Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 67 A, Issue 4, 2012, Pages 336-344

  Shin, Yu Kyong ^a   Cong, Wei Na ^b   Cai, Huan ^b   Kim, Wook ^a   Maudsley, Stuart ^a   Egan, Josephine M ^a   Martin, Bronwen ^b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b Metabolism Unit   (United States)

Author keywords

Aging; Glucagon like peptide 1; Sweet taste; T1R3; Taste buds

Indexed keywords

ANIMALIA; ERINACEIDAE; MUS;

G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1; SHH PROTEIN, MOUSE; SONIC HEDGEHOG PROTEIN; TASTE RECEPTORS, TYPE 1;

AGING; ANIMAL; ARTICLE; CYTOLOGY; MALE; METABOLISM; MOUSE; TASTE; TASTE BUD;

AGING; ANIMALS; GLUCAGON-LIKE PEPTIDE 1; HEDGEHOG PROTEINS; MALE; MICE; RECEPTORS, G-PROTEIN-COUPLED; TASTE; TASTE BUDS;

EID: 84859047043     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glr192     Document Type: Article

References (58)

1. Kline DW. Optimizing the visibility of displays for older observers. Exp Aging Res. 1994;20:11-23. (Pubitemid 24117064)
2. Schiffman SS. Perception of taste and smell in elderly persons. Crit Rev Food Sci Nutr. 1993;33:17-26.
3. Scott K. Taste recognition: food for thought. Neuron. 2005;48:455-464. (Pubitemid 41551950)
4. Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS. The receptors and cells for mammalian taste. Nature. 2006;444:288-294. (Pubitemid 44764097)
5. Roper SD. Cell communication in taste buds. Cell Mol Life Sci. 2006;63:1494-1500. (Pubitemid 44156746)
6. Pumplin DW, Yu C, Smith DV. Light and dark cells of rat vallate taste buds are morphologically distinct cell types. J Comp Neurol. 1997;378:389-410. (Pubitemid 27061464)
7. Vandenbeuch A, Clapp TR, Kinnamon SC. Amiloride-sensitive channels in type I fungiform taste cells in mouse. BMC Neurosci. 2008;9:1-13.
8. Tomchik SM, Berg S, Kim JW, Chaudhari N, Roper SD. Breadth of tuning and taste coding in mammalian taste buds. J Neurosci. 2007;27:10840-10848. (Pubitemid 47535853)
9. Akabas MH, Dodd J, Al-Awqati Q. A bitter substance induces a rise in intracellular calcium in a subpopulation of rat taste cells. Science. 1988;242:1047-1050.
10. Rössler P, Kroner C, Freitag J, Noè J, Breer H. Identification of a phospholipase C beta subtype in rat taste cells. Eur J Cell Biol. 1998;77:253-261. (Pubitemid 28529067)
11. Zhang Y, Hoon MA, Chandrashekar J, et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 2003;112:293-301. (Pubitemid 36183651)
12. DeFazio RA, Dvoryanchikov G, Maruyama Y, et al. Separate populations of receptor cells and presynaptic cells in mouse taste buds. J Neurosci. 2006;26:3971-3980. (Pubitemid 44315417)
13. Huang YJ, Maruyama Y, Dvoryanchikov G, Pereira E, Chaudhari N, Roper SD. The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci USA. 2007;104:6436-6441. (Pubitemid 47186112)
14. Finger TE, Danilova v, Barrows J, et al. ATP signaling is crucial for communication from taste buds to gustatory nerves. Science. 2005;310:1495-1499. (Pubitemid 41746346)
15. Yang R, Stoick CL, Kinnamon JC. Synaptobrevin-2-like immunoreactivity is associated with vesicles at synapses in rat circumvallate taste buds. J Comp Neurol. 2004;471:59-71. (Pubitemid 38282965)
16. Huang YJ, Maruyama Y, Lu KS, et al. Using biosensors to detect the release of serotonin from taste buds during taste stimulation. Arch Ital Biol. 2005;143:87-96. (Pubitemid 40942943)
17. Takeda M, Suzuki Y, Obara N, Nagai Y. Neural cell adhesion molecule of taste buds. J Electron Microsc (Tokyo). 1992;41:375-380.
18. Huang AL, Chen XK, Hoon MA, et al. The cells and logic for mammalian sour taste detection. Nature. 2006;442:934-938. (Pubitemid 44285950)
19. Doran JF, Jackson P, Kynoch PA, Thompson RJ. Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis. J Neurochem. 1983;40:1542-1547. (Pubitemid 13106931)
20. Thompson RJ, Doran JF, Jackson P, Dhillon AP, Rode J. PGP 9.5-a new marker for vertebrate neurons and neuroendocrine cells. Brain Res. 1983;278:224-228. (Pubitemid 14219291)
21. Miura H, Kusakabe Y, Harada S. Cell lineage and differentiation in taste buds. Arch Histol Cytol. 2006;69:209-225.
22. Jaskoll T, Leo T, Witcher D, et al. Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis. Dev Dyn. 2004;229:722-732. (Pubitemid 38429101)
23. Miura H, Kusakabe Y, Sugiyama C, et al. Shh and Ptc are associated with taste bud maintenance in the adult mouse. Mech Dev. 2001;106:143-145. (Pubitemid 32701083)
24. Martin B, Maudsley S, White CM, Egan JM. Hormones in the naso-oropharynx: endocrine modulation of taste and smell. Trends Endocrinol Metab. 2009;20:163-170.
25. Shin YK, Martin B, Golden E, et al. Modulation of taste sensitivity by GLP-1 signaling. J Neurochem. 2008;106:455-463. (Pubitemid 351840219)
26. Martin B, Dotson CD, Shin YK, et al. Modulation of taste sensitivity by GLP-1 signaling in taste buds. Ann N Y Acad Sci. 2009;1170:98-101.
27. Kawai K, Sugimoto K, Nakashima K, Miura H, Ninomiya Y. Leptin as a modulator of sweet taste sensitivities in mice. Proc Natl Acad Sci USA. 2000;97:11044-11049.
28. Shigemura N, Miura H, Kusakabe Y, Hino A, Ninomiya Y. Expression of leptin receptor (Ob-R) isoforms and signal transducers and activators of transcription (STATs) mRNAs in the mouse taste buds. Arch Histol Cytol. 2003;66:253-260. (Pubitemid 37221577)
29. Shigemura N, Ohta R, Kusakabe Y, et al. Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology. 2004;145:839-847. (Pubitemid 38183828)
30. Martin B, Shin YK, White CM, et al. Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression. Diabetes. 2010;59:1143-1152.
31. Shin YK, Martin B, Kim W, et al. Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants. PLoS One. 2010;5:e12729.
32. Schiffman SS. Effects of aging on the human taste system. Ann N Y Acad Sci. 2009;1170:725-729.
33. McBride MR, Mistretta CM. Taste responses from the chorda tympani nerve in young and old Fischer rats. J Gerontol. 1986;41:306-314. (Pubitemid 16069320)
34. Smith JC. The history of the "Davis Rig". Appetite. 2001;36:93-98.
35. Bartel DL, Sullivan SL, Lavoie EG, Sévigny J, Finger TE. Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds. J Comp Neurol. 2006;497:1-12. (Pubitemid 43844564)
36. Boughter JD Jr., St John SJ, Noel DT, Ndubuizu O, Smith DV. A brief-access test for bitter taste in mice. Chem Senses. 2002;27:133-142. (Pubitemid 34223962)
37. Glendinning JI, Gresack J, Spector AC. A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function. Chem Senses. 2002;27:461-474. (Pubitemid 34693006)
38. Dotson CD, Spector AC. The relative affective potency of glycine, L-serine and sucrose as assessed by a brief-access taste test in inbred strains of mice. Chem Senses. 2004;29:489-498. (Pubitemid 41289307)
39. Glendinning JI, Yiin YM, Ackroff K, Sclafani A. Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents. Physiol Behav. 2008;93:757-765. (Pubitemid 351381073)
40. Damak S, Rong M, Yasumatsu K, et al. Detection of sweet and umami taste in the absence of taste receptor T1r3. Science. 2003;301:850-853. (Pubitemid 36962629)
41. Zhao GQ, Zhang Y, Hoon MA, et al. The receptors for mammalian sweet and umami taste. Cell. 2003;115:255-266. (Pubitemid 37487700)
42. Nelson TM, Munger SD, Boughter JD Jr. Taste sensitivities to PROP and PTC vary independently in mice. Chem Senses. 2003;28:695-704. (Pubitemid 39144862)
43. Beidler LM, Smallman RL. Renewal of cells within taste buds. J Cell Biol. 1965;27:263-272.
44. Farbman AI. Renewal of taste bud cells in rat circumvallate papillae. Cell Tissue Kinet. 1980;13:349-357. (Pubitemid 10078641)
45. Delay RJ, Kinnamon JC, Roper SD. Ultrastructure of mouse vallate taste buds: II. Cell types and cell lineage. J Comp Neurol. 1986;253:242-252. (Pubitemid 17170393)
46. Fukunada A. Age-related changes in renewal of taste bud cells and expression of taste cell-specific proteins in mice. Kokubyo Gakkai Zasshi. 2005;72:84-89.
47. Gaillard D, Barlow LA. Taste bud cells of adult mice are responsive to Wnt/b-catenin signaling: implications for the renewal of mature taste cells. Genesis. 2011;49:295-306.
48. Takeda M, Suzuki Y, Obara N, Nagai Y. Apoptosis in mouse taste buds after denervation. Cell Tissue Res. 1996;286:55-62. (Pubitemid 26345202)
49. Zeng Q, Oakley B. p53 and Bax: putative death factors in taste cell turnover. J Comp Neurol. 1999;413:168-180. (Pubitemid 29409759)
50. Zeng Q, Kwan A, Oakley B. Gustatory innervations and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells. J Comp Neurol. 2000;424:640-650. (Pubitemid 30643056)
51. Yee CL, Yang R, Böttger B, Finger TE, Kinnamon JC. "Type III" cells of rat taste buds: immunohistochemical and ultrastructural studies of neuron-specific enolase, protein gene product 9.5, and serotonin. J Comp Neurol. 2001;440:97-108.
52. Arvidson K. Location and variation in number of taste buds in human fungiform papillae. Scand J Dent Res. 1979;87:435-442. (Pubitemid 10152427)
53. Miller IJ Jr. Human taste bud density across adult age groups. J Gerontol. 1988;43:B26-B30. (Pubitemid 18029931)
54. Miller IJ Jr. Variation in human taste bud density as a function of age. Ann N Y Acad Sci. 1989;561:307-319. (Pubitemid 19195621)
55. Shimizu Y. A histomorphometric study of the age-related changes of the human taste buds in circumvallate papillae. Oral Med Pathol. 1997;2:17-24.
56. Bradley RM, Stedman HM, Mistretta CM. Age does not affect numbers of taste buds and papillae in adult rhesus monkeys. Anat Rec. 1985;212:246-249. (Pubitemid 15247829)
57. Toffanello ED, Inelmen EM, Minicuci N, et al. Ten-year trends in dietary intake, health status and mortality rates in free-living elderly people. J Nutr Health Aging. 2010;14:259-264.
58. Elson AE, Dotson CD, Egan JM, Munger SD. Glucagon signaling modulates sweet taste responsiveness. FASEB J. 2010;24:3960-3969.