Lutein, but not α-tocopherol, supplementation improves visual function in patients with age-related cataracts: A 2-y double-blind, placebo-controlled pilot study

Nutrition

Volumn 19, Issue 1, 2003, Pages 21-24

  Olmedilla, B ^a   Granado, F ^a   Blanco, I ^a   Vaquero, M ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

tocopherol; Cataracts; Lutein; Supplementation study

Indexed keywords

ALPHA TOCOPHEROL; PLACEBO; XANTHOPHYLL;

ADULT; AGED; ANALYTIC METHOD; ANTIOXIDANT ACTIVITY; ARTICLE; BIOLOGICAL MONITORING; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FOOD INTAKE; FRUIT; GLARE; HEMATOLOGICAL PARAMETERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LONG TERM CARE; MALE; PARAMETER; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SENILE CATARACT; TREATMENT OUTCOME; VEGETABLE; VISION; VISUAL ACUITY; VITAMIN SUPPLEMENTATION;

AGE FACTORS; AGED; ALPHA-TOCOPHEROL; ANTIOXIDANTS; CATARACT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GLARE; HUMANS; LONGITUDINAL STUDIES; LUTEIN; MALE; MIDDLE AGED; PILOT PROJECTS; VISUAL ACUITY;

EID: 0037221102     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(02)00861-4     Document Type: Article

References (26)

1. Varma S. D. Scientific basis for medical therapy of cataracts by antioxidants. Am J Clin Nutr. 53:1991;3 35S.
2. Taylor A. Beyond deficiency new views on the function and health effects of vitamins. Ann NY Acad Sci. 669:1992;111.
3. Bunce G.E. Nutrition and eye disease of the elderly. J Nutr Biochem. 5:1994;66.
4. Hankinson S.E., Stampfer M.J., Seddon J.M. Nutrient intake and cataract extraction in women a prospective study. BMJ. 305:1992;335.
5. Jacques P.F., Chylack L.T. Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention. Am J Clin Nutr. 53:1991;53:352S.
6. Mares-Perlman J.A., Brady W.E., Klein B.E., et al. Serum carotenoids and tocopherols and severity of nuclear and cortical opacities. Invest Ophthalmol Vis Sci. 36:(2):1995;276.
7. Tavani A., Negri E., La Vecchia C. Food and nutrient intake and risk of cataract. Ann Epidemiol. 6:1996;41.
8. Chasan-Traber L., Willett W.C., Seddon J.M., et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr. 70:1999;509.
9. Bone R.A., Landrum J.T., Tarsis S.L. Preliminary identification of the human macular pigment. Vis Res. 25:1985;1531.
10. Alvarez R.A., Liou G.Y., Fong S.-L., et al. Levels of α- and γ-tocopherol in human eyes evaluation of the possible role of IRBP in intraocular α-tocopherol transport. Am J Clin Nutr. 46:1987;481.
11. Bates C.J., Chen S.-J., MacDonald A., et al. Quantitation of vitamin E and a carotenoid pigment in cataractous human lenses and the effect of a dietary supplement. Int J Vitam Nutr Res. 66:1996;316.
12. Yeum K.-J., Taylor A., Tang G., et al. Measurement of carotenoids, retinoids and tocopherols in human lenses. Invest Ophthalmol Vis Sci. 36:1995;2756.
13. Hammond B.R., Wooten B.R., Snodderly D.M. Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. Optom Vis Sci. 74:1997;499.
14. Handelman G.J., Dratz E.A., Reay C.C., et al. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci. 29:1988;850.
15. Handelman G.J., Snodderly D.M., Adler A.J., et al. Measurement of carotenoids in human and monkey retinas. Methods Enzymol. 213:1992;220.
16. Hammond B.R., Johnson E.J., Russell R.M., et al. Dietary modification of human macular pigment density. Invest Ophthalmol Vis Sci. 38:1997;1795.
17. Landrum J.T., Bone R.A., Joa H., et al. A one year study of the macular pigment the effect of 140 days of a lutein supplement. Exp Eye Res. 65:1997;57.
18. Johnson E., Hammond B.R., Yeum K.-J., et al. Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. Am J Clin Nutr. 71:2000;1555.
19. Olmedilla B, Granado F, Blanco I, et al. Serum status of carotenoids and tocopherols in patients with cataracts: a case-control study. J Nutr Health Ageing 2001;6:66.
20. Olmedilla B., Granado F., Blanco I., Vaquero M., Cajigal C. Lutein in patients with cataracts and age-related macular degeneration a long-term supplementation study. J Sci Food Agric. 81:2001;904.
21. Olmedilla B., Granado F., Gil-Martínez E., et al. Reference levels of retinol,α-tocopherol and main carotenoids in serum of control and insulin-dependent diabetic Spanish subjects. Clin Chem. 43:1997;1066.
22. Dereferldt G., Lennestran S.G., Wund B. Age variation in normal human contrast sensitivity. Acta Ophthalmol. 57:1979;679.
23. Vaquero M., Encinas J.L., Jimenez F. Visual function with monofocal versus multifocal IOLs. J Cataract Refract Surg. 22:1996;1222.
24. Hammond B.R., Wooten B.R., Curran-Celentano J. Carotenoids in the retina and lens possible acute and chronic effects on human visual performance. Arch Biochem Biophys. 385:2001;41.
25. Mares-Perlman J.A. Too soon for lutein supplements. Am J Clin Nutr. 70:1999;431.
26. Granado F., Olmedilla B., Gil-Martinez E., et al. Lutein ester in serum after lutein supplementation in humans. Br J Nutr. 80:1998;445.