Sour taste finds closure in a potassium channel

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 2, 2016, Pages 246-247

  Challis, Rosemary C ^a   Ma, Minghong ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL; PROTON;

ACIDIFICATION; ACTION POTENTIAL; CELL FUNCTION; CELL SURFACE; HETEROLOGOUS EXPRESSION; MEMBRANE DEPOLARIZATION; NONHUMAN; NOTE; PRIORITY JOURNAL; SALTINESS; SOUR TASTE; SWEETNESS; TASTE BUD; UMAMI; ANIMAL; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TASTE;

ANIMALS; HUMANS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTONS; SIGNAL TRANSDUCTION; TASTE;

EID: 84954549245     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1523319113     Document Type: Note

References (20)

1. Yarmolinsky DA, Zuker CS, Ryba NJ (2009) Common sense about taste: From mammals to insects. Cell 139(2):234-244.
2. Liman ER, Zhang YV, Montell C (2014) Peripheral coding of taste. Neuron 81(5):984-1000.
3. + channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction. Proc Natl Acad Sci USA 113:E229-E238.
4. Ugawa S, et al. (1998) Receptor that leaves a sour taste in the mouth. Nature 395(6702):555-556.
5. Stevens DR, et al. (2001) Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. Nature 413(6856):631-635.
6. Lin W, Ogura T, Kinnamon SC (2002) Acid-activated cation currents in rat vallate taste receptor cells. J Neurophysiol 88(1):133-141.
7. Ishimaru Y, et al. (2006) Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci USA 103(33): 12569-12574.
8. Huang AL, et al. (2006) The cells and logic for mammalian sour taste detection. Nature 442(7105):934-938.
9. Richter TA, Dvoryanchikov GA, Chaudhari N, Roper SD (2004) Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste buds. J Neurophysiol 92(3):1928-1936.
10. Miyamoto T, Fujiyama R, Okada Y, Sato T (1998) Sour transduction involves activation of NPPB-sensitive conductance in mouse taste cells. J Neurophysiol 80(4): 1852-1859.
11. Lin W, Burks CA, Hansen DR, Kinnamon SC, Gilbertson TA (2004) Taste receptor cells express pH-sensitive leak K+ channels. J Neurophysiol 92(5):2909-2919.
12. Chandrashekar J, et al. (2009) The taste of carbonation. Science 326(5951):443-445.
13. Nelson TM, et al. (2010) Taste function in mice with a targeted mutation of the pkd1l3 gene. Chem Senses 35(7):565-577.
14. Horio N, et al. (2011) Sour taste responses in mice lacking PKD channels. PLoS One 6(5):e20007.
15. Chang RB, Waters H, Liman ER (2010) A proton current drives action potentials in genetically identified sour taste cells. Proc Natl Acad Sci USA 107(51): 22320-22325.
16. Lyall V, et al. (2001) Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction. Am J Physiol Cell Physiol 281(3): C1005-C1013.
17. Ogiso K, Shimizu Y, Watanabe K, Tonosaki K (2000) Possible involvement of undissociated acid molecules in the acid response of the chorda tympani nerve of the rat. J Neurophysiol 83(5):2776-2779.
18. Bushman JD, Ye W, Liman ER (2015) A proton current associated with sour taste: Distribution and functional properties. FASEB J 29(7):3014-3026.
19. Stephan AB, et al. (2009) ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proc Natl Acad Sci USA 106(28): 11776-11781.
20. Kubo Y, Baldwin TJ, Jan YN, Jan LY (1993) Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature 362(6416):127-133.