G protein-coupled receptors in human fat taste perception

Chemical Senses

Volumn 37, Issue 2, 2012, Pages 123-139

  Galindo, Maria Mercedes ^a   Voigt, Nadine ^a   Stein, Julia ^b   Van lengerich, Jessica ^a   Raguse, Jan Dirk ^c   Hofmann, Thomas ^b   Meyerhof, Wolfgang ^a   Behrens, Maik ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Calcium imaging; Fatty acid; G protein coupled receptors; Papillae; Taste perception

Indexed keywords

G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR 40; LONG CHAIN FATTY ACID; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FATTY ACID ANALYSIS; G PROTEIN COUPLED RECEPTOR 120 GENE; G PROTEIN COUPLED RECEPTOR 40 GENE; GENE; GENE EXPRESSION SYSTEM; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; LIPID METABOLISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLFACTORY RECEPTOR; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SENSITIVITY ANALYSIS; SENSORY ANALYSIS; TASTE ACUITY; TASTE BUD; TASTE DISCRIMINATION;

RODENTIA;

EID: 84855900663     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjr069     Document Type: Article

References (68)

1. Behrens M, Bartelt J, Reichling C, Winnig M, Kuhn C, Meyerhof W. 2006. Members of RTP and REEP gene families influence functional bitter taste receptor expression. J Biol Chem. 281:20650-20659.
2. Behrens M, Foerster S, Staehler F, Raguse JD, Meyerhof W. 2007. Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells. J Neurosci. 27:12630-12640.
3. Behrens M, Meyerhof W, Hellfritsch C, Hofmann T. 2011. Sweet and umami taste: natural products, their chemosensory targets, and beyond. Angew Chem Int Ed Engl. 50:2220-2242.
4. Bourne HR. 1997. How receptors talk to trimeric G proteins. Curr Opin Cell Biol. 9:134-142.
5. Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, et al. 2003. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem. 278:11303-11311.
6. Brockhoff A, Behrens M, Massarotti A, Appendino G, Meyerhof W. 2007. Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium. J Agric Food Chem. 55:6236-6243.
7. Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, et al. 2003. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem. 278:11312-11319.
8. Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. 2002. The human TAS2R16 receptor mediates bitter taste in response to betaglucopyranosides. Nat Genet. 32:397-401.
9. Cartoni C, Yasumatsu K, Ohkuri T, Shigemura N, Yoshida R, Godinot N, le Coutre J, Ninomiya Y, Damak S. 2010. Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci. 30:8376-8382.
10. Chale-Rush A, Burgess JR, Mattes RD. 2007a. Evidence for human orosensory (taste?) sensitivity to free fatty acids. Chem Senses. 32: 423-431.
11. Chale-Rush A, Burgess JR, Mattes RD. 2007b. Multiple routes of chemosensitivity to free fatty acids in humans. Am J Physiol Gastrointest Liver Physiol. 292:G1206-G1212.
12. Chaudhari N, Landin AM, Roper SD. 2000. A metabotropic glutamate receptor variant functions as a taste receptor. Nat Neurosci. 3:113-119.
13. Conklin BR, Bourne HR. 1993. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors. Cell. 73:631-641.
14. Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR. 1993. Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 363:274-276.
15. Coort SL, Willems J, Coumans WA, van der Vusse GJ, Bonen A, Glatz JF, Luiken JJ. 2002. Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake. Mol Cell Biochem. 239:213-219.
16. Fang G, Weiser B, Visosky A, Moran T, Burger H. 1999. PCR-mediated recombination: a general method applied to construct chimeric infectious molecular clones of plasma-derived HIV-1 RNA. Nat Med. 5:239-242.
17. Fukuwatari T, Kawada T, Tsuruta M, Hiraoka T, Iwanaga T, Sugimoto E, Fushiki T. 1997. Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats. FEBS Lett. 414:461-464.
18. Fukuwatari T, Shibata K, Iguchi K, Saeki T, Iwata A, Tani K, Sugimoto E, Fushiki T. 2003. Role of gustation in the recognition of oleate and triolein in anosmic rats. Physiol Behav. 78:579-583.
19. Gaillard D, Laugerette F, Darcel N, El-Yassimi A, Passilly-Degrace P, Hichami A, Khan NA, Montmayeur JP, Besnard P. 2008. The gustatory pathway is involved in CD36-mediated orosensory perception of longchain fatty acids in the mouse. FASEB J. 22:1458-1468.
20. Gilbertson TA, Fontenot DT, Liu L, Zhang H, Monroe WT. 1997. Fatty acid modulation of K+ channels in taste receptor cells: gustatory cues for dietary fat. Am J Physiol. 272:C1203-C1210.
21. Gilbertson TA, Liu L, Kim I, Burks CA, Hansen DR. 2005. Fatty acid responses in taste cells from obesity-prone and -resistant rats. Physiol Behav. 86:681-690.
22. Greenberg D, Smith GP. 1996. The controls of fat intake. Psychosom Med. 58:559-569.
23. Hiraoka T, Fukuwatari T, Imaizumi M, Fushiki T. 2003. Effects of oral stimulation with fats on the cephalic phase of pancreatic enzyme secretion in esophagostomized rats. Physiol Behav. 79:713-717.
24. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G. 2005. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med. 11:90-94.
25. Honore E, Barhanin J, Attali B, Lesage F, Lazdunski M. 1994. External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. Proc Natl Acad Sci U S A. 91:1937-1941.
26. Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi K, Hosoya M, Tanaka Y, Uejima H, et al. 2003. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature. 422:173-176.
27. Kawai T, Fushiki T. 2003. Importance of lipolysis in oral cavity for orosensory detection of fat. Am J Physiol Regul Integr Comp Physiol. 285: R447-R454.
28. Laugerette F, Passilly-Degrace P, Patris B, Niot I, Febbraio M, Montmayeur JP, Besnard P. 2005. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest. 115:3177-3184.
29. Lawson H. 1995. Food oils and fats: technology, utilization, and nutrition. New York: Chapman & Hall.
30. Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, Van Damme J, et al. 2003. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem. 278: 25481-25489.
31. Lichtarge O, Bourne HR, Cohen FE. 1996. Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G proteinreceptor complex. Proc Natl Acad Sci U S A. 93:7507-7511.
32. Liu L, Hansen DR, Kim I, Gilbertson TA. 2005. Expression and characterization of delayed rectifying K+ channels in anterior rat taste buds. Am J Physiol Cell Physiol. 289:C868-C880.
33. Matsumura S, Eguchi A, Mizushige T, Kitabayashi N, Tsuzuki S, Inoue K, Fushiki T. 2009. Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice. Neurosci Lett. 450:186-190.
34. Matsumura S, Mizushige T, Yoneda T, Iwanaga T, Tsuzuki S, Inoue K, Fushiki T. 2007. GPR expression in the rat taste bud relating to fatty acid sensing. Biomed Res. 28:49-55.
35. Mattes RD. 2007. Effects of linoleic acid on sweet, sour, salty, and bitter taste thresholds and intensity ratings of adults. Am J Physiol Gastrointest Liver Physiol. 292:G1243-G1248.
36. Mattes RD. 2009a. Oral detection of short-, medium-, and long-chain free fatty acids in humans. Chem Senses. 34:145-150.
37. Mattes RD. 2009b. Oral thresholds and suprathreshold intensity ratings for free fatty acids on 3 tongue sites in humans: implications for transduction mechanisms. Chem Senses. 34:415-423.
38. McCormack DN, Clyburn VL, Pittman DW. 2006. Detection of free fatty acids following a conditioned taste aversion in rats. Physiol Behav. 87:582-594.
39. McKay MC, Worley JF3rd. 2001. Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms. Am J Physiol Cell Physiol. 281:C1277-C1284.
40. McLaughlin SK, McKinnon PJ, Margolskee RF. 1992. Gustducin is a tastecell-specific G protein closely related to the transducins. Nature. 357:563-569.
41. Miller IJ Jr, editor. 1995. Anatomy of the peripheral taste system. New York: Dekker. p. 521-547.
42. Mindell S, Smith GP, Greenberg D. 1990. Corn oil and mineral oil stimulate sham feeding in rats. Physiol Behav. 48:283-287.
43. Ming D, Ninomiya Y, Margolskee RF. 1999. Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds. Proc Natl Acad Sci U S A. 96:9903-9908.
44. Mombaerts P. 2004. Genes and ligands for odorant, vomeronasal and taste receptors. Nat Rev Neurosci. 5:263-278.
45. Moore K, Zhang Q, Murgolo N, Hosted T, Duffy R. 2009. Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants. Comp Biochem Physiol B Biochem Mol Biol. 154:419-426.
46. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS. 2002. An amino-acid taste receptor. Nature. 416:199-202.
47. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS. 2001. Mammalian sweet taste receptors. Cell. 106:381-390.
48. Offermanns S, Simon MI. 1995. G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C. J Biol Chem. 270:15175-15180.
49. Pittman D, Crawley ME, Corbin CH, Smith KR. 2007. Chorda tympani nerve transection impairs the gustatory detection of free fatty acids in male and female rats. Brain Res. 1151:74-83.
50. Pittman DW, Labban CE, Anderson AA, O'Connor HE. 2006. Linoleic and oleic acids alter the licking responses to sweet, salt, sour, and bitter tastants in rats. Chem Senses. 31:835-843.
51. Ramirez I. 1993. Role of olfaction in starch and oil preference. Am J Physiol. 265:R1404-R1409.
52. Reichling C, Meyerhof W, Behrens M. 2008. Functions of human bitter taste receptors depend on N-glycosylation. J Neurochem. 106:1138-1148.
53. Rolls ET, Critchley HD, Browning AS, Hernadi I, Lenard L. 1999. Responses to the sensory properties of fat of neurons in the primate orbitofrontal cortex. J Neurosci. 19:1532-1540.
54. Ruiz-Avila L, Wong GT, Damak S, Margolskee RF. 2001. Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in alpha-gustducin. Proc Natl Acad Sci U S A. 98:8868-8873.
55. Schiffman S, Dackis C. 1975. Taste of nutrients: amino acids, vitamins, and fatty acids. Atten Percept Psychophys. 17:140-146.
56. Schlutt B, Moran N, Schieberle P, Hofmann T. 2007. Sensory-directed identification of creaminess-enhancing volatiles and semivolatiles in fullfat cream. J Agric Food Chem. 55:9634-9645.
57. Simons PJ, Kummer JA, Luiken JJ, Boon L. 2010. Apical CD36 immunolocalization in human and porcine taste buds from circumvallate and foliate papillae. Acta Histochem. doi:10.1016/j.acthis.2010.08.006.
58. Slack JP, Brockhoff A, Batram C, Menzel S, Sonnabend C, Born S, Galindo MM, Kohl S, Thalmann S, Ostopovici-Halip L, et al. 2010. Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr Biol. 20:1104-1109.
59. Smith JC, Fisher EM, Maleszewski V, McClain B. 2000. Orosensory factors in the ingestion of corn oil/sucrose mixtures by the rat. Physiol Behav. 69:135-146.
60. Stewart JE, Feinle-Bisset C, Golding M, Delahunty C, Clifton PM, Keast RS. 2010. Oral sensitivity to fatty acids, food consumption and BMI in human subjects. Br J Nutr. 104:145-152.
61. Stratford JM, Curtis KS, Contreras RJ. 2006. Chorda tympani nerve transection alters linoleic acid taste discrimination by male and female rats. Physiol Behav. 89:311-319.
62. Takeda M, Sawano S, Imaizumi M, Fushiki T. 2001. Preference for corn oil in olfactory-blocked mice in the conditioned place preference test and the two-bottle choice test. Life Sci. 69:847-854.
63. Tepper BJ, Nurse RJ. 1997. Fat perception is related to PROP taster status. Physiol Behav. 61:949-954.
64. Tsuruta M, Kawada T, Fukuwatari T, Fushiki T. 1999. The orosensory recognition of long-chain fatty acids in rats. Physiol Behav. 66:285-288.
65. Ueda T, Ugawa S, Yamamura H, Imaizumi Y, Shimada S. 2003. Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells. J Neurosci. 23:7376-7380.
66. Wong GT, Gannon KS, Margolskee RF. 1996. Transduction of bitter and sweet taste by gustducin. Nature. 381:796-800.
67. Wood FW, Goff TC. 1973. The determination of the effective shear rate in the Brabender Viscograph and in other systems of complex geometry. Starch-Stärke. 25:89-91.
68. Zhu X, Birnbaumer L. 1996. G protein subunits and the stimulation of phospholipase C by Gs-and Gi-coupled receptors: lack of receptor selectivity of Galpha(16) and evidence for a synergic interaction between Gbeta gamma and the alpha subunit of a receptor activated G protein. Proc Natl Acad Sci U S A. 93:2827-2831.