22:2002;1752-1762.
31. Levitt A.J., Karlinsky H. Folate, vitamin B12 and cognitive impairment in patients with Alzheimer's disease. Acta Psychiatr. Scand. 86:1992;301-305.
32. Lucock M.D., Daskalakis I.G., Wild J., Anderson A., Schorah C.J., Lean M.E.J., Levene M.I. The influence of dietary folate and methionine on the metabolic disposition of endotoxic homocysteine. Biochem. Mol. Med. 59:1996;104-111.
33. Mattson, M.M., Shea, T.B., 2002. Folate and homocysteine in neural plasticity and neurodegenerative disorders. Trends Neurosci., in press.
34. McCaddon A., Kelly C.L. Familial Alzheimer's disease and vitamin B12 deficiency. Age Ageing. 23:1992;334-337.
35. Miller J.W. Homocysteine, Alzheimer's disease and cognitive function. Nutrition. 16:2000;675-677.
36. Mitchell J.R., Jollow D.J., Potter W.Z., Gillette J.R., Brodie B.B. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J. Pharmacol. Exp. Ther. 187:1973;211-217.
37. Mosharov E., Cranfored M.R., Banerjee R. The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. Biochemistry. 39:2000;13005-13011.
38. Nilsson K., Gustafson L., Faldt R., Anderson A., Hultberg B. Plasma homocysteine in relation to serum cobalamin and blood folate in a psychogeriatric population. Eur. J. Clin. Invest. 24:1994;600-606.
39. Nilsson-Ehle H. Age-related changes in cobalamin (vitamin B12) handling. Implications for therapy. Drugs Aging. 12:1998;277-292.
40. Oliveri G., Baysang G., Meier F., Müller-Spahn F., Stähelin H.B., Brockhaus Brack C.H. N-Acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity effects on β-amyloid secretion and tau phosphorylation . J. Neurochem. 76:2001;224-233.
41. Ou Y.C., White C.C., Krejsa C.M., Ponce R.A., Kavanaugh T.J., Faustman E.M. The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. Neurotoxicology. 20:1999;793-804.
42. Pietrzik K., Bronstrup A. Vitamins B12, B6 and folate as determinants of homocysteine concentration in the healthy population. Eur. J. Pediatr. 157:1998;S135-S138.
43. Reers M., Smith T.W., Chen L.B. Aggregate formation of a carbocyanide as a quantitative fluorescent indicator of membrane potential. Biochemistry. 30:1991;4480-4486.
44. Regland B., Blennow K., Germgard T., Kock-Schmidt A.-C., Gottfries C.-G. The role of the polymorphic genes apolipoprotein E and methylene-tetrahydrofolate reductase in the development of dementia of the Alzheimer type. Dement. Geriatr. Cogn. Disord. 10:1999;245-251.
45. Regland B., Gottfries C.G., Oreland L., Svennerholm L. Low B12 levels related to high activity of platelet MAO in patients with dementia disorders. A retrospective study. Acta Psychiatr. Scand. 78:1988;451-457.
46. Regland B., Abrahamsson L., Blennow K., Gottfries C.G., Wallin A. Vitamin B12 in CSF reduced CSF/serum B12 ratio in demented men . Acta Neurol. Scand. 85:1992;276-281.
47. Renvall M.J., Spindler A.A., Ramsdell J.W., Paskvan M. Nutritional status of free-living Alzheimer's patients. Am. J. Med. Sci. 298:1989;20-27.
48. Rimon G., Bazenet C.E., Philpott K.L., Rubin L.L. Increased surface phosphatidylserine is an early marker of neuronal apoptosis. J. Neurosci. Res. 48:1997;563-570.
49. Schulz J.B., Kindenau J., Dichgans J. Glutathione, oxidative stress and neurodegeneration. Eur. J. Biochem. 267:2000;4904-4911.
50. Serot J.M., Christman D., Dubost T., Bene M.C., Faure G.C. CSF-folate levels are decreased in late-onset AD patients. J. Neural Transm. 108:2001;93-99.
51. Shea T.B., Rogers E. Homocysteine as a risk factor for Alzheimer's disease. N. Engl. J. Med. 346:2002;2007.
52. Shea, T.B., Rogers, E., 2002b. Folate quenches oxidative damage in brains of apolipoprotein E-deficient mice: augmentation by vitamin E. Mol. Brain Res., in press.
53. Shea, T.B., Lyons-Wieler, J., Rogers, E., 2002. Homocysteine, folate deprivation and Alzheimer's disease. J. Alz. Dis., in press.
54. Snowdon D.A., Tully C.L., Smith C.D., Riley D., Markesbery W. Serum folate and the severity of atrophy of the neocortex in Alzheimer disease findings from the Nun Study . Am. J. Clin. Nutr. 71:2000;993-998.
55. Trolin C.G., Regland B., Oreland L. Decreased methionine adenosyltransferase activity in erythrocytes of patients with dementia disorders. Eur. Neuropsychopharmacol. 5:1995;107-114.
56. 2+ channels a possible involvement of free radicals . J. Neurochem. 68:1997;265-271.
57. Ueland P.M., Hustad S., Schneede J.M., Refsum H., Vollset S.E. Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharm. Sci. 22:2001;195-201.
58. Upchurch G.R., Welch G.N., Fabian A.J., Freedman J.E., Johnson J.L., Keaney J.F., Loscalzo J. Homocysteine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J. Biol. Chem. 272:1997;17012-17017.
59. Wadia J.S., Chalmers-Redman R.M., Ju W.J., Carlile G.W., Phillips J.L., Fraser A.D., Tatton W.G. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal time course and modification by (-)-deprenyl . J. Neurosci. 18:1998;932-947.
60. Wang H.-X., Wahlin A., Basun H., Fastom J., Winblad B., Fratiglioni L. Vitamin B12 and folate in relation to the development of Alzheimer's disease. Neurology. 56:2001;1188-1194.
61. Wevers R.A., Hansen S.I., Hubar J.L.MvH., Holm J., Hoier-Madsen M., Jongen P.J.H. Folate deficiency in cerebrospinal fluid associated with a defect in folate binding protein in the centra nervous system. J. Neurol. Neurosurg. Psych. 57:1994;223-226.
62. White A.R., Huang X., Jobling M.F., Barrow C.H., Beyreuther K., Masters C.L., Bush A.I., Cappai R. Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary cultures possible risk factors in the Alzheimer's-type neurodegenerative pathways . J. Neurochem. 76:2001;1509-1520.
63. Wynn M., Wynn A. The danger of B12 deficiency in the elderly. Nutr. Health. 12:1998;215-226.
64. Wynn M., Wynn A. Fortification of grain products with folate should Britain follow the American example? Nutr. Health. 12:1998;147-161.
65. Zuttiun J. Congenital effors of folate metabolism. Baillierels Clin. Haematol. 8:1995;603-616.