Functional interaction of CFTR and ENaC in sweat glands

Pflugers Archiv European Journal of Physiology

Volumn 445, Issue 4, 2003, Pages 499-503

  Reddy, M M ^a   Quinton, P M ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

cAMP; cGMP; Chloride; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Epithelial Na+ channel; G proteins; Interaction

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TOXIN; CHLORIDE CHANNEL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; SODIUM CHANNEL; SODIUM CHLORIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

APICAL MEMBRANE; CELL MEMBRANE; CONFERENCE PAPER; CORRELATION ANALYSIS; CYSTIC FIBROSIS; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIUM CELL; HUMAN; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SWEAT GLAND;

EID: 0037277853     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-002-0959-x     Document Type: Conference Paper

References (19)

1. + channels. J Membr Biol 143:1-18
2. + transport in cystic fibrosis respiratory epithelia: abnormal basal rate and response to adenylate cyclase activation. J Clin Invest 78:1245-1252
3. + permeability in cystic fibrosis human primary cell cultures. J Physiol (Paris) 405:77-103
4. + channels in planar bilayer membranes. J Biol Chem 269:10235-10241
5. Ismailov II, Awayda MS, Jovov B, Berdiev BK, Fuller CM, Dedman JR, Kaetzel M, Benos DJ (1996) Regulation of epithelial sodium channels by the cystic fibrosis transmembrane conductance regulator. J Biol Chem 271:4725-4732
6. Knowles MR, Stutts MJ, Spock A, Fischer N, Gatzy JT, Boucher RC (1983) Abnormal ion permeation through cystic fibrosis respiratory epithelium. Science 221:1067-1070
7. Knowles MR, Robinson JM, Wood RE, Pue CA, Mentz WM, Wager GC, Gatzy JT, Boucher RC (1997) Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects. J Clin Invest 100:2588-2595
8. Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis W, Boucher RC (1998) Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airway disease. Cell 95:1005-1015
9. Quinton PM (1986) Missing Cl conductance in cystic fibrosis. Am J Physiol 251:C649-C652
10. Quinton PM (1990) Cystic fibrosis: a disease in electrolyte transport. FASEB J 4:2709-2717
11. Quinton PM, Reddy MM (1992) Control of CFTR Cl conductance by ATP levels through non-hydrolytic binding. Nature 360:79-81
12. Reddy MM, Quinton PM (1989) Altered electrical potential profile of human reabsorptive sweat duct cells in cystic fibrosis. Am J Physiol 257:C722-C727
13. Reddy MM, Quinton PM (1996) Deactivation of CFTR-Cl conductance by endogenous phosphatases in the native sweat duct. Am J Physiol 270:C474-C480
14. Reddy MM, Quinton PM (2000) CFTR independent cytosolic basic pH activation of ENaC in the native sweat duct (abstract). Pediatr Pulmonol [Suppl 20] R3:179
15. Reddy MM, Quinton PM (2001) cAMP-independent phosphorylation activation of CFTR by G-proteins in native human sweat duct. Am J Physiol 280:C604-C613
16. - channel function. Nature 402:301-304
17. Stutts MJ, Rossier BC, Boucher RC (1997) Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics. J Biol Chem 272:14037-14040
18. Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn JA, Rossier BC, Boucher RC (1995) CFTR as a cAMP-dependent regulator of sodium channels. Science 269:847-850
19. Welsh MJ (1987) Electrolyte transport by airway epithelia. Physiol Rev 67:1143-1184