The expression of bitter taste receptors in mesenteric, cerebral and omental arteries

Life Sciences

Volumn 170, Issue , 2017, Pages 16-24

  Chen, Jing Guo ^a   Ping, Na Na ^a   Liang, Dong ^a   Li, Meng Yi ^b   Mi, Yan Ni ^a   Li, Sen ^a   Cao, Lei ^a   Cai, Yan ^c   Cao, Yong Xiao ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^c THE SECOND AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Bitter taste receptor; Cerebral artery; Mesenteric artery; Omental artery; Vasodilation

Indexed keywords

BITTER TASTE RECEPTOR; CHLOROQUINE; MESSENGER RNA; QUININE; RECEPTOR; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; TAS2R7 PROTEIN, HUMAN; TAS2R7 PROTEIN, RAT; TASTE RECEPTORS, TYPE 2;

ADULT; ANIMAL TISSUE; ARTERY; ARTICLE; BITTER TASTE; BRAIN ARTERY; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GENE SEQUENCE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; MALE; MESENTERIC ARTERY; NONHUMAN; OMENTAL ARTERY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TASTE BUD; VASCULAR SMOOTH MUSCLE CELL; WESTERN BLOTTING; ANIMAL; BRAIN CIRCULATION; CHEMISTRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; LIVER; MESENTERY; METABOLISM; MIDDLE AGED; OMENTUM; SPRAGUE DAWLEY RAT; TASTE; TONGUE; VASCULARIZATION; VASODILATATION;

ANIMALS; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; CHLOROQUINE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LIVER; MALE; MESENTERY; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; OMENTUM; QUININE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TASTE; TONGUE; VASODILATION;

EID: 85008657173     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2016.11.010     Document Type: Article

References (35)

1. [1] Chandrashekar, J., Mueller, K.L., Hoon, M.A., Adler, E., Feng, L.X., Guo, W., T2Rs function as bitter taste receptors. Cell 100 (2000), 703–711.
2. [2] Adler, E., Hoon, M.A., Mueller, K.L., Chandrashekar, J., Ryba, N.J.P., Zuker, C.S., A novel family of mammalian taste receptors. Cell 100 (2000), 693–702.
3. [3] Matsunami, H., Montmayeur, J.P., Buck, L.B., A family of candidate taste receptors in human and mouse. Nature 404 (2000), 601–603.
4. [4] Kaji, I., Karaki, S., Fukami, Y., Terasaki, M., Kuwahara, A., Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine. Am. J. Phys. Gastrointest. Liver 296 (2009), 971–981.
5. [5] Prandi, S., Bromke, M., Hubner, S., Voigt, A., Boehm, U., Meyerhof, W., et al. A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS One, 8, 2013.
6. [6] Grassin-Delyle, S., Abrial, C., Fayad-Kobeissi, S., Brollo, M., Faisy, C., Alvarez, J.C., et al. The expression and relaxant effect of bitter taste receptors in human bronchi. Respir. Res., 14, 2013.
7. [7] Deshpande, D.A., Wang, W.C., Mcilmoyle, E.L., Robinett, K.S., Schillinger, R.M., An, S.S., et al. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat. Med. 16 (2010), 1299–1304.
8. [8] Singh, N., Vrontakis, M., Parkinson, F., Chelikani, P., Functional bitter taste receptors are expressed in brain cells. Biochem. Biophys. Res. Commun. 406 (2011), 146–151.
9. [9] Foster, S.R., Porrello, E.R., Purdue, B., Chan, H.W., Voigt, A., Frenzel, S., et al. Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart. PLoS One, 8, 2013.
10. [10] Xu, J., Cao, J., Iguchi, N., Riethmacher, D., Huang, L.Q., Functional characterization of bitter-taste receptors expressed in mammalian testis. Mol. Hum. Reprod. 19 (2013), 17–28.
11. [11] Dotson, C.D., Zhang, L., Xu, H., Shin, Y.K., Vigues, S., Ott, S.H., et al. Bitter taste receptors influence glucose homeostasis. PLoS One, 3, 2008, e3974.
12. [12] Zhang, C.H., Lifshitz, L.M., Uy, K.F., Ikebe, M., Fogarty, K.E., Zhuge, R., The cellular and molecular basis of bitter tastant-induced bronchodilation. PLoS Biol., 11, 2013, e1001501.
13. [13] Shah, A.S., Ben-Shahar, Y., Moninger, T.O., Kline, J.N., Welsh, M.J., Motile cilia of human airway epithelia are chemosensory. Science 325 (2009), 1131–1134.
14. [14] Foster, S.R., Blank, K., See Hoe, L.E., Behrens, M., Meyerhof, W., Peart, J.N., et al. Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart. FASEB J. 28 (2014), 4497–4508.
15. [15] Lund, T.C., Kobs, A.J., Kramer, A., Nyquist, M., Kuroki, M.T., Osborn, J., et al. Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression. PLoS One, 8, 2013.
16. [16] Manson, M.L., Safholm, J., Al-Ameri, M., Bergman, P., Orre, A.C., Sward, K., et al. Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle. Eur. J. Pharmacol. 740 (2014), 302–311.
17. [17] Upadhyaya, J.D., Singh, N., Sikarwar, A.S., Chakraborty, R., Pydi, S.P., Bhullar, R.P., et al. Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction. PLoS One, 9, 2014.
18. [18] Xiao, X., Ping, N.N., Li, S., Cao, L., Cao, Y.X., An optimal initial tension for rat basilar artery in wire myography. Microvasc. Res. 97 (2015), 156–158.
19. [19] Cao, L., Zhang, Y., Cao, Y.X., Edvinsson, L., Xu, C.B., Cigarette smoke upregulates rat coronary artery endothelin receptors in vivo. PLoS One, 7, 2012, e33008.
20. [20] Xiao, X., Wang, R., Cao, L., Shen, Z.X., Cao, Y.X., The role of MAPK pathways in airborne fine particulate matter-induced upregulation of endothelin receptors in rat basilar arteries. Toxicol. Sci. 149 (2016), 213–226.
21. [21] Meyerhof, W., Batram, C., Kuhn, C., Brockhoff, A., Chudoba, E., Bufe, B., et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem. Senses 35 (2010), 157–170.
22. [22] Kinnamon, S.C., Taste receptor signalling - from tongues to lungs. Acta Physiol. 204 (2012), 158–168.
23. [23] Gerthoffer, W.T., Solway, J., Camoretti-Mercado, B., Emerging targets for novel therapy of asthma. Curr. Opin. Pharmacol. 13 (2013), 324–330.
24. [24] Avau, B., Depoortere, I., The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity. Acta Physiol. 216 (2016), 407–420.
25. [25] Pronin, A.N., Tang, H., Connor, J., Keung, W., Identification of ligands for two human bitter T2R receptors. Chem. Senses 29 (2004), 583–593.
26. [26] Dehkordi, O., Rose, J.E., Fatemi, M., Allard, J.S., Balan, K.V., Young, J.K., et al. Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem. Brain Res. 1475 (2012), 1–10.
27. [27] Wu, S.V., Chen, M.C., Rozengurt, E., Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat. Physiol. Genomics 22 (2005), 139–149.
28. [28] Hatano, Y., Mizumoto, K., Yoshiyama, T., Yamamoto, M., Iranami, H., Endothelium-dependent and -independent vasodilation of isolated rat aorta induced by caffeine. Am. J. Phys. 269 (1995), H1679–H1684.
29. [29] Sainz, E., Cavenagh, M.M., Gutierrez, J., Battey, J.F., Northup, J.K., Sullivan, S.L., Functional characterization of human bitter taste receptors. Biochem. J. 403 (2007), 537–543.
30. [30] Behrens, M., Meyerhof, W., Bitter taste receptor research comes of age: from characterization to modulation of TAS2Rs. Semin. Cell Dev. Biol. 24 (2013), 215–221.
31. [31] Slack, J.P., Brockhoff, A., Batram, C., Menzel, S., Sonnabend, C., Born, S., et al. Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr. Biol. 20 (2010), 1104–1109.
32. [32] Roland, W.S.U., Gouka, R.J., Gruppen, H., Driesse, M., Van Buren, L., Smit, G., et al. 6-Methoxyflavanones as bitter taste receptor blockers for hTAS2R39. PLoS One, 9, 2014.
33. [33] Pydi, S.P., Jaggupilli, A., Nelson, K.M., Abrams, S.R., Bhullar, R.P., Loewen, M.C., et al. Abscisic acid acts as a blocker of the bitter taste G protein-coupled receptor T2R4. Biochemistry-Us 54 (2015), 2622–2631.
34. [34] Pydi, S.P., Sobotkiewicz, T., Billakanti, R., Bhullar, R.P., Loewen, M.C., Chelikani, P., Amino acid derivatives as bitter taste receptor (T2R) blockers. J. Biol. Chem. 289 (2014), 25054–25066.
35. [35] Clark, A.A., Liggett, S.B., Munger, S.D., Extraoral bitter taste receptors as mediators of off-target drug effects. FASEB J. 26 (2012), 4827–4831.