메뉴 건너뛰기




Volumn 10, Issue 9, 2015, Pages

The effects of the endocannabinoids anandamide and 2-arachidonoylglycerol on human osteoblast proliferation and differentiation

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ALKALINE PHOSPHATASE; ANANDAMIDE; CALCIUM; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; COLLAGEN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OSTEOCALCIN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; VANILLOID RECEPTOR 1; ACYLGLYCEROL; AMIDE; ARACHIDONIC ACID DERIVATIVE; CNR2 PROTEIN, HUMAN; CREB1 PROTEIN, HUMAN; DIFFERENTIATION ANTIGEN; ENDOCANNABINOID; GLYCERYL 2-ARACHIDONATE; MITOGEN ACTIVATED PROTEIN KINASE; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

EID: 84946944843     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0136546     Document Type: Article
Times cited : (26)

References (49)
  • 1
    • 58149387662 scopus 로고    scopus 로고
    • Normal bone anatomy and physiology
    • PMID: 18988698
    • Clarke B (2008) Normal bone anatomy and physiology. Clin J Am Soc Nephrol 3 Suppl 3: S131-139. doi: 10.2215/CJN.04151206 PMID: 18988698
    • (2008) Clin J Am Soc Nephrol , vol.3 , pp. S131-139
    • Clarke, B.1
  • 3
    • 33947128224 scopus 로고    scopus 로고
    • Endocannabinoids and the regulation of their levels in health and disease
    • PMID: 17353660
    • Di Marzo V, Petrosino S (2007) Endocannabinoids and the regulation of their levels in health and disease. Curr Opin Lipidol 18: 129-140. PMID: 17353660
    • (2007) Curr Opin Lipidol , vol.18 , pp. 129-140
    • Di Marzo, V.1    Petrosino, S.2
  • 4
    • 79961222952 scopus 로고    scopus 로고
    • Endocannabinoids: An appetite for fat
    • PMID: 21778404
    • Di Marzo V (2011) Endocannabinoids: an appetite for fat. Proc Natl Acad Sci U S A 108: 12567-12568. doi: 10.1073/pnas.1109567108 PMID: 21778404
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 12567-12568
    • Di Marzo, V.1
  • 5
    • 77950653576 scopus 로고    scopus 로고
    • Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists
    • PMID: 20166927
    • Pertwee RG (2010) Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists. Curr Med Chem 17: 1360-1381. PMID: 20166927
    • (2010) Curr Med Chem , vol.17 , pp. 1360-1381
    • Pertwee, R.G.1
  • 6
    • 59649083643 scopus 로고    scopus 로고
    • The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption
    • PMID: 19059369
    • Rossi F, Siniscalco D, Luongo L, De Petrocellis L, Bellini G, et al. (2009) The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption. Bone 44: 476-484. doi: 10.1016/j.bone.2008.10.056 PMID: 19059369
    • (2009) Bone , vol.44 , pp. 476-484
    • Rossi, F.1    Siniscalco, D.2    Luongo, L.3    De Petrocellis, L.4    Bellini, G.5
  • 7
    • 70349510641 scopus 로고    scopus 로고
    • The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo
    • PMID: 19805329
    • Whyte LS, Ryberg E, Sims NA, Ridge SA, Mackie K, et al. (2009) The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci U S A 106: 16511-16516. doi: 10.1073/pnas.0902743106 PMID: 19805329
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 16511-16516
    • Whyte, L.S.1    Ryberg, E.2    Sims, N.A.3    Ridge, S.A.4    Mackie, K.5
  • 8
    • 22544439953 scopus 로고    scopus 로고
    • Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors
    • PMID: 15908955
    • Idris AI, van 't Hof RJ, Greig IR, Ridge SA, Baker D, et al. (2005) Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nat Med 11: 774-779. PMID: 15908955
    • (2005) Nat Med , vol.11 , pp. 774-779
    • Idris, A.I.1    Van 'T Hof, R.J.2    Greig, I.R.3    Ridge, S.A.4    Baker, D.5
  • 9
    • 67849129193 scopus 로고    scopus 로고
    • Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells
    • PMID: 19656492
    • Idris AI, Sophocleous A, Landao-Bassonga E, Canals M, Milligan G, et al. (2009) Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells. Cell Metab 10: 139-147. doi: 10.1016/j.cmet.2009.07.006 PMID: 19656492
    • (2009) Cell Metab , vol.10 , pp. 139-147
    • Idris, A.I.1    Sophocleous, A.2    Landao-Bassonga, E.3    Canals, M.4    Milligan, G.5
  • 10
    • 31444437185 scopus 로고    scopus 로고
    • Peripheral cannabinoid receptor, CB2, regulates bone mass
    • PMID: 16407142
    • Ofek O, Karsak M, Leclerc N, Fogel M, Frenkel B, et al. (2006) Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci U S A 103: 696-701. PMID: 16407142
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 696-701
    • Ofek, O.1    Karsak, M.2    Leclerc, N.3    Fogel, M.4    Frenkel, B.5
  • 11
    • 77950544608 scopus 로고    scopus 로고
    • The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo
    • PMID: 20096813
    • Idris AI, Landao-Bassonga E, Ralston SH (2010) The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo. Bone 46: 1089-1099. doi: 10.1016/j.bone.2010.01.368 PMID: 20096813
    • (2010) Bone , vol.46 , pp. 1089-1099
    • Idris, A.I.1    Landao-Bassonga, E.2    Ralston, S.H.3
  • 12
    • 20144388484 scopus 로고    scopus 로고
    • Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain
    • PMID: 15788769
    • Ghilardi JR, Rohrich H, Lindsay TH, Sevcik MA, Schwei MJ, et al. (2005) Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J Neurosci 25: 3126-3131. PMID: 15788769
    • (2005) J Neurosci , vol.25 , pp. 3126-3131
    • Ghilardi, J.R.1    Rohrich, H.2    Lindsay, T.H.3    Sevcik, M.A.4    Schwei, M.J.5
  • 13
    • 33747598488 scopus 로고    scopus 로고
    • Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling
    • PMID: 16772520
    • Tam J, Ofek O, Fride E, Ledent C, Gabet Y, et al. (2006) Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling. Mol Pharmacol 70: 786-792. PMID: 16772520
    • (2006) Mol Pharmacol , vol.70 , pp. 786-792
    • Tam, J.1    Ofek, O.2    Fride, E.3    Ledent, C.4    Gabet, Y.5
  • 14
    • 84859049109 scopus 로고    scopus 로고
    • Cannabinoids and bone: Endocannabinoids modulate human osteoclast function in vitro
    • PMID: 21649637
    • Whyte LS, Ford L, Ridge SA, Cameron GA, Rogers MJ, et al. (2012) Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro. Br J Pharmacol 165: 2584-2597. doi: 10.1111/ j.1476-5381.2011.01519.x PMID: 21649637
    • (2012) Br J Pharmacol , vol.165 , pp. 2584-2597
    • Whyte, L.S.1    Ford, L.2    Ridge, S.A.3    Cameron, G.A.4    Rogers, M.J.5
  • 15
    • 38049132712 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
    • PMID: 17704191
    • Tam J, Trembovler V, Di Marzo V, Petrosino S, Leo G, et al. (2008) The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. FASEB J 22: 285-294. PMID: 17704191
    • (2008) FASEB J , vol.22 , pp. 285-294
    • Tam, J.1    Trembovler, V.2    Di Marzo, V.3    Petrosino, S.4    Leo, G.5
  • 16
    • 79954624849 scopus 로고    scopus 로고
    • The endovanilloid/endocannabinoid system: A new potential target for osteoporosis therapy
    • PMID: 21237298
    • Rossi F, Bellini G, Luongo L, Torella M, Mancusi S, et al. (2011) The endovanilloid/endocannabinoid system: a new potential target for osteoporosis therapy. Bone 48: 997-1007. doi: 10.1016/j.bone. 2011.01.001 PMID: 21237298
    • (2011) Bone , vol.48 , pp. 997-1007
    • Rossi, F.1    Bellini, G.2    Luongo, L.3    Torella, M.4    Mancusi, S.5
  • 17
    • 78651231132 scopus 로고    scopus 로고
    • Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells
    • PMID: 20951563
    • Hutchins HL, Li Y, Hannon K, Watkins BA (2011) Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells. J Nutr Biochem 22: 195-200. doi: 10.1016/j.jnutbio.2010.06.001 PMID: 20951563
    • (2011) J Nutr Biochem , vol.22 , pp. 195-200
    • Hutchins, H.L.1    Li, Y.2    Hannon, K.3    Watkins, B.A.4
  • 18
    • 42349086864 scopus 로고    scopus 로고
    • Endocannabinoids and the regulation of bone metabolism
    • PMID: 18426503
    • Bab I, Ofek O, Tam J, Rehnelt J, Zimmer A (2008) Endocannabinoids and the regulation of bone metabolism. J Neuroendocrinol 20 Suppl 1: 69-74. doi: 10.1111/j.1365-2826.2008.01675.x PMID: 18426503
    • (2008) J Neuroendocrinol , vol.20 , pp. 69-74
    • Bab, I.1    Ofek, O.2    Tam, J.3    Rehnelt, J.4    Zimmer, A.5
  • 19
    • 54349124546 scopus 로고    scopus 로고
    • Regulation of bone mass, osteoclast function, and ovariectomy-induced bone loss by the type 2 cannabinoid receptor
    • PMID: 18635663
    • Idris AI, Sophocleous A, Landao-Bassonga E, van't Hof RJ, Ralston SH (2008) Regulation of bone mass, osteoclast function, and ovariectomy-induced bone loss by the type 2 cannabinoid receptor. Endocrinology 149: 5619-5626. doi: 10.1210/en.2008-0150 PMID: 18635663
    • (2008) Endocrinology , vol.149 , pp. 5619-5626
    • Idris, A.I.1    Sophocleous, A.2    Landao-Bassonga, E.3    Van'T Hof, R.J.4    Ralston, S.H.5
  • 20
    • 79956333187 scopus 로고    scopus 로고
    • The type 2 cannabinoid receptor regulates bone mass and ovariectomy-induced bone loss by affecting osteoblast differentiation and bone formation
    • PMID: 21447627
    • Sophocleous A, Landao-Bassonga E, Van't Hof RJ, Idris AI, Ralston SH (2011) The type 2 cannabinoid receptor regulates bone mass and ovariectomy-induced bone loss by affecting osteoblast differentiation and bone formation. Endocrinology 152: 2141-2149. doi: 10.1210/en.2010-0930 PMID: 21447627
    • (2011) Endocrinology , vol.152 , pp. 2141-2149
    • Sophocleous, A.1    Landao-Bassonga, E.2    Van'T Hof, R.J.3    Idris, A.I.4    Ralston, S.H.5
  • 21
    • 33846223892 scopus 로고    scopus 로고
    • Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors
    • PMID: 17205329
    • Scutt A, Williamson EM (2007) Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. Calcif Tissue Int 80: 50-59. PMID: 17205329
    • (2007) Calcif Tissue Int , vol.80 , pp. 50-59
    • Scutt, A.1    Williamson, E.M.2
  • 22
    • 84897068466 scopus 로고    scopus 로고
    • Porous silicon confers bioactivity to polycaprolactone composites in vitro
    • PMID: 24398914
    • Henstock JR, Ruktanonchai UR, Canham LT, Anderson SI (2014) Porous silicon confers bioactivity to polycaprolactone composites in vitro. J Mater Sci Mater Med 25: 1087-1097. doi: 10.1007/s10856- 014-5140-5 PMID: 24398914
    • (2014) J Mater Sci Mater Med , vol.25 , pp. 1087-1097
    • Henstock, J.R.1    Ruktanonchai, U.R.2    Canham, L.T.3    Anderson, S.I.4
  • 23
    • 0032425918 scopus 로고    scopus 로고
    • Evaluation of the osteoblast response to a silica gel in vitro
    • PMID: 15348931
    • Anderson SI, Downes S, Perry CC, Caballero AM (1998) Evaluation of the osteoblast response to a silica gel in vitro. J Mater Sci Mater Med 9: 731-735. PMID: 15348931
    • (1998) J Mater Sci Mater Med , vol.9 , pp. 731-735
    • Anderson, S.I.1    Downes, S.2    Perry, C.C.3    Caballero, A.M.4
  • 25
    • 0031452189 scopus 로고    scopus 로고
    • In vitro mechanical and biological assessment of hydroxyapatite-reinforced polyethylene composite
    • PMID: 15348789
    • Huang J, Di Silvio L, Wang M, Tanner KE, BonfieldW(1997) In vitro mechanical and biological assessment of hydroxyapatite-reinforced polyethylene composite. J Mater Sci Mater Med 8: 775-779. PMID: 15348789
    • (1997) J Mater Sci Mater Med , vol.8 , pp. 775-779
    • Huang, J.1    Di Silvio, L.2    Wang, M.3    Tanner, K.E.4    Bonfield, W.5
  • 26
    • 0028242767 scopus 로고
    • Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells
    • PMID: 8079660
    • Franceschi RT, Iyer BS, Cui Y (1994) Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells. J Bone Miner Res 9: 843-854. PMID: 8079660
    • (1994) J Bone Miner Res , vol.9 , pp. 843-854
    • Franceschi, R.T.1    Iyer, B.S.2    Cui, Y.3
  • 28
    • 0141614895 scopus 로고    scopus 로고
    • Effects of dexamethasone on proliferation, differentiation and apoptosis of adult human osteoblasts in vitro
    • Yang L, Tao T, Wang X, Du N, Chen W, et al. (2003) Effects of dexamethasone on proliferation, differentiation and apoptosis of adult human osteoblasts in vitro. Chin Med J (Engl) 116: 1357-1360.
    • (2003) Chin Med J (Engl) , vol.116 , pp. 1357-1360
    • Yang, L.1    Tao, T.2    Wang, X.3    Du, N.4    Chen, W.5
  • 29
    • 0032403055 scopus 로고    scopus 로고
    • Matrix mineralization in MC3T3-E1 cell cultures initiated by beta-glycerophosphate pulse
    • PMID: 9855459
    • Fratzl-Zelman N, Fratzl P, Horandner H, Grabner B, Varga F, et al. (1998) Matrix mineralization in MC3T3-E1 cell cultures initiated by beta-glycerophosphate pulse. Bone 23: 511-520. PMID: 9855459
    • (1998) Bone , vol.23 , pp. 511-520
    • Fratzl-Zelman, N.1    Fratzl, P.2    Horandner, H.3    Grabner, B.4    Varga, F.5
  • 31
    • 84930206791 scopus 로고    scopus 로고
    • Endocannabinoids modulate human blood-brain barrier permeability in vitro
    • PMID: 25651941
    • Hind WH, Tufarelli C, Neophytou M, Anderson SI, England TJ, et al. (2015) Endocannabinoids modulate human blood-brain barrier permeability in vitro. Br J Pharmacol 172: 3015-3027. doi: 10.1111/ bph.13106 PMID: 25651941
    • (2015) Br J Pharmacol , vol.172 , pp. 3015-3027
    • Hind, W.H.1    Tufarelli, C.2    Neophytou, M.3    Anderson, S.I.4    England, T.J.5
  • 32
    • 0035236997 scopus 로고    scopus 로고
    • Regulation of osteoblast formation and function
    • PMID: 11704982
    • Aubin JE (2001) Regulation of osteoblast formation and function. Rev Endocr Metab Disord 2: 81-94. PMID: 11704982
    • (2001) Rev Endocr Metab Disord , vol.2 , pp. 81-94
    • Aubin, J.E.1
  • 34
    • 0028067469 scopus 로고
    • In situ hybridization to show sequential expression of osteoblast gene markers during bone formation in vivo
    • PMID: 7817834
    • Zhou H, Choong P, McCarthy R, Chou ST, Martin TJ, et al. (1994) In situ hybridization to show sequential expression of osteoblast gene markers during bone formation in vivo. J Bone Miner Res 9: 1489-1499. PMID: 7817834
    • (1994) J Bone Miner Res , vol.9 , pp. 1489-1499
    • Zhou, H.1    Choong, P.2    McCarthy, R.3    Chou, S.T.4    Martin, T.J.5
  • 35
    • 27944510259 scopus 로고    scopus 로고
    • Cannabinoid receptor type 2 gene is associated with human osteoporosis
    • PMID: 16204352
    • Karsak M, Cohen-Solal M, Freudenberg J, Ostertag A, Morieux C, et al. (2005) Cannabinoid receptor type 2 gene is associated with human osteoporosis. Hum Mol Genet 14: 3389-3396. PMID: 16204352
    • (2005) Hum Mol Genet , vol.14 , pp. 3389-3396
    • Karsak, M.1    Cohen-Solal, M.2    Freudenberg, J.3    Ostertag, A.4    Morieux, C.5
  • 36
    • 72949117074 scopus 로고    scopus 로고
    • Cannabinoids and the skeleton: From marijuana to reversal of bone loss
    • PMID: 19634029
    • Bab I, Zimmer A, Melamed E (2009) Cannabinoids and the skeleton: from marijuana to reversal of bone loss. Ann Med 41: 560-567. doi: 10.1080/07853890903121025 PMID: 19634029
    • (2009) Ann Med , vol.41 , pp. 560-567
    • Bab, I.1    Zimmer, A.2    Melamed, E.3
  • 37
    • 84925428378 scopus 로고    scopus 로고
    • The endocannabinoid system and its therapeutic implications in rheumatoid arthritis
    • PMID: 25791728
    • Gui H, Tong Q, Qu W, Mao CM, Dai SM (2015) The endocannabinoid system and its therapeutic implications in rheumatoid arthritis. Int Immunopharmacol 26: 86-91. doi: 10.1016/j.intimp.2015.03.006 PMID: 25791728
    • (2015) Int Immunopharmacol , vol.26 , pp. 86-91
    • Gui, H.1    Tong, Q.2    Qu, W.3    Mao, C.M.4    Dai, S.M.5
  • 38
    • 0034737742 scopus 로고    scopus 로고
    • Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase
    • PMID: 10734116
    • Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, et al. (2000) Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem 275: 9645-9652. PMID: 10734116
    • (2000) J Biol Chem , vol.275 , pp. 9645-9652
    • Jaiswal, R.K.1    Jaiswal, N.2    Bruder, S.P.3    Mbalaviele, G.4    Marshak, D.R.5
  • 39
    • 33847375078 scopus 로고    scopus 로고
    • Critical role of the extracellular signal-regulated kinase- MAPK pathway in osteoblast differentiation and skeletal development
    • PMID: 17325210
    • Ge C, Xiao G, Jiang D, Franceschi RT (2007) Critical role of the extracellular signal-regulated kinase- MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol 176: 709-718. PMID: 17325210
    • (2007) J Cell Biol , vol.176 , pp. 709-718
    • Ge, C.1    Xiao, G.2    Jiang, D.3    Franceschi, R.T.4
  • 40
    • 79958249441 scopus 로고    scopus 로고
    • Transcriptional regulation of BMP2 expression by the PTH-CREB signaling pathway in osteoblasts
    • PMID: 21695256
    • Zhang R, Edwards JR, Ko SY, Dong S, Liu H, et al. (2011) Transcriptional regulation of BMP2 expression by the PTH-CREB signaling pathway in osteoblasts. PLoS One 6: e20780. doi: 10.1371/journal. pone.0020780 PMID: 21695256
    • (2011) PLoS One , vol.6
    • Zhang, R.1    Edwards, J.R.2    Ko, S.Y.3    Dong, S.4    Liu, H.5
  • 41
    • 84859902202 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104
    • PMID: 22247071
    • Huang YF, Lin JJ, Lin CH, Su Y, Hung SC (2012) c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104. J Bone Miner Res 27: 1093-1105. doi: 10.1002/jbmr.1548 PMID: 22247071
    • (2012) J Bone Miner Res , vol.27 , pp. 1093-1105
    • Huang, Y.F.1    Lin, J.J.2    Lin, C.H.3    Su, Y.4    Hung, S.C.5
  • 42
    • 84881465095 scopus 로고    scopus 로고
    • Inhibition of JNK and ERK pathways by SP600125- and U0126-enhanced osteogenic differentiation of bone marrow stromal cells
    • Doan TKP, Park KS, Kim HK, Park DS, Kim JH, et al. (2012) Inhibition of JNK and ERK pathways by SP600125- and U0126-enhanced osteogenic differentiation of bone marrow stromal cells. Tissue Engineering and Regenerative Medicine 9: 283-294.
    • (2012) Tissue Engineering and Regenerative Medicine , vol.9 , pp. 283-294
    • Doan, T.K.P.1    Park, K.S.2    Kim, H.K.3    Park, D.S.4    Kim, J.H.5
  • 43
    • 84928011509 scopus 로고    scopus 로고
    • Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells
    • PMID: 25572360
    • Kim BS, Kang HJ, Park JY, Lee J (2015) Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells. Exp Mol Med 47: e128. doi: 10.1038/emm.2014.95 PMID: 25572360
    • (2015) Exp Mol Med , vol.47 , pp. e128
    • Kim, B.S.1    Kang, H.J.2    Park, J.Y.3    Lee, J.4
  • 44
    • 84939263812 scopus 로고    scopus 로고
    • Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways
    • Zhang X, Zhou C, Zha X, Xu Z, Li L, et al. (2015) Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways. Mol Cell Biochem.
    • (2015) Mol Cell Biochem
    • Zhang, X.1    Zhou, C.2    Zha, X.3    Xu, Z.4    Li, L.5
  • 45
    • 80052545899 scopus 로고    scopus 로고
    • The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism
    • PMID: 21503740
    • Ducy P (2011) The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism. Diabetologia 54: 1291-1297. doi: 10.1007/s00125-011-2155-z PMID: 21503740
    • (2011) Diabetologia , vol.54 , pp. 1291-1297
    • Ducy, P.1
  • 46
    • 15844412402 scopus 로고    scopus 로고
    • Increased bone formation in osteocalcindeficient mice
    • PMID: 8684484
    • Ducy P, Desbois C, Boyce B, Pinero G, Story B, et al. (1996) Increased bone formation in osteocalcindeficient mice. Nature 382: 448-452. PMID: 8684484
    • (1996) Nature , vol.382 , pp. 448-452
    • Ducy, P.1    Desbois, C.2    Boyce, B.3    Pinero, G.4    Story, B.5
  • 47
    • 77953193743 scopus 로고    scopus 로고
    • CREB induces BMP2 transcription in osteoblasts and CREB knockout reduces bone mass in mice
    • Zhao M, Edwards J, Ko S, Parlato R, Harris S, et al. (2009) CREB induces BMP2 transcription in osteoblasts and CREB knockout reduces bone mass in mice. Bone 44: S27.
    • (2009) Bone , vol.44 , pp. S27
    • Zhao, M.1    Edwards, J.2    Ko, S.3    Parlato, R.4    Harris, S.5
  • 48
    • 0038624395 scopus 로고    scopus 로고
    • Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    • PMID: 12782654
    • Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, et al. (2003) Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17: 1352-1365. PMID: 12782654
    • (2003) Genes Dev , vol.17 , pp. 1352-1365
    • Peng, X.D.1    Xu, P.Z.2    Chen, M.L.3    Hahn-Windgassen, A.4    Skeen, J.5
  • 49
    • 66149119052 scopus 로고    scopus 로고
    • Akt promotes BMP2-mediated osteoblast differentiation and bone development
    • PMID: 19208758
    • Mukherjee A, Rotwein P (2009) Akt promotes BMP2-mediated osteoblast differentiation and bone development. J Cell Sci 122: 716-726. doi: 10.1242/jcs.042770 PMID: 19208758
    • (2009) J Cell Sci , vol.122 , pp. 716-726
    • Mukherjee, A.1    Rotwein, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.