Garlic and its active metabolite allicin produce endothelium- and nitric oxide-dependent relaxation in rat pulmonary arteries

Clinical and Experimental Pharmacology and Physiology

Volumn 29, Issue 1-2, 2002, Pages 84-91

  Ku, David D ^a   Abdel Razek, Tarek T ^a   Dai, Jun ^a   Kim Park, SangAe ^a   Fallon, Michael B ^b   Abrams, Gary A ^b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Allicin; Alliinase; Endothelium; Garlic; Nitric oxide; Pulmonary; Vasorelaxation

Indexed keywords

ACETYLCHOLINE; ALLICIN; ALLIIN LYASE; GARLIC EXTRACT; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE DONOR; PHENYLEPHRINE; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; MALE; MICROFILTRATION; NONHUMAN; PULMONARY ARTERY; RAT; TACHYPHYLAXIS; VASODILATATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; GARLIC; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANT STEMS; PULMONARY ARTERY; RATS; SULFINIC ACIDS; VASODILATION;

EID: 0036151125     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2002.03596.x     Document Type: Article

References (32)

1. Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes
2. Effects of garlic coated tablets in peripheral arterial occlusive disease
3. A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel wall in an in vivo porcine experimental model
4. An evaluation of garlic and onion as antithrombotic agents
5. Garlic preserves patency and delays hyperthermia-induced thrombosis in pial microcirculation
6. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosyntheses in primary rat hepatocyte culture
7. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids
8. Prolongation of life span in hypertensive rats by dietary interventions. Effects of garlic and linseed oil
9. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease
10. Treatment of hepatopulmonary syndrome with Allium sativum L. (garlic): A pilot trial
11. Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism: A randomized controlled trial
12. Garlic powder and plasma lipids and lipoproteins: A multicenter, randomized, placebo-controlled trial
13. Garlic prevents hypoxic pulmonary hypertension in rats
14. The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome
15. Release of endothelium-derived relaxing factors from canine cardiac valves
16. Coronary vascular and antiplatelet effects of peroxynitrite in human tissues
17. Nitric oxide- and nitric oxide donor-induced relaxation
18. Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats
19. Direct relaxant effects of garlic juice on smooth and cardiac muscles
20. Endothelium-dependent and independent effects of garlic on rat aorta
21. The composition and chemistry of garlic cloves and processed garlic
22. The antibacterial principle ofAllium sativum. III. Its precursor and 'essential oil of garlic'
23. Inhibition of whole blood platelet-aggregation by compounds in garlic clove extracts and commercial garlic products
24. Antioxidant activity of allicin, an active principle in garlic
25. The effect of the aged garlic extract, 'Kyolic', on the development of experimental atherosclerosis
26. Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract
27. Daily supplementation with aged garlic extract, but not raw garlic, protects low density lipoprotein againstin vitro oxidation
28. Analysis of responses of garlic derivatives in the pulmonary vascular bed of the rat
29. Effects of garlic preparations on super-oxide production by phorbol ester activated granulocytes
30. Superoxide and peroxynitrite in atherosclerosis
31. Potassium channel activation in vascular smooth muscle
32. Garlic extract modulation of human coronary vascular tone: Comparisons between near normal and atherosclerotic arteries