Taste responses to naringin, a flavonoid, and the acceptance of grapefruit juice are related to genetic sensitivity to 6-n-propylthiouracil

American Journal of Clinical Nutrition

Volumn 66, Issue 2, 1997, Pages 391-397

  Drewnowski, Adam ^a,b   Henderson, Susan Ahlstrom ^a   Shore, Amy B ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Human Nutrition Program   (United States)

Author keywords

6 n Propylthiouracil; Cytochrome P 450; Dietary change; Genetic taste markers; Grapefruit juice; Naringin; Nontasters; Supertasters; Tasters

Indexed keywords

AURANTIIN; CYTOCHROME P450; PROPYLTHIOURACIL; SODIUM CHLORIDE;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; FRUIT; GENETIC MARKER; HEALTH PROGRAM; HERITABILITY; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; NUTRITION; TASTE ACUITY; TASTE AVERSION; TASTE PREFERENCE; VEGETABLE;

CITRUS X PARADISI;

EID: 1842338086     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/66.2.391     Document Type: Article

References (53)

1. Kennedy E, Meyers L, Layden W. The 1995 Dietary Guidelines for Americans: an overview. J Am Diet Assoc 1996;96:234-7.
2. Healthy People 2000. National Health Promotion and Disease Prevention Objectives. Washington, DC: US Department of Health and Human Services, Public Health Service, 1991. [DHHS Publication No. (PHS) 91-50213.]
3. US Department of Agriculture's Food Guide Pyramid. Human Nutrition Information Service. Washington, DC: US Department of Agriculture and USDHHS, 1992. (Home and Garden Bulletin no. 249.)
4. Glanz K, Hewitt A, Rudd J. Consumer behavior and nutrition education: an integrative review. J Nutr Educ 1992;24:267-77.
5. Havas S, Heimendinger J, Reynolds K. et al. 5-A-Day for better health: a new research initiative. J Am Diet Assoc 1994;94:32-6.
6. Contento I. The effectiveness of nutrition education and implications for nutrition education policy, programs, and research: a review of research. J Nutr Educ 1995;27:284-365.
7. Kristal AR, Beresford SAA, Lazovich D. Assessing change in diet-intervention research. Am J Clin Nutr 1994;59(suppl):185S-9S.
8. Kristal AR, White E, Shattuck AL, et al. Long-term maintenance of a low-fat diet: durability of fat-related dietary habits in the Women's Health Trial. J Am Diet Assoc 1992;92:553-9.
9. Moskowitz HR. Taste and food technology: acceptability, aesthetics, and preference. In: Carterette EC, Friedman MP, eds. Handbook of perception. New York: Academic Press, 1978:157-94.
10. Drewnowski A, Rock CL. The influence of genetic taste markers on food acceptance. Am J Clin Nutr 1995;62:506-11.
11. Rozin P, Vollmecke TA. Food likes and dislikes. Annu Rev Nutr 1986;6:433-56.
12. Meiselman HL, Waterman D, Symington LE. Armed Forces food preferences. Natick, MA: US Army Natick Development Center, 1974. (Technical report 75-63-FSL.)
13. Jerzsa-Latta M, Krondl M, Coleman P. Use and perceived attributes of cruciferous vegetables in terms of genetically-mediated taste sensitivity. Appetite 1990;15:127-34.
14. Kalmus H, Genetics of taste. In: Beidler LM, ed. Handbook of sensory physiology. Berlin: Springer-Verlag, 1971:165-79.
15. Fischer R. Gustatory, behavioral and pharmacological manifestations of chemoreception in man. In: Ohloff G, Thomas AF, eds. Gustation and olfaction. London: Academic Press, 1971:187-237.
16. Bartoshuk LM. Bitter taste of saccharin related to the genetic ability to taste the bitter substance 6-n-propylthiouracil. Science 1979;205:934-5.
17. Bartoshuk LM, Rifkin B, Marks LE, Hooper JE. Bitterness of KCl and benzoate: related to genetic status for sensitivity to PTC/Prop. Chem Senses 1988;13:517-28.
18. Gent JF, Bartoshuk LM. Sweetness of sucrose, neohesperidin dihydrochalcone, and saccharin is related to the genetic ability to taste the bitter substance 6-n-propylthiouracil. Chem Senses 1983;7:265-72.
19. Fischer R, Griffin F, England S, Garn SM. Taste thresholds and food dislikes. Nature 1961;191:1328.
20. Glanville EV, Kaplan AR. Food preference and sensitivity of taste for bitter compounds. Nature 1965;205:851-3.
21. Niewind A, Krondl M, Shrott M. Genetic influences on the selection of brassica vegetables by elderly individuals. Nutr Res 1988;8:13-20.
22. Mattes R, Labov J. Bitter taste responses to phenylthiocarbamide are not related to dietary goitrogen intake in human beings. J Am Diet Assoc 1989;89:692-4.
23. Guadagni DG, Maier VP, Turnbaugh JG. Effect of some citrus juice constituents on taste thresholds for limonin and naringin bitterness. J Sci Food Agric 1973;24:1277-88.
24. Guadagni DG, Maier VP, Turnbaugh JH. Some factors affecting sensory thresholds and relative bitterness of limonin and naringin. J Sci Food Agric 1974;25:1199-205.
25. Gaffield W, Lundin RE, Gentili B, Horowitz RM. C-2 Stereochemistry of naringin and its relation to taste and biosynthesis in maturing grapefruit. Bioorg Chem 1975;4:259-69.
26. Block G, Dresser CM, Hartman AM, Carroll MD. Nutrient sources in the American diet: quantitative data from the NHANES II Survey. II. Macronutrients and fats. Am J Epidemiol 1985;122:27-40.
27. Guengerich FP. Influence of nutrients and other dietary materials on cytochrome P-450 enzymes. Am J Clin Nutr 1995:61(suppl):651S-8S.
28. Bailey DG, Arnold JM, Spence JD. Grapefruit juice and drugs: how significant is the interaction? Clin Pharmacokinet 1994;26:91-8.
29. Bailey DG, Spence JD, Munoz C, Arnold JMO. Interaction of citrus juices with felodipine and nifedipine. Lancet 1991;337:268-9.
30. Fuhr U, Klittich K, Staib AH. Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br J Clin Pharmacol 1993;35:431-6.
31. Fuhr U, Kummert AL. The fate of naringin in humans: a key to grapefruit juice-drug interactions. Clin Pharmacol Ther 1995;58:365-73.
32. Ducharme MP, Warbasse LH, Edwards DJ. Disposition of intravenous and oral cyclosporine after administration with grapefruit juice. Clin Pharmacol Ther 1995;57:485-91.
33. Gordon PB, Holen I, Seglen PO. Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid. J Biol Chem 1995;270:5830-8.
34. Reedy FE, Bartoshuk LM, Miller IJ, Duffy VB, Yanagisawa K. Relationship among papillae, taste pores and 6-n-propylthiouracil (Prop) suprathreshold taste sensitivity. Chem Senses 1993;18:618-9.
35. Garner DM, Garfinkel PE. The Eating Attitudes Test: an index of the symptoms of anorexia nervosa. Psychol Med 1979;9:273-9.
36. Herman CP. Restrained eating. Psychiatr Clin North Am 1978;1: 595-607.
37. Fischer R. Genetics and gustatory chemoreception in man and other primates. In: Kare M, Maller O, eds. The chemicals senses and nutrition. Baltimore: Johns Hopkins University Press, 1967:61-81.
38. Fischer R, Griffin F. Pharmacogenetic aspects of gustation. Drug Res 1964;14:673-86.
39. Peryam DR, Pilgrim PJ. Hedonic scale method for measuring food preferences. Food Technol 1957;11:9-14.
40. Drewnowski A. Sweetness and obesity. In: Dobbing J, ed. Sweetness. Berlin: Spinger-Verlag, 1987:177-92.
41. Fischer R, Griffin F, Kaplan AR. Taste thresholds, cigarette smoking and food dislikes. Med Exp 1963;9:151-67.
42. Bartoshuk LM. The biological basis of food perception and acceptance. Food Qual Pref 1993;4:21-32.
43. Ducharme MP, Provenzano R, Dehoorne-Smith M, Edwards DJ. Trough concentration of cyclosporine following administration with grapefruit juice. Br J Clin Pharmacol 1993;36:457-9.
44. Adlercreutz H, Mousavi Y, Hockerstedt K. Diet and breast cancer. Acta Oncol 1992;31:175-81.
45. Boyd WC. Taste reactions to antithyroid substances. Science 1950; 112:153.
46. Anliker JA, Bartoshuk L, Ferris AM, Hooks LD. Children's food preferences and genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP). Am J Clin Nutr 1991;54:316-20.
47. Drewnowski A, Kurth C, Holden-Wiltse J, Saari J. Food preferences in human obesity: carbohydrates versus fats. Appetite 1992;18:207-21.
48. Drewnowski A, Henderson SA, Shore AB. Genetic sensitivity to 6-n-propylthiouracil (PROP) and hedonic responses to bitter and sweet tastes. Chem Senses 1997;22:27-37.
49. Fred Hutchinson Cancer Research Center. Food frequency questionnaire. Seattle: Fred Hutchinson Cancer Research Center, 1992.
50. Willett W. Food frequency methods. In: Nutritional epidemiology. New York: Oxford University Press, 1990:69-91.
51. Block G, Subar AF. Estimates of nutrient intake from a food frequency questionnaire: The 1987 National Health Interview Survey. J Am Diet Assoc 1992;92:969-77.
52. Bartoshuk LM. Separate worlds of taste. Psychol Today 1980;14: 48-63.
53. Glanz K, Lewis F, Rimer B. Health behavior and health education: theory, research and practice. San Francisco: Jossey-Bass, 1990.