Transient receptor potential vanilloid 4 ion channel functions as a pruriceptor in epidermal keratinocytes to evoke histaminergic itch

Journal of Biological Chemistry

Volumn 291, Issue 19, 2016, Pages 10252-10262

  Chen, Yong ^a   Fang, Quan ^a   Wang, Zilong ^a   Zhang, Jennifer Y ^a   MacLeod, Amanda S ^a   Hall, Russell P ^a   Liedtke, Wolfgang B ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELLS; CHEMICAL ACTIVATION; CYTOLOGY; ENZYMES; MACHINERY; NEURONS; PHOSPHORYLATION;

BASIC CONCEPTS; CALCIUM INFLUX; CRITICAL COMPONENT; MITOGEN ACTIVATED PROTEIN KINASE; SELECTIVE INHIBITORS; SENSORY NEURONS; TOPICAL APPLICATION; TRANSIENT RECEPTOR POTENTIAL VANILLOID;

CELL SIGNALING;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CALCIUM ION; CHLOROQUINE; ENDOTHELIN 1; GSK 1016790A; GSK 205; GSK 2193874; HISTAMINE; MITOGEN ACTIVATED PROTEIN KINASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 4; TRPV4 PROTEIN, MOUSE; VANILLOID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; INTRACELLULAR SIGNALING; KERATINOCYTE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PRURITUS; SKIN PRURITUS; TREATMENT OUTCOME; TRPV4 GENE; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIBODY SPECIFICITY; BIOSYNTHESIS; CALCIUM SIGNALING; DRUG EFFECTS; EPIDERMIS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; RADIATION RESPONSE; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

ANIMALS; CALCIUM SIGNALING; ENDOTHELIN-1; EPIDERMIS; GENE EXPRESSION REGULATION; HISTAMINE; KERATINOCYTES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; ORGAN SPECIFICITY; PRURITUS; TRPV CATION CHANNELS; ULTRAVIOLET RAYS;

EID: 84966389702     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.716464     Document Type: Article

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