Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology

Evidence-based Complementary and Alternative Medicine

Volumn 2017, Issue , 2017, Pages

  Gilca, Marilena ^a   Dragos, Dorin ^a,b  

^a CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b UNIVERSITY EMERGENCY HOSPITAL BUCHAREST   (Romania)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSIENT RECEPTOR POTENTIAL CHANNEL;

ANTIDIABETIC ACTIVITY; ANTIMICROBIAL ACTIVITY; ASTRINGENCY; AYURVEDA; BIOLOGICAL FUNCTIONS; BITTER TASTE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR FUNCTION; CONTRACEPTION; DIABETOGENESIS; DIGESTION; ETHNOPHARMACOLOGY; HUMAN; INTESTINE MOTILITY; METABOLISM; NONHUMAN; PUNGENCY; REVIEW; SALTINESS; SOUR TASTE; SWEETNESS; TASTE; TASTE BUD; WOUND HEALING;

EID: 85021666879     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2017/5435831     Document Type: Review

References (364)

1. S. D. Roper, "TRPs in Taste and Chemesthesis," Hand book of Experimental Pharmacology, vol. 223, pp. 827-871, 2014.
2. B. Lindemann, "Taste reception," Physiological Reviews, vol. 76, no. 3, pp. 718-766, 1996.
3. E. R. Liman, Y. V. Zhang, and C. Montell, "Peripheral coding of taste," Neuron, vol. 81, no. 5, pp. 984-1000, 2014.
4. Y. A. Huang, Y. Maruyama, R. Stimac, and S. D. Roper, "Presynaptic (Type III) cells in mouse taste buds sense sour (acid) taste," Journal of Physiology, vol. 586, no. 12, pp. 2903-2912, 2008.
5. A. Bigiani, "Mouse taste cells with glialike membrane properties," Journal of Neurophysiology, vol. 85, no. 4, pp. 1552-1560, 2001.
6. B. C. Lewand owski, S. K. Sukumaran, R. F. Margolskee, and A. A. Bachmanov, "Amiloride-insensitive salt taste is mediated by two populations of type III taste cells with distinct transduction mechanisms," Journal of Neuroscience, vol. 36, no. 6, pp. 1942-1953, 2016.
7. J. Chand rashekar, C. Kuhn, Y. Oka et al. , "The cells and peripheral representation of sodium taste in mice," Nature, vol. 464, no. 7286, pp. 297-301, 2010.
8. R. Yoshida, N. Horio, Y. Murata, K. Yasumatsu, N. Shigemura, and Y. Ninomiya, "NaCl responsive taste cells in the mouse fungiform taste buds," Neuroscience, vol. 159, no. 2, pp. 795-803, 2009.
9. S. D. Roper, "The cell biology of vertebrate taste receptors," Annual Review of Neuroscience, vol. 12, no. 1, pp. 329-353, 1989.
10. J. M. Sullivan, A. A. Borecki, and S. Oleskevich, "Stem and progenitor cell compartments within adult mouse taste buds," European Journal of Neuroscience, vol. 31, no. 9, pp. 1549-1560, 2010.
11. G. Q. Zhao, Y. Zhang, M. A. Hoon et al. , "The receptors for mammalian sweet and umami taste," Cell, vol. 115, no. 3, pp. 255-266, 2003.
12. N. Schobel, D. Radtke, J. Kyereme et al. , "Astringency is a trigeminal sensation that involves the activation of G proteincoupled signaling by phenolic compounds," Chemical Senses, vol. 39, no. 6, pp. 471-487, 2014.
13. A. L. Huang, X. Chen, M. A. Hoon et al. , "The cells and logic for mammalian sour taste detection," Nature, vol. 442, no. 7105, pp. 934-938, 2006.
14. F. Li, "Taste perception: Fromthe tongue to the testis,"Molecular Human Reproduction, vol. 19, no. 6, pp. 349-360, 2013.
15. J.-C. Henquin, "Do pancreatic cells "taste" nutrients to secrete insulin" Science Signaling, vol. 5, no. 239, p. pe36, 2012.
16. X. Ren, L. Zhou, R. Terwilliger, S. S. Newton, and I. E. deAraujo, "Sweet taste signaling functions as a hypothalamic glucose sensor," Frontiers in Integrative Neuroscience, vol. 3, article 12, 2009.
17. H. E. Raybould, "Does your gut taste Sensory transduction in the gastrointestinal tract," News in Physiological Sciences, vol. 13, no. 6, pp. 275-280, 1998.
18. O. Dehkordi, J. E. Rose, M. Fatemi et al. , "Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem," Brain Research, vol. 1475, pp. 1-10, 2012.
19. K. Yamamoto and Y. Ishimaru, "Oral and extra-oral taste perception," Seminars inCell and Developmental Biology, vol. 24, no. 3, pp. 240-246, 2013.
20. S. R. Foster, E. R. Porrello, B. Purdue et al. , "Expression, regulation and putative nutrient-sensing function of taste gpcrs in the heart," PLoS ONE, vol. 8, no. 5,Article ID e64579, 2013.
21. Y. Masubuchi, Y. Nakagawa, J. Ma et al. , "A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells," PLoS ONE, vol. 8, no. 1, Article ID e54500, 2013.
22. N. Hass, K. Schwarzenbacher, and H. Breer, "T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach," Cell and Tissue Research, vol. 339, no. 3, pp. 493-504, 2010.
23. N. Rozengurt, S. V. Wu, M. C. Chen, C. Huang, C. Sternini, and E. Rozengurt, "Colocalization of the-subunit of gustducin with PYY and GLP-1 in L cells of human colon," The American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 291, no. 5, pp. G792-G802, 2006.
24. S. V. Wu, N. Rozengurt,M. Yang, S. H. Young, J. Sinnett-Smith, and E. Rozengurt, "Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells," Proceedings of the National Academy of Sciences, vol. 99, no. 4, pp. 2392-2397, 2002.
25. A. D. Medhurst, G. Rennie, C. G. Chapman et al. , "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery," Brain Research Molecular Brain Research, vol. 86, no. 1-2, pp. 101-114, 2001.
26. D. H. Malinowska, A. M. Sherry, K. P. Tewari, and J. Cuppoletti, "Gastric parietal cell secretory membrane contains PKA-and acid-activated Kir2. 1 K+ channels," American Journal of Physiology, vol. 286, no. 3, pp. C495-C506, 2004.
27. H. Yamamura, S. Ugawa, T. Ueda, M. Nagao, and S. Shimada, "Protons activate the-subunit of the epithelial Na+ channel in humans," Journal of Biological Chemistry, vol. 279, no. 13, pp. 12529-12534, 2004.
28. H. Mihara, N. Suzuki, A. A. Boudaka et al. , "Transient receptor potential vanilloid 4-dependent calciuminflux and ATP release in mouse and rat gastric epithelia," World Journal of Gastroenterology, vol. 22, no. 24, pp. 5512-5519, 2016.
29. J. Dyer, K. S. H. Salmon, L. Zibrik, and S. P. Shirazi-Beechey, "Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells," Biochemical Society Transactions, vol. 33, no. 1, pp. 302-305, 2005.
30. K. Koyama, I. Sasaki, and H. Naito et al. , "nduction of epithelial Na+ channel in rat ileum after proctocolectomy," American Journal of Physiology, vol. 276, no. 4, part 1, pp. G975-G984, 1999.
31. H. Yamawaki, H. Mihara, N. Suzuki et al. , "Role of transient receptor potential vanilloid 4 activation in indomethacininduced intestinal damage," American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 307, no. 1, pp. G33-G40, 2014.
32. I. Kaji, S.-I. Karaki, Y. Fukami, M. Terasaki, and A. Kuwahara, "Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine," The American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 296, no. 5, pp. G971-G981, 2009.
33. F. Duprat, F. Lesage, M. Fink, R. Reyes, C. Heurteaux, and M. Lazdunski, "TASK, a human background K+ channel to sense external pH variations near physiological pH," EMBO Journal, vol. 16, no. 17, pp. 5464-5471, 1997.
34. K. Kunzelmann and M. Mall, "Electrolyte transport in the mammalian colon: mechanisms and implications for disease," Physiological Reviews, vol. 82, no. 1, pp. 245-289, 2002.
35. E. D'Aldebert, N. Cenac, P. Rousset et al. , "Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice,"Gastroenterology, vol. 140, no. 1, pp. 275-285, 2011.
36. Y. Nakagawa,M. Nagasawa, S. Yamada et al. , "Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion," PLoS ONE, vol. 4, no. 4, Article ID e5106, 2009.
37. M. M. Gaida, C. Mayer, U. Dapunt et al. , "Expression of the bitter receptor T2R38 in pancreatic cancer: Localization in lipid droplets and activation by a bacteria-derived quorum-sensing molecule," Oncotarget, vol. 7, no. 11, pp. 12623-12632, 2016.
38. R. Waldmann, G. Champigny, F. Bassilana, N. Voilley, and M. Lazdunski, "Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel," Journal of Biological Chemistry, vol. 270, no. 46, pp. 27411-27414, 1995.
39. F. J. McDonald, P. M. Snyder, P. B. J. McCray, and M. J. Welsh, "Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel," American Journal of Physiology, vol. 266, no. 6, Part 1, pp. L728-L734, June 1994.
40. A. J. Fagelskiold, K. Kannisto, and A. Bostrom et al. , "Insulinsecreting INS-1E cells express functional TRPV1 channels," Islets, vol. 4, no. 1, pp. 56-63, 2012.
41. M. Uhlen, L. Fagerberg, B. M. Hallstrom et al. , "Tissue-based map of the human proteome," Science, vol. 347, no. 6620, Article ID 1260419, 2015.
42. http://www. proteinatlas. org/.
43. B. Nilius, J. Vriens, J. Prenen, G. Droogmans, and T. Voets, "TRPV4 calcium entry channel: A paradigm for gating diversity," The American Journal of Physiology-Cell Physiology, vol. 286, no. 2, pp. C195-C205, 2004.
44. K. Taniguchi, "Expression of the sweet receptor protein, T1R3, in the human liver and pancreas," Journal of Veterinary Medical Science, vol. 66, no. 11, pp. 1311-1314, 2004.
45. S. Kiuchi, T. Yamada, N. Kiyokawa, T. Saito, J. Fujimoto, and H. Yasue, "Genomic structure of swine taste receptor family 1 member 3, TAS1R3, and its expression in tissues," Cytogenetic and Genome Research, vol. 115, no. 1, pp. 51-61, 2006.
46. X. Liu, F. Gu, L. Jiang, F. Chen, and F. Li, "Expression of bitter taste receptor Tas2r105 inmouse kidney," Biochemical and Biophysical Research Communications, vol. 458, no. 4, Article ID 33320, pp. 733-738, 2015.
47. R. Reyes, F. Duprat, F. Lesage et al. , "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney," Journal of Biological Chemistry, vol. 273, no. 47, pp. 30863-30869, 1998.
48. U. Wissenbach, M. Bodding, M. Freichel, and V. Flockerzi, "Trp12, a novel Trp related protein from kidney," FEBS Letters, vol. 485, no. 2-3, pp. 127-134, 2000.
49. R. A. Elliott, S. Kapoor, and D. G. Tincello, "Expression and distribution of the sweet taste receptor isoforms T1R2 and T1R3 in human and rat bladders," Journal of Urology, vol. 186, no. 6, pp. 2455-2462, 2011.
50. Q. Lei, X.-Q. Pan, S. Chang, S. B. Malkowicz, T. J. Guzzo, and A. P. Malykhina, "Response of the human detrusor to stretch is regulated by TREK-1, a two-pore-domain (K2P) mechanogated potassium channel," Journal of Physiology, vol. 592, no. 14, pp. 3013-3030, 2014.
51. I. Araki, S. Du, M. Kamiyama et al. , "Overexpression of epithelial sodium channels in epithelium of human urinary bladder with outlet obstruction," Urology, vol. 64, no. 6, pp. 1255-1260, 2004.
52. H. Y. Zhang, J. F. Chu, P. Li, N. Li, and Z. H. Lv, "Expression and diagnosis of transient receptor potential vanilloid1 in urothelium of patients with overactive bladder," Journal of Biological Regulators and Homeostatic Agents, vol. 29, no. 4, pp. 875-879, 2015.
53. S. R. Foster, K. Blank, L. E. See Hoe et al. , "Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart," FASEB Journal, vol. 28, no. 10, pp. 4497-4508, 2014.
54. Y. Kubo, T. J. Baldwin, Y. Nung Jan, and L. Y. Jan, "Primary structure and functional expression of a mouse inward rectifier potassiumchannel," Nature, vol. 362, no. 6416, pp. 127-133, 1993.
55. M. Matamoros, M. Perez-Herńand ez, G. Guerrero-Serna et al. , "Nav1. 5 N-terminal domain binding to 1-syntrophin increases membrane density of human Kir2. 1, Kir2. 2 and Nav1. 5 channels," Cardiovascular Research, vol. 110, no. 2, pp. 279-290, 2016.
56. P. K. Rand hawa and A. S. Jaggi, "TRPV4 channels: physiological and pathological role in cardiovascular system," Basic Research in Cardiology, vol. 110, no. 6, article 54, pp. 1-19, 2015.
57. J. G. Chen, N. N. Ping, and D. Liang et al. , "The expression of bitter taste receptors in mesenteric, cerebral and omental arteries," Life Sciences, vol. 170, pp. 16-24, 2017.
58. H. A. Drummond, D. Gebremedhin, and D. R. Harder, "Degenerin/epithelial Na+ channel proteins: Components of a vascular mechanosensor," Hypertension, vol. 44, no. 5, pp. 643-648, 2004.
59. J. Pu, Z. Wang, and H. Zhou et al. , "Role of TRPV4 channels in regulation of eNOS expression in brain microvascular endothelial cells under the condition of mechanical stretch," Journal of Central South University, vol. 40, no. 9, pp. 960-966, 2015.
60. A. Voigt, S. Hubner, L. Doring et al. , "Cre-mediated recombination in Tas2r131 cells-A unique way to explore bitter taste receptor function inside and outside of the taste system," Chemical Senses, vol. 40, no. 9, pp. 627-639, 2015.
61. Z. Rusznak, K. Pocsai, and I. Kovacs et al. , "Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum," Cellular and Molecular Life Sciences, vol. 61, no. 12, pp. 1532-1542, 2004.
62. H. M. Nguyen, E. M. Grossinger, M. Horiuchi et al. , "Differential Kv1. 3, KCa3. 1, and Kir2. 1 expression in "classically" and "alternatively" activated microglia," Glia, vol. 65, no. 1, pp. 106-121, 2017.
63. R. Teruyama, M. Sakuraba, L. L. Wilson, N. E. J. Wand rey, and W. E. Armstrong, "Epithelial Na+ sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei," American Journal of Physiology-Endocrinology and Metabolism, vol. 302, no. 3, pp. E273-E285, 2012.
64. T. Braun, B. Mack, and M. F. Kramer, "Solitary chemosensory cells in the respiratory and vomeronasal epithelium of the human nose: A pilot study," Rhinology, vol. 49, no. 5, pp. 507-512, 2011.
65. A. S. Shah, B.-S. Yehuda, T. O. Moninger, J. N. Kline, and M. J. Welsh, "Motile cilia of human airway epithelia are chemosensory," Science, vol. 325, no. 5944, pp. 1131-1134, 2009.
66. J. M. Ferńand ez-Ferńand ez, M. Nobles, A. Currid, E. Vazquez, and M. A. Valverde, "Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line,"The American Journal of Physiology-Cell Physiology, vol. 283, no. 6, pp. C1705-C1714, 2002.
67. X. Ning, J. He, X. Shi, and G. Yang, "Regulation of adipogenesis by quinine through the ERK/S6 pathway," International Journal of Molecular Sciences, vol. 17, no. 4, article 504, 2016.
68. D. F. Pisani, G. E. Beranger, A. Corinus et al. , "The K+ channel TASK1 modulates b-adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway," FASEB Journal, vol. 30, no. 2, pp. 909-922, 2016.
69. M. Gaida, U. Dapunt, and G. M. Hansch, "Sensing developing biofilms: the bitter receptor T2R38 on myeloid cells," Pathogens and Disease, vol. 74, no. 3, 2016.
70. S. Hughes, J. Magnay, M. Foreman, S. J. Publicover, J. P. Dobson, and A. J. El Haj, "Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts," Journal of Cellular Physiology, vol. 206, no. 3, pp. 738-748, 2006.
71. X. Li, X. Dong, S. Zheng, and J. Xiao, "Expression and localization of TASK-1,-2 and-3 channels inMG63 human osteoblastlike cells," Oncology Letters, vol. 5, no. 3, pp. 865-869, 2013.
72. A. Mobasheri, R. Barrett-Jolley, M. Shakibaei, C. M. Canessa, and P. Martin-Vasallo, Enigmatic Roles of the Epithelial Sodium Channel (ENaC) in Articular Chondrocytes and Osteoblasts: Mechanotransduction, Sodium Transport or Extracellular Sodium Sensingedited by A. Kamkin and I. Kiseleva, Moscow, Russia, 2005.
73. L. Lu, L. Wu, H. Jia et al. , "The epithelial sodium channel is involved in dexamethasone-induced osteoblast differentiation and mineralization," Cell Biology and Toxicology, vol. 28, no. 5, pp. 279-289, 2012.
74. M. Smith, R. Wilson, S. O'Brien, C. Tufarelli, S. I. Anderson, and S. E. O'Sullivan, "The effects of the endocannabinoids anand amide and 2-arachidonoylglycerol on human osteoblast proliferation and differentiation," PLoS ONE, vol. 10, no. 9, Article ID e0136546, 2015.
75. T. C. Lund, A. J. Kobs, A. Kramer et al. , "Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression," PLoS ONE, vol. 8, no. 3, Article ID e58945, 2013.
76. J. M. Kanczler, H. S. Sura, J. Magnay et al. , "Controlled differentiation of human bone marrow stromal cells using magnetic nanoparticle technology," Tissue Engineering-Part A, vol. 16, no. 10, pp. 3241-3250, 2010.
77. W. Zou, H. Lin, W. Liu et al. , "Moxibustion relieves visceral hyperalgesia via inhibition of transient receptor potential vanilloid 1 (TRPV1) and heat shock protein (HSP) 70 expression in rat bone marrow cells," Acupuncture in Medicine, vol. 34, no. 2, pp. 114-119, 2016.
78. E. Trujillo, D. Alvarez de la Rosa, and A. Mobasheri et al. , "Sodium transport systems in human chondrocytes. II. Expression of ENaC, Na+/K+/2Cl-cotransporter and Na+/H+ exchangers in healthy and arthritic chondrocytes," Histology and Histopathology, vol. 14, no. 4, pp. 1023-1031, 1999.
79. C. J. O'Conor, H. A. Leddy, H. C. Benefield, W. B. Liedtke, and F. Guilak, "TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading," Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 4, pp. 1316-1321, 2014.
80. A. Malki, J. Fiedler, K. Fricke, I. Ballweg, M. W. Pfaffl, and D. Krautwurst, "Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes," Journal of Leukocyte Biology, vol. 97, no. 3, pp. 533-545, 2015.
81. M. Max, Y. G. Shanker, L. Huang et al. , "Tas1r3, encoding a new cand idate taste receptor, is allelic to the sweet responsiveness locus Sac," Nature Genetics, vol. 28, no. 1, pp. 58-63, 2001.
82. S. Maurer, G. H. Wabnitz, N. A. Kahle et al. , "Tasting Pseudomonas aeruginosa biofilms: human neutrophils express the bitter receptor T2R38 as sensor for the quorum sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone," Frontiers in Immunology, vol. 6, article 369, 2015.
83. J. H. Nam, D. H. Shin, H. Zheng et al. , "Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells," American Journal of Physiology-Cell Physiology, vol. 300, no. 5, pp. C1013-C1022, 2011.
84. J. Yin, L. Michalick, C. Tang et al. , "Role of transient receptor potential vanilloid 4 in neutrophil activation and acute lung injury," American Journal of Respiratory Cell and Molecular Biology, vol. 54, no. 3, pp. 370-383, 2016.
85. B. Mosinger, K. M. Redding, M. R. Parker et al. , "Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility," Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 30, pp. 12319-12324, 2013.
86. F. Li and M. Zhou, "Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice,"MolecularHuman Reproduction, vol. 18, no. 6, pp. 289-297, 2012.
87. G. E. Chow, C. H. Muller, E. C. Curnow, and E. S. Hayes, "Expression of two-pore domain potassium channels in nonhuman primate sperm," Fertility and Sterility, vol. 87, no. 2, pp. 397-404, 2007.
88. P. G. Kumar and M. Shoeb, "The role of TRP ion channels in testicular function," Advances in Experimental Medicine and Biology, vol. 704, pp. 881-908, 2011.
89. M. Richter, G. Tscheudschilsuren, D. Eschke, G. Aust, K. Spanel-Borowski, and K. Nieber, "Voltage-dependent potassium channels in cytokeratin-positive and cytokeratin-negative microvascular endothelial cells of the corpus luteum," Cell and Tissue Research, vol. 310, no. 1, pp. 103-108, 2002.
90. E. Lizanecz, Z. Bagi, E. T. Pasztor et al. , "Phosphorylationdependent desensitization by anand amide of vanilloid receptor-1 (TRPV1) function in rat skeletal muscle arterioles and in Chinese hamster ovary cells expressing TRPV1," Molecular Pharmacology, vol. 69, no. 3, pp. 1015-1023, 2006.
91. S. C. Teilmann, A. G. Byskov, P. A. Pedersen, D. N. Wheatley, G. J. Pazour, and S. T. Christensen, "Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs," Molecular Reproduction and Development, vol. 71, no. 4, pp. 444-452, 2005.
92. Y. C. Ruan, J. H. Guo, X. Liu et al. , "Activation of the epithelial Na+ channel triggers prostagland in E2 release and production required for embryo implantation," Nature Medicine, vol. 18, no. 7, pp. 1112-1117, 2012.
93. K. Pohoczky, J. Kun, B. Szalontai et al. , "Estrogen-dependent up-regulation of TRPA1 and TRPV1 receptor proteins in the rat endometrium," Journal of Molecular Endocrinology, vol. 56, no. 2, pp. 135-149, 2016.
94. N. Singh, R. Chakraborty, R. P. Bhullar, and P. Chelikani, "Differential expression of bitter taste receptors in non-cancerous breast epithelial and breast cancer cells," Biochemical and Biophysical Research Communications, vol. 446, no. 2, pp. 499-503, 2014.
95. A. Kamikawa and T. Ishikawa, "Functional expression of a Kir2. 1-like inwardly rectifying potassium channel in mouse mammary secretory cells,"American Journal of Physiology-Cell Physiology, vol. 306, no. 3, pp. C230-C240, 2014.
96. Y. L. So, M. L. Palmer, P. J. Maniak, H. J. Soo, D. R. Pan, and S. M. O'Grady, "P2Y receptor regulation of sodium transport in human mammary epithelial cells," American Journal of Physiology-Cell Physiology, vol. 293, no. 5, pp. C1472-C1480, 2007.
97. T. T. L. Wu, A. A. Peters, P. T. Tan, S. J. Roberts-Thomson, and G. R. Monteith, "Consequences of activating the calciumpermeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression," Cell Calcium, vol. 56, no. 2, pp. 59-67, 2014.
98. U. Wolfle, F. A. Elsholz, A. Kersten, B. Haarhaus, W. E. Muller, and C. M. Schempp, "Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes," Skin Pharmacology and Physiology, vol. 28, no. 3, pp. 137-146, 2015.
99. D. Kim, A. Fujita, Y. Horio, and Y. Kurachi, "Cloning and functional expression of a novel cardiac two-pore background K+ channel (cTBAK-1)," Circulation Research, vol. 82, no. 4, pp. 513-518, 1998.
100. M. Brouard, M. Casado, S. Djelidi, Y. Barrand on, and N. Farman, "Epithelial sodium channel in human epidermal keratinocytes: expression of its subunits and relation to sodium transport and differentiation," Journal of Cell Science, vol. 112, no. 19, part 1, pp. 3343-3352, 1999.
101. Y. S. Yang, S. I. Cho, M. G. Choi et al. , "Increased expression of three types of transient receptor potential channels (TRPA1, TRPV4 and TRPV3) in burn scars with postburn pruritus," Acta Dermato-Venereologica, vol. 95, no. 1, pp. 20-24, 2015.
102. N. Kida, T. Sokabe, M. Kashio et al. , "Importance of transient receptor potential vanilloid 4 (TRPV4) in epidermal barrier function in human skin keratinocytes," Pflugers Archiv European Journal of Physiology, vol. 463, no. 5, pp. 715-725, 2012.
103. A. A. Clark, C. D. Dotson, A. E. T. Elson et al. , "TAS2R bitter taste receptors regulate thyroid function," FASEB Journal, vol. 29, no. 1, pp. 164-172, 2015.
104. D. Kim and C. Gnatenco, "TASK-5, a new member of the tand em-pore K+ channel family," Biochemical and Biophysical Research Communications, vol. 284, no. 4, pp. 923-930, 2001.
105. B. Verrier, G. Champigny, P. Barbry, C. Gerard, J. Mauchamp, and M. Lazdunski, "Identification and properties of a novel type of Na+-permeable amiloride-sensitive channel in thyroid cells," European Journal of Biochemistry, vol. 183, no. 3, pp. 499-505, 1989.
106. M. Salinas, R. Reyes, F. Lesage et al. , "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure," Journal of Biological Chemistry, vol. 274, no. 17, pp. 11751-11760, 1999.
107. E. R. Grimm and N. I. Steinle, "Genetics of eating behavior: established and emerging concepts," Nutrition Reviews, vol. 69, no. 1, pp. 52-60, 2011.
108. G. Czirjak, "TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa cells of rat adrenal cortex and inhibited by Angiotensin II," Molecular Endocrinology, vol. 14, no. 6, pp. 863-874, 2000.
109. R. Sharma and B. Dash, Caraka Samhita, vol. 23, Chowkhamba Sanskrit Series Office, Varanasi, India, 2006th edition, 2006.
110. E. Stefan, Astanga Hrdayam/Vagbhata, Performantica, Iasi, 2005.
111. J. Zostawa, J. Adamczyk, P. Sowa, and M. Adamczyk-Sowa, "The influence of sodium on pathophysiology of multiple sclerosis," Neurological Sciences, vol. 38, no. 3, pp. 389-398, 2017.
112. T. Luo,W.-J. Ji, F. Yuan et al. , "Th17/Treg imbalance induced by dietary salt variation indicates inflammation of target organs in humans," Scientific Reports, vol. 6, Article ID 26767, 2016.
113. Y. Wei, C. Lu, J. Chen et al. , "High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice," Oncotarget, 2016.
114. B. M. Alharbi, M. K. Tso, and R. L. Macdonald, "Animal models of spontaneous intracerebral hemorrhage," Neurological Research, vol. 38, no. 5, pp. 448-455, 2016.
115. G. MacGregor, "Salt and hypertension. ," British Journal of Clinical Pharmacology, vol. 21, supplement 2, pp. 123S-128S, 1986.
116. J. T. Loh, J. A. Gaddy, H. M. Scott Algood, S. Gaudieri, S. Mallal, and T. L. Cover, "Helicobacter pylori adaptation in vivo in response to a high-salt diet," Infection and Immunity, vol. 83, no. 12, pp. 4871-4883, 2015.
117. H. Wiig, A. Schroder,W. Neuhofer et al. , "Immune cells control skin lymphatic electrolyte homeostasis and blood pressure," Journal of Clinical Investigation, vol. 123, no. 7, pp. 2803-2815, 2013.
118. R. C. Fellner, A. K. Cook, P. M. O'Connor, S. Zhang, D. M. Pollock, and E. W. Inscho, "High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism," American Journal of Physiology-Renal Physiology, vol. 307, no. 1, pp. F33-F40, 2014.
119. G. Pand ey, Dravyaguna vijnana, Chowkhamba Krishnadas Academy, Varanasi, India, 3rd edition, 2005.
120. K. Dallmeier and E. A. Carlini, "Anesthetic, hypothermic, myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues," Pharmacology, vol. 22, no. 2, pp. 113-127, 1981.
121. K. Talavera, K. Yasumatsu, T. Voets et al. , "Heat activation of TRPM5 underlies thermal sensitivity of sweet taste," Nature, vol. 438, no. 7070, pp. 1022-1025, 2005.
122. G. Mancuso, G. Borgonovo, L. Scaglioni, and A. Bassoli, "Phytochemicals from Ruta graveolens activate TAS2R bitter taste receptors and TRP channels involved in gustation and nociception," Molecules, vol. 20, no. 10, pp. 18907-18922, 2015.
123. A. M. Peier, A. Moqrich, A. C. Hergarden et al. , "A TRP channel that senses cold stimuli and menthol," Cell, vol. 108, no. 5, pp. 705-715, 2002.
124. R. Latorre, S. Brauchi, G. Orta, C. Zaelzer, and G. Vargas, "ThermoTRP channels as modular proteins with allosteric gating," Cell Calcium, vol. 42, no. 4-5, pp. 427-438, 2007.
125. I. Vetter and R. J. Lewis, "Natural product ligand s of TRP channels," Advances in Experimental Medicine and Biology, vol. 704, pp. 41-85, 2011.
126. L. J. Macpherson, S. W. Hwang, T. Miyamoto, A. E. Dubin, A. Patapoutian, and G. M. Story, "More than cool: Promiscuous relationships ofmenthol and other sensory compounds,"Molecular and Cellular Neuroscience, vol. 32, no. 4, pp. 335-343, 2006.
127. G. M. Story, A. M. Peier, A. J. Reeve et al. , "ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures," Cell, vol. 112, no. 6, pp. 819-829, 2003.
128. M. Band ell, G. M. Story, S. W. Hwang et al. , "Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin," Neuron, vol. 41, no. 6, pp. 849-857, 2004.
129. A. D. Guler, H. Lee, T. Iida, I. Shimizu, M. Tominaga, and M. Caterina, "Heat-evoked activation of the ion channel, TRPV4," Journal of Neuroscience, vol. 22, no. 15, pp. 6408-6414, 2002.
130. P. L. Smith, K. N. Maloney, R. G. Pothen, J. Clardy, and D. E. Clapham, "Bisand rographolide from Andrographis paniculata activates TRPV4 channels," The Journal of Biological Chemistry, vol. 281, no. 40, pp. 29897-29904, 2006.
131. D. Peixoto-Neves, Q. Wang, J. H. Leal-Cardoso, L. V. Rossoni, and J. H. Jaggar, "Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV4 channels," British Journal of Pharmacology, vol. 172, no. 14, pp. 3484-3494, 2015.
132. L. Marwaha, Y. Bansal, R. Singh, P. Saroj, R. Bhand ari, and A. Kuhad, "TRP channels: potential drug target for neuropathic pain," Inflammopharmacology, vol. 24, no. 6, pp. 305-317, 2016.
133. H. Xu, M. Delling, J. C. Jun, and D. E. Clapham, "Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels," Nature Neuroscience, vol. 9, no. 5, pp. 628-635, 2006.
134. A. Moqrich, S. W. Hwang, T. J. Earley et al. , "Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin," Science, vol. 307, no. 5714, pp. 1468-1472, 2005.
135. T. Sokabe and M. Tominaga, "Molecular mechanisms underlying thermosensation in mammals," Brain and Nerve, vol. 61, no. 7, pp. 867-873, 2009.
136. M. J. Caterina, M. A. Schumacher, M. Tominaga, T. A. Rosen, J. D. Levine, and D. Julius, "The capsaicin receptor: A heatactivated ion channel in the pain pathway," Nature, vol. 389, no. 6653, pp. 816-824, 1997.
137. F. N. McNamara, A. Rand all, and M. J. Gunthorpe, "Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)," British Journal of Pharmacology, vol. 144, no. 6, pp. 781-790, 2005.
138. M. Tominaga, M. J. Caterina, A. B. Malmberg et al. , "Thecloned capsaicin receptor integrates multiple pain-producing stimuli," Neuron, vol. 21, no. 3, pp. 531-543, 1998.
139. L. De Petrocellis, A. Ligresti, A. S. Moriello et al. , "Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes," British Journal of Pharmacology, vol. 163, no. 7, pp. 1479-1494, 2011.
140. N. Qin, M. P. Neeper, Y. Liu, T. L. Hutchinson, M. L. Lubin, and C. M. Flores, "TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root Ganglion neurons," Journal of Neuroscience, vol. 28, no. 24, pp. 6231-6238, 2008.
141. L. J. Macpherson, B. H. Geierstanger, V. Viswanath et al. , "The pungency of garlic: Activation of TRPA1 and TRPV1 in response to allicin," Current Biology, vol. 15, no. 10, pp. 929-934, 2005.
142. Y.-S. Kim, C. S. Hong, S. W. Lee, J. H. Nam, and B. J. Kim, "Effects of ginger and its pungent constituents on transient receptor potential channels," International Journal of Molecular Medicine, vol. 38, no. 6, pp. 1905-1914, 2016.
143. S.-E. Jordt, D. M. Bautista, H.-H. Chuang et al. , "Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1," Nature, vol. 427, no. 6971, pp. 260-265, 2004.
144. K. Tsuchiya, K. Kubota, K. Ohbuchi et al. , "Transient receptor potential ankyrin 1 agonists improve intestinal transit in a murine model of postoperative ileus," Neurogastroenterology and Motility, vol. 28, no. 12, pp. 1792-1805, 2016.
145. C. Peyrot des Gachons, K. Uchida, B. Bryant et al. , "Unusual pungency fromextra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal," Journal of Neuroscience, vol. 31, no. 3, pp. 999-1009, 2011.
146. Y. Y. Wang, R. B. Chang, and E. R. Liman, "TRPA1 is a component of the nociceptive response to CO2," Journal of Neuroscience, vol. 30, no. 39, pp. 12958-12963, 2010.
147. J. Escalera, C. A. Von Hehn, B. F. Bessac, M. Sivula, and S.-E. Jordt, "TRPA1 mediates the noxious effects of natural sesquiterpene deterrents," Journal of Biological Chemistry, vol. 283, no. 35, pp. 24136-24144, 2008.
148. A. Bassoli, G. Borgonovo, S. Caimi et al. , "Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens," Bioorganic and Medicinal Chemistry, vol. 17, no. 4, pp. 1636-1639, 2009.
149. G. Nelson, M. A. Hoon, J. Chand rashekar, Y. Zhang, N. J. P. Ryba, and C. S. Zuker, "Mammalian sweet taste receptors," Cell, vol. 106, no. 3, pp. 381-390, 2001.
150. A. Laffitte, F. Neiers, and L. Briand , "Functional roles of the sweet taste receptor in oral and extraoral tissues," Current Opinion in Clinical Nutrition and Metabolic Care, vol. 17, no. 4, pp. 379-385, 2014.
151. M. Behrens and W. Meyerhof, "Gustatory and extragustatory functions ofmammalian taste receptors," Physiology and Behavior, vol. 105, no. 1, pp. 4-13, 2011.
152. M. Behrens and W. Meyerhof, "Bitter taste receptors and human bitter taste perception," Cellular and Molecular Life Sciences, vol. 63, no. 13, pp. 1501-1509, 2006.
153. A. Wiener, M. Shudler, A. Levit, and M. Y. Niv, "BitterDB: A database of bitter compounds," Nucleic Acids Research, vol. 40, pp. D413-D419, 2012.
154. S. Rodgers, J. Busch, H. Peters, and E. Christ-Hazelhof, "Building a tree of knowledge: Analysis of bitter molecules," Chemical Senses, vol. 30, no. 7, pp. 547-557, 2005.
155. W. Meyerhof, C. Batram, C. Kuhn et al. , "The molecular receptive ranges of human TAS2R bitter taste receptors," Chemical Senses, vol. 35, no. 2, pp. 157-170, 2009.
156. M. Behrens, S. I. Korsching, and W. Meyerhof, "Tuning properties of avian and frog bitter taste receptors dynamically fit gene repertoire sizes,"Molecular Biology and Evolution, vol. 31, no. 12, pp. 3216-3227, 2014.
157. K. Lossow, S. Hubner, N. Roudnitzky et al. , "Comprehensive analysis of mouse bitter taste receptors reveals different molecular receptive ranges for orthologous receptors in mice and humans," Journal of Biological Chemistry, vol. 291, no. 29, pp. 15358-15377, 2016.
158. Y. Zhang, M. A. Hoon, J. Chand rashekar et al. , "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways," Cell, vol. 112, no. 3, pp. 293-301, 2003.
159. M. Gilca and A. Barbulescu, "Taste of medicinal plants: A potential tool in predicting ethnopharmacological activities" Journal of Ethnopharmacology, vol. 174, pp. 464-473, 2015.
160. M. Behrens and W. Meyerhof, Flavour Development, Analysis and Perception in Food and Beverages, Elsevier, 2015.
161. L. N. Saites, Z. Goldsmith, J. Densky, V. A. Guedes, and J. D. J. Boughter, "Mice perceive synergistic umami mixtures as tasting sweet," Chemical Senses, vol. 40, no. 5, pp. 295-303, 2015.
162. Y. Kusuhara, R. Yoshida, T. Ohkuri et al. , "Taste responses in mice lacking taste receptor subunit T1R1," The Journal of Physiology, vol. 591, no. 7, pp. 1967-1985, 2013.
163. Susruta and K. K. L. Bhishagratna (translator), Susruta Samhita, Chowkhamba Sanskrit SeriesOffice,Varanasi, India, 1st edition, 1998.
164. S. Iwata, R. Yoshida, and Y. Ninomiya, "Taste transductions in taste receptor cells: basic tastes and moreover," Current Pharmaceutical Design, vol. 20, no. 16, pp. 2684-2692, 2014.
165. M. M. Galindo, N. Voigt, J. Stein et al. , "G protein-coupled receptors in human fat taste perception," Chemical Senses, vol. 37, no. 2, pp. 123-139, 2012.
166. C. Cartoni, K. Yasumatsu, T. Ohkuri et al. , "Taste preference for fatty acids is mediated by GPR40 and GPR120," The Journal of Neuroscience, vol. 30, no. 25, pp. 8376-8382, 2010.
167. M. Febbraio, D. P. Hajjar, and R. L. Silverstein, "CD36: A class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism," Journal of Clinical Investigation, vol. 108, no. 6, pp. 785-791, 2001.
168. P. Besnard, P. Passilly-Degrace, and N. A. Khan, "Taste of fat: A sixth taste modality" Physiological Reviews, vol. 96, no. 1, pp. 151-176, 2015.
169. M. H. Ozdener, S. Subramaniam, S. Sundaresan et al. , "CD36-and GPR120-mediated Ca2+ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice," Gastroenterology, vol. 146, no. 4, pp. 995-1005, 2014.
170. C. Martin, P. Passilly-Degrace, D. Gaillard, J.-F. Merlin, M. Chevrot, and P. Besnard, "The lipid-sensor cand idates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference," PLoS ONE, vol. 6, no. 8,Article ID e24014, 2011.
171. Z. J. Ren, M.-R. Rhyu, T.-H. T. Phan et al. , "TRPM5-dependent amiloride-and benzamil-insensitive NaCl chorda tympani taste nerve response," American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 305, no. 1, pp. G106-G117, 2013.
172. A. Sclafani and K. Ackroff, "Role of gut nutrient sensing in stimulating appetite and conditioning food preferences," American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 302, no. 10, pp. R1119-R1133, 2012.
173. J. Limand H. T. Lawless, "Oral sensations fromiron and copper sulfate," Physiology and Behavior, vol. 85, no. 3, pp. 308-313, 2005.
174. C. P. des Gachons, E. Mura, C. Speziale, C. J. Favreau, G. F. Dubreuil, and P. A. S. Breslin, "Opponency of astringent and fat sensations," Current Biology, vol. 22, no. 19, pp. R829-R830, 2012.
175. Y. Jiang, N. N. Gong, and H. Matsunami, "Astringency: A more stringent definition," Chemical Senses, vol. 39, no. 6, Article ID bju021, pp. 467-469, 2014.
176. S. S. Schiffman, M. S. Suggs, L. Sostman, and S. A. Simon, "Chorda tympani and lingual nerve responses to astringent compounds in rodents," Physiology and Behavior, vol. 51, no. 1, pp. 51-63, 1992.
177. N. Schobel, D. Radtke, M. Lubbert et al. , "Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses," PLoS ONE, vol. 7, no. 11,Article ID e48005, 2012.
178. G. Luck, H. Liao, N. J. Murray et al. , "Polyphenols, astringency and proline-rich proteins," Phytochemistry, vol. 37, no. 2, pp. 357-371, 1994.
179. S. D. Roper, "The taste of table salt," Pflugers Archiv, vol. 467, no. 3, pp. 457-463, 2015.
180. A. Vand enbeuch, T. R. Clapp, and S. C. Kinnamon, "Amiloridesensitive channels in type I fungiformtaste cells inmouse,"BMC Neuroscience, vol. 9, article 1, 2008.
181. Y. Oka, M. Butnaru, L. Von Buchholtz, N. J. P. Ryba, and C. S. Zuker, "High salt recruits aversive taste pathways," Nature, vol. 494, no. 7438, pp. 472-475, 2013.
182. G. L. Heck, S. Mierson, and J. A. Desimone, "Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway," Science, vol. 223, no. 4634, pp. 403-405, 1984.
183. F. Sẗahler, K. Riedel, S. Demgensky et al. , "A role of the epithelial sodium channel in human salt taste transduction" Chemosensory Perception, vol. 1, no. 1, pp. 78-90, 2008.
184. J. A. DeSimone and V. Lyall, "Taste receptors in the gastrointestinal tract III. Salty and sour taste: sensing of sodium and protons by the tongue," American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 291, no. 6, pp. G1005-G1010, 2006.
185. W. Ye, R. B. Chang, and J. D. Bushman et al. , "The K+ channel KIR2. 1 functions in tand em with proton influx to mediate sour taste transduction," Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 2, pp. E229-E238, 2016.
186. S. D. Roper, "Signal transduction and information processing in mammalian taste buds," Pflugers Archiv, vol. 454, no. 5, pp. 759-776, 2007.
187. Y. Ishimaru, H. Inada, M. Kubota, H. Zhuang, M. Tominaga, and H. Matsunami, "Transient receptor potential family members PKD1L3 and PKD2L1 forma cand idate sour taste receptor," Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 33, pp. 12569-12574, 2006.
188. S. Kataoka, R. Yang, Y. Ishimaru et al. , "The cand idate sour taste receptor, PKD2L1, Is expressed by type III taste cells in the mouse," Chemical Senses, vol. 33, no. 3, pp. 243-254, 2008.
189. T. A. Richter, G. A. Dvoryanchikov, N. Chaudhari, and S. D. Roper, "Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste buds," Journal of Neurophysiology, vol. 92, no. 3, pp. 1928-1936, 2004.
190. W. Lin, C. A. Burks, D. R. Hansen, S. C. Kinnamon, and T. A. Gilbertson, "Taste receptor cells express pH-sensitive leak K+ channels," Journal of Neurophysiology, vol. 92, no. 5, pp. 2909-2919, 2004.
191. R. C. Challis and M. Ma, "Sour taste finds closure in a potassium channel," Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 2, pp. 246-247, 2016.
192. E. M. Talley, J. E. Sirois, Q. Lei, and D. A. Bayliss, "Twopore-domain (KCNK) potassium channels: dynamic roles in neuronal function," Neuroscientist, vol. 9, no. 1, pp. 46-56, 2003.
193. A. D. O'Connell, M. J. Morton, and M. Hunter, "Two-pore domain K+ channels-Molecular sensors," Biochimica et Biophysica Acta-Biomembranes, vol. 1566, no. 1-2, pp. 152-161, 2002.
194. R. A. Chavez, A. T. Gray, B. B. Zhao et al. , "TWIK-2, a new weak inward rectifying member of the tand em pore domain potassium channel family," Journal of Biological Chemistry, vol. 274, no. 12, pp. 7887-7892, 1999.
195. M. Kurogi, M. Miyashita, Y. Emoto, Y. Kubo, and O. Saitoh, "Green tea polyphenol epigallocatechin gallate activates trpa1 in an intestinal enteroendocrine cell Line, STC-1," Chemical Senses, vol. 37, no. 2, pp. 167-177, 2012.
196. A. Sbarbati and F. Osculati, "The taste cell-related diffuse chemosensory system," Progress in Neurobiology, vol. 75, no. 4, pp. 295-307, 2005.
197. A. Sbarbati, P. Bramanti, D. Benati, and F. Merigo, "The diffuse chemosensory system: exploring the iceberg toward the definition of functional roles," Progress in Neurobiology, vol. 91, no. 1, pp. 77-89, 2010.
198. F. Osculati, M. Bentivoglio, M. Castellucci, S. Cinti, C. Zancanaro, and A. Sbarbati, "The solitary chemosensory cells and the diffuse chemosensory system of the airway," European Journal of Histochemistry, vol. 51, supplement 1, pp. 65-72, 2007.
199. P. Sharma, A. Panebra, T. Pera et al. , "Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells," American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 310, no. 4, pp. L365-L376, 2016.
200. S. Grassin-Delyle, E. Naline, and P. Devillier, "Taste receptors in asthma," Current Opinion in Allergy and Clinical Immunology, vol. 15, no. 1, pp. 63-69, 2015.
201. R. J. Lee and N. A. Cohen, "Taste receptors in innate immunity," Cellular and Molecular Life Sciences, vol. 72, no. 2, pp. 217-236, 2015.
202. D. V. Smith and C. H. Lemon, Neural Coding in the rNST, edited by R. M. Bradley, Boca Raton, Fla, USA, 2007.
203. S. Rath, A. Panja, A. Shinde, and L. Nagar, "The scientific basis of rasa (taste) of a substance as a tool to explore its pharmacological behavior," Ancient Science of Life, vol. 33, no. 4, pp. 198-202, 2014.
204. R. Pushpan and K. Nishtewsar, "Rasa Nirdharana (assessment of taste) of Leonotis nepetifolia (L. ) R. Br. : A preliminary study in healthy volunteers," Ancient Science of Life, vol. 33, no. 3, pp. 186-191, 2014.
205. C. Leslie, A. Young, and D. C. American Anthropological Association, Paths to Asian Medical Knowledge, University of California Press, Berkeley, Calif, USA, 84th edition, 1992.
206. J. K. U. Nam, "Medieval European medicine and Asian spices," Uisahak, vol. 23, no. 2, pp. 319-342, 2014.
207. E. Messer, "The hot and cold in mesoamerican indigenous and hispanicized thought," Social Science and Medicine, vol. 25, no. 4, pp. 339-346, 1987.
208. M. S. Geck, S. Cabras, L. Casu, A. J. ReyesGarcia, and M. Leonti, "The taste of heat: how humoral qualities act as a cultural filter for chemosensory properties guiding herbal medicine," Journal of Ethnopharmacology, vol. 198, pp. 499-515, 2017.
209. P. M. de Medeiros, B. L. Santos Pinto, and V. T. do Nascimento, "Can organoleptic properties explain the differential use of medicinal plants Evidence from Northeastern Brazil," Journal of Ethnopharmacology, vol. 159, pp. 43-48, 2015.
210. M. Leonti, O. Sticher, and M. Heinrich, "Medicinal plants of the Popoluca, Mexico: organoleptic properties as indigenous selection criteria," Journal of Ethnopharmacology, vol. 81, no. 3, pp. 307-315, 2002.
211. Y. J. Qadri, A. K. Rooj, and C. M. Fuller, "ENaCs and ASICs as therapeutic targets," American Journal of Physiology-Cell Physiology, vol. 302, no. 7, pp. C943-C965, 2012.
212. H.-J. Jang, Z. Kokrashvili, M. J. Theodorakis et al. , "Gutexpressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1," Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 38, pp. 15069-15074, 2007.
213. E. Dazert and M. N. Hall, "mTOR signaling in disease," Current Opinion in Cell Biology, vol. 23, no. 6, pp. 744-755, 2011.
214. S. F. Bortvedt and P. K. Lund, "Insulin-like growth factor 1: Common mediator of multiple enterotrophic hormones and growth factors," Current Opinion in Gastroenterology, vol. 28, no. 2, pp. 89-98, 2012.
215. M. R. Aburto, M. Magarĩnos, Y. Leon, I. Varela-Nieto, and H. Sanchez-Calderon, "AKT signaling mediates IGF-I survival actions on otic neural progenitors," PLoS ONE, vol. 7, no. 1, Article ID e30790, 2012.
216. V. O. Murovets, A. A. Bachmanov, and V. A. Zolotarev, "Impaired glucose metabolism in mice lacking the Tas1r3 taste receptor gene," PLoS ONE, vol. 10, no. 6, Article ID e0130997, 2015.
217. Y.-J. Shin, J.-H. Park, J.-S. Choi, M.-H. Chun, Y. W. Moon, and M.-Y. Lee, "Enhanced expression of the sweet taste receptors and alpha-gustducin in reactive astrocytes of the rat hippocampus following ischemic injury," Neurochemical Research, vol. 35, no. 10, pp. 1628-1634, 2010.
218. B. R. Simon, B. S. Learman, S. D. Parlee et al. , "Sweet taste receptor deficient mice have decreased adiposity and increased bone mass," PLoS ONE, vol. 9, no. 1,Article ID e86454, 2014.
219. S. Kokabu, J. W. Lowery, T. Toyono et al. , "Muscle regulatory factors regulate T1R3 taste receptor expression," Biochemical and Biophysical Research Communications, vol. 468, no. 4, pp. 568-573, 2015.
220. E. M. Wauson, E. Zaganjor, A.-Y. Lee et al. , "The G proteincoupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy," Molecular Cell, vol. 47, no. 6, pp. 851-862, 2012.
221. T. Gong, Q. Wei, D. Mao, and F. Shi, "Expression patterns of taste receptor type 1 subunit 3 and-gustducin in the mouse testis during development," Acta Histochemica, vol. 118, no. 1, pp. 20-30, 2016.
222. D. Meyer, A. Voigt, P. Widmayer et al. , "Expression of tas1 taste receptors in mammalian spermatozoa: Functional role of Tas1r1 in regulating basal Ca2+ and camp concentrations in spermatozoa," PLoS ONE, vol. 7, no. 2, Article ID e32354, 2012.
223. E. L. Maillet, R. F. Margolskee, and B. Mosinger, "Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3," Journal of Medicinal Chemistry, vol. 52, no. 21, pp. 6931-6935, 2009.
224. G. Hellekant, J. Schmolling, P. Marambaud, and T. A. Rose-Hellekant, "CALHM1 deletion in mice affects glossopharyngeal taste responses, food intake, body weight, and life span," Chemical Senses, vol. 40, no. 6, pp. 373-379, 2015.
225. J. Z. Morris, H. A. Tissenbaum, and G. Ruvkun, "A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans," Nature, vol. 382, no. 6591, pp. 536-539, 1996.
226. K. D. Kimura, H. A. Tissenbaum, Y. Liu, and G. Ruvkun, "Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans," Science, vol. 277, no. 5328, pp. 942-946, 1997.
227. I. Ostojic, W. Boll, M. J. Waterson et al. , "Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signaling," Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 22, pp. 8143-8148, 2014.
228. Y.-K. Shin, W.-N. Cong, H. Cai et al. , "Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity," Journals of Gerontology-Series A Biological Sciences and Medical Sciences, vol. 67, no. 4, pp. 336-344, 2012.
229. H. Cronin and Z. D. Draelos, "Top 10 botanical ingredients in 2010 anti-aging creams," Journal of Cosmetic Dermatology, vol. 9, no. 3, pp. 218-225, 2010.
230. B. R. Simon, S. D. Parlee, B. S. Learmanet al. , "Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors," Journal of Biological Chemistry, vol. 288, no. 45, pp. 32475-32489, 2013.
231. Y. Matsumoto, T. Matsuura, H. Aoyagi et al. , "Antiviral activity of glycyrrhizin against hepatitisCvirus in vitro," PLoSONE, vol. 8, no. 7, Article ID e68992, 2013.
232. B. Avau, D. Bauters, S. Steensels et al. , "The gustatory signaling pathway and bitter taste receptors affect the development of obesity and adipocyte metabolism in mice," PLoS ONE, vol. 10, no. 12, Article ID e0145538, 2015.
233. N. Gupta and R. Tiwari, "An Ayurvedic approach to hypercholesterolemia," International AyurvedicMedical Journal, vol. 3, no. 7, pp. 2104-2109, 2015.
234. A. Drewnowski and C. Gomez-Carneros, "Bitter taste, phytonutrients, and the consumer: A review," American Journal of Clinical Nutrition, vol. 1-3, no. 22, pp. 1424-1435, 2000.
235. J. T. Sparks and J. C. Dickens, "Bitter-sensitive gustatory receptor neuron responds to chemically diverse insect repellents in the common malaria mosquito Anopheles quadrimaculatus," Naturwissenschaften, vol. 103, no. 5-6, p. 39, 2016.
236. S. Janssen, J. Laermans, P.-J. Verhulst, T. Thijs, J. Tack, and I. Depoortere, "Bitter taste receptors and-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying," Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 5, pp. 2094-2099, 2011.
237. B. Avau, A. Rotondo, T. Thijs et al. , "Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation," Scientific Reports, vol. 5, Article ID 15985, 2015.
238. J. I. Glendinning, "Is the bitter rejection response always adaptive" Physiology and Behavior, vol. 56, no. 6, pp. 1217-1227, 1994.
239. A. Drewnowski, S. A. Henderson, and A. B. Shore, "Taste responses to naringin, a flavonoid, and the acceptance of grapefruit juice are related to genetic sensitivity to 6-npropylthiouracil," American Journal of Clinical Nutrition, vol. 66, no. 2, pp. 391-397, 1997.
240. A. Drewnowski, "Genetic markers, taste responses, and food preferences," in Chemistry of Taste, vol. 825, pp. 5-52, American Chemical Society,Washington,Wash, USA, 2002.
241. J. M. Olson, M. Boehnke, K. Neiswanger, A. F. Roche, R. M. Siervogel, and J. W. MacCluer, "Alternative genetic models for the inheritance of the phenylthiocarbamide taste deficiency," Genetic Epidemiology, vol. 6, no. 3, pp. 423-434, 1989.
242. J. W. Fahey, Y. Zhang, and P. Talalay, "Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens," Proceedings of the National Academy of Sciences of theUnited States ofAmerica, vol. 94, no. 19, pp. 10367-10372, 1997.
243. O. Warburg, "On the origin of cancer cells," Science, vol. 123, no. 3191, pp. 309-314, 1956.
244. R. Luc, S. M. Tortorella, K. Ververis, and T. C. Karagiannis, "Lactate as an insidious metabolite due to the Warburg effect," Molecular Biology Reports, vol. 42, no. 4, pp. 835-840, 2015.
245. H. Ngo, S. M. Tortorella, K. Ververis, and T. C. Karagiannis, "The Warburg effect: molecular aspects and therapeutic possibilities," Molecular biology reports, vol. 42, no. 4, pp. 825-834, 2015.
246. S. H. Sharma, S. Thulasingam, D. R. Chellappan, P. Chinnaswamy, and S. Nagarajan, "Morin and Esculetin supplementation modulates c-myc induced energy metabolism and attenuates neoplastic changes in rats challenged with the procarcinogen 1,2-dimethylhydrazine," European Journal of Pharmacology, vol. 796, pp. 20-31, 2017.
247. V. Chen, R. E. Staub, S. Baggett et al. , "Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle," PLoS ONE, vol. 7, no. 1,Article IDe30107, 2012.
248. A. W. Harmon and Y. M. Patel, "Naringenin inhibits glucose uptake inMCF-7 breast cancer cells: Amechanism for impaired cellular proliferation," Breast Cancer Research and Treatment, vol. 85, no. 2, pp. 103-110, 2004.
249. F. Martel, M. Guedes, and E. Keating, "Effect of polyphenols on glucose and lactate transport by breast cancer cells," Breast Cancer Research and Treatment, vol. 157, no. 1, pp. 1-11, 2016.
250. L. Moreira, I. Araujo, T. Costa et al. , "Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism," Experimental Cell Research, vol. 319, no. 12, pp. 1784-1795, 2013.
251. Y. Yang, J. Wolfram, K. Boom, X. Fang,H. Shen, and M. Ferrari, "Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells," Cell Biochemistry and Function, vol. 31, no. 5, pp. 374-379, 2013.
252. M. Neri, V. Fineschi, M. Di Paolo et al. , "Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction," Current Vascular Pharmacology, vol. 13, no. 1, pp. 26-36, 2015.
253. A. Faria and S. J. Persaud, "Cardiac oxidative stress in diabetes: mechanisms and therapeutic potential," Pharmacology &Therapeutics, 2016.
254. A. Piasecka, N. Jedrzejczak-Rey, and P. Bednarek, "Secondary metabolites in plant innate immunity: Conserved function of divergent chemicals," New Phytologist, vol. 206, no. 3, pp. 948-964, 2015.
255. J. B. Harborne, "Twenty-five years of chemical ecology," Natural Product Reports, vol. 18, no. 4, pp. 361-379, 2001.
256. R. J. Lee, J. M. Kofonow, P. L. Rosen et al. , "Bitter and sweet taste receptors regulate human upper respiratory innate immunity," The Journal of Clinical Investigation, vol. 124, no. 3, pp. 1393-1405, 2014.
257. R. J. Lee and N. A. Cohen, "The emerging role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis," American Journal of Rhinology and Allergy, vol. 27, no. 4, pp. 283-286, 2013.
258. S. Gil, S. Coldwell, J. L. Drury et al. , "Genotype-specific regulation of oral innate immunity by T2R38 taste receptor," Molecular Immunology, vol. 68, no. 2, pp. 663-670, 2015.
259. R. J. Lee and N. A. Cohen, "Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis," CurrentOpinion in Allergy and Clinical Immunology, vol. 15, no. 1, pp. 14-20, 2015.
260. D. A. Deshpand e, W. C. H. Wang, and E. L. McIlmoyle et al. , "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction," Journal of Natural Medicines, vol. 16, no. 11, pp. 1299-1304, 2010.
261. W. R. Leonard, "Food for thought. Dietary change was a driving force in human evolution," Scientific American, vol. 287, no. 6, pp. 106-115, 2002.
262. A. Brockhoff, M. Behrens, N. Roudnitzky, G. Appendino, C. Avonto, and W. Meyerhof, "Receptor agonism and antagonism of dietary bitter compounds," Journal of Neuroscience, vol. 31, no. 41, pp. 14775-14872, 2011.
263. H. D. Belitz and H. Wieser, "Bitter compounds: occurrence and structure-Activity relationships," Food Reviews International, vol. 1, no. 2, pp. 271-354, 1985.
264. F. D. Tierson, C. L. Olsen, and E. B. Hook, "Nausea and vomiting of pregnancy and association with pregnancy outcome," American Journal of Obstetrics and Gynecology, vol. 155, no. 5, pp. 1017-1022, 1986.
265. R. E. Little, "Maternal alcohol and tobacco use and nausea and vomiting during pregnancy: relation to infant birthweight," Acta Obstetricia et Gynecologica Scand inavica, vol. 59, no. 6, pp. 495-497, 1980.
266. R. M. Weigel and M. M. Weigel, "Nausea and vomiting of early pregnancy and pregnancy outcome. A meta-analytical review," British Journal of Obstetrics and Gynaecology, vol. 96, no. 11, pp. 1312-1318, 1989.
267. M. M. Weigel and R. M. Weigel, "Nausea and vomiting of early pregnancy and pregnancy outcome. An epidemiological study," British Journal of Obstetrics and Gynaecology, vol. 96, no. 11, pp. 1304-1311, 1989.
268. P. A. S. Breslin, "An evolutionary perspective on food and human taste," Current Biology, vol. 23, no. 9, pp. R409-R418, 2013.
269. P. Lu, C. Zhang, L. M. Lifshitz, and R. ZhuGe, "Extraoral bitter taste receptors in health and disease," The Journal of General Physiology, vol. 149, no. 2, pp. 181-197, 2017.
270. J. A. Mennella, A. C. Spector, D. R. Reed, and S. E. Coldwell, "The bad taste ofmedicines: overview of basic research on bitter taste," Clinical Therapeutics, vol. 35, no. 8, pp. 1225-1246, 2013.
271. T. S. Pavlov, V. Levchenko, D. V. Ilatovskaya, O. Palygin, and A. Staruschenko, "Impaired epithelialNa+ channel activity contributes to cystogenesis and development of autosomal recessive polycystic kidney disease in PCK rats," Pediatric Research, vol. 77, no. 1, pp. 64-69, 2015.
272. S. H. Lee and S. Somlo, "Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease," Kidney Research and Clinical Practice, vol. 33, no. 2, pp. 73-78, 2014.
273. M. Bondarava, T. Li, E. Endl, and F. Wehner, "-ENaC is a functional element of the hypertonicity-induced cation channel in HepG2 cells and it mediates proliferation," Pflugers Archiv, vol. 458, no. 4, pp. 675-687, 2009.
274. N. N. Zheleznova, P. D. Wilson, and A. Staruschenko, "Epidermal growth factor-mediated proliferation and sodiumtransport in normal and PKD epithelial cells," Biochimica et Biophysica Acta, vol. 1812, no. 10, pp. 1301-1313, 2011.
275. G. del Popolo,M. Mencarini, F. Nelli, and M. Lazzeri, "Controversy over the pharmacological treatments of storage symptoms in spinal cord injury patients: A literature overview," Spinal Cord, vol. 50, no. 1, pp. 8-13, 2012.
276. S. Matalon, R. Bartoszewski, and J. F. Collawn, "Role of epithelial sodium channels in the regulation of lung fluid homeostasis," American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 309, no. 11, pp. L1229-L1238, 2015.
277. I. Fajac,M. Viel, S. Sublemontier, D. Hubert, and T. Bienvenu, "Could a defective epithelial sodium channel lead to bronchiectasis," Respiratory Research, vol. 9, article 46, 2008.
278. J. Dahlberg, G. Smith, B. Norrving et al. , "Genetic variants in serum and glucocortocoid regulated kinase 1, a regulator of the epithelial sodium channel, are associated with ischaemic stroke," Journal ofHypertension, vol. 29, no. 5, pp. 884-889, 2011.
279. M. M. Reddy and P. M. Quinton, "Functional interaction of CFTR and ENaC in sweat gland s," Pflugers Archiv, vol. 445, no. 4, pp. 499-503, 2003.
280. I.-Y. Seo, M. Kim, J. Lee, and S.-Y. Ryu, "Altered expression of sodium transporters and water channels in the submand ibular gland of rats treated with nitric oxide synthesis inhibitors," Electrolyte and Blood Pressure, vol. 6, no. 1, pp. 9-14, 2008.
281. T. Sakamoto, A. Fujii, N. Saito, H. Kondo, and A. Ohuchi, "Alteration of amiloride-sensitive salt taste nerve responses in aldosterone/NaCl-induced hypertensive rats," Neuroscience Research, vol. 108, pp. 60-66, 2016.
282. C. Planes and G. H. Caughey, "Regulation of the epithelial Na+ channel by peptidases," Current Topics in Developmental Biology, vol. 78, pp. 23-46, 2007.
283. R. A. Shimkets, D. G. Warnock, C. M. Bositis et al. , "Liddle's syndrome: heritable human hypertension caused by mutations in the subunit of the epithelial sodium channel," Cell, vol. 79, no. 3, pp. 407-414, 1994.
284. S. N. Chilton, J. P. Burton, G. Reid, and G. Reid, "Inclusion of fermented foods in food guides around the world," Nutrients, vol. 7, no. 1, pp. 390-404, 2015.
285. E. R. D. C. Neta, S. D. Johanningsmeier, and R. F. McFeeters, "The chemistry and physiology of sour taste-Areview," Journal of Food Science, vol. 72, no. 2, pp. R33-R38, 2007.
286. J. Lim, C. J. Henry, and S. Haldar, "Vinegar as a functional ingredient to improve postprand ial glycemic control-human intervention findings and molecular mechanisms," Molecular Nutrition and Food Research, vol. 60, no. 8, pp. 1837-1849, 2016.
287. D. S. Eweis, F. Abed, and J. Stiban, "Carbon dioxide in carbonated beverages induces ghrelin release and increased food consumption inmale rats: implications on the onset of obesity," Obesity Research & Clinical Practice, 2017.
288. J. Hu, I. Kyrou, B. K. Tan et al. , "Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes," Endocrinology, vol. 157, no. 5, pp. 1881-1894, 2016.
289. P. Trayhurn, "Origins and early development of the concept that brown adipose tissue thermogenesis is linked to energy balance and obesity," Biochimie, vol. 134, pp. 62-70, 2017.
290. S. A. Bingham, C. Gill, A. Welch et al. , "Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers," International Journal of Epidemiology, vol. 26, supplement 1, pp. 137S-S151, 1997.
291. R. Pfister, G. Michels, J. Bragelmann et al. , "Plasma vitamin C and risk of hospitalisation with diagnosis of atrial fibrillation in men and women in EPIC-Norfolk prospective study," International Journal of Cardiology, vol. 177, no. 3, pp. 830-835, 2014.
292. L. A. Savory, S. J. Griffin, K. M. Williams et al. , "Changes in diet, cardiovascular risk factors and modelled cardiovascular risk following diagnosis of diabetes: 1-year results from the ADDITION-Cambridge trial cohort," DiabeticMedicine, vol. 31, no. 2, pp. 148-155, 2014.
293. R. Pfister, S. J. Sharp, R. Luben, N. J. Wareham, and K.-T. Khaw, "Plasma vitamin C predicts incident heart failure in men and women in european prospective investigation into cancer and nutrition-norfolk prospective study," American Heart Journal, vol. 162, no. 2, pp. 246-253, 2011.
294. E. D. Lewand owski, R. K. Kudej, L. T. White, J. M. O'Donnell, and S. F. Vatner, "Mitochondrial preference for short chain fatty acid oxidation during coronary artery constriction," Circulation, vol. 105, no. 3, pp. 367-372, 2002.
295. A. A. Bachmanov and G. K. Beauchamp, "Taste receptor genes," Annual Review of Nutrition, vol. 27, pp. 389-414, 2007.
296. B. Liang, M. Soka, A. H. Christensen et al. , "Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis," Journal of Molecular and Cellular Cardiology, vol. 67, pp. 69-76, 2014.
297. B. C. Donner, M. Schullenberg, N. Geduldig et al. , "Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability," Basic Research in Cardiology, vol. 106, no. 1, pp. 75-87, 2011.
298. N. Decher, K. Wemhoner, S. Rinne et al. , "Knock-out of the potassiumchannel TASK-1 leads toaprolongedqt interval and a disturbed QRS complex," Cellular Physiology and Biochemistry, vol. 28, no. 1, pp. 77-86, 2011.
299. S. Rezazadeh, J. Guo, H. J. Duff, R. A. Ferrier, and B. Gerull, "Reversible dilated cardiomyopathy caused by a high burden of ventricular arrhythmias in and ersen-tawil syndrome," Canadian Journal of Cardiology, vol. 32, no. 12, pp. 1576. e15-1576. e18, 2016.
300. J. M. Statland , R. Tawil, and S. L. Venance, Andersen-Tawil Syndrome, University ofWashington, Seattle,Wash, USA, 1993.
301. Global. , "Global Market Study on Dressing Vinegar & Condiments: Apple Cider Vinegar and Red Wine Vinegar Segments Projected to Gain High BPS Shares During 2016-2024," http://www. persistencemarketresearch. com/samples/ 13723, Accessed: on March 2017.
302. K. B. Panara and R. Acharya, "Consequences of excessive use of Amlarasa (sour taste): A case-control study," An International Quarterly Journal of Research inAyurveda, vol. 35, no. 2, pp. 124-128, 2014.
303. R. Cuomo, G. Sarnelli, M. F. Savarese, and M. Buyckx, "Carbonated beverages and gastrointestinal system: between myth and reality," Nutrition,Metabolism and Cardiovascular Diseases, vol. 19, no. 10, pp. 683-689, 2009.
304. H. R. Haghgou, R. Haghgoo, and F. M. Asdollah, "Comparison of the microhardness of primary and permanent teeth after immersion in two types of carbonated beverages," Journal of International Society of Preventive and Community Dentistry, vol. 6, no. 4, pp. 344-348, 2016.
305. M. A. Rabie, S. Elsaidy, A.-A. El-Badawy, H. Siliha, and F. X. Malcata, "Biogenic amine contents in selected egyptian fermented foods as determined by ion-exchange chromatography," Journal of Food Protection, vol. 74, no. 4, pp. 681-685, 2011.
306. J. W. Teener, "Inflammatory and toxic myopathy," Seminars in Neurology, vol. 32, no. 5, pp. 491-499, 2012.
307. D. C. Tabor, "Ripe and unripe: Concepts of health and sickness in ayurvedic medicine," Social Science and Medicine. Part B Medical Anthropology, vol. 15, no. 4, pp. 439-455, 1981.
308. A. Someya, S. Horie, H. Yamamoto, and T. Murayama, "Modification of capsaicin-sensitive neurons in isolated guinea pig ileum by [6]-gingerol and lafutidine," Journal of Pharmacological Sciences, vol. 92, no. 4, pp. 359-366, 2003.
309. C. Shibata, I. Sasaki, H. Naito, T. Ueno, and S. Matsuno, "Intragastric capsaicin stimulates motility of upper gut and proximal colon via distinct pathways in conscious dogs," Digestive Diseases and Sciences, vol. 44, no. 6, pp. 1083-1089, 1999.
310. M.-S. Lee, C.-T. Kim, I.-H. Kim, and Y. Kim, "Effects of capsaicin on lipid catabolism in 3T3-L1 adipocytes," Phytotherapy Research, vol. 25, no. 6, pp. 935-939, 2011.
311. J.-H. Kang, G. Tsuyoshi, I.-S. Han, T. Kawada, Y. M. Kim, and R. Yu, "Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet," Obesity, vol. 18, no. 4, pp. 780-787, 2010.
312. J. A. Filosa, X. Yao, and G. Rath, "TRPV4 and the regulation of vascular tone," Journal of Cardiovascular Pharmacology, vol. 61, no. 2, pp. 113-119, 2013.
313. S. Earley, A. L. Gonzales, and Z. I. Garcia, "A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation," Molecular Pharmacology, vol. 77, no. 4, pp. 612-620, 2010.
314. R. L. Baylie and J. E. Brayden, "TRPV channels and vascular function," Acta Physiologica, vol. 203, no. 1, pp. 99-116, 2011.
315. E. S. Fernand es, M. A. Fernand es, and J. E. Keeble, "The functions of TRPA1 and TRPV1: moving away from sensory nerves," British Journal of Pharmacology, vol. 166, no. 2, pp. 510-521, 2012.
316. J. V. Bodkin and E. S. Fernand es, "TRPV1 and SP: key elements for sepsis outcome" British Journal of Pharmacology, vol. 170, no. 7, pp. 1279-1292, 2013.
317. E. S. Fernand es, L. Liang, S. Smillie et al. , "TRPV1 deletion enhances local inflammation and accelerates the onset of systemic inflammatory response syndrome," Journal of Immunology, vol. 188, no. 11, pp. 5741-5751, 2012.
318. V. Guptill, X. Cui, A. Khaibullina et al. , "Disruption of the transient receptor potential vanilloid 1 can affect survival, bacterial clearance, and cytokine gene expression during murine sepsis," Anesthesiology, vol. 114, no. 5, pp. 1190-1199, 2011.
319. S. J. F. Mendes, F. I. A. B. Sousa, D. M. S. Pereira et al. , "Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms," International Immunopharmacology, vol. 34, pp. 60-70, 2016.
320. Y. Chen, Q. Fang, Z. Wang et al. , "Transient receptor potential vanilloid 4 ion channel functions as a pruriceptor in epidermal keratinocytes to evoke histaminergic itch," Journal of Biological Chemistry, vol. 291, no. 19, pp. 10252-10262, 2016.
321. T. Akiyama, M. Ivanov, M. Nagamine et al. , "Involvement of TRPV4 in serotonin-evoked scratching," Journal of Investigative Dermatology, vol. 136, no. 1, pp. 154-160, 2016.
322. H. Andersen, C. Melholt, and S. Hilborg et al. , "Antipruritic effect of cold-induced and transient receptor potential-agonistinduced counter-irritation on histaminergic itch in humans," Acta Dermato Venereologica, vol. 97, no. 1, pp. 63-67, 2017.
323. G. Yu,N. Yang, F. Li et al. , "Enhanced itch elicited by capsaicin in a chronic itch model," Molecular Pain, vol. 12, 2016.
324. R. de La Iglesia, F. I. Milagro, J. Campion, N. Boque, and J. A. Martnez, "Healthy properties of proanthocyanidins," BioFactors, vol. 36, no. 3, pp. 159-168, 2010.
325. B. Lu, T. Wang, Z. Li et al. , "Healing of skin wounds with a chitosan-gelatin sponge loaded with tannins and platelet-rich plasma," International Journal of BiologicalMacromolecules, vol. 82, pp. 884-891, 2016.
326. K.-T. Chung, T. Y. Wong, C.-I. Wei, Y.-W. Huang, and Y. Lin, "Tannins and human health: A review," Critical Reviews in Food Science and Nutrition, vol. 38, no. 6, pp. 421-464, 1998.
327. S. W. Lim, "Aluminum potassium sulfate and tannic acid injection for hemorrhoids," Journal of the Korean Society of Coloproctology, vol. 28, no. 2, pp. 73-77, 2012.
328. K. Kim, H. Lee, and S. Hong, "TAPE: A biodegradable hemostatic glue inspired by a ubiquitous compound in plants for surgical application," Journal of Visualized Experiments, vol. 2016, no. 112, Article ID e53930, 2016.
329. J. M. D. Bas, M.-L. Ricketts, M. Vaque et al. , "Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner," Molecular Nutrition and Food Research, vol. 53, no. 7, pp. 805-814, 2009.
330. A. Jadoun and R. Dwivedi, "Effect of selected samana and vicitra pratyayarabdha dravya w. s. r. to vipaka," An International Quarterly Journal of Research in Ayurveda, vol. 34, no. 4, pp. 373-378, 2013.
331. M. Gilca, D. Dragos, and S. Irina, Medicinal plants and biologically active phytochemicals. Iasi, Performantica, Romania, 2016.
332. K. Y. Garcia-Hernand ez, H. Vibrans,M. Rivas-Guevara, and A. Aguilar-Contreras, "This plant treats that illness the hot-cold system and therapeutic procedures mediate medicinal plant use in San Miguel Tulancingo, Oaxaca, Mexico," Journal of Ethnopharmacology, vol. 163, pp. 12-30, 2015.
333. A. Ankli, O. Sticher, and M. Heinrich, "Yucatec maya medicinal plants versus nonmedicinal plants: indigenous characterization and selection," Human Ecology, vol. 27, no. 4, pp. 557-580, 1999.
334. S. Parvinroo, S. Zahediasl,M. Sabetkasaei,M. Kamalinejad, and F. Naghibi, "The effects of selected hot and cold temperament herbs based on Iranian traditional medicine on somemetabolic parameters in normal rats," Iranian Journal of Pharmaceutical Research, vol. 13, pp. 177-184, 2014.
335. M. Gonzales de La Cruz, S. Baldeon Malpartida, H. Beltran Santiago, V. Jullian, and G. Bourdy, "Hot and cold: medicinal plant uses inQuechua speaking communities in the high Andes (Callejon de Huaylas, Ancash, Peru)," Journal of Ethnopharmacology, vol. 155, no. 2, pp. 1093-1117, 2014.
336. B. Tedlock, "An interpretive solution to the problemof humoral medicine in Latin America," Social Science and Medicine, vol. 24, no. 12, pp. 1069-1083, 1987.
337. M. R. S. Ardekani, R. Rahimi, B. Javadi, L. Abdi, and M. Khanavi, "Relationship between temperaments of medicinal plants and their major chemical compounds," Journal of Traditional Chinese Medicine, vol. 31, no. 1, pp. 27-31, 2011.
338. X.-J. Fu, Z.-G. Wang, Y. Qu, P. Wang, Y. Zhou, and H.-Y. Yu, "Study on the networks of "nature-family-component" of Chinese medicinal herbs based on association rules mining," Chinese Journal of Integrative Medicine, vol. 19, no. 9, pp. 663-667, 2013.
339. D.-P. Chao, J.-J. Chen, S.-Y. Huang, C.-C. Tyan, C.-L. Hsieh, and L.-Y. Sheen, "Effects of hot and cold foods on signals of heart rate variability and nail fold microcirculation of healthy young humans: A pilot study," Chinese Journal of Physiology, vol. 54,no. 3, pp. 145-152, 2011.
340. D.-P. Chao, C.-C. Tyan, J.-J. Chen, C.-L. Hsieh, and L.-Y. Sheen, "Effect of hot-attribute aged ginger tea on Chinesemedical pulse condition of healthy young humans," Journal of Traditional and Complementary Medicine, vol. 1, no. 1, pp. 69-75, 2011.
341. S. Parvinroo, F. Naghibi, S. Zahediasl, M. Kamalinejad, and M. Sabetkasaei, "The effects of seeds with hot and cold temperaments on serum thyroid hormones, corticosterone and urine vanillylmand elic acid concentrations of healthy rats," Journal of Ethnopharmacology, vol. 156, pp. 216-221, 2014.
342. L.-P. Hlang, M.-F. Zhu, R.-Y. Yu, J.-Q. Du, and H.-N. Liu, "Study on discrimination mode of cold and hot properties of traditional Chinese medicines based on biological effects," Zhongguo Zhong Yao Za Zhi, vol. 39, no. 17, pp. 3353-3358, 2014.
343. A. Dhaka, T. J. Earley, J. Watson, and A. Patapoutian, "Visualizing cold spots: TRPM8-expressing sensory neurons and their projections," Journal of Neuroscience, vol. 28, no. 3, pp. 566-575, 2008.
344. R. Fujiyama and K. Toda, "Functional effects of cold stimulation on taste perception in humans," Odontology, pp. 1-8, 2016.
345. K. F. Medler, "Multiple roles for TRPs in the taste system: not your typical TRPs," Advances in Experimental Medicine and Biology, vol. 704, pp. 831-846, 2011.
346. V. Lyall, G. L. Heck, A. K. Vinnikova et al. , "The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant," Journal of Physiology, vol. 558, no. 1,part 1, pp. 147-159, 2004.
347. J. D. Levine and N. Alessand ri-Haber, "TRP channels: targets for the relief of pain," Biochimica et Biophysica Acta: Molecular Basis of Disease, vol. 1772, no. 8, pp. 989-1003, 2007.
348. R. Zhao and S. Y. Tsang, "Versatile roles of intracellularly located TRPV1 channel," Journal of Cellular Physiology, 2016.
349. F. Viana, "Chemosensory properties of the trigeminal system," ACS Chemical Neuroscience, vol. 2, no. 1, pp. 38-50, 2011.
350. B. Bufe, P. A. S. Breslin, C. Kuhn et al. , "The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception," Current Biology, vol. 15, no. 4, pp. 322-327, 2005.
351. J. Prutkin, V. B. Duffy, L. Etter et al. , "Genetic variation and inferences about perceived taste intensity in mice and men," Physiology and Behavior, vol. 69, no. 1, pp. 161-173, 2000.
352. L. M. Bartoshuk, "Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception," Chemical Senses, vol. 25,no. 4, pp. 447-460, 2000.
353. V. B. Duffy, J. M. Peterson, and L. M. Bartoshuk, "Associations between taste genetics, oral sensation and alcohol intake," Physiology and Behavior, vol. 82, no. 2-3, pp. 435-445, 2004.
354. WorldHealthOrganisation, Quality ControlMethods forHerbal Materials, World Health Organization, Geneva, Switzerland , 2011.
355. S. Reinberger, "Bitter could be better," Scientific AmericanMind, vol. 17, no. 3, pp. 56-61, 2006.
356. M. Leonti, "The future is written: impact of scripts on the cognition, selection, knowledge and transmission of medicinal plant use and its implications for ethnobotany and ethnopharmacology," Journal of Ethnopharmacology, vol. 134, no. 3, pp. 542-555, 2011.
357. L. J. Martin and S. I. Sollars, "Contributory role of sex differences in the variations of gustatory function," Journal of Neuroscience Research, vol. 95, no. 1-2, pp. 594-603, 2017.
358. J. P. Ley, "Masking bitter taste by molecules," Chemosensory Perception, vol. 1, no. 1, pp. 58-77, 2008.
359. P. Imming, C. Sinning, and A. Meyer, "Drugs, their targets and the nature and number of drug targets," Nature Reviews Drug Discovery, vol. 5, no. 10, pp. 821-834, 2006.
360. W. S. U. Roland , R. J. Gouka,H. Gruppen et al. , "6-Methoxyflavanones as bitter taste receptor blockers for hTAS2R39," PLoS ONE, vol. 9, no. 4, Article ID e94451, 2014.
361. N. Cocco and J. I. Glendinning, "Not all sugars are created equal: some mask aversive tastes better than others in an herbivorousinsect," Journal of Experimental Biology, vol. 215, no. 8, pp. 1412-1421, 2012.
362. M. Behrens, S. Born, U. Redel et al. , "Immunohistochemical detection of TAS2R38 protein in human taste cells," PLoS ONE, vol. 7, no. 7, Article ID e40304, 2012.
363. A. Voigt, S. Hubner, K. Lossow, I. Hermans-Borgmeyer, U. Boehm, and W. Meyerhof, "Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in mice," Chemical Senses, vol. 37, no. 9, pp. 897-911, 2012.
364. V. Reyes-Garcia, "The relevance of traditional knowledge systems for ethnopharmacological research: theoretical and methodological contributions," Journal of Ethnobiology and Ethnomedicine, vol. 6, article 32, 2010.