Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in mice

Chemical Senses

Volumn 37, Issue 9, 2012, Pages 897-911

  Voigt, Anja ^a,b   Hübner, Sandra ^a   Lossow, Kristina ^a   Hermans Borgmeyer, Irm ^b   Boehm, Ulrich ^b,c   Meyerhof, Wolfgang ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

Bitter; Gene targeting; Knock in; Knock out; Taste receptor; Umami

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GREEN FLUORESCENT PROTEIN; PROTEIN TAS1R1; PROTEIN TAS2R131; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BITTER TASTE; CELL LABELING; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FLUORESCENCE; GENE; GENETIC LABELING; GENETIC PROCEDURES; MOUSE; NONHUMAN; OPEN READING FRAME; PALATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; SENSORY NERVE CELL; TAS1R1 GENE; TAS2R131 GENE; TASTE RECEPTOR CELL; TESTIS; THYMUS; TISSUE DISTRIBUTION; VOMERONASAL ORGAN;

ALLELES; ANIMALS; GENE KNOCK-IN TECHNIQUES; GENETIC VECTORS; IN SITU HYBRIDIZATION, FLUORESCENCE; LUMINESCENT PROTEINS; MICE; MICE, INBRED C57BL; OPEN READING FRAMES; PALATE; RECEPTORS, G-PROTEIN-COUPLED; TASTE BUDS;

EID: 84867778180     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjs082     Document Type: Article

References (64)

1. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS. 2000. A novel family of mammalian taste receptors. Cell. 100:693-702.
2. Bartel DL, Sullivan SL, Lavoie EG, Sevigny J, Finger TE. 2006. Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds. J Comp Neurol. 497: 1-12.
3. Behrens M, Foerster S, Staehler F, Raguse JD, Meyerhof W. 2007. Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogeneous population of bitter responsive taste receptor cells. J Neurosci. 27:12630-12640.
4. Behrens M, Meyerhof W. 2011. Gustatory and extragustatory functions of mammalian taste receptors. Physiol Behav. 105:4-13.
5. Behrens M, Meyerhof W, Hellfritsch C, Hofmann T. 2011. Sweet and umami taste: natural products, their chemosensory targets, and beyond. Angew Chem Int Ed Engl. 50:2220-2242.
6. Bezencon C, le Coutre J, Damak S. 2007. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses. 32:41-49.
7. Bunting M, Bernstein KE, Greer JM, Capecchi MR, Thomas KR. 1999. Targeting genes for self-excision in the germ line. Genes Dev. 13:1524-1528.
8. Caicedo A, Roper SD. 2001. Taste receptor cells that discriminate between bitter stimuli. Science. 291(5508):1557-60.
9. Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJ, Zuker CS. 2010. The cells and peripheral representation of sodium taste in mice. Nature. 464:297-301.
10. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ. 2000. T2Rs function as bitter taste receptors. Cell. 100:703-711.
11. Chang RB, Waters H, Liman ER. 2010. A proton current drives action potentials in genetically identified sour taste cells. Proc Natl Acad Sci USA. 107:22320-22325.
12. Chaudhari N, Roper SD. 2010. The cell biology of taste. J Cell Biol. 190:285-296.
13. Clapp TR, Medler KF, Damak S, Margolskee RF, Kinnamon SC. 2006. Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25. BMC Biol. 4:7.
14. Damak S, Mosinger B, Margolskee RF. 2008. Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice. BMC Neurosci. 9:96.
15. Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Perez CA, Shigemura N, Yoshida R, Mosinger B, Jr., Glendinning JI, Ninomiya Y, Margolskee RF. 2006. Trpm5 null mice respond to bitter, sweet, and umami compounds. Chem Senses. 31:253-264.
16. Danilova V, Hellekant, G. 2003. Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice. BMC Neurosci 4: 5.
17. DeFazio RA, Dvoryanchikov G, Maruyama Y, Kim JW, Pereira E, Roper SD, Chaudhari N. 2006. Separate populations of receptor cells and presynaptic cells in mouse taste buds. J Neurosci. 26:3971-3980.
18. Elliott RA, Kapoor S, Tincello DG. 2011. Expression and distribution of the sweet taste receptor isoforms T1R2 and T1R3 in human and rat bladders. J Urol. 186:2455-2462.
19. Finger TE, Bottger B, Hansen A, Anderson KT, Alimohammadi H, Silver WL. Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration. Proc Natl Acad Sci USA. 100:8981-8986.
20. Hoon MA, Adler E, Lindemeier J, Battey JF, Ryba NJ, Zuker CS. 1999. Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 96:541-551.
21. Horowitz LF, Montmayeur JP, Echelard Y, Buck LB. 1999. A genetic approach to trace neural circuits. Proc Natl Acad Sci USA. 96:3194-3199.
22. Huang AL, Chen X, Hoon MA, Chandrashekar J, Guo W, Trankner D, Ryba NJ, Zuker CS. 2006. The cells and logic for mammalian sour taste detection. Nature. 442:934-938.
23. Huang YJ, Maruyama Y, Dvoryanchikov G, Pereira E, Chaudhari N, Roper SD. 2007. The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci USA. 104:6436-6441.
24. Iwatsuki K, Ichikawa R, Hiasa M, Moriyama Y, Torii K, Uneyama H. 2009. Identification of the vesicular nucleotide transporter (VNUT) in taste cells. Biochem Biophys Res Commun. 388:1-5.
25. Iwatsuki K, Nomura M, Shibata A, Ichikawa R, Enciso PL, Wang L, Takayanagi R, Torii K, Uneyama H. 2010. Generation and characterization of T1R2-LacZ knock-in mouse. Biochem Biophys Res Commun. 402:495-499.
26. Kim MR, Kusakabe Y, Miura H, Shindo Y, Ninomiya Y, Hino A. 2003. Regional expression patterns of taste receptors and gustducin in the mouse tongue. Biochem Biophys Res Commun. 312:500-506.
27. Kim JW, Roberts C, Maruyama Y, Berg S, Roper S, Chaudhari N. 2006. Faithful expression of GFP from the PLCbeta2 promoter in a functional class of taste receptor cells. Chem Senses. 31:213-219.
28. Kinnamon SC, Vandenbeuch A. 2009. Receptors and transduction of umami taste stimuli. International Symposium on Olfaction and Taste, 55-59.
29. Kusuhara Y, Yasumatsu K, Ohkuri T, Yoshida R, Boehm U, Voigt A, Hübner S, Maeda K, Meyerhof W, Ninomiya Y. 2011. Involvement of T1R-independent receptors in detection of umami taste in mice. The European Chemoreception Research Organisation. XXIth Congress. Program and Abstracts Book, Manchester, UK, 107.
30. Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E. 2002. Human receptors for sweet and umami taste. Proc Natl Acad Sci USA. 99:4692-4696.
31. Li F, Zhou M. 2012. Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice. Mol Hum Reprod. 18:289-297.
32. Liu D, Liman ER. 2003. Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc Natl Acad Sci USA. 100:15160-15165.
33. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP. 2007. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci USA. 104:15075-15080.
34. Matsunami H, Montmayeur JP, Buck LB. 2000. A family of candidate taste receptors in human and mouse. Nature. 404:601-604.
35. Max M, Shanker YG, Huang L, Rong M, Liu Z, Campagne F, Weinstein H, Damak S, Margolskee RF. 2001. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat Genet. 28:58-63.
36. McLaughlin SK, McKinnon PJ, Margolskee RF. 1992. Gustducin is a tastecell-specific G protein closely related to the transducins. Nature. 357:563-569.
37. Meyer D, Voigt A, Widmayer P, Borth H, Huebner S, Breit A, Marschall S, de Angelis MH, Boehm U, Meyerhof W, et al. 2012. Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca(2)(+) and cAMP concentrations in spermatozoa. PLoS ONE. 7:e32354.
38. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M. 2010. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses. 35:157-170.
39. Mitsui S, Saito M, Mori K, Yoshihara Y. 2007. A transcriptional enhancer that directs telencephalon-specific transgene expression in mouse brain. Cereb Cortex. 17:522-530.
40. Mueller KL, Hoon MA, Erlenbach I, Chandrashekar J, Zuker CS, Ryba NJ. 2005. The receptors and coding logic for bitter taste. Nature. 434:225-229.
41. Murray RG. 1973. The ultrastructure of taste buds. In: Friedmann, I. (ed.) The Ultrastructure of Sensory Organs. North Holland, Amsterdam.: 1-81.
42. Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC. 1993. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA. 90:8424-8428.
43. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS. An amino-acid taste receptor. Nature. 416:199-202.
44. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS. 2001. Mammalian sweet taste receptors. Cell. 106:381-390.
45. Ohmoto M, Matsumoto I, Yasuoka A, Yoshihara Y, Abe K. 2008. Genetic tracing of the gustatory and trigeminal neural pathways originating from T1R3-expressing taste receptor cells and solitary chemoreceptor cells. Mol Cell Neurosci. 38:505-517.
46. Ohmoto M, Okada S, Nakamura S, Abe K, Matsumoto I. 2011. Mutually exclusive expression of Galphaia and Galpha14 reveals diversification of taste receptor cells in zebrafish. J Comp Neurol. 519:1616-1629.
47. Perez CA, Huang L, Rong M, Kozak JA, Preuss AK, Zhang H, Max M, Margolskee RF. 2002. A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci. 5:1169-1176.
48. Prawitt D, Monteilh-Zoller MK, Brixel L, Spangenberg C, Zabel B, Fleig A, Penner R. 2003. TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i. Proc Natl Acad Sci USA. 100:15166-15171.
49. Romanov RA, Rogachevskaja OA, Bystrova MF, Jiang P, Margolskee RF, Kolesnikov SS. 2007. Afferent neurotransmission mediated by hemichannels in mammalian taste cells. EMBO J. 26:657-667.
50. Rossler P, Kroner C, Freitag J, Noe J, Breer H. 1998. Identification of a phospholipase C beta subtype in rat taste cells. Eur J Cell Biol. 77:253-261.
51. Rozengurt E. 2006. Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and alpha-gustducin in the mammalian gut. Am J Physiol Gastrointest Liver Physiol. 291:G171-G177.
52. Singh N, Vrontakis M, Parkinson F, Chelikani P. 2011. Functional bitter taste receptors are expressed in brain cells. Biochem Biophys Res Commun. 406:146-151.
53. Stone LM, Barrows J, Finger TE, Kinnamon SC. 2007. Expression of T1Rs and gustducin in palatal taste buds of mice. Chem Senses. 32:255-262.
54. Tamamaki N, Yanagawa Y, Tomioka R, Miyazaki J, Obata K, Kaneko T. 2003. Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. J Comp Neurol. 467:60-79.
55. Tizzano M, Cristofoletti M, Sbarbati A, Finger TE. 2011. Expression of taste receptors in solitary chemosensory cells of rodent airways. BMC Pulm Med. 11:3.
56. Tizzano M, Gulbransen BD, Vandenbeuch A, Clapp TR, Herman JP, Sibhatu HM, Churchill ME, Silver WL, Kinnamon SC, Finger TE. 2010. Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals. Proc Natl Acad Sci USA. 107:3210-3215.
57. Tomchik SM, Berg S, Kim JW, Chaudhari N, Roper SD. 2007. Breadth of tuning and taste coding in mammalian taste buds. J Neurosci. 27:10840-10848.
58. Wong GT, Gannon KS, Margolskee RF. 1996. Transduction of bitter and sweet taste by gustducin. Nature. 381:796-800.
59. Wu SV, Chen MC, Rozengurt E. 2005. Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat. Physiol Genomics. 22:139-149.
60. Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E. Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci USA. 99:2392-2397.
61. Yasumatsu K, Ogiwara Y, Takai S, Yoshida R, Iwatsuki K, Torii K, Margolskee RF, Ninomiya Y. 2012. Umami taste in mice uses multiple receptors and transduction pathways. J Physiol. 590:1155-1170.
62. Yasuo T, Kusuhara Y, Yasumatsu K, Ninomiya Y. 2008. Multiple receptor systems for glutamate detection in the taste organ. Biol Pharm Bull. 31:1833-1837.
63. Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ. 2003. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 112:293-301.
64. Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, Zuker CS. 2003. The receptors for mammalian sweet and umami taste. Cell. 115:255-266.