Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 495, Issue 1-2, 2001, Pages 135-145

  Guyonnet, Denis ^a   Belloir, Christine ^a   Suschetet, Marc ^a   Siess, Marie Hélène ^a   Le Bon, Anne Marie ^a  

^a CEMAGREF   (France)

Author keywords

Ames test; Antimutagenicity; Ethoxyquin; Liver subcellular fractions; Organosulfur compounds; Phase II enzymes

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; 7BETA,8ALPHA DIHYDROXY 9ALPHA,10ALPHA OXY 7,8,9,10 TETRAHYDROBENZO[A]PYRENE; BENZO[A]PYRENE DERIVATIVE; DIALLYLDISULFIDE; DIALLYLSULFIDE; DIPROPYL DISULFIDE; DIPROPYLSULFIDE; EPOXIDE HYDROLASE; ETHOXYQUIN; GLUTATHIONE TRANSFERASE; ORGANOSULFUR DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); STYRENE OXIDE; SULFIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; GARLIC; GENOTOXICITY; LIVER CYTOSOL; MALE; MICROSOME; MUTAGENIC ACTIVITY; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ALLIUM; ALLYL COMPOUNDS; ANIMALS; ANTIMUTAGENIC AGENTS; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; EPOXIDE HYDROLASES; GLUTATHIONE TRANSFERASE; LIVER; MALE; MUTAGENICITY TESTS; MUTAGENS; NAD(P)H DEHYDROGENASE (QUINONE); PROPANE; RATS; RATS, WISTAR; SALMONELLA TYPHIMURIUM; SPECIFIC PATHOGEN-FREE ORGANISMS; SUBCELLULAR FRACTIONS; SULFIDES;

EID: 0035934441     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(01)00205-4     Document Type: Article

References (50)

1. Protective effect of allium vegetables against both esophageal and stomach cancer: A simultaneous case-referent study of a high-epidemic area in Jiangsu province, China
2. A case-control study of gastric cancer and diet in Italy
3. Allium vegetables and reduced risk of stomach cancer
4. Consumption of onions and a reduced risk of stomach carcinoma
5. Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse
6. Chemoprevention of colon carcinogenesis by organosulfur compounds
7. Inhibition of aflatoxin B1- and N-nitrosodiethylamine-induced liver preneoplastic foci in rats fed naturally occurring allyl sulfides
8. Inhibition of benzoyl peroxide-mediated tumor promotion in 7,12-dimethylbenz(a)anthracene-initiated skin of Sencar mice by antioxidants nordihydroguaiaretic acid and diallyl sulfide
9. Differentiating and growth inhibitory effects of diallyl disulfide on cancer cells
10. Mammary cancer prevention by regular garlic and selenium-enriched garlic
11. Induction of glutathione S-transferase pi as a bioassay for the evaluation of potency of inhibitors of benzo(a)pyrene-induced cancer in a murine model
12. Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes
13. Modulation of phase II enzymes by organosulfur compounds from allium vegetables in rat tissues
14. Effect of diallyl sulfide on rat liver microsomal nitrosamine metabolism and other monooxygenase activities
15. Differential effects of dietary diallyl sulfide and diallyl disulfide on rat intestinal and hepatic drug-metabolizing enzymes
16. Modification of hepatic drug-metabolizing enzymes in rats treated with alkyl sulfides
17. Low doses of diallyl disulfide, a compound derived from garlic, increase tissue activities of quinone reductase and glutathione transferase in the gastrointestinal tract of the rat
18. Molecular mechanism for alkyl sulfide-modulated carbon tetrachloride-induced hepatotoxicity: The role of cytochrome P450 2E1, P450 2B and glutathione S-transferase expression
19. Modification of hepatic drug-metabolizing enzymes in rat fed naturally occurring allyl sulphides
20. Liver subcellular fractions from rats treated by organosulfur compounds from allium modulate mutagen activation
21. Chemoprotection against cancer by phase 2 enzyme induction
22. Detoxication enzymes and chemoprevention
23. Rapid detection of inducers of enzymes that protect against carcinogens
24. Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones
25. The role of glutathione and glutathione transferases in chemical carcinogenesis
26. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
27. Differential induction of NAD(P)H:Quinone oxidoreductase by anti-carcinogenic organosulfides from garlic
28. Mechanism of action of dietary chemoprotective agents in rat liver: Induction of phase I and II drug-metabolizing enzymes and aflatoxin B1 metabolism
29. Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:Quinone oxidoreductase in rat liver
30. Benzo[alpha]pyrene metabolism, activation and carcinogenesis: Role and regulation of mixed-function oxidases and related enzymes
31. Microsomal epoxide hydrolase: Properties, regulation and function
32. Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
33. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
34. Glutathione S-transferases: The first enzymatic step in mercapturic acid formation
35. Revised methods for the Salmonella mutagenicity test
36. Glutathione conjugation of styrene 7,8-oxide enantiomers by major glutathione transferase isoenzymes isolated from rat livers
37. Glutathione conjugate-mediated toxicities
38. Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes
39. Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1
40. Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens
41. Inhibition of benzo[a]pyrene-induced bone marrow micronuclei formation by diallyl thioethers in mice
42. Inhibition of carcinogenesis by minor nutrient constituents of the diet
43. Glutathione transferases in rat lung: The presence of transferase 7-7, highly efficient in the conjugation of glutathione with the carcinogenic (+)-7-beta,8-alpha-dihydroxy-9-alpha,10-alpha-oxy-7,8,9,10- tetrahydrobenzo[a]pyrene
44. Roles of UDP-glucuronosyltransferases in chemical carcinogenesis
45. NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) specifically prevents the formation of benzo[a]pyrene quinone-DNA adducts generated by cytochrome P4501A1 and P450 reductase
46. Molecular mechanisms of quinone cytotoxicity
47. NAD(P)H:Quinone oxidoreductase 1 reduces the mutagenicity of DNA caused by NADPH:P450 reductase-activated metabolites of benzo(a)pyrene quinones
48. Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: Role of induction of glutathione S-transferases
49. Inhibitors of chemical carcinogenesis
50. Inhibition of skin tumor initiation, promotion, and progression by antioxidants and related compounds