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Volumn 29, Issue 1, 2015, Pages 164-172

TAS2R bitter taste receptors regulate thyroid function

Author keywords

G protein coupled receptor; Iodide; T2R; Thyrocyte; Thyroxine

Indexed keywords

CALCIUM; G PROTEIN COUPLED RECEPTOR; IODIDE; LIOTHYRONINE; PROPYLTHIOURACIL; THYROGLOBULIN; THYROID HORMONE; THYROTROPIN; THYROXINE; TYPE 2 TASTE RECEPTOR; UNCLASSIFIED DRUG; LIGAND; TASTE RECEPTORS, TYPE 2;

EID: 84936098219     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-262246     Document Type: Article
Times cited : (120)

References (59)
  • 1
    • 83455220371 scopus 로고    scopus 로고
    • Thyroid iodide efflux: A team effort?
    • Fong, P. (2011) Thyroid iodide efflux: a team effort? J. Physiol. 589, 5929-5939
    • (2011) J. Physiol. , vol.589 , pp. 5929-5939
    • Fong, P.1
  • 2
    • 79960176452 scopus 로고    scopus 로고
    • Progress in structure based drug design for G protein-coupled receptors
    • Congreve, M., Langmead, C. J., Mason, J. S., and Marshall, F. H. (2011) Progress in structure based drug design for G protein-coupled receptors. J. Med. Chem. 54, 4283-4311
    • (2011) J. Med. Chem. , vol.54 , pp. 4283-4311
    • Congreve, M.1    Langmead, C.J.2    Mason, J.S.3    Marshall, F.H.4
  • 3
    • 80053459477 scopus 로고    scopus 로고
    • Gustatory and extragustatory functions of mammalian taste receptors
    • Behrens, M., and Meyerhof, W. (2011) Gustatory and extragustatory functions of mammalian taste receptors. Physiol. Behav. 105, 4-13
    • (2011) Physiol. Behav. , vol.105 , pp. 4-13
    • Behrens, M.1    Meyerhof, W.2
  • 7
    • 0034611738 scopus 로고    scopus 로고
    • A family of candidate taste receptors in human and mouse
    • Matsunami, H., Montmayeur, J. P., and Buck, L. B. (2000) A family of candidate taste receptors in human and mouse. Nature 404,601-604
    • (2000) Nature , vol.404 , pp. 601-604
    • Matsunami, H.1    Montmayeur, J.P.2    Buck, L.B.3
  • 8
    • 36248977649 scopus 로고    scopus 로고
    • Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells
    • Behrens, M., Foerster, S., Staehler, F., Raguse, J. D., and Meyerhof, W. (2007) Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells. J Neurosci. 27, 12630-12640
    • (2007) J Neurosci. , vol.27 , pp. 12630-12640
    • Behrens, M.1    Foerster, S.2    Staehler, F.3    Raguse, J.D.4    Meyerhof, W.5
  • 9
    • 84870314938 scopus 로고    scopus 로고
    • Extraoral bitter taste receptors as mediators of off-target drug effects
    • Clark, A. A., Liggett, S. B., and Munger, S. D. (2012) Extraoral bitter taste receptors as mediators of off-target drug effects. FASEB J. 26, 4827-4831
    • (2012) FASEB J. , vol.26 , pp. 4827-4831
    • Clark, A.A.1    Liggett, S.B.2    Munger, S.D.3
  • 10
    • 78651282172 scopus 로고    scopus 로고
    • Expression of taste receptors in solitary chemosensory cells of rodent airways
    • Tizzano, M., Cristofoletti, M., Sbarbati, A., and Finger, T. E. (2011) Expression of taste receptors in solitary chemosensory cells of rodent airways. BMC Pulm. Med. 11, 3
    • (2011) BMC Pulm. Med. , vol.11 , pp. 3
    • Tizzano, M.1    Cristofoletti, M.2    Sbarbati, A.3    Finger, T.E.4
  • 12
    • 78149355561 scopus 로고    scopus 로고
    • Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
    • Deshpande, D. A., Wang, W. C., McIlmoyle, E. L., Robinett, K. S., Schillinger, R. M., An, S. S., Sham, J. S., and Liggett, S. B. (2010) Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat. Med. 16, 1299-1304
    • (2010) Nat. Med. , vol.16 , pp. 1299-1304
    • Deshpande, D.A.1    Wang, W.C.2    McIlmoyle, E.L.3    Robinett, K.S.4    Schillinger, R.M.5    An, S.S.6    Sham, J.S.7    Liggett, S.B.8
  • 13
    • 80555156680 scopus 로고    scopus 로고
    • Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors
    • Robinett, K. S., Deshpande, D. A., Malone, M. M., and Liggett, S. B. (2011) Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. Am. J. Respir. Cell Mol. Biol. 45, 1069-1074
    • (2011) Am. J. Respir. Cell Mol. Biol. , vol.45 , pp. 1069-1074
    • Robinett, K.S.1    Deshpande, D.A.2    Malone, M.M.3    Liggett, S.B.4
  • 14
    • 0037133261 scopus 로고    scopus 로고
    • Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells
    • Wu, S. V., Rozengurt, N., Yang, M., Young, S. H., Sinnett-Smith, J., and Rozengurt, E. (2002) Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc. Natl. Acad. Sci. USA 99, 2392-2397
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 2392-2397
    • Wu, S.V.1    Rozengurt, N.2    Yang, M.3    Young, S.H.4    Sinnett-Smith, J.5    Rozengurt, E.6
  • 17
    • 69549084858 scopus 로고    scopus 로고
    • Motile cilia of human airway epithelia are chemosensory
    • Shah, A. S., Ben-Shahar, Y., Moninger, T. O., Kline, J. N., and Welsh, M. J. (2009) Motile cilia of human airway epithelia are chemosensory. Science 325, 1131-1134
    • (2009) Science , vol.325 , pp. 1131-1134
    • Shah, A.S.1    Ben-Shahar, Y.2    Moninger, T.O.3    Kline, J.N.4    Welsh, M.J.5
  • 18
    • 79960786009 scopus 로고    scopus 로고
    • Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK
    • Jeon, T. I., Seo, Y. K., and Osborne, T. F. (2011) Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK. Biochem. J. 438, 33-37
    • (2011) Biochem. J. , vol.438 , pp. 33-37
    • Jeon, T.I.1    Seo, Y.K.2    Osborne, T.F.3
  • 19
    • 55849136194 scopus 로고    scopus 로고
    • SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice
    • Jeon, T. I., Zhu, B., Larson, J. L., and Osborne, T. F. (2008) SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice. J. Clin. Invest. 118, 3693-3700
    • (2008) J. Clin. Invest. , vol.118 , pp. 3693-3700
    • Jeon, T.I.1    Zhu, B.2    Larson, J.L.3    Osborne, T.F.4
  • 20
    • 84907692946 scopus 로고    scopus 로고
    • Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart
    • Foster, S. R., Blank, K., See Hoe, L. E., Behrens, M., Meyerhof, W., Peart, J. N., and Thomas, W. G. (2014) Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart. FASEB J. 28, 4497-4508
    • (2014) FASEB J. , vol.28 , pp. 4497-4508
    • Foster, S.R.1    Blank, K.2    See Hoe, L.E.3    Behrens, M.4    Meyerhof, W.5    Peart, J.N.6    Thomas, W.G.7
  • 21
    • 84871129066 scopus 로고    scopus 로고
    • Functional characterization of bitter-taste receptors expressed in mammalian testis
    • Xu, J., Cao, J., Iguchi, N., Riethmacher, D., and Huang, L. (2013) Functional characterization of bitter-taste receptors expressed in mammalian testis. Mol. Hum. Reprod. 19, 17-28
    • (2013) Mol. Hum. Reprod. , vol.19 , pp. 17-28
    • Xu, J.1    Cao, J.2    Iguchi, N.3    Riethmacher, D.4    Huang, L.5
  • 23
    • 85077257460 scopus 로고    scopus 로고
    • Relative quantification
    • Dorak, M. T., ed. Taylor & Francis, New York
    • Pfaffl, M. W. (2006) Relative quantification. In Real-Time PCR (Dorak, M. T., ed.), pp. 63-82, Taylor & Francis, New York
    • (2006) Real-Time PCR , pp. 63-82
    • Pfaffl, M.W.1
  • 30
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • International HapMap Consortium. (2005) A haplotype map of the human genome. Nature 437, 1299-1320
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 32
    • 24344435450 scopus 로고    scopus 로고
    • Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci
    • Kim, U., Wooding, S., Ricci, D., Jorde, L. B., and Drayna, D. (2005) Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum. Mutat. 26, 199-204
    • (2005) Hum. Mutat. , vol.26 , pp. 199-204
    • Kim, U.1    Wooding, S.2    Ricci, D.3    Jorde, L.B.4    Drayna, D.5
  • 33
    • 0031966959 scopus 로고    scopus 로고
    • Multipoint quantitative-trait linkage analysis in general pedigrees
    • Almasy, L., and Blangero, J. (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 62, 1198-1211
    • (1998) Am. J. Hum. Genet. , vol.62 , pp. 1198-1211
    • Almasy, L.1    Blangero, J.2
  • 34
    • 36749079336 scopus 로고    scopus 로고
    • So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests
    • Conneely, K. N., and Boehnke, M. (2007) So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am. J. Hum. Genet. 81, 1158-1168
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 1158-1168
    • Conneely, K.N.1    Boehnke, M.2
  • 35
    • 0026718951 scopus 로고
    • Gustducin is a taste-cell-specific G protein closely related to the transducins
    • McLaughlin, S. K., McKinnon, P. J., and Margolskee, R. F. (1992) Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 357, 563-569
    • (1992) Nature , vol.357 , pp. 563-569
    • McLaughlin, S.K.1    McKinnon, P.J.2    Margolskee, R.F.3
  • 36
    • 13944250257 scopus 로고    scopus 로고
    • The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception
    • Bufe, B., Breslin, P. A., Kuhn, C., Reed, D. R., Tharp, C. D., Slack, J. P., Kim, U. K., Drayna, D., and Meyerhof, W. (2005) The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr. Biol. 15, 322-327
    • (2005) Curr. Biol. , vol.15 , pp. 322-327
    • Bufe, B.1    Breslin, P.A.2    Kuhn, C.3    Reed, D.R.4    Tharp, C.D.5    Slack, J.P.6    Kim, U.K.7    Drayna, D.8    Meyerhof, W.9
  • 37
    • 0022257232 scopus 로고
    • 2+ and iodide efflux induced by thyrotropin and by the stimulation of alpha 1-adrenergic receptors in cultured rat thyroid cells
    • 2+ and iodide efflux induced by thyrotropin and by the stimulation of alpha 1-adrenergic receptors in cultured rat thyroid cells. J. Biol. Chem. 260, 9230-9236
    • (1985) J. Biol. Chem. , vol.260 , pp. 9230-9236
    • Corda, D.1    Marcocci, C.2    Kohn, L.D.3    Axelrod, J.4    Luini, A.5
  • 40
    • 34249327746 scopus 로고    scopus 로고
    • Immunocytochemical analysis of syntaxin-1 in rat circumvallate taste buds
    • Yang, R., Ma, H., Thomas, S. M., and Kinnamon, J. C. (2007) Immunocytochemical analysis of syntaxin-1 in rat circumvallate taste buds. J. Comp. Neurol. 502, 883-893
    • (2007) J. Comp. Neurol. , vol.502 , pp. 883-893
    • Yang, R.1    Ma, H.2    Thomas, S.M.3    Kinnamon, J.C.4
  • 41
  • 43
    • 0028120342 scopus 로고
    • Control of the dog thyrocyte plasma membrane iodide permeability by the Ca(2+)-phosphatidylinositol and adenosine 3′,5′-monophosphate cascades
    • Raspé, E., and Dumont, J. E. (1994) Control of the dog thyrocyte plasma membrane iodide permeability by the Ca(2+)-phosphatidylinositol and adenosine 3′,5′-monophosphate cascades. Endocrinology 135, 986-995
    • (1994) Endocrinology , vol.135 , pp. 986-995
    • Raspé, E.1    Dumont, J.E.2
  • 44
    • 0021273667 scopus 로고
    • Iodide transport in a continuous line of cultured cells from rat thyroid
    • Weiss, S. J., Philp, N. J., and Grollman, E. F. (1984) Iodide transport in a continuous line of cultured cells from rat thyroid. Endocrinology 114, 1090-1098
    • (1984) Endocrinology , vol.114 , pp. 1090-1098
    • Weiss, S.J.1    Philp, N.J.2    Grollman, E.F.3
  • 45
    • 0017195606 scopus 로고
    • Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase
    • Nagasaka, A., and Hidaka, H. (1976) Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase. J. Clin. Endocrinol. Metab. 43, 152-158
    • (1976) J. Clin. Endocrinol. Metab. , vol.43 , pp. 152-158
    • Nagasaka, A.1    Hidaka, H.2
  • 46
    • 40349101820 scopus 로고    scopus 로고
    • Thyroid disrupting chemicals: Mechanisms and mixtures
    • Crofton, K. M. (2008) Thyroid disrupting chemicals: mechanisms and mixtures. Int. J. Androl. 31, 209-223
    • (2008) Int. J. Androl. , vol.31 , pp. 209-223
    • Crofton, K.M.1
  • 47
    • 0037458815 scopus 로고    scopus 로고
    • Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
    • Kim, U. K., Jorgenson, E., Coon, H., Leppert, M., Risch, N., and Drayna, D. (2003) Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299, 1221-1225
    • (2003) Science , vol.299 , pp. 1221-1225
    • Kim, U.K.1    Jorgenson, E.2    Coon, H.3    Leppert, M.4    Risch, N.5    Drayna, D.6
  • 48
    • 34547858150 scopus 로고    scopus 로고
    • Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin
    • Pronin, A. N., Xu, H., Tang, H., Zhang, L., Li, Q., and Li, X. (2007) Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Curr. Biol. 17, 1403-1408
    • (2007) Curr. Biol. , vol.17 , pp. 1403-1408
    • Pronin, A.N.1    Xu, H.2    Tang, H.3    Zhang, L.4    Li, Q.5    Li, X.6
  • 49
    • 84878438759 scopus 로고    scopus 로고
    • Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31
    • Allen, A. L., McGeary, J. E., Knopik, V. S., and Hayes, J. E. (2013) Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31. Chem. Senses 38, 379-389
    • (2013) Chem. Senses , vol.38 , pp. 379-389
    • Allen, A.L.1    McGeary, J.E.2    Knopik, V.S.3    Hayes, J.E.4
  • 50
    • 74449087964 scopus 로고    scopus 로고
    • Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women
    • Dotson, C. D., Shaw, H. L., Mitchell, B. D., Munger, S. D., and Steinle, N. I. (2010) Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women. Appetite 54, 93-99
    • (2010) Appetite , vol.54 , pp. 93-99
    • Dotson, C.D.1    Shaw, H.L.2    Mitchell, B.D.3    Munger, S.D.4    Steinle, N.I.5
  • 51
    • 20544467498 scopus 로고    scopus 로고
    • TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study
    • Timpson, N. J., Christensen, M., Lawlor, D. A., Gaunt, T. R., Day, I. N., Ebrahim, S., and Davey Smith, G. (2005) TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study. Am. J. Clin. Nutr. 81, 1005-1011
    • (2005) Am. J. Clin. Nutr. , vol.81 , pp. 1005-1011
    • Timpson, N.J.1    Christensen, M.2    Lawlor, D.A.3    Gaunt, T.R.4    Day, I.N.5    Ebrahim, S.6    Davey Smith, G.7
  • 54
    • 84866351612 scopus 로고    scopus 로고
    • Variation in the gene TAS2R13 is associated with differences in alcohol consumption in patients with head and neck cancer
    • Dotson, C. D., Wallace, M. R., Bartoshuk, L. M., and Logan, H. L. (2012) Variation in the gene TAS2R13 is associated with differences in alcohol consumption in patients with head and neck cancer. Chem. Senses 37, 737-744
    • (2012) Chem. Senses , vol.37 , pp. 737-744
    • Dotson, C.D.1    Wallace, M.R.2    Bartoshuk, L.M.3    Logan, H.L.4
  • 55
    • 79951805645 scopus 로고    scopus 로고
    • Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults
    • Hayes, J. E., Wallace, M. R., Knopik, V. S., Herbstman, D. M., Bartoshuk, L. M., and Duffy, V. B. (2011) Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults. Chem. Senses 36, 311-319
    • (2011) Chem. Senses , vol.36 , pp. 311-319
    • Hayes, J.E.1    Wallace, M.R.2    Knopik, V.S.3    Herbstman, D.M.4    Bartoshuk, L.M.5    Duffy, V.B.6
  • 58
    • 84859102483 scopus 로고    scopus 로고
    • Thyrotoxicosis
    • Franklyn, J. A., and Boelaert, K. (2012) Thyrotoxicosis. Lancet 379, 1155-1166
    • (2012) Lancet , vol.379 , pp. 1155-1166
    • Franklyn, J.A.1    Boelaert, K.2
  • 59
    • 84899503308 scopus 로고    scopus 로고
    • The bitter pill: Clinical drugs that activate the human bitter taste receptor TAS2R14
    • Levit, A., Nowak, S., Peters, M., Wiener, A., Meyerhof, W., Behrens, M., and Niv, M. Y. (2014) The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14. FASEB J. 28, 1181-1197
    • (2014) FASEB J. , vol.28 , pp. 1181-1197
    • Levit, A.1    Nowak, S.2    Peters, M.3    Wiener, A.4    Meyerhof, W.5    Behrens, M.6    Niv, M.Y.7


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