-
1
-
-
0015319592
-
The biologic clock: The mitochondria?
-
Harman D. The biologic clock: the mitochondria? J Am Geriatr Soc 1972;20:145-7.
-
(1972)
J Am Geriatr Soc
, vol.20
, pp. 145-147
-
-
Harman, D.1
-
2
-
-
0036710886
-
Mechanisms of aging: An appraisal of the oxidative stress hypothesis
-
Sohal RS, Mockett RJ, Orr WC. Mechanisms of aging: an appraisal of the oxidative stress hypothesis. Free Radic Biol Med 2002;33: 575-86.
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 575-586
-
-
Sohal, R.S.1
Mockett, R.J.2
Orr, W.C.3
-
3
-
-
0023811053
-
Normal oxidative damage to mitochondrial and nuclear DNA is extensive
-
Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 1988;85:6465-7.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 6465-6467
-
-
Richter, C.1
Park, J.W.2
Ames, B.N.3
-
4
-
-
0027527023
-
Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain
-
Mecocci P, MacGarvey U, Kaufman AE, et al. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol 1993;34:609-16.
-
(1993)
Ann Neurol
, vol.34
, pp. 609-616
-
-
Mecocci, P.1
MacGarvey, U.2
Kaufman, A.E.3
-
5
-
-
0036829433
-
Rate of generation of oxidative stress-related damage and animal longevity
-
Barja G. Rate of generation of oxidative stress-related damage and animal longevity. Free Radic Biol Med 2002;33:1167-72.
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 1167-1172
-
-
Barja, G.1
-
6
-
-
0033972463
-
Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
-
Barja G, Herrero A. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J 2000;14:312-8.
-
(2000)
FASEB J
, vol.14
, pp. 312-318
-
-
Barja, G.1
Herrero, A.2
-
7
-
-
0027175484
-
Age-dependent impairment of mitochondrial function in primate brain
-
Bowling AC, Mutisya EM, Walker LC, Price DL, Cork LC, Beal MF. Age-dependent impairment of mitochondrial function in primate brain. J Neurochem 1993;60:1964-7.
-
(1993)
J Neurochem
, vol.60
, pp. 1964-1967
-
-
Bowling, A.C.1
Mutisya, E.M.2
Walker, L.C.3
Price, D.L.4
Cork, L.C.5
Beal, M.F.6
-
8
-
-
0028349236
-
Decline with age of the respiratory chain activity in human skeletal muscle
-
Boffoli D, Scacco SC, Vergari R, Solarino G, Santacroce G, Papa S. Decline with age of the respiratory chain activity in human skeletal muscle. Biochim Biophys Acta 1994;1226:73-82.
-
(1994)
Biochim Biophys Acta
, vol.1226
, pp. 73-82
-
-
Boffoli, D.1
Scacco, S.C.2
Vergari, R.3
Solarino, G.4
Santacroce, G.5
Papa, S.6
-
9
-
-
0031205455
-
Mitochondrial DNA in aging and disease
-
Wallace DC, Mitochondrial DNA in aging and disease. Sci Am 1997;277:40-7.
-
(1997)
Sci Am
, vol.277
, pp. 40-47
-
-
Wallace, D.C.1
-
10
-
-
0026671245
-
Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease
-
Corral-Debrinski M, Shoffner JM, Lott MT, Wallace DC. Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease. Mutat Res 1992;275:169-80.
-
(1992)
Mutat Res
, vol.275
, pp. 169-180
-
-
Corral-Debrinski, M.1
Shoffner, J.M.2
Lott, M.T.3
Wallace, D.C.4
-
11
-
-
0027017232
-
Mitochondrial DNA deletions in human brain: Regional variability and increase with advanced age
-
Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, Wallace DC. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat Genet 1992;2: 324-9.
-
(1992)
Nat Genet
, vol.2
, pp. 324-329
-
-
Corral-Debrinski, M.1
Horton, T.2
Lott, M.T.3
Shoffner, J.M.4
Beal, M.F.5
Wallace, D.C.6
-
12
-
-
0025948247
-
Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm
-
Hayakawa M, Torii K, Sugiyama S, Tanaka M, Ozawa T. Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm. Biochem Biophys Res Commun 1991;179:1023-9.
-
(1991)
Biochem Biophys Res Commun
, vol.179
, pp. 1023-1029
-
-
Hayakawa, M.1
Torii, K.2
Sugiyama, S.3
Tanaka, M.4
Ozawa, T.5
-
13
-
-
0027513262
-
Age-associated damage in mitochondrial DNA in human hearts
-
Hayakawa M, Sugiyama S, Hattori K, Takasawa M, Ozawa T. Age-associated damage in mitochondrial DNA in human hearts. Mol Cell Biochem 1993;119:95-103.
-
(1993)
Mol Cell Biochem
, vol.119
, pp. 95-103
-
-
Hayakawa, M.1
Sugiyama, S.2
Hattori, K.3
Takasawa, M.4
Ozawa, T.5
-
14
-
-
0032955553
-
Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle
-
Mecocci P, Fano G, Fulle S, et al. Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radic Biol Med 1999;26:303-8.
-
(1999)
Free Radic Biol Med
, vol.26
, pp. 303-308
-
-
Mecocci, P.1
Fano, G.2
Fulle, S.3
-
15
-
-
0033807443
-
Increased oxidative damage to DNA in ALS patients
-
Bogdanov M, Brown RH, Matson W, et al. Increased oxidative damage to DNA in ALS patients. Free Radic Biol Med 2000;29: 652-8.
-
(2000)
Free Radic Biol Med
, vol.29
, pp. 652-658
-
-
Bogdanov, M.1
Brown, R.H.2
Matson, W.3
-
16
-
-
0036570159
-
Oxidatively modified proteins in aging and disease
-
Beal MF. Oxidatively modified proteins in aging and disease. Free Radic Biol Med 2002;32:797-803.
-
(2002)
Free Radic Biol Med
, vol.32
, pp. 797-803
-
-
Beal, M.F.1
-
17
-
-
0030841350
-
Protein oxidation in aging, disease, and oxidative stress
-
Berlett BS, Stadtman ER. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 1997;272:20313-6.
-
(1997)
J Biol Chem
, vol.272
, pp. 20313-20316
-
-
Berlett, B.S.1
Stadtman, E.R.2
-
18
-
-
0032147208
-
Biological tyrosine nitration: A pathophysiological function of nitric oxide and reactive oxygen species
-
Ischiropoulos H. Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species. Arch Biochem Biophys 1998;356:1-11.
-
(1998)
Arch Biochem Biophys
, vol.356
, pp. 1-11
-
-
Ischiropoulos, H.1
-
19
-
-
0027328852
-
Protein oxidative damage is associated with life expectancy of houseflies
-
Sohal RS, Agarwal S, Dubey A, Orr WC. Protein oxidative damage is associated with life expectancy of houseflies. Proc Natl Acad Sci USA 1993;90:7255-9.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7255-7259
-
-
Sohal, R.S.1
Agarwal, S.2
Dubey, A.3
Orr, W.C.4
-
20
-
-
0028342438
-
Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
-
Sohal RS, Ku HH, Agarwal S, Forster MJ, Lal H. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev 1994;74:121-33.
-
(1994)
Mech Ageing Dev
, vol.74
, pp. 121-133
-
-
Sohal, R.S.1
Ku, H.H.2
Agarwal, S.3
Forster, M.J.4
Lal, H.5
-
21
-
-
0029007378
-
Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)
-
Sohal RS, Agarwal S, Sohal BH. Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus). Mech Ageing Dev 1995; 81:15-25.
-
(1995)
Mech Ageing Dev
, vol.81
, pp. 15-25
-
-
Sohal, R.S.1
Agarwal, S.2
Sohal, B.H.3
-
22
-
-
0023607180
-
Aging effects of vitamin C on a human lens protein produced in vitro
-
Russell P, Garland D, Zigler Jr JS, Meakin SO, Tsui LC, Breitman ML. Aging effects of vitamin C on a human lens protein produced in vitro. FASEB J 1987;1:32-5.
-
(1987)
FASEB J
, vol.1
, pp. 32-35
-
-
Russell, P.1
Garland, D.2
Zigler Jr., J.S.3
Meakin, S.O.4
Tsui, L.C.5
Breitman, M.L.6
-
23
-
-
0025790342
-
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease
-
Smith CD, Carney JM, Starke-Reed PE, et al. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl Acad Sci USA 1991;88:10540-3.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 10540-10543
-
-
Smith, C.D.1
Carney, J.M.2
Starke-Reed, P.E.3
-
24
-
-
0023181066
-
Age-related changes in oxidized proteins
-
Oliver CN, Ahn BW, Moerman EJ, Goldstein S, Stadtman ER. Age-related changes in oxidized proteins. J Biol Chem 1987;262: 5488-91.
-
(1987)
J Biol Chem
, vol.262
, pp. 5488-5491
-
-
Oliver, C.N.1
Ahn, B.W.2
Moerman, E.J.3
Goldstein, S.4
Stadtman, E.R.5
-
25
-
-
0030881686
-
Oxidative damage during aging targets mitochondrial aconitase
-
Yan LJ, Levine RL, Sohal RS. Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci USA 1997;94: 11168-72.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 11168-11172
-
-
Yan, L.J.1
Levine, R.L.2
Sohal, R.S.3
-
26
-
-
0032573066
-
Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
-
Yan LJ, Sohal RS. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Proc Natl Acad Sci USA 1998; 95:12896-901.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 12896-12901
-
-
Yan, L.J.1
Sohal, R.S.2
-
27
-
-
0035834101
-
Proteomic method identifies proteins nitrated in vivo during inflammatory challenge
-
Aulak KS, Miyagi M, Yan L, et al. Proteomic method identifies proteins nitrated in vivo during inflammatory challenge. Proc Natl Acad Sci USA 2001;98:12056-61.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12056-12061
-
-
Aulak, K.S.1
Miyagi, M.2
Yan, L.3
-
28
-
-
0029862502
-
Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts
-
MacMillan-Crow LA, Crow JP, Kerby JD, Beckman JS, Thompson JA. Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts. Proc Natl Acad Sci USA 1996;93:11853-8.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 11853-11858
-
-
MacMillan-Crow, L.A.1
Crow, J.P.2
Kerby, J.D.3
Beckman, J.S.4
Thompson, J.A.5
-
29
-
-
0034176278
-
Rapid reactions of peroxynitrite with heme-thiolate proteins as the basis for protection of prostacyclin synthase from inactivation by nitration
-
Zou MH, Daiber A, Peterson JA, Shoun H, Ullrich V. Rapid reactions of peroxynitrite with heme-thiolate proteins as the basis for protection of prostacyclin synthase from inactivation by nitration. Arch Biochem Biophys 2000;376:149-55.
-
(2000)
Arch Biochem Biophys
, vol.376
, pp. 149-155
-
-
Zou, M.H.1
Daiber, A.2
Peterson, J.A.3
Shoun, H.4
Ullrich, V.5
-
30
-
-
0029983162
-
Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide
-
Kong SK, Yim MB, Stadtman ER, Chock PB. Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide. Proc Natl Acad Sci USA 1996;93: 3377-82.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3377-3382
-
-
Kong, S.K.1
Yim, M.B.2
Stadtman, E.R.3
Chock, P.B.4
-
31
-
-
0032479147
-
Mitochondrial creatine kinase is a prime target of peroxynitrite-induced modification and inactivation
-
Stachowiak O, Dolder M, Wallimann T, Richter C. Mitochondrial creatine kinase is a prime target of peroxynitrite-induced modification and inactivation. J Biol Chem 1998;273:16694-9.
-
(1998)
J Biol Chem
, vol.273
, pp. 16694-16699
-
-
Stachowiak, O.1
Dolder, M.2
Wallimann, T.3
Richter, C.4
-
32
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996;273:59-63.
-
(1996)
Science
, vol.273
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
33
-
-
0034284973
-
Extension of life-span with superoxide dismutase/catalase mimetics
-
Melov S, Ravenscroft J, Malik S, et al. Extension of life-span with superoxide dismutase/catalase mimetics. Science 2000;289:1567-9.
-
(2000)
Science
, vol.289
, pp. 1567-1569
-
-
Melov, S.1
Ravenscroft, J.2
Malik, S.3
-
34
-
-
0029058728
-
The spin-trap N-tert-alpha-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse
-
Edamatsu R, Mori A, Packer L. The spin-trap N-tert-alpha-phenyl- butylnitrone prolongs the life span of the senescence accelerated mouse. Biochem Biophys Res Commun 1995;211:847-9.
-
(1995)
Biochem Biophys Res Commun
, vol.211
, pp. 847-849
-
-
Edamatsu, R.1
Mori, A.2
Packer, L.3
-
36
-
-
0031864164
-
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
-
Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat Genet 1998;19:171-4.
-
(1998)
Nat Genet
, vol.19
, pp. 171-174
-
-
Parkes, T.L.1
Elia, A.J.2
Dickinson, D.3
Hilliker, A.J.4
Phillips, J.P.5
Boulianne, G.L.6
-
37
-
-
0032908347
-
FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies
-
Sun J, Tower J. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol 1999; 19: 216-28.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 216-228
-
-
Sun, J.1
Tower, J.2
-
38
-
-
0035989388
-
Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster
-
Sun J, Folk D, Bradley TJ, Tower J. Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics 2002;161:661-72.
-
(2002)
Genetics
, vol.161
, pp. 661-672
-
-
Sun, J.1
Folk, D.2
Bradley, T.J.3
Tower, J.4
-
39
-
-
0029935647
-
Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins
-
Moskovitz J, Weissbach H, Brot N. Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins. Proc Natl Acad Sci USA 1996;93:2095-9.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 2095-2099
-
-
Moskovitz, J.1
Weissbach, H.2
Brot, N.3
-
40
-
-
0035818520
-
Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals
-
Moskovitz J, Bar-Noy S, Williams WM, Requena J, Berlett BS, Stadtman ER. Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proc Natl Acad Sci USA 2001;98:12920-5.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12920-12925
-
-
Moskovitz, J.1
Bar-Noy, S.2
Williams, W.M.3
Requena, J.4
Berlett, B.S.5
Stadtman, E.R.6
-
41
-
-
0037022556
-
High-quality life extension by the enzyme peptide methionine sulfoxide reductase
-
Ruan H, Tang XD, Chen ML, et al. High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Proc Natl Acad Sci USA 2002;99:2748-53.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 2748-2753
-
-
Ruan, H.1
Tang, X.D.2
Chen, M.L.3
-
42
-
-
0028152717
-
Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
-
Mecocci P, MacGarvey U, Seal MF. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 1994;36:747-51.
-
(1994)
Ann Neurol
, vol.36
, pp. 747-751
-
-
Mecocci, P.1
MacGarvey, U.2
Seal, M.F.3
-
43
-
-
0036094092
-
Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease
-
Mecocci P, Polidori MC, Cherubini A, et al. Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease. Arch Neurol 2002;59:794-8.
-
(2002)
Arch Neurol
, vol.59
, pp. 794-798
-
-
Mecocci, P.1
Polidori, M.C.2
Cherubini, A.3
-
44
-
-
0037010314
-
Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease
-
Abe T, Tohgi H, Isobe C, Murata T, Sato C. Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res 2002;70:447-50.
-
(2002)
J Neurosci Res
, vol.70
, pp. 447-450
-
-
Abe, T.1
Tohgi, H.2
Isobe, C.3
Murata, T.4
Sato, C.5
-
45
-
-
18744374615
-
Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?
-
Perry G, Nunomura A, Hirai K, et al. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radic Biol Med 2002;33:1475-9.
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 1475-1479
-
-
Perry, G.1
Nunomura, A.2
Hirai, K.3
-
46
-
-
0031939204
-
Protein nitration in Parkinson's disease
-
Good PF, Hsu A, Werner P, Perl DP, Olanow CW. Protein nitration in Parkinson's disease. J Neuropathol Exp Neurol 1998;57:338-42.
-
(1998)
J Neuropathol Exp Neurol
, vol.57
, pp. 338-342
-
-
Good, P.F.1
Hsu, A.2
Werner, P.3
Perl, D.P.4
Olanow, C.W.5
-
47
-
-
0034602442
-
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
-
Giasson BI, Duda JE, Murray IV, et al. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 2000;290:985-9.
-
(2000)
Science
, vol.290
, pp. 985-989
-
-
Giasson, B.I.1
Duda, J.E.2
Murray, I.V.3
-
48
-
-
0037178579
-
Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study
-
Morris MC, Evans DA, Bienias JL, et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. J Am Med Assoc 2002;287:3230-7.
-
(2002)
J Am Med Assoc
, vol.287
, pp. 3230-3237
-
-
Morris, M.C.1
Evans, D.A.2
Bienias, J.L.3
-
49
-
-
0037178573
-
Dietary intake of antioxidants and risk of Alzheimer disease
-
Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Dietary intake of antioxidants and risk of Alzheimer disease. J Am Med Assoc 2002; 287:3223-9.
-
(2002)
J Am Med Assoc
, vol.287
, pp. 3223-3229
-
-
Engelhart, M.J.1
Geerlings, M.I.2
Ruitenberg, A.3
-
50
-
-
0036310718
-
Vitamin E. and cognitive decline in older persons
-
Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS, Vitamin E. and cognitive decline in older persons. Arch Neurol 2002;59:1125-32.
-
(2002)
Arch Neurol
, vol.59
, pp. 1125-1132
-
-
Morris, M.C.1
Evans, D.A.2
Bienias, J.L.3
Tangney, C.C.4
Wilson, R.S.5
-
51
-
-
0034724365
-
Association of vitamin e and C supplement use with cognitive function and dementia in elderly men
-
Masaki KH, Losonczy KG, Izmirlian G, et al. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 2000;54:1265-72.
-
(2000)
Neurology
, vol.54
, pp. 1265-1272
-
-
Masaki, K.H.1
Losonczy, K.G.2
Izmirlian, G.3
-
52
-
-
0033835543
-
Intake of flavonoids and risk of dementia
-
Commenges D, Scotet V, Renaud S, Jacqmin-Gadda H, Barberger-Gateau P, Dartigues JF. Intake of flavonoids and risk of dementia. Eur J Epidemiol 2000;16:357-63.
-
(2000)
Eur J Epidemiol
, vol.16
, pp. 357-363
-
-
Commenges, D.1
Scotet, V.2
Renaud, S.3
Jacqmin-Gadda, H.4
Barberger-Gateau, P.5
Dartigues, J.F.6
-
53
-
-
0037075257
-
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
-
Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002; 346:476-83.
-
(2002)
N Engl J Med
, vol.346
, pp. 476-483
-
-
Seshadri, S.1
Beiser, A.2
Selhub, J.3
-
54
-
-
0036525567
-
Coenzyme Q10 as a possible treatment for neurodegenerative diseases
-
Beal MF. Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Radic Res 2002;36:455-60.
-
(2002)
Free Radic Res
, vol.36
, pp. 455-460
-
-
Beal, M.F.1
-
55
-
-
0036771852
-
Effects of coenzyme Q10 in early Parkinson disease: Evidence of slowing of the functional decline
-
Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002;59:1541 -50.
-
(2002)
Arch Neurol
, vol.59
, pp. 1541-1550
-
-
Shults, C.W.1
Oakes, D.2
Kieburtz, K.3
-
56
-
-
0020066839
-
Is cell aging caused by respiration-dependent injury to the mitochondrial genome?
-
Fleming JE, Miquel J, Cottrell SF, Yengoyan LS, Economos AC. Is cell aging caused by respiration-dependent injury to the mitochondrial genome? Gerontology 1982;28:44-53.
-
(1982)
Gerontology
, vol.28
, pp. 44-53
-
-
Fleming, J.E.1
Miquel, J.2
Cottrell, S.F.3
Yengoyan, L.S.4
Economos, A.C.5
-
57
-
-
0024541837
-
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
-
Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989;1:642-5.
-
(1989)
Lancet
, vol.1
, pp. 642-645
-
-
Linnane, A.W.1
Marzuki, S.2
Ozawa, T.3
Tanaka, M.4
-
58
-
-
0019423856
-
Sequence and organization of the human mitochondrial genome
-
Anderson S, Bankier AT, Barrell BG, et al. Sequence and organization of the human mitochondrial genome. Nature 1981; 290:457-65.
-
(1981)
Nature
, vol.290
, pp. 457-465
-
-
Anderson, S.1
Bankier, A.T.2
Barrell, B.G.3
-
59
-
-
0023883150
-
Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
-
Holt IJ, Harding AE, Morgan-Hughes JA. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 1988;331:717-9.
-
(1988)
Nature
, vol.331
, pp. 717-719
-
-
Holt, I.J.1
Harding, A.E.2
Morgan-Hughes, J.A.3
-
60
-
-
0024242545
-
Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy
-
Wallace DC, Singh G, Lott MT, et al. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science 1988; 242:1427-30.
-
(1988)
Science
, vol.242
, pp. 1427-1430
-
-
Wallace, D.C.1
Singh, G.2
Lott, M.T.3
-
61
-
-
0003545939
-
-
Center for Molecular Medicine, Emory University, Atlanta, GA, USA
-
MITOMAP. A Human Mitochondrial Genome Database. Center for Molecular Medicine, Emory University, Atlanta, GA, USA. http://www.mitomap.org/. 2001
-
(2001)
A Human Mitochondrial Genome Database
-
-
-
62
-
-
0020680904
-
Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
-
Langston JW, Ballard P, Tetrad JW, Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983;219:979-80.
-
(1983)
Science
, vol.219
, pp. 979-980
-
-
Langston, J.W.1
Ballard, P.2
Tetrad, J.W.3
Irwin, I.4
-
63
-
-
0021829406
-
Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP): Seven cases
-
Ballard PA, Tetrad JW, Langston JW. Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases. Neurology 1985;35:949-56.
-
(1985)
Neurology
, vol.35
, pp. 949-956
-
-
Ballard, P.A.1
Tetrad, J.W.2
Langston, J.W.3
-
64
-
-
0021810979
-
Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1, 2,5,6-tetrahydro-pyridine
-
Nicklas WJ, Vyas I, Heikkila RE. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydro-pyridine. Life Sci 1985;36:2503-8.
-
(1985)
Life Sci
, vol.36
, pp. 2503-2508
-
-
Nicklas, W.J.1
Vyas, I.2
Heikkila, R.E.3
-
65
-
-
0033681149
-
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
-
Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 2000;3:1301-6.
-
(2000)
Nat Neurosci
, vol.3
, pp. 1301-1306
-
-
Betarbet, R.1
Sherer, T.B.2
MacKenzie, G.3
Garcia-Osuna, M.4
Panov, A.V.5
Greenamyre, J.T.6
-
66
-
-
0029118136
-
Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates
-
Brouillet E, Hantraye P, Ferrante RJ, et al. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates. Proc Natl Acad Sci USA 1995;92:7105-9.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 7105-7109
-
-
Brouillet, E.1
Hantraye, P.2
Ferrante, R.J.3
-
67
-
-
0030059079
-
Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells
-
Laderman KA, Penny JR, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G. Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells. J Biol Chem 1996;271:15891-7.
-
(1996)
J Biol Chem
, vol.271
, pp. 15891-15897
-
-
Laderman, K.A.1
Penny, J.R.2
Mazzucchelli, F.3
Bresolin, N.4
Scarlato, G.5
Attardi, G.6
-
68
-
-
0029908226
-
Origin and functional consequences of the complex I defect in Parkinson's disease
-
Swerdlow RH, Parks JK, Miller SW, et al. Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 1996;40:663-71.
-
(1996)
Ann Neurol
, vol.40
, pp. 663-671
-
-
Swerdlow, R.H.1
Parks, J.K.2
Miller, S.W.3
-
69
-
-
0031859395
-
Mitochondrial DNA transmission of the mitochondrial defect in Parkinson' s disease
-
Gu M, Cooper JM, Taanman JW, Schapira AH. Mitochondrial DNA transmission of the mitochondrial defect in Parkinson' s disease. Ann Neurol 1998;44:177-86.
-
(1998)
Ann Neurol
, vol.44
, pp. 177-186
-
-
Gu, M.1
Cooper, J.M.2
Taanman, J.W.3
Schapira, A.H.4
-
70
-
-
0030724118
-
Cybrids in Alzheimer' s disease: A cellular model of the disease?
-
Swerdlow RH, Parks JK, Cassarino DS, et al. Cybrids in Alzheimer' s disease: a cellular model of the disease? [see comments]. Neurology 1997;49:918-25.
-
(1997)
Neurology
, vol.49
, pp. 918-925
-
-
Swerdlow, R.H.1
Parks, J.K.2
Cassarino, D.S.3
-
71
-
-
0033515075
-
Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease
-
Ito S, Ohta S, Nishimaki K, et al. Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease. Proc Natl Acad Sci USA 1999;96:2099-103.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 2099-2103
-
-
Ito, S.1
Ohta, S.2
Nishimaki, K.3
-
72
-
-
0034809341
-
Cytoplasmic transfer of platelet mtDNA from elderly patients with Parkinson's disease to mtDNA-less HeLa cells restores complete mitochondrial respiratory function
-
Aomi Y, Chen CS, Nakada K, et al. Cytoplasmic transfer of platelet mtDNA from elderly patients with Parkinson's disease to mtDNA-less HeLa cells restores complete mitochondrial respiratory function. Biochem Biophys Res Commun 2001;280:265-73.
-
(2001)
Biochem Biophys Res Commun
, vol.280
, pp. 265-273
-
-
Aomi, Y.1
Chen, C.S.2
Nakada, K.3
-
73
-
-
0033544323
-
Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation
-
Simon DK, Pulst SM, Sutton JP, Browne SE, Beal MF, Johns DR. Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation. Neurology 1999;53: 1787-93.
-
(1999)
Neurology
, vol.53
, pp. 1787-1793
-
-
Simon, D.K.1
Pulst, S.M.2
Sutton, J.P.3
Browne, S.E.4
Beal, M.F.5
Johns, D.R.6
-
74
-
-
0036297660
-
Sequence analysis of the entire mitochondrial genome in Parkinson's disease
-
Vives-Bauza C, Andreu AL, Manfredi G, et al. Sequence analysis of the entire mitochondrial genome in Parkinson's disease. Biochem Biophys Res Commun 2002;290:1593-601.
-
(2002)
Biochem Biophys Res Commun
, vol.290
, pp. 1593-1601
-
-
Vives-Bauza, C.1
Andreu, A.L.2
Manfredi, G.3
-
75
-
-
0034620483
-
Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease
-
Simon DK, Mayeux R, Marder K, Kowall NW, Beal MF, Johns DR. Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease. Neurology 2000;54:703-9.
-
(2000)
Neurology
, vol.54
, pp. 703-709
-
-
Simon, D.K.1
Mayeux, R.2
Marder, K.3
Kowall, N.W.4
Beal, M.F.5
Johns, D.R.6
-
76
-
-
0027200741
-
Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients
-
Shoffner JM, Brown MD, Torroni A, et al. Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients. Genomics 1993;17:171-84.
-
(1993)
Genomics
, vol.17
, pp. 171-184
-
-
Shoffner, J.M.1
Brown, M.D.2
Torroni, A.3
-
77
-
-
0030811838
-
Association of the mitochondrial tRNA(A4336G) mutation with Alzheimer's and Parkinson's diseases
-
Egensperger R, Kosel S, Schnopp NM, Mehraein P, Graeber MB. Association of the mitochondrial tRNA(A4336G) mutation with Alzheimer's and Parkinson's diseases. Neuropathol Appl Neurobiol 1997;23:315-21.
-
(1997)
Neuropathol Appl Neurobiol
, vol.23
, pp. 315-321
-
-
Egensperger, R.1
Kosel, S.2
Schnopp, N.M.3
Mehraein, P.4
Graeber, M.B.5
-
79
-
-
0030299996
-
The tRNA(Gln) 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years
-
Tysoe C, Robinson D, Brayne C, et al. The tRNA(Gln) 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years. J Med Genet 1996;33:1002-6.
-
(1996)
J Med Genet
, vol.33
, pp. 1002-1006
-
-
Tysoe, C.1
Robinson, D.2
Brayne, C.3
-
80
-
-
0026584717
-
Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains
-
Lin FH, Lin R, Wisniewski HM, et al. Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains. Biochem Biophys Res Commun 1992;182: 238-46.
-
(1992)
Biochem Biophys Res Commun
, vol.182
, pp. 238-246
-
-
Lin, F.H.1
Lin, R.2
Wisniewski, H.M.3
-
81
-
-
0026672905
-
Is a point mutation in the mitochondrial ND2 gene associated with Alzheimer's disease
-
Petruzzella V, Chen X, Schon EA. Is a point mutation in the mitochondrial ND2 gene associated with Alzheimer's disease. Biochem Biophys Res Commun 1992;186:491-7.
-
(1992)
Biochem Biophys Res Commun
, vol.186
, pp. 491-497
-
-
Petruzzella, V.1
Chen, X.2
Schon, E.A.3
-
82
-
-
0027935035
-
No association of mutations at nucleotide 5460 of mitochondrial NADH dehydrogenase with Alzheimer's disease
-
Kosel S, Egensperger R, Mehraein P, Graeber MB. No association of mutations at nucleotide 5460 of mitochondrial NADH dehydrogenase with Alzheimer's disease. Biochem Biophys Res Commun 1994; 203:745-9.
-
(1994)
Biochem Biophys Res Commun
, vol.203
, pp. 745-749
-
-
Kosel, S.1
Egensperger, R.2
Mehraein, P.3
Graeber, M.B.4
-
83
-
-
0028843809
-
No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant
-
Wragg MA, Talbot CJ, Morris JC, Lendon CL, Goate AM. No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant. Neurosci Lett 1995;201:107-10.
-
(1995)
Neurosci Lett
, vol.201
, pp. 107-110
-
-
Wragg, M.A.1
Talbot, C.J.2
Morris, J.C.3
Lendon, C.L.4
Goate, A.M.5
-
84
-
-
12644257598
-
Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease
-
Davis RE, Miller S, Herrnstadt C, et al. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc Natl Acad Sci USA 1997;94:4526-31.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4526-4531
-
-
Davis, R.E.1
Miller, S.2
Herrnstadt, C.3
-
85
-
-
0031449003
-
Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes
-
Hirano M, Shtilbans A, Mayeux R, et al. Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes. Proc Natl Acad Sci USA 1997;94:14894-9.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 14894-14899
-
-
Hirano, M.1
Shtilbans, A.2
Mayeux, R.3
-
86
-
-
0031464288
-
Ancient mtDNA sequences in the human nuclear genome: A potential source of errors in identifying pathogenic mutations
-
Wallace DC, Stugard C, Murdock D, Schurr T, Brown MD. Ancient mtDNA sequences in the human nuclear genome: a potential source of errors in identifying pathogenic mutations. Proc Natl Acad Sci USA 1997;94:14900-5.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 14900-14905
-
-
Wallace, D.C.1
Stugard, C.2
Murdock, D.3
Schurr, T.4
Brown, M.D.5
-
87
-
-
0344625398
-
No mitochondrial haplotype was found to increase risk for Alzheimer's disease
-
Zsurka G, Kaiman J, Csaszar A, Rasko I, Janka Z, Venetianer P. No mitochondrial haplotype was found to increase risk for Alzheimer's disease. Biol Psychiatry 1998;44:371-3.
-
(1998)
Biol Psychiatry
, vol.44
, pp. 371-373
-
-
Zsurka, G.1
Kaiman, J.2
Csaszar, A.3
Rasko, I.4
Janka, Z.5
Venetianer, P.6
-
88
-
-
0033852515
-
Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies
-
Chinnery PF, Taylor GA, Howell N, et al. Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies. Neurology 2000;55:302-4.
-
(2000)
Neurology
, vol.55
, pp. 302-304
-
-
Chinnery, P.F.1
Taylor, G.A.2
Howell, N.3
-
89
-
-
0015882341
-
The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
-
Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 1973;134:707-16.
-
(1973)
Biochem J
, vol.134
, pp. 707-716
-
-
Boveris, A.1
Chance, B.2
-
90
-
-
0018776894
-
Hydroperoxide metabolism in mammalian organs
-
Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979;59:527-605.
-
(1979)
Physiol Rev
, vol.59
, pp. 527-605
-
-
Chance, B.1
Sies, H.2
Boveris, A.3
-
91
-
-
0027171266
-
Oxidants, antioxidants, and the degenerative diseases of aging
-
Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993; 90:7915-22.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7915-7922
-
-
Ames, B.N.1
Shigenaga, M.K.2
Hagen, T.M.3
-
92
-
-
0026592966
-
8-Hydroxyguuanine, an abundant form of oxidative DNA damage, causes G → T and a → C substitutions
-
Cheng KC, Cahill DS, Kasai H, Nishimura S, Loeb LA. 8-Hydroxyguuanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions. J Biol Chem 1992;267:166-72.
-
(1992)
J Biol Chem
, vol.267
, pp. 166-172
-
-
Cheng, K.C.1
Cahill, D.S.2
Kasai, H.3
Nishimura, S.4
Loeb, L.A.5
-
93
-
-
0032813088
-
Repair of DNA damage in mitochondria
-
Sawyer DE, Van Houten B. Repair of DNA damage in mitochondria. Mutat Res 1999;434:161-76.
-
(1999)
Mutat Res
, vol.434
, pp. 161-176
-
-
Sawyer, D.E.1
Van Houten, B.2
-
94
-
-
0026469073
-
Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing
-
Cooper JM, Mann VM, Schapira AH. Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing. J Neurol Sci 1992;113: 91-8.
-
(1992)
J Neurol Sci
, vol.113
, pp. 91-98
-
-
Cooper, J.M.1
Mann, V.M.2
Schapira, A.H.3
-
95
-
-
0026732706
-
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
-
Cortopassi GA, Shibata D, Soong NW, Arnheim N. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci USA 1992;89:7370-4.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 7370-7374
-
-
Cortopassi, G.A.1
Shibata, D.2
Soong, N.W.3
Arnheim, N.4
-
96
-
-
0028349234
-
Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing
-
Lee HC, Pang CY, Hsu HS, Wei YH. Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing. Biochim Biophys Acta 1994;1226:37-43.
-
(1994)
Biochim Biophys Acta
, vol.1226
, pp. 37-43
-
-
Lee, H.C.1
Pang, C.Y.2
Hsu, H.S.3
Wei, Y.H.4
-
97
-
-
0029113657
-
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys
-
Schwarze SR, Lee CM, Chung SS, Roecker EB, Weindruch R, Aiken JM. High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev 1995;83:91-101.
-
(1995)
Mech Ageing Dev
, vol.83
, pp. 91-101
-
-
Schwarze, S.R.1
Lee, C.M.2
Chung, S.S.3
Roecker, E.B.4
Weindruch, R.5
Aiken, J.M.6
-
98
-
-
0030877134
-
Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age
-
Melov S, Hinerfeld D, Esposito L, Wallace DC. Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age. Nucleic Acids Res 1997;25: 974-82.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 974-982
-
-
Melov, S.1
Hinerfeld, D.2
Esposito, L.3
Wallace, D.C.4
-
99
-
-
0034972303
-
High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection
-
Coller HA, Khrapko K, Bodyak ND, Nekhaeva E, Herrero-Jimenez P, Thilly WG. High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection. Nat Genet 2001;28:147-50.
-
(2001)
Nat Genet
, vol.28
, pp. 147-150
-
-
Coller, H.A.1
Khrapko, K.2
Bodyak, N.D.3
Nekhaeva, E.4
Herrero-Jimenez, P.5
Thilly, W.G.6
-
100
-
-
0031736203
-
Somatic mutations of the mitochondrial genome in human colorectal tumours
-
Polyak K, Li Y, Zhu H, et al. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 1998;20:291-3.
-
(1998)
Nat Genet
, vol.20
, pp. 291-293
-
-
Polyak, K.1
Li, Y.2
Zhu, H.3
-
101
-
-
0039250954
-
Facile detection of mitochondrial DNA mutations in tumors and bodily fluids
-
Fliss MS, Usadel H, Caballero OL, et al. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science 2000;287:2017-9.
-
(2000)
Science
, vol.287
, pp. 2017-2019
-
-
Fliss, M.S.1
Usadel, H.2
Caballero, O.L.3
-
102
-
-
0033595684
-
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
-
Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication [see comments]. Science 1999;286:774-9.
-
(1999)
Science
, vol.286
, pp. 774-779
-
-
Michikawa, Y.1
Mazzucchelli, F.2
Bresolin, N.3
Scarlato, G.4
Attardi, G.5
-
103
-
-
0035309740
-
Low mutational burden of individual acquired mitochondrial DNA mutations in brain
-
Simon DK, Lin MT, Ahn CH, et al. Low mutational burden of individual acquired mitochondrial DNA mutations in brain. Genomics 2001;73:113-6.
-
(2001)
Genomics
, vol.73
, pp. 113-116
-
-
Simon, D.K.1
Lin, M.T.2
Ahn, C.H.3
-
104
-
-
0035125774
-
Point mutations of the mtDNA control region in normal and neurodegenerative human brains
-
Chinnery PF, Taylor GA, Howell N, Brown DT, Parsons TJ, Turnbull DM. Point mutations of the mtDNA control region in normal and neurodegenerative human brains. Am J Hum Genet 2001;68:529-32.
-
(2001)
Am J Hum Genet
, vol.68
, pp. 529-532
-
-
Chinnery, P.F.1
Taylor, G.A.2
Howell, N.3
Brown, D.T.4
Parsons, T.J.5
Turnbull, D.M.6
-
105
-
-
0035957323
-
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication
-
Wang Y, Michikawa Y, Mallidis C, et al. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci USA 2001;98:4022-7.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4022-4027
-
-
Wang, Y.1
Michikawa, Y.2
Mallidis, C.3
-
106
-
-
0037081814
-
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer' s disease brain
-
Lin MT, Simon DK, Ahn CH, Kim LM, Beal MF. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer' s disease brain. Hum Mol Gen 2002;11:133-45.
-
(2002)
Hum Mol Gen
, vol.11
, pp. 133-145
-
-
Lin, M.T.1
Simon, D.K.2
Ahn, C.H.3
Kim, L.M.4
Beal, M.F.5
-
107
-
-
33644577523
-
Somatic mtDNA mutations in cortex and substantia nigra in aging and Parkinson's disease
-
in press
-
Simon DK, Lin MT, Zheng LY, et al. Somatic mtDNA mutations in cortex and substantia nigra in aging and Parkinson's disease. Neurobiol Aging (2003) (in press).
-
(2003)
Neurobiol Aging
-
-
Simon, D.K.1
Lin, M.T.2
Zheng, L.Y.3
-
108
-
-
0029864498
-
Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA
-
Jazin EE, Cavelier L, Eriksson I, Oreland L, Gyllensten U. Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA. Proc Natl Acad Sci USA 1996;93:12382-7.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12382-12387
-
-
Jazin, E.E.1
Cavelier, L.2
Eriksson, I.3
Oreland, L.4
Gyllensten, U.5
-
109
-
-
0033610865
-
Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types
-
Villani G, Greco M, Papa S, Attardi G. Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types. J Biol Chem 1998;273:31829-36.
-
(1998)
J Biol Chem
, vol.273
, pp. 31829-31836
-
-
Villani, G.1
Greco, M.2
Papa, S.3
Attardi, G.4
-
110
-
-
0035861593
-
In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I
-
D'Aurelio M, Pallotti F, Barrientos A, et al. In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I. J Biol Chem 2001;276:46925-32.
-
(2001)
J Biol Chem
, vol.276
, pp. 46925-46932
-
-
D'Aurelio, M.1
Pallotti, F.2
Barrientos, A.3
-
111
-
-
0034938453
-
Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria
-
Ono T, Isobe K, Nakada K, Hayashi JI. Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria. Nat Genet 2001;28:272-5.
-
(2001)
Nat Genet
, vol.28
, pp. 272-275
-
-
Ono, T.1
Isobe, K.2
Nakada, K.3
Hayashi, J.I.4
-
112
-
-
0031885843
-
Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle
-
Brierley EJ, Johnson MA, Lightowlers RN, James OF, Turnbull DM. Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle. Ann Neurol 1998;43: 217-23.
-
(1998)
Ann Neurol
, vol.43
, pp. 217-223
-
-
Brierley, E.J.1
Johnson, M.A.2
Lightowlers, R.N.3
James, O.F.4
Turnbull, D.M.5
-
113
-
-
0035943058
-
Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD
-
Cottrell DA, Blakely EL, Johnson MA, Ince PG, Turnbull DM. Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD. Neurology 2001;57:260-4.
-
(2001)
Neurology
, vol.57
, pp. 260-264
-
-
Cottrell, D.A.1
Blakely, E.L.2
Johnson, M.A.3
Ince, P.G.4
Turnbull, D.M.5
-
114
-
-
0036408915
-
The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease
-
Cottrell DA, Borthwick GM, Johnson MA, Ince PG, Turnbull DM. The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease. Neuropathol Appl Neurobiol 2002;28:390-6.
-
(2002)
Neuropathol Appl Neurobiol
, vol.28
, pp. 390-396
-
-
Cottrell, D.A.1
Borthwick, G.M.2
Johnson, M.A.3
Ince, P.G.4
Turnbull, D.M.5
-
115
-
-
0034943967
-
Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions
-
Van Goethem G, Dermaut B, Lofgren A, Martin JJ, Van Broeckhoven C. Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions. Nat Genet 2001;28:211-2.
-
(2001)
Nat Genet
, vol.28
, pp. 211-212
-
-
Van Goethem, G.1
Dermaut, B.2
Lofgren, A.3
Martin, J.J.4
Van Broeckhoven, C.5
-
116
-
-
0034938364
-
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria
-
Spelbrink JN, Li FY, Tiranti V, et al. Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nat Genet 2001;28:223-31.
-
(2001)
Nat Genet
, vol.28
, pp. 223-231
-
-
Spelbrink, J.N.1
Li, F.Y.2
Tiranti, V.3
-
117
-
-
0037214525
-
Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy
-
Zhang D, Mott JL, Farrar P, et al. Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy. Cardiovasc Res 2003;57:147-57.
-
(2003)
Cardiovasc Res
, vol.57
, pp. 147-157
-
-
Zhang, D.1
Mott, J.L.2
Farrar, P.3
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