Plant polyphenols in cancer and heart disease: Implications as nutritional antioxidants

Nutrition Research Reviews

Volumn 13, Issue 1, 2000, Pages 79-106

  Duthie, Garry G ^a   Duthie, Susan J ^a   Kyle, Janet A M ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Antioxidants; Bioavailability; Cancer; Heart disease; Polyphenols

Indexed keywords

ALPHA TOCOPHEROL; ANTHOCYANIN; ANTITHROMBOCYTIC AGENT; ASCORBIC ACID; CHALCONE; FLAVANOL DERIVATIVE; FLAVANONE; FLAVONE DERIVATIVE; LOW DENSITY LIPOPROTEIN; POLYPHENOL;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; BIOAVAILABILITY; CANCER; DIET SUPPLEMENTATION; DIETARY INTAKE; EPIDEMIOLOGICAL DATA; HEART DISEASE; MAMMAL; METABOLISM; NONHUMAN; REVIEW; THROMBOCYTE AGGREGATION; VASODILATATION;

EID: 0033915810     PISSN: 09544224     EISSN: None     Source Type: Journal    
DOI: 10.1079/095442200108729016     Document Type: Review

References (216)

1. Agullo G, Garnet L, Besson C, Demigne C & Remesy C (1994) Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT29 and Caco-2 cells. Cancer Letters 87, 55-63.
2. Ahmad N, Feyes DK, Nieminen AL, Agarwal R & Mukhtar H (1997) Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. Journal of The National Cancer Institute 89, 1881-1886.
3. Ahmed MS, Ainley K, Parish JH & Hadi SM (1994a) Free radical-induced fragmentation of proteins by quercetin. Carcinogenesis 15, 1627-1630.
4. Ahmed MS, Ramesh V, Nagaraja V, Parish JH & Hadi SM (1994b) Mode of binding of quercetin to DNA. Mutagenesis 9, 193-197.
5. Alvi NK, Rizvi RY & Hadi SM (1986) Interaction of quercetin with DNA. Bioscience Reports 6, 861-868.
6. Aviram M & Fuhram B (1998) Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis. Atherosclerosis 137, S45-S50.
7. Barrow A & Griffiths LA (1971) The biliary excretion of hydroxyethylrutosides and other flavonoids in the rat. Biochemical Journal 125, 24P-25P.
8. Beecher GR, Warden B A & Merken H (1999) Analysis of tea polyphenols. Proceedings of the Society for Experimental Biology and Medicine 220, 267-270.
9. Benzie IF, Szeto YT, Strain JJ & Tomlinson B (1999) Consumption of green tea causes rapid increase in plasma antioxidant power in humans. Nutrition & Cancer 34, 83-87.
10. Blot WJ, Chow WH & McLaughlin N (1996) Tea and cancer: a review of the epidemiological evidence. European Journal of Cancer Prevention 5, 425-438.
11. Bourne LC & RiceEvans CA (1997) The effect of the phenolic antioxidant ferulic acid on the oxidation of low density lipoprotein depends on the pro-oxidant used. Free Radical Research 27, 337-344.
12. Bourne LC & RiceEvans CA (1999) Detecting and measuring bioavailability of phenolics and flavonoids in human: Pharmacokinetics of urinary excretion of dietary ferulic acid. Methods in Enzymology 299, 91-106.
13. Bravo L (1998) Polyphenols: Chemistry, dietary sources, metabolism and nutritional significance. Nutrition Reviews 56, 317-333.
14. Brown JE & RiceEvans CA (1998) Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radical Research 29, 247-255.
15. Brusick D (1993) Genotoxicity of phenolic antioxidants. Toxicology and Industrial Health 9, 223-230.
16. Cao GH & Prior RL (1999) Anthocyanins are detected in human plasma after oral administration of an elderberry extract. Clinical Chemistry 45, 574-576.
17. Caltagirone S, Ranelletti FO, Rinelli A, Maggiano N, Colasante A, Musiani P, Aiello FB & Piantelli M (1997) Interaction with type II estrogen binding sites and antiproliferative activity of tamoxifen and quercetin in human non-small-cell lung cancer. American Journal of Respiratory Cell & Molecular Biology 17, 51-59.
18. Carbonneau MA, Leger CL, Descomps B, Michel F & Monnier L (1998) Improvement in the antioxidant status of plasma and low density lipoprotein in subjects receiving a red wine phenolics mixture. Journal of the American Oil Chemists Society 75, 235-240.
19. Casalini C, Lodovici M, Briani C, Paganelli G, Remy S, Cheynier V & Dolara P (1999) Effect of complex polyphenols and tannins from red wine (WCPT) on chemically induced oxidative DNA damage in the rat. European Journal of Nutrition 38, 190-195.
20. Chaumontet C, Bex V, GaillardSanchez I, Seillanheberden C, Suschetet M & Martel P (1994) Apigenin and tangeretin enhance gap junctional intercellular communication in rat-liver epithelial-cells. Carcinogenesis 15, 2325-2330.
21. Chaumontet C, Suschetet M, HonikmanLeban E, Krutovskikh VA, Berges R, LeBon AM, Heberden C, Shahin MM, Yamasaki H & Martel P (1996) Lack of tumor-promoting effects of flavonoids: Studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. Nutrition and Cancer 26, 251-263.
22. Chen L, Lee MJ, Li H & Yang CS (1997) Absorption, distribution, elimination of tea polyphenols in rats. Drug Metabolism & Disposition 25, 1045-1050.
23. Chen ZP, Schell JB, Ho CT & Chen KY (1998) Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts. Cancer Letters 129, 173-179.
24. Cherubini A, Beal MF & Frei B (1999) Black tea increases the resistance of human plasma to lipid peroxidation in vitro but not ex vivo. Free Radical Biology & Medicine 27, 381-387.
25. Chesson A, Russell WR & Provan GJ (1997) Metabolites of the phenylpropanoid pathway - common origin, common properties. In Polyphenols in Foods, pp. 17-23. Luxembourg: Office for Official Publications of the European Communities.
26. Chi CW, Chang YF, Ou YR, Hsieh CC, Lui YW, Peng FK & Liu TY (1997) Effect of quercetin on the in vitro and in vivo growth of mouse hepatoma cells. Oncology Reports 4, 1021-1024.
27. Chimi H, Morel I, Lescoat G, Pasdeloup N, Cillard P & Cillard J (1995) Inhibition of iron toxicity in rat hepatocyte culture by natural phenolic-compounds. Toxicology In Vitro 9, 695-702.
28. Choudhury R, Srai SK, Debnam E & RiceEvans CA (1999) Urinary excretion of hydroxycinnamates and flavonoids after oral intravenous administration. Free Radical Biology & Medicine 27, 278-286.
29. Combs GF (1992) The Vitamins. Fundamental Aspects in Nutrition and Health. London: Academic Press Inc.
30. Critchfield JW, Welsh CJ, Phang JM & Yeh GC (1994) Modulation of adriamycin(r) accumulation and efflux by flavonoids in hct-15 colon cells - activation of p-glycoprotein as a putative mechanism. Biochemical Pharmacology 48, 1437-1445.
31. Croft KG (1998) The chemistry and biological effects of flavonoids and phenolic acids. Annals of the New York Academy of Sciences 20, 435-442.
32. Crozier A, Lean MEJ, McDonald MS & Black C (1997) Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce and celery. Journal of Agricultural and Food Chemistry 45, 490-495.
33. Csokay B, Prajda N, Weber G & Olah E (1997) Molecular mechanisms in the antiproliferative action of quercetin. Life Sciences 60, 2157-2163.
34. Das NP (1969) Studies on flavonoid metabolism. Degradation of (+)-catechin by rat intestinal contents. Biochimica et Biophysica Acta 177, 668-670.
35. Davila JC, Lenherr A & Acosta D (1989) Protective effect of flavonoids on drug-induced hepatotoxicity in vitro. Toxicology 57, 267-286.
36. Dewick PM (1997) Medicinal Natural Products: A Biosynthetic Approach. Chichester, England: John Wiley & Sons Ltd.
37. Diaz MN, Frei B, Vita JA & Keaney JF (1997) Antioxidants and atherosclerotic heart disease. New England Journal of Medicine 337, 408-416.
38. Di Carlo G, Mascolo N, Izzo AA & Capasso F (1999) Flavonoids: Old and new aspects of a class of natural therapeutic drugs. Life Sciences 65, 337-353.
39. Diplock AT, Charleux JL, Crozier-Willi G, Kok FJ, RiceEvans CA, Roberfroid M, Stahl W & Vina-Ribes J (1998) Functional food science and defence against reactive oxidative species. British Journal of Nutrition 80, S77-S112.
40. Dong X, Shou-Peng Z & Zhen-Lun G (1997) Quercetin induced apoptosis in human leukemia HL-60 cells. Acta Pharmacologica Sinica 18, 280-283.
41. Donovan JL, Bell JR, Kasim-Karakas S, German JB, Walzem RL, Hansen RJ & Waterhouse AL (1999) Catechin is present as metabolites in human plasma after consumption of red wine. Journal of Nutrition 129, 1662-1668.
42. Duthie GG (1999) Determination of activity of antioxidants in human subjects. Proceedings of the Nutrition Society 58, 1-10.
43. Duthie GG & Crozier A (2000) Plant-derived phenolic antioxidants. Current Opinions in Lipidology 11, 43-47.
44. Duthie GG, Pedersen MW, Gardner PT, Morrice PC, Jenkinson A McE, McPhail DB & Steele GM (1998) The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers. European Journal of Clinical Nutrition 52, 733-736.
45. Duthie SJ, Collins AR, Duthie GG & Dobson VL (1997a) Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidized pyrimidines) in human lymphocytes. Mutation Research Genetic Toxicology EM 393, 223-231.
46. Duthie SJ & Dobson VL (1999) Dietary flavonoids protect human colonocyte DNA from oxidative attack in vitro. European Journal of Nutrition 38, 28-34.
47. Duthie SJ, Johnson W & Dobson VL (1997b) The effect of dietary flavonoids on DNA damage (strand breaks and oxidized pyrimidines) and growth in human cells. Mutation Research Genetic Toxicology EM 390, 141-151.
48. Elangovan V, Sekar N & Govindasamy S (1994) Chemopreventive potential of dietary biflavonoids against 20-methylcholanthrene-induced tumorigenesis. Cancer Letters 87, 107-113.
49. Fenech M, Stockly C & Aitken C (1997) Moderate wine consumption protects against hydrogen peroxide-induced damage. Mutagenesis 12, 289-296.
50. Ferrali M, Signorini C, Caciotti B, Sugherini L, Ciccoli L, Giachetti D & Comporti M (1997) Protection against oxidative damage of erythrocyte membrane by the flavonoid quercetin and its relation to iron chelating activity. FEBS Letters 416, 123-129.
51. Fieschi M, Codignola A & Luppi Mosa AM (1989) Mutagenic flavonol aglycones in infusions and in fresh and pickled vegetables. Food Science 54, 1492-1495.
52. Formica JV & Regelson AW (1995) Review of the biology of quercetin and related bioflavanoids. Food and Chemical Toxicology 33, 1061-1080.
53. Franke AA, Cooney RV, Custer LJ, Mordan LJ & Tanka Y (1998) Inhibition of neoplastic transformation and bioavailability of dietary flavonoid agents. Advances in Experimental Medicine and Biology 439, 237-248.
54. Frankel EN, Kanner J, German JB, Parks E & Kinsella JE (1993) Inhibition of oxidation of human low density lipoprotein by phenolic substances in red wine. Lancet 341, 454-457.
55. Freese R, Basu S, Hietanen E, Nair J, Nakachi K, Bartsch H & Mutanen M (1999) Green tea extract decreases plasma malonaldehyde concentration but does not affect other indicators of oxidative stress, nitric oxide production, or hemostatic factors during a high-linoleic acid diet in healthy volunteers. European Journal of Nutrition 38, 149-157.
56. Fremont L, Gozzelino MT, Franchi MP & Linard A (1998) Dietary flavonoids reduce lipid peroxidation in rats fed polyunsaturated or monounsaturated fat diets. Journal of Nutrition 128, 1495-1502.
57. Fuhrman B, Lavy A & Aviram M (1995) Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. American Journal of Clinical Nutrition 61, 549-554.
58. Funabiki R, Takeshita K, Miura Y, Shibasto M & Nagasawa T (1999) Dietary supplement of G-rutin reduces oxidative damage in the rodent model. Journal of Agricultural and Food Chemistry 47, 1078-1082.
59. Gandhi RK & Khanduja KL (1993) Impact of quercetin consumption on phase-i and phase-ii drug metabolizing enzymes in mice. Journal of Clinical Biochemistry and Nutrition 14, 107-112.
60. Caspar J, Rodrigues A, Laires A, Silva F, Costa S, Monteiro MJ & Rueff J (1994) On the mechanisms of genotoxicity and metabolism of quercetin. Mutagenesis 9, 445-449.
61. Geleijnse JM, Launer LJ, Hofman A, Pols HAP & Witteman JCM (1999) Tea flavonoids may protect against atherosclerosis - The Rotterdam Study. Archives of Internal Medicine 159, 2170-2174.
62. Gradelet S, Astorg P, Leclerc J, Chevalier J, Vernevaut MF & Siess MH (1996) Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic-metabolizing enzymes in the rat. Xenobiotica 26, 49-63.
63. Graefe EU, Derendorf H & Veit M (1999) Pharmacokinetics and bioavailability of the flavonol quercetin in humans. International Journal of Clinical Pharmacology & Therapeutics 37, 219-233.
64. Grinberg LN, Newmark H, Kitrossky N, Rahamim E, Chevion M & Rachmilewitz EA (1997) Protective effects of tea polyphenols against oxidative damage to red blood cells. Biochemical Pharmacology 54, 973-978.
65. Grinberg LN, Rachmilewitz EA & Newmark H (1994) Protective effects of rutin against hemoglobin oxidation. Biochemical Pharmacology 48, 643-649.
66. Halliwell B (1987) Oxidants and human disease: some new concepts. FASEB Journal 1, 358-364.
67. Harborne JB (1994) The Flavonoids: Advances in Research Since 1986. London: Chapman & Hall.
68. Hayek T, Fuhrman B, Vaya J, Rosenblat M, Belinky P, Coleman R, Elis A & Aviram M (1997) Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arteriosclerosis Thrombosis & Vascular Biology 17, 2744-2752.
69. Hermann K (1988) On the occurrence of flavone glycosides in vegetables. Zeitschrift für Lebensmittel-Untersuchung und -Forschung 186, 1-5.
70. Hertog MGL, Hollman PCH & Katan MB (1992a) Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. Journal of Agricultural and Food Chemistry 40, 2379-2383.
71. Hertog MGL, Hollman PCH & Venema DP (1992b) Optimization of a quantitative HPLC determination of potentially anticarcinogenic flavonoids in vegetables and fruits. Journal of Agricultural and Food Chemistry 40, 1591-1598.
72. Hertog MGL, Feskens EJM, Hollman PCH, Katan MB & Kromhout D (1993a) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen elderly study. Lancet 342, 1007-1011.
73. Hertog MGL, Hollman PCH, Katan MB & Kromhout D (1993b) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutrition & Cancer 20, 21-29.
74. Hertog MGL, Hollman PCH & van de Putte B (1993c) Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices. Journal of Agricultural and Food Chemistry 41, 1242-1246.
75. Hertog MGL, Feskens EJM, Hollman PCH, Katan MB & Kromhout D (1994) Dietary flavonoids and cancer risk in the Zutphen elderly study. Nutrition & Cancer 22, 175-184.
76. Hertog MGL, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, Giampaoli S, Jansen A, Menotti A & Nedeljkovic S (1995) Flavonoid intake and long-term risk of coronary heart disease. Archives of Internal Medicine 27, 381-386.
77. Hertog MGL, Sweetnam PM, Fehily AM, Elwood PC & Kromhout D (1997) Antioxidant flavonols and ischemic heart disease in a Welsh population of men: the Caerphilly Study. American Journal of Clinical Nutrition 65, 1489-1494.
78. Hirano T, Abe K, Gotoh M & Oka K (1995) Citrus flavone tangeretin inhibits leukaemic HL-60 cell-growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. British Journal of Cancer 72, 1380-1388.
79. Hirano T, Gotoh M & Oka K (1994) Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. Life Sciences 55, 1061-1069.
80. Hirono I, Ueno I, Hosaka S, Takanashi H, Matsushima T, Sugimura T & Natori S (1981) Carcinogenicity examination of quercetin and rutin in aci rats. Cancer Letters 13, 15-21.
81. Hirose M, Hoshiya T, Akagi K, Futakuchi M & Ito N (1994) Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[alpha]anthracene. Cancer Letters 83, 149-156.
82. Hodgson JM, Proudfoot JM, Croft KD, Puddey IB, Mori TA & Beilin LJ (1999) Comparison of the effects of black and green tea on in vitro lipoprotein oxidation in human serum. Journal of the Science of Food and Agriculture 79, 561-566.
83. Hollman PCH, de Vries JHM, van Leeuwen SD, Mengelers MJB & Katan MB (1995) Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. American Journal of Clinical Nutrition 62, 1276-1282.
84. Hollman PCH & Katan MB (1997) Absorption, metabolism and health effects of dietary flavonoids in man. Biomedicine and Pharmacotherapeutics 51, 305-310.
85. Hollman PCH & Katan MB (1998) Bioavailability and health effects of dietary flavonols in man. Archives of Toxicology Supplement 20, 237-248.
86. Hollman PCH & Katan MB (1999) Dietary flavonoids: Intake, health effects and bioavailability. Food and Chemical Toxicology 37, 937-942.
87. Hollman PCH, van Trijp JMP, Buysman MNCP, Gaag MSvd, Mengelers MJB, de Vries JHM & Katan MB (1997a) Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Letters 418, 152-156.
88. Hollman PCH, van Trijp JMP, Mengelers MJB, de Vries JHM & Katan MB (1997b) Bioavailability of the dietary antioxidant flavonol quercetin in man. Cancer Letters 114, 139-140.
89. Holvoet P & Collen D (1998) Oxidation of low density lipoproteins in the pathogenesis of atherosclerosis. Atherosclerosis 137, S33-S38.
90. Holvoet P, Perez G & Zhao Z (1995) Malonaldehyde-modifled low density lipoproteins in patients with atherosclerotic disease. Journal of Clinical Investigation 95, 2611-2619.
91. Ishikawa T, Suzukawa M, Ito T, Yoshida H, Ayaori M, Nishiwaki M, Yonemura A, Hara Y & Nakamura H (1997) Effect of tea flavonoid supplementation on the susceptibility of low density lipoprotein to oxidative modification. American Journal of Clinical Nutrition 66, 261-266.
92. Ito M, Kawaguchi H, Sakota Y, Otonari J & Nitahara H (1993) Effects of polyphenols, including flavonoids, on glutathione-S-transferase and glutathione-reductase. Bioscience, Biotechnology and Biochemistry 57, 1678-1680.
93. Jackson MJ (1997) The assessment of bioavailability of micronutrients: Introduction. European Journal of Clinical Nutrition 51, 51-52.
94. Kanazawa K, Yamashita T, Ashida H & Danno G (1998) Antimutagenicity of flavones and flavonols to heterocyclic amines by specific and strong inhibition of the cytochrome p450 1a family. Bioscience, Biotechnology and Biochemistry 62, 970-977.
95. Kandaswami C, Perkins E, Drzewiecki G, Soloniuk DS & Middleton E Jr (1992) Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids. Anticancer Drugs 3, 525-530.
96. Kang TB & Liang NC (1997) Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells. Biochemical Pharmacology 54, 1013-1018.
97. Kappus H, Koster-Albrecht D & Remmer H (1979) 2-Hydroxyoestradiol and (+)-cyanidanol-3 prevent lipid peroxidation of isolated rat hepatocytes. Archives of Toxicology Supplement 2, 321-326.
98. Katdare M, Osborne MP & Telang NT (1998) Inhibition of aberrant proliferation and induction of apoptosis in preneoplastic human mammary epithelial cells by natural phytochemicals. Oncology Reports 5, 311-315.
99. Kerry N & Abbey M (1999) The isoflavone genistein inhibits copper and peroxyl radical mediated low density lipoprotein oxidation in vitro. Atherosclerosis 140, 341-347.
100. Kimira M, Arai Y, Shimoi K & Watanabe S (1998) Japanese intake of flavonoids and isoflavonoids from foods. Journal of Epidemiology 8, 168-175.
101. King A & Young G (1999) Characteristics and occurrence of phenolic phytochemicals. Journal of the American Dietetic Association 99, 213-218.
102. Kirk EA, Sutherland P, Wang SA, Chait A & LeBoeuf RC (1998) Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. Journal of Nutrition 128, 954-959.
103. Klaunig JE, Xu Y, Han C, Kamendulis LM, Chen JS, Heiser C, Gordon MS & Mohler ER (1999) The effect of tea consumption on oxidative stress in smokers and non-smokers. Proceedings of the Society of Experimental Biology & Medicine 220, 249-254.
104. Knekt P, Jarvinen R, Seppanen R, Hellovaara M, Teppo L, Pukkala E & Aromaa A (1997) Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. American Journal of Epidemiology 146, 223-230.
105. Knekt P, Reunanen A & Maatela J (1996) Flavonoid intake and coronary mortality in Finland: a cohort study. British Medical Journal 312, 478-481.
106. Koga T, Moro K, Nakamori K, Yamakoshi J, Hosoyama H, Kataoka S & Ariga T (1999) Increase in antioxidative potential of rat plasma by oral administration of proanthocyanidin-rich extract from grape seeds. Journal of Agricultural and Food Chemistry 47, 1892-1897.
107. Krinsky NI (1992) Mechanism of action of biological antioxidants. Proceedings of the Society of Experimental Biology and Medicine 200, 248-254.
108. Kritz H & Sinzinger H (1997) Tea consumption, lipid metabolism and atherosclerosis. Weiner Klinische Wochenschrift 109, 944-988.
109. Kuhnau J (1976) The flavonoids. A class of semi-essential food components: Their role in human nutrition. World Review of Nutrition & Dietetics 24, 1117-1191.
110. Kuo SM (1996) Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Letters 110, 41-48.
111. Kuo SM, Morehouse HF & Lin CP (1997) Effect of antiproliferative flavonoids on ascorbic acid accumulation in human colon adenocarcinoma cells. Cancer Letters 116, 131-137.
112. Lagarrigue S, Chaumontet C, Heberden C, Martel P & GaillardSanchez I (1995) Suppression of oncogene-induced transformation by quercetin and retinoic acid in rat liver epithelial cells. Cellular & Molecular Biology Research 41, 551-560.
113. Lairon D & Amiot MJ (1999) Flavonoids in food and natural antioxidants in wine. Current Opinions in Lipidology 10, 23-28.
114. Laranjinha JAN, Almeida LM & Madeira VMC (1994) Reactivity of dietary phenolic acids and peroxyl radicals: antioxidant activity upon low density lipoprotein peroxidation. Biochemical Pharmacology 48, 487-494.
115. Leanderson P, Faresjo AO & Tagesson C (1997) Green tea polyphenols inhibit oxidant-induced DNA strand breakage in cultured lung cells. Free Radical Biology and Medicine 23, 235-242.
116. Lin JK, Chen YC, Huang YT & Lin-Shiau SY (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. Journal of Cellular Biochemistry Supplements 28/29, 39-48.
117. Linseisen J, Radtke J & Wolfram G (1997) Flavonoid intake of adults in a Bavarian subgroup of the national food consumption survey. Zeitschrift für Ernahrungswissenschaft 36, 403-412.
118. Lu HQ, Niggemann B & Zanker KS (1996) Suppression of the proliferation and migration of oncogenic ras-dependent cell lines, cultured in a three-dimensional collagen matrix, by flavonoid-structured molecules. Journal of Cancer Research and Clinical Oncology 122, 335-342.
119. McAnlis GT, McEneny J, Pearce J & Young IS (1999) Absorption and antioxidant effects of quercetin from onions, in man. European Journal of Clinical Nutrition 53, 92-96.
120. McCarty MF (1998) Polyphenol-mediated inhibition of ap-1 transactivating activity may slow cancer growth by impeding angiogenesis and tumor invasiveness. Medical Hypotheses 50, 511-514.
121. McDonald MS, Hughes M, Burns J, Lean MEJ, Matthews D & Crozier A (1998) Survey of the free and conjugated myricetin and quercetin content of red wines of different geographical origins. Journal of Agricultural and Food Chemistry 46, 368-375.
122. Majima T, Tsutsumi M, Nishino H, Tsunoda T & Konishi Y (1998) Inhibitory effects of beta-carotene, palm carotene, and green tea polyphenols on pancreatic carcinogenesis initiated by N-nitrosobis(2-oxopropyl)amine in Syrian golden hamsters. Pancreas 16, 13-18.
123. Malaveille C, Hautefeuille A, Pignatelli B, Talaska G, Vineis P & Bartsch H (1998) Antimutagenic dietary phenolics as antigenotoxic substances in urothelium of smokers. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 402, 219-224.
124. Manach C, Morand C, Texier O, Favier ML, Agullo G, Demigné C, Régérat F & Rémésy C (1995) Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin. Journal of Nutrition 125, 1911-1922.
125. Manach C, Texier O, Régérat F, Agullo G, Demigné C & Rémésy C (1996) Dietary quercetin is recovered in rat plasma as conjugated derivatives of isorhamnetin and quercetin. Nutritional Biochemistry 7, 375-380.
126. + loss and lipid peroxidation induced by oxygen-free radicals in human red cells. Pharmacological Research Communications 18, 61-72.
127. Martin-Aragon S, Benedi JM & Villar AM (1997) Modifications of antioxidant capacity and liquid peroxidation in mice under fraxetin treatment. Journal of Pharmacy and Pharmacology 49, 49-52.
128. Mehta K, Pantazis P, McQueen T & Aggarwal BB (1997) Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anticancer Drugs 8, 470-481.
129. Melzig MF, Loose R & Schonherr G (1997) Effect of flavonoids on daunomycin-induced toxicity in cultivated endothelial cells. Pharmazie 52, 793-796.
130. Miura YH, Tomita I, Watanabe T, Hirayama T & Fukui S (1998) Active oxygen generations by flavonoids. Biological & Pharmacological Bulletin 21, 93-96.
131. Miura S, Watanabe J, Sano M, Tomita T, Osawa T, Hara T & Tomita I (1995) Effects of various natural antioxidants on the Cu (2+)-mediated oxidative modification of low density lipoprotein. Biological & Pharmacological Bulletin 18, 1-4.
132. 2+ mediated oxidative modification of low density lipoprotein. Biological & Pharmacological Bulletin 17, 1567-1572.
133. Miyake Y, Yamamoto K, Tsujhara N & Osawa T (1998) Protective effects of lemon flavonoids on oxidative stress in diabetic rats. Lipids 33, 689-695.
134. Miyazawa T, Nakagawa K, Kudo M, Muraishi K & Someya K (1999) Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans. Journal of Agricultural & Food Chemistry 47, 1083-1092.
135. Morel I, Lescoat G, Cogrel P, Sergent O, Pasdeloup N, Brissot P, Cillard P & Cillard J (1993) Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. Biochemical Pharmacology 45, 13-19.
136. Morino K, Matsukura N, Kawachi T, Ohgaki H, Sugimura T & Hirono I (1982) Carcinogenicity test of quercetin and rutin in golden-hamsters by oral-administration. Carcinogenesis 3, 93-97.
137. Morrice PC, Wood SG & Duthie GG (2000) High performance liquid chromatographic determination of quercetin and isorhamnetin in rat tissues using beta-glucuronidase and acid hydrolysis. Journal of Chromatography B 738, 413-417.
138. Murray CW, Booth AN, de Eds F & Jones FT (1954) Absorption and metabolism of rutin and quercetin in the rabbit. Journal of the American Pharmacological Association 43, 361-364.
139. Musonda CA, Helsby N & Chipman JK (1997) Effects of quercetin on drug metabolizing enzymes and oxidation of 2′,7-dichlorofluorescein in hepg2 cells. Human & Experimental Toxicology 16, 700-708.
140. Nakagawa K, Ninomiya M, Okubo T, Aoi N, Juneja LR, Kim M, Yamanaka K & Miyazawa T (1999) Tea catechin supplementation increases antioxidant capacity and prevents phospholipid hydroperoxidation in plasma of humans. Journal of Agricultural and Food Chemistry 47, 39967-39973.
141. Nakagawa Y, Shetlar ME & Wender SH (1965) Urinary products from quercetin in neomycin-treated rats. Biochimica et Biophysica Acta 97, 233-241.
142. Nakayama T. Yamada M, Osawa T & Kawakishi S (1993) Suppression of active oxygen-induced cytotoxicity by flavonoids. Biochemical Pharmacology 45, 265-267.
143. Negre Salvayre A, Mabile L, Delchambre J & Salvayre R (1995) α-Tocopherol, ascorbic acid, and rutin inhibit synergistically the copper-promoted LDL oxidation and the cytotoxicity of oxidized LDL to cultured endothelial cells. Biological Trace Element Research 47, 81-91.
144. Negre Salvayre A & Salvayre R (1992) Quercetin prevents the cytotoxicity of oxidized LDL on lymphoid cell lines. Free Radical Biology and Medicine 12, 101-106.
145. Ngomuo AJ & Jones RS (1996) Genotoxicity studies of quercetin and shikimate in vivo in the bone marrow of mice and gastric mucosal cells of rats. Veterinary and Human Toxicology 38, 176-180.
146. Nielsen SE, Young JF, Daneshvar B, Lauridsen ST, Knuthsen P, Sandstrom B & Dragsted LO (1999) Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects. British Journal of Nutrition 81, 447-455.
147. Nigdikar SV, Williams NR, Griffin BA & Howard AN (1998) Consumption of red wine polyphenols reduces the susceptibility of low density lipoproteins to oxidation in vivo. American Journal of Clinical Nutrition 68, 258-265.
148. Noroozi M, Angerson WJ & Lean MEJ (1998) Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes. American Journal of Clinical Nutrition 67, 1210-1218.
149. Noteborn HPJM, Jansen E, Benito S & Mengelers MJB (1997) Oral absorption and metabolism of quercetin and sugar-conjugated derivatives in specific transport systems. Cancer Letters 114, 175-177.
150. Obermeier MT, White RE & Yang CS (1995) Effects of bioflavonoids on hepatic P450 activities. Xenobiotica 25, 575-584.
151. Okushio K, Suzuki M, Matsumoto N, Nanjo F & Hara Y (1999) Identification of (-)-epicatechin metabolites and their metabolic fate in the rat. Drug Metabolism & Disposition 27, 309-316.
152. Omenn GS, Goodman GE & Thornquist MD (1996) Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. New England Journal of Medicine 334, 1150-1155.
153. Parshad R, Sanford KK, Price FM, Steele VE, Tarone RE, Kelloff GJ & Boone CW (1998) Protective action of plant polyphenols on radiation-induced chromatid breaks in cultured human cells. Anticancer Research 18, 3263-3266.
154. Peterson J & Dwyer J (1998) Flavonoids: dietary occurrence and biochemical activity. Nutrition Research 18, 1995-2018.
155. Plaumann B, Fritsche M, Rimpler H, Brandner G & Hess RD (1996) Flavonoids activate wild-type p53. Oncogene 13, 1605-1614.
156. Pratico D, Iuliano L & Mauriello A (1997) Localization of distinct F2-isoprostanes in human atherosclerotic lesions. Journal of Clinical Investigation 100, 2028-2034.
157. Princen HMG, van Duyvenvoorde W, Buytenhek R, Blonk C, Tijburg LBM, Langius JAE, Meinders E & Pijl H (1998) No effect of consumption of green and black tea on plasma lipid and antioxidant levels and on LDL oxidation in smokers. Arteriosclerosis, Thrombosis & Vascular Biology 18, 833-841.
158. Puddey IB & Croft KD (1999) Alcohol, stroke and coronary heart disease. Are there anti-oxidants and pro-oxidants in alcoholic beverages that might influence the development of atherosclerotic cardiovascular disease. Neuroepidemiology 18, 292-302.
159. Raeissi SD, Guo ZY, Dobson GL, Artursson P & Hidalgo IJ (1997) Comparison of cyp3a activities in a subclone of caco-2 cells (tc7) and human intestine. Pharmaceutical Research 14, 1019-1025.
160. Rahman A, Fazal F, Greensill J, Ainley K, Parish JH & Hadi SM (1992) Strand scission in DNA induced by dietary flavonoids: role of Cu(I) and oxygen free radicals and biological consequences of scission. Molecular and Cellular Biochemistry 111, 3-9.
161. Rapola J, Virtamo J & Ripatti S (1997) Randomized trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet 349, 1715-1720.
162. Renaud S & de Longeril M (1992) Wine alcohol, platelets and the French paradox for coronary heart disease. Lancet 339, 1523-1526.
163. Ricchi P, Pignata S, DiPopolo A, Memoli A, Apicella A, Zarrilli R & Acquaviva AM (1997) Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma caco2 cells. International Journal of Cancer 73, 880-884.
164. RiceEvans CA, Miller NJ & Paganga G (1997) Antioxidant properties of phenolic compounds. Trends in Plant Science 2, 152-159.
165. Rifici VA, Stephen EM, Schneider SH & Khachadurian AK (1999) Red wine inhibits the cell-mediated oxidation of LDL and HDL. Journal of the American College of Nutrition 18, 137-143.
166. Rimm EB, Katan MB, Ascherio A, Stampfer MJ & Willett WC (1996) Relation between intake of flavonoids and risk for coronary heart disease in male health professionals. Annals of Internal Medicine 125, 384-389.
167. Robards K & Antolovich M (1997) Analytical chemistry of fruit bioflavonoids. Analyst 122, R11-R34.
168. Roig P, Cascon E, Arola L, Blade C & Salvado MJ (1999) Moderate red wine consumption protects the rat against oxidation in vivo. Life Sciences 6, 1517-1524.
169. Sahu SC & Gray GC (1993) Interactions of flavonoids, trace metals and oxygen: nuclear DNA damage and lipid peroxidation induced by myricetin. Cancer Letters 70, 73-79.
170. Sahu SC & Gray GC (1994) Kaempferol-induced nuclear DNA damage and lipid peroxidation. Cancer Letters 85, 159-164.
171. Sahu SC & Washington MC (1991a) Effects of antioxidants on quercetin-induced nuclear DNA damage and lipid peroxidation. Cancer Letters 60, 259-264.
172. Sahu SC & Washington MC (1991b) Quercetin-induced lipid peroxidation and DNA damage in isolated rat-liver nuclei. Cancer Letters 58, 75-79.
173. Saito D, Shirai A, Matsushima T, Sugimura T & Hirono I (1980) Test of carcinogenicity of quercetin, a widely distributed mutagen in food. Teratogenesis, Carcinogenesis and Mutagenesis 1, 213-221.
174. Scambia G, Panici PB, Ranelletti FO, Ferrandina G, Devincenzo R, Piantelli M, Masciullo V, Bonanno G, Isola G & Mancuso S (1994a) Quercetin enhances transforming growth-factor beta(1) secretion by human ovarian-cancer cells. International Journal of Cancer 57, 211-215.
175. Scambia G, Ranelletti FO, Panici PB, Devincenzo R, Bonanno G, Ferrandina G, Piantelli M, Bussa S, Rumi C, Cianfriglia M & Mancuso S (1994b) Quercetin potentiates the effect of adriamycin in a multidrug-resistant mcf-7 human breast-cancer cell-line - p-glycoprotein as a possible target. Cancer Chemotherapy and Pharmacology 34, 459-464.
176. Schramm DD, Collins HE & German JB (1999) Flavonoid transport by mammalian endothelial cells. Journal of Nutritional Biochemistry 10, 193-197.
177. Serafini M, Ghiselli A & Ferro-Luzzi A (1996) In vivo antioxidant effect of green and black tea in man. European Journal of Clinical Nutrition 50, 28-32.
178. Serafini M, Maiani G & Ferro-Luzzi A (1998) Alcohol-free red wine enhances plasma antioxidant capacity in humans. Journal of Nutrition 128, 1003-1007.
179. Sestili P, Guidarelli A, Dachá M, & Cantoni O (1998) Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scvenging versus iron chelating mechanism. Free Radical Biology Medicine 25, 196-200.
180. Shimoi K, Okada H, Furugori M, Goda T, Suzuki M, Hara Y, Yamamoto H & Kinae N (1998) Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. FEBS Letters 438, 220-224.
181. Siess MH, Mas JP, Canivenc-Lavier MC & Suschetet M (1996) Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids. Journal of Toxicology and Environmental Health 49, 481-496.
182. Skaper SD, Fabris M, Ferrari V, Carbonare MD & Leon A (1997) Quercetin protects cutaneous tissue-associated cell types including sensory neurons from oxidative stress induced by glutathione depletion: Cooperative effects of ascorbic acid. Free Radical Biology and Medicine 22, 669-678.
183. Slater TF (1984) Free-radical mechanisms in tissue injury. Biochemical Journal 222, 1-15.
184. So FV, Guthrie N, Chambers AF, Moussa M & Carroll KK (1996) Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutrition and Cancer 26, 167-181.
185. Spencer JPE, Chowrimoto G, Choudry R, Debham ES, Srai SK & RiceEvans CA (1999) The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Letters 458, 224-230.
186. Stagg GV & Millin DJ (1975) The nutritional and therapeutic value of tea - a review. Journal of the Science of Food and Agriculture 26, 1439-1459.
187. Steinberg D (1997) Low density lipoprotein and its pathological significance. Journal of Biological Chemistry 272, 20963-20966.
188. St Leger AS, Cochrane AL & Moore F (1979) Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 12, 1017-1020.
189. 3H](-)-epigallocatechin gallate, a cancer preventative tea polyphenol in mouse tissue. Carcinogenesis 19, 1771-1776.
190. Tamura M, Kagawa S, Tsuruo Y, Ishimura K & Morita K (1994) Effects of flavonoid compounds on the activity of NADPH diaphorase prepared from the mouse-brain. Japanese Journal of Pharmacology 65, 372-373.
191. Tijburg LBM, Wiseman SA, Meijer GW & Weststrate JA (1997) Effects of green tea, black tea and dietary lipophilic antioxidants on LDL oxidizability and atherosclerosis in hypercholesterolaemic rabbits. Atherosclerosis 135, 37-47.
192. Tsuda T, Horio F & Osawa T (1999) Absorption and metabolism of cyan-O-beta-D-glucoside in rats. FEBS Letters 449, 179-182.
193. Uda Y, Price KR, Williamson J & Rhodes MJC (1997) Induction of the anticarcinogenic marker enzyme quinone reductase in murine hepaloma cells in vitro by flavonoids. Cancer Letters 120, 213-216.
194. Uddin S & Choudhry MA (1995) Quercetin, a bioflavonoid, inhibits the DNA synthesis of human leukemia cells. Biochemistry amd Molecular Biology International 36, 545-550.
195. Ursini F, Tubaro F, Rong J & Sevanian A (1999) Optimization of nutrition: Polyphenols and vascular protection. Nutrition Reviews 57, 241-249.
196. van het Hof KH, de Boer HS, Wiseman SA, Lien N, Weststrate JA & Tijburg LB (1997) Consumption of green or black tea does not increase resistance of low-density lipoprotein to oxidation in humans. American Journal of Clinical Nutrition 66, 1125-1132.
197. van het Hof KH, Wiseman SA, Yang CS & Tijburg LBM (1999) Plasma and lipoprotein levels of tea catechins following repeated tea consumption. Proceedings of the Society for Experimental Biology and Medicine 220, 203-209.
198. Venturi M, Hambly RJ, Glinghammar B, Rafter JJ & Rowland IR (1997) Genotoxic activity in human faecal water and the role of bile acids: a study using the alkaline comet assay. Carcinogenesis 18, 2353-2359.
199. Verma AK, Johnson JA, Gould MN & Tanner MA (1988) Inhibition of 7,12-dimethylbenz(a)anthracene-and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin. Cancer Research 48, 5754-5758.
200. Vertommen J, Vandenenden M, Simoens L & Deleeuw I (1994) Flavonoid treatment reduces glycation and lipid peroxidation in experimental diabetic rats. Phytotherapy Research 8, 430-432.
201. Viana M, Barbas C, Bonet B, Bonet MV, Castro M, Fraile MV & Herrera E (1996) In vitro effects of a flavonoid-rich extract on LDL oxidation. Atherosclerosis 123, 83-91.
202. Wang WQ & Goodman MT (1999) Antioxidant property of dietary phenolic agents in a human LDL-oxidation ex vivo model. Nutrition Research 19, 191-202.
203. Waterhouse AL, German JB, Walzem RL, Hansen RJ & Kasim-Karakas SE (1998) Is it time for a wine trial? American Journal of Clinical Nutrition 68, 220-221.
204. Watson DG & Oliveira EJ (1999) Solid-phase extraction and gas chromatography mass spectrometry determination of kaempferol and quercetin in human urine after consumption of Ginkgo biloba tablets. Journal of Chromatography B 723, 203-210.
205. Westhuyzen J (1997) The oxidation hypothesis of atherosclerosis: an update. Annals of Clinical & Laboratory Science 27, 1-10.
206. Whitehead TP, Robinson D, Allaway S, Syms J & Hale A (1995) Effect of red wine ingestion on the antioxidant capacity of serum. Clinical Chemistry 41, 32-35.
207. Williamson G, Plumb GW, Uda Y, Price KR & Rhodes MJC (1996) Dietary quercetin glycosides: antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells. Carcinogenesis 17, 2385-2387.
208. Woodford FP & Whitehead TP (1998) Is measuring serum antioxidant capacity clinically useful? Annals of Clinical Biochemistry 35, 48-56.
209. Yang CS, Yang GY, Landau JM, Kim S & Liao J (1998) Tea and tea polyphenols inhibit cell hyperproliferation, lung tumorigenesis, and tumor progression. Experimental Lung Research 24, 629-639.
210. Yochum L, Kushi LH, Meyer K & Folsom AR (1999) Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. American Journal of Epidemiology 149, 943-949.
211. Yokozawa T & Dong E (1997) Influence of green tea and its three major components upon low-density lipoprotein oxidation. Experimental Toxicology and Pathology 49, 329-335.
212. Yoshina K, Tomita I, Sano M, Oguni I, Hara Y & Nakano M (1994) Effects of long term dietary supplementation of tea polyphenols on lipid peroxide levels in rats. Age 17, 79-85.
213. Young JF, Nielsen SE, Haraldsdottir J, Daneshvar B, Lauridsen ST, Knuthsen P, Crozier A, Sandstrøm B & Dragsted LO (1999) Effect of fruit juice intake on urinary excretion and biomarkers of antioxidative status. American Journal of Clinical Nutrition 69, 87-94.
214. Zhai S, Dai RK, Friedman FK & Vestal RE (1998) Comparative inhibition of human cytochromes P450 1a1 and 1a2 by flavonoids. Drug Metabolism and Disposition 26, 989-992.
215. Zhang K, Yang EB, Tang WY, Wong KP & Mack P (1997) Inhibition of glutathione reductase by plant polyphenols. Biochemical Pharmacology 54, 1047-1053.
216. Zhu QY, Huang Y, Tsang D & Chen ZY (1999) Regeneration of alpha-tocopherol in human low-density lipoprotein by green tea catechin. Journal of Agricultural and Food Chemistry 47, 2020-2025.