Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation

Journal of Neuroscience

Volumn 19, Issue 18, 1999, Pages 8114-8121

  Joseph, James A ^a   Shukitt Hale, Barbara ^a   Denisova, Natalia A ^a   Bielinski, Donna ^a   Martin, Antonio ^a   McEwen, John J ^a   Bickford, Paula C ^b  

^a TUFTS UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Aging; Cognitive behavior; Dopamine; Motor behavior; Phytonutrients; Striatum

Indexed keywords

AGING; ANIMAL EXPERIMENT; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DIET SUPPLEMENTATION; FOOD; FRUIT; LOCOMOTION; MALE; MOTOR ACTIVITY; MOTOR DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPINACH;

EID: 0033568849     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-18-08114.1999     Document Type: Article

References (76)

1. Armstrong BK, Mann JI, Adelstein AM, Eskin F (1975) Commodity consumption and ischemic heart disease mortality, with special reference to dietary practices. J Chron Dis 28:455-469.
2. Bartus RT (1990) Drugs to treat age-related neurodegenerative problems. The final frontier of medical science? J Am Geriat Soc 38:680-695.
3. Brandeis R, Brandys Y, Yehuda S (1989) The use of the Morris water maze in the study of memory and learning. Int J Neurosci 48:29-69.
4. Cao G, Verden CP, Wu AHB, Wang H, Prior RL (1995) Automated oxygen radical absorbance capacity assay using the COBAS FARA II. Clin Chem 41:1738-1744.
5. Cao G, Sofic E, Prior RL (1996) Antioxidant capacity of tea and common vegetables. J Agric Food Chem 44:3426-3431.
6. Cao G, Sofic E, Prior RL (1997) Antioxidant and pro-oxidant behavior of flavonoids: Structure-activity relationships. Free Radic Biol Med 22:749-760.
7. Carney JM, Smith CD, Carney AM, Butterfield DA (1994) Aging- and oxygen-induced modifications in brain biochemistry and behavior. Ann NY Acad Sci 738:44-53.
8. Cassel D, Selinger Z (1976) Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes. Biochem Biophys Acta 452:538-551.
9. Daniels WM, van Rensburg SJ, van Zyl JM, Taljaard JJ (1998) Melatonin prevents β-amyloid-induced lipid peroxidation. J Pineal Res 24:78-82.
10. Denisova NA, Erat SA, Kelly JF, Roth GS (1998) Differential effect of aging on cholesterol modulation of carbachol stimulated Low-Km GTPase in striatal synaptosomes. Exp Gerontol 33:249-265.
11. Dell R (1990) An overview of the epidemiological evidence linking diet and cancer. Proc Nutr Soc 49:119-131.
12. Egashira T, Takayama F, Yamanaka Y (1996) Effects of bifemelane on muscarinic receptors and choline acetyltransferase in the brains of aged rats following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries. Jpn J Pharmacol 72:57-65.
13. Finch CE, Cohen DM (1997) Aging, metabolism, and Alzheimer's disease: review and hypotheses. Exp Neurol 143:82-102.
14. Gould TJ, Bickford P (1997) Age-related deficits in the cerebellar β adrenergic signal transduction cascade in Fischer 344 rats. J Pharmacol Exp Ther 281:965-971.
15. Graybiel AM (1998) The basal ganglia and chunking of action repertoires. Neurobiol Learn Mem 70:119-136.
16. Halder J, Bhaduri AN (1998) Protective role of black tea against oxidative damage of human red blood cells. Biochem Biophys Res Comm 244:903-907.
17. Hughes K (1995) Diet and coronary heart disease - a review. Ann Acad Med Singapore 24:224-229.
18. Ingram DK, Jucker M, Spangler E (1994) Behavioral manifestations of aging. In: Pathobiology of the aging rat, Vol 2 (Mohr U, Cungworth DL, Capen CC, eds), pp 149-170. Washington: ILSI.
19. Jenner P (1996) Oxidative stress in Parkinson's disease and other neurodegenerative disorders. Pathol Biol 44:57-64.
20. Joseph JA, Berger RE, Engel BT, Roth GS (1978) Age-related changes in the nigrostriatum: a behavioral and biochemical analysis. J Gerontol 33:643-649.
21. Joseph JA, Bartus RT, Clody DE, Morgan D, Finch C, Beer B, Sesack S (1983) Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation. Neurobiol Aging 4:313-319.
22. +-evoked release of endogenous striatal dopamine: an indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence. Brain Res 454:140-148.
23. Joseph JA, Dalton TK, Roth GS, Hunt WA (1988b) Alterations in muscarinic control of striatal dopamine autoreceptors in senescence: a deficit at the ligand-muscarinic receptor interface? Brain Res 454:149-155.
24. Joseph JA, Kowatch MA, Maki T, Roth GS (1990) Selective cross activation/inhibition of second messenger systems and the reduction of age-related deficits in the muscarinic control of dopamine release from perifused rat striata. Brain Res 537:40-48.
25. +-evoked dopamine release from striatal slices by cholesterol and S-adenosyl-L-methionine. Brain Res 673:185-193.
26. +-evoked dopamine release from superfused striatal slices: reversals by PBN or Trolox. Free Radic Biol Med 20:821-830.
27. Joseph JA, Shukitt-Hale B, Denisova NA, Prior RL, Cao G, Martin A, Taglialatela G, Bickford PC (1998) Long-term dietary strawberry, spinach or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J Neurosci 18:8047-8055.
28. Kanowski S, Herrmann WM, Stephan K, Wierich W, Horr R (1996) Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 29:47-56.
29. Kleijnen J, Knipschild P (1992a) Ginkgo biloba. Lancet 340:1136-1139.
30. Kleijnen J, Knipschild P (1992b) Ginkgo biloba for cerebral insufficiency. Br J Clin Pharmacol 34:352-358.
31. Kluger A, Gianutsos JG, Golomb J, Ferris S H, George AE, Frannssen E, Reisberg B (1997) Patterns of motor impairment in normal aging, mild cognitive decline, and early Alzheimer's disease. J Gerontol 52:28-39.
32. Kornhuber J, Schoppmeyer K, Bendig, C, Riederer P (1996) Characterization of [3H] pentazocine binding sites in post-mortem human frontal cortex. J Neural Transm 103:45-53.
33. Krischer SM, Eisemann M, Bock A, Mueller MJ (1997) Protein-facilitated export of arachidonic acid from pig neutrophils. J Biol Chem 272:10601-10607.
34. Kuhnau J (1976) The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet 24:117-191.
35. 2+. Ann NY Acad Sci 746:308-321.
36. Lebel CP, Ischiropolos H, Bondy SC (1992) Evaluation of the probe 2′,7′-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5:227-231.
37. Levine MS, Cepeda C (1998) Dopamine modulation of responses mediated by excitatory amino acids in the neostriatum. Adv Pharmacol 42:724-729.
38. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:256-275.
39. Martin A, Janigian D, Shukitt-Hale B, Prior RL, Joseph JA (1999) Vitamin E intake and levels of vitamins E and C in the central nervous system and peripheral tissues: implications for health recommendations. Brain Res, in press.
40. Martin A, Blumberg J, Foxall T, Meydani M (1997) Vitamin E inhibits low-density lipoprotein-induced adhesion of monocytes to human aortic endothelial cells in vitro. Arterioscler Thromb Vase Biol 17:429-436.
41. Mayne ST (1996) Beta-carotene, carotenoids and disease prevention in humans. FASEB J 10:690-701.
42. Migheli A, Cavalla P, Piva R, Giordana MT, Schiffer D (1994) Bcl-2 protein expression in aged brain and neurodegenerative diseases. NeuroReport 5:1906-1908.
43. Mirzoeva OK, Calder PC (1996) The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot Essent Fatty Acids 55:441-449.
44. Moriguchi T, Saito H, Nishiyama N (1997) Anti-aging effect of aged garlic extract in the inbred brain atrophy mouse model. Clin Exp Pharmacol Physiol 24:235-242.
45. Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47-60.
46. Nagahara AH, Gill TM, Nicolle M, Gallagher M (1996) Alterations in opiate receptor binding in the hippocampus of aged Long-Evans rats. Brain Res 707:22-30.
47. Nishiyama N, Moriguchi T, Saito H (1997) Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse. Exp Gerontol 32:149-160.
48. Olanow CW (1992) An introduction to the free radical hypothesis in Parkinson's disease. Ann Neurol 32:S2-S9.
49. +2-induced increase in oxidative metabolism of dissociated mammalian brain neurons: effect of extract of Ginkgo Biloba leaves. Jpn J Pharmacol 61:367-370.
50. +2-loaded brain neurons. Brain Res 635:125-129.
51. Pike CJ, Ramezan-Arab N, Cotman CW (1997) β-amyloid neurotoxicity in vitro: evidence of oxidative stress but not protection by antioxidants. J Neurochem 69:1601-1611.
52. Pinto JT, Qiao C, Xing J, Rivilin RS, Protomastro MLW, Weissler ML, Tao Y, Thaler H, Heston WD (1997) The effects of garlic thioallyl derivatives on growth glutathione concentration and polyamine formation of human prostate carcinoma cells in culture. Am J Clin Nutr 66:398-405.
53. Prior RL, Cao G, Martin A, Sofic E, McEwen J, O'Brien C, Lischner N, Ehlenfeldt M, Kalt W, Krewer G, Mainland M (1998) Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity and variety of Vaccinium species. J Agric Food Chem 46:2586-2593.
54. Rai SS, Shovlin C, Wesnes KA (1991) A double-blind placebo controlled study of Ginkgo biloba extract ("tanakan") in elderly outpatients with mild to moderate memory impairment. Curr Med Res Opin 12:350-355.
55. 2+-induced decrease in synaptosomal membrane fluidity. Free Radic Res Commun 19:341-350.
56. Rapp PR, Rosenberg RA, Gallagher M (1987) An evaluation of spatial information processing in aged rats. Behav Neurosci 101:3-12.
57. Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon R G, Smith MA (1997) 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's Disease. J Neurochem 68:2092-2097.
58. Sharoni Y, Giron E, Rise M, Levy J (1997) Effects of lycopene-enriched tomato oleoresin on 7,12-dimethyl-benz[a]anthracene-induced rat mammary tumors. Cancer Detect Prevent 21:118-123.
59. Shear DA, Dong J, Haik-Creguer KL, Bazzett TJ, Albin RL, Dunbar GL (1998) Chronic administration of quinolinic acid in the rat striatum causes spatial learning deficits in a radial arm water maze. Exp Neurol 150:305-311.
60. Shukitt-Hale B, Erat SA, Joseph JA (1998a) Spatial learning and memory deficits induced by dopamine administration with decreased glutathione. Free Radic Biol Med 24:1149-1158.
61. Shukitt-Hale B, Mouzakis G, Joseph J A (1998b) Psychomotor and spatial memory performance in aging male Fischer 344 rats. Exp Gerontol 33:615-624.
62. Smith CD, Carney JM, Starke-Reed PE, Oliver CN, Stadtman ER, Floyd RA, Markesbery WR (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer's disease. Proc Natl Acad Sci USA 88:10540-10543.
63. Smith MA, Udnicka-Nawrot M, Richey PL, Praprotnik D, Mulvihill P, Miller CA, Sayre, LM, Perry G (1995) Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease. J Neurochem 64:2660-2666.
64. Smith MA, Perry G, Richey PL, Sayre LM, Anderson VE, Beal MF, Kowall N (1996) Oxidative damage in Alzheimer's. Nature 382:120-121.
65. Stoll S, Scheur K, Pohl O, Muller WE (1996) Ginkgo biloba extract Egb761 independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse. Pharmacopsychiatry 29:144-149.
66. Tanila H, Bjorklund M, Riekkinen Jr P (1998) Cognitive changes in mice following moderate MPTP exposure. Brain Res Bull 45:577-582.
67. 2+ channels: a possible involvement of free radicals. J Neurochem 68:265-271.
68. Van der Staay FJ, de Jonge M (1993) Effects of age on water escape behavior and on repeated acquisition in rats. Behav Neural Biol 60:33-41.
69. Verlangieri AJ, Kapeghian JC, el-Dean S, Bush M (1985) Fruit and vegetable consumption and cardiovascular mortality. Medical Hypothesis 16:7-15.
70. Wang H, Cao G, Prior R (1996) Total antioxidant capacity of fruits. J Agric Food Chem 44:701-705.
71. Wattenberg LW, Coccia JB (1991) Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-bulanone carcinogenesis in mice by D-limonene and citrus fruit oils. Carcinogenesis 12:115-117.
72. Willett CW (1994a) Diet and health: what should we eat? Science 264:532-537.
73. Willett CW (1994b) Micronutrients and cancer risk. Am J Clin Nutr 59:162S-165S.
74. Yamagami K, Joseph JA, Roth GS (1992) Decrement in muscarinic-receptor stimulated low KM GTPase in striata and hippocampus from aged rat. Brain Res 57:327-331.
75. Yu BP (1994) Cellular defenses against damage from reactive oxygen species. Physiol Rev 76:139-162.
76. Yufu F, Egashira T, Ymanaka Y (1994) Age-related changes of cholinergic markers in the rat brain. Jpn J Pharmacol 66:247-255.