Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 62, Issue 4, 2000, Pages 253-259

  Ali, M ^a   Al Qattan, K K ^a   Al Enezi, F ^a   Khanafer, R M A ^a   Mustafa, T ^b  

^a KUWAIT UNIVERSITY   (Kuwait)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALLICIN; CHOLESTEROL; GLUCOSE; LIPID; PROTEIN; THROMBOXANE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; FEMALE; GARLIC; GLUCOSE BLOOD LEVEL; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; HYPERTENSION; LIPID BLOOD LEVEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL;

ALLIUM SATIVUM; ANIMALIA;

EID: 0034097881     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1054/plef.2000.0152     Document Type: Article

References (41)

1. Roser D. Garlic, garlic for health. 1991;Martin Books, Cambridge.
2. Arch Intern Med. 157:1997.
3. Ruffin J., Hunter S. A. An evaluation of the side effects of garlic as an antihypertensive agent. Cytobios. 37:1983;85-89.
4. Al-Qattan K. K., Alnaqeeb M. A., Ali M. The antihypertensive effect of garlic (Allium sativum) in the rat two-kidney, one-clip Goldblatt model. J Ethanopharmacology. 66:1999;217-222.
5. Bolton S., Null G., Troetel W. M. The medical uses of garlic: fact and fiction. Am Pharmacy. 22:1982;448-451.
6. Kwiterovich. P. O Jr. Detection and treatment of elevated blood lipids and other risk factors for coronary artery disease in youth. In: Atherosclerosis III. Recent Advances in Atherosclerosis Research: Ann N Y Acad Sci. 748:1995;343-332.
7. Warshafsky S., Kamer R. S., Sivak S. L. Effect of garlic on total serum cholesterol. A meta-analysis. Ann Intern Med. 119:1993;599-605.
8. Mader F. H. Treatment of hyperlipidamia with garlic-powder tablets. Evidence from the German Association of General Practitioners' multicentric placebo-controlled double-blind study. Arzneimittelforschung. 40:1990;1111-1116.
9. Ismail M. F., Gad M. Z., Hamdy M. A. Study of the hypolipidemic properties of pectin, garlic, and ginseng in hypercholesterolemic rabbits. Pharmacol Res. 39:1999;157-166.
10. Steiner M., Khan A. H., Holbert D., Lin R. I. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic and placebo administration on blood lipids. Am J Clin Nutr. 64:1996;866-870.
11. Issacsohn J. L., Moser M., Stein E. A., Dudley K., Davey J. A., Liskov E., Black H. R. Garlic powder and plasma lipids and lipoproteins: a multicenter, randomized, placebo-controlled trial. Arch Intern Med. 158:1998;1189-1194.
12. Berthold H. K., Sudhop T., Bergman K. V. Effect of garlic oil preparation on serum lipoproteins and cholesterol metabolism. A randomized controlled trial. JAMA. 279:1998;1900-1902.
13. Neil H. A. W., Silagy C. A., Lancaster T. Garlic powder in the treatment of moderate hyperlipidemia : a controlled trial and meta-analysis. J Roy Coll Physicians. 30:1996;329-334.
14. McCrindle B. W., Helden E., Conner W. T. Garlic extract therapy in children with hypercholesterolemia. Arch Pediatr Adolesc Med. 152:1998;1089-1094.
15. Eilat S., Oestraicher Y., Rabinkov A., Ohad D., Mirelman D., Battler A., Elder M., Vered Z. Alteration of lipid porfiles in hyperlipidemic rabbits by allicin, an active constituent of garlic. Coron Artery Dis. 6:1995;985-990.
16. Ahmed R. S., Sharma S. B. Biochemical studies on combined effects of garlic (Allium sativum Linn) and ginger (Zingiber officinale Rosc.) in albino rats. Indian J Exp Biol. 35:1997;841-843.
17. Sodimu O., Joseph P. K., Augusti K. T. Certain biochemical effects of garlic on rats maintained on high fat-high cholesterol diet. Experientia. 40:1984;78-80.
18. Bordia A., Verma S. K. Effect of garlic feeding on regression of experimental atherosclerosis in rabbits. Artery. 7:1980;428-437.
19. Koscielny J., Klussendorf D., Latza R., Schmitt R., Radtke H., Siegel G., Kiesewetter H. The antiatherosclerotic effect of Allium sativum. Atherosclerosis. 144:1999;237-249.
20. Gebhardt R. Inhibition of cholesterol biosynthesis by a water-soluble garlic extract in primary cultures of rat hepatocytes. Arzneimittelforschung. 41:1991;800-804.
21. Gebhardt R. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triglyceride synthesis. Lipids. 28:1993;613-619.
22. Gebhardt R., Beck H. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Lipids. 31:1996;1269-1279.
23. Yeh Y. Y., Yeh S. M. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis. Lipids. 29:1994;189-193.
24. Vorberg G., Schneider B. Therapy with garlic: results of placebo-controlled, double-blind study. Br J Clin Pract Suppl. 69:1990;7-11.
25. Auer W., Eiber A., Hertkorn E., Hoehfeld F., Koehrle U. Hypertension and hyperlipidaemia: garlic helps in mild cases. Br J Clin Pract Suppl. 69:1990;3-6.
26. Kiesewetter H., Jung F., Pindur G., Jung E. M., Morwietz C., Wenzel E. Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. Int J Clin Pharmacol Ther Toxicol. 29:1991;151-155.
27. Jain A. K., Vargas R., Gotzkowsky S., McMahon F. G. Can garlic reduce levels of serum lipids? A controlled clinical study. Am J Med. 94:1993;632-535.
28. Simons L. A., Balasubramaniam S., von Knigsmark M., Parfitt A., Simons J., Peters W. On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemia. Atherosclerosis. 113:1995;219-225.
29. Rietz B., Isensee H., Strobach H., Makdessi S., Jacob R. Cardioprotective actions of wild garlic (allium ursinum) in ischemia and reperfusion. Mol. Cell Biochem. 119:1993;143-150.
30. Fallon M. B., Abrams G. A., Abdel-Razek T. T., Dai J., Chen S. J., Chen Y. F., Luo B., Oparil S., Ku D. D. Garlic prevents hypoxic pulmonary hypertension in rats. Am J Physiol. 275:1998;L283-287.
31. Kaye A. D., Nossaman B. D., Ibrahim I. N., Feng C. J., McNamara D. B., Agarwal K. C., Kadowitz P. J. Analysis of responses of allicin, a compound from garlic, in the pulmonary vascular bed of the cat and in the rat. Eur J Pharmacol. 276:1995;21-26.
32. Kozarsky K., Kingsley D., Krieger M. Use of a mutant cell line to study the kinetics and function of O-linked glycosylation of low densitylipoprotein receptors. Proc Natl Acad Sci USA. 85:1988;4335-4339.
33. Ganong, W. F. Review of medical physiology, 1995, 422.
34. Sendl A., Elbl G., Steinke B., Redl K., Breu W., Wagner H. Comparative pharmacological investigations of Allium ursinum and Allium sativum. Planta Med. 58:1992;1-7.
35. Pantoja C. V., Chiang L. C., Norris B. C., Concha J. B. Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anesthetized dogs. J Ethnopharmacology. 31:1991;325-331.
36. Pantoja C. V., Norris B. C., Contreras C. M. Diuretic and natriuretic effects of chromatographically purified fraction of garlic (Allium sativum). Ethnopharmacology. 52:1996;101-105.
37. Martin N., Bardissa L., Pantoja C., Roman R., Vargas M. Experimental cardiovascular depressant effects of garlic (Allium sativum) dialysate. Ethnopharmacology. 37:1992;145-149.
38. Pedraza-Chaverri J., Tapia E., Medina-Campos O. N., de los Angeles Granados M., Franco M. Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis. Life Sci. 62:1998;71-77.
39. Ali M., Mohammed S. Y. Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extract of garlic in rabbits. Prostaglandins Leukot Medicine. 25:1986;139-146.
40. Ali M., Bordia T., Mustafa T. Effect of raw versus boiled aqueous extract of garlic and onion on platelet aggregation. Prostaglandins Leuktrienes Essent Fatty Acids. 60:1999;43-47.
41. Siess W., Roth P., Scherer B., Kurzmann I., Bohlig B., Weber P. C. Platelet membrane fatty acids, platelet aggregation, and thromboxane formation during a mackerel diet. Lancet. 1:1981;441-444.