Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis

Journal of Molecular and Cellular Cardiology

Volumn 67, Issue , 2014, Pages 69-76

  Liang, Bo ^a   Soka, Magdalena ^b   Christensen, Alex Horby ^b   Olesen, Morten S ^a   Larsen, Anders P ^a,c   Knop, Filip K ^b   Wang, Fan ^a   Nielsen, Jonas B ^a   Andersen, Martin N ^a   Humphreys, David ^b   Mann, Stefan A ^b   Huttner, Inken G ^b   Vandenberg, Jamie I ^b,d   Svendsen, Jesper H ^a   Haunsø, Stig ^a   Preiss, Thomas ^e   Seebohm, Guiscard ^f   Olesen, Søren Peter ^a   Schmitt, Nicole ^a   Fatkin, Diane ^b,d,g  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e Biology and Environment   (Australia)

^f UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^g ST VINCENT S HOSPITAL   (Australia)

Author keywords

Atrial action potential duration; Atrial fibrillation; TASK 1; Two pore domain potassium channels

Indexed keywords

POTASSIUM CHANNEL; PROTEIN TASK1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCATION; GENE SILENCING; GENETIC VARIABILITY; GENOMIC INSTABILITY; HEART ATRIUM; HEART ATRIUM FIBRILLATION; HEART RATE; HEART VENTRICLE; HUMAN; KCNK3A GENE; KCNK3B GENE; MAJOR CLINICAL STUDY; MALE; MEMBRANE STEADY POTENTIAL; MIDDLE AGED; NONHUMAN; PH; PRIORITY JOURNAL; VERY ELDERLY; ZEBRA FISH;

ACTION POTENTIAL DURATION; AF; APD; ATRIAL ACTION POTENTIAL DURATION; ATRIAL FIBRILLATION; BASIC CYCLE LENGTH; BCL; CHINESE HAMSTER OVARY; CHO; EFFECTIVE REFRACTORY PERIOD; ERP; HEART RATE VARIABILITY; HOURS POST FERTILIZATION; HPF; HRV; K(2)(P); SINGLE NUCLEOTIDE POLYMORPHISMS; SNP; TASK-1; TWO-PORE DOMAIN K(+) CHANNELS; TWO-PORE DOMAIN POTASSIUM CHANNELS; WILD-TYPE; WT;

AMINO ACID MOTIFS; ANIMALS; ATRIAL FIBRILLATION; CHO CELLS; CRICETULUS; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HEART ATRIA; HUMANS; MODELS, ANIMAL; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; ZEBRAFISH;

EID: 84892884303     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.12.014     Document Type: Article

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