Colocalization of the α-subunit of gustducin with PYY and GLP-1 in L cells of human colon

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 291, Issue 5, 2006, Pages

  Rozengurt, Nora ^a   Wu, S Vincent ^a   Chen, Monica C ^a   Huang, Carlos ^a   Sternini, Catia ^a   Rozengurt, Enrique ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chromogranin A; Gastrointestinal peptides; Glucagon like peptide 1; Peptide YY; Phenylthiocarbamide; Serotonin; Type 2 receptor family

Indexed keywords

CALCIUM ION; CHROMOGRANIN A; GLUCAGON LIKE PEPTIDE 1; GUANINE NUCLEOTIDE BINDING PROTEIN; PEPTIDE YY; PHENYLTHIOUREA; PROTEIN GUSTDUCIN; PROTEIN HUMAN TYPE 1 RECEPTOR 3; PROTEIN HUMAN TYPE 2 RECEPTOR 38; PROTEIN SUBUNIT; RECEPTOR; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ARTICLE; CALCIUM CELL LEVEL; CELL STIMULATION; COLON MUCOSA; CONTROLLED STUDY; ENDOCRINE CELL; ENTEROENDOCRINE CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; L CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SENSORY RECEPTOR; SIGNAL TRANSDUCTION; TASTE;

CALCIUM; CELL LINE; CHROMOGRANIN A; COLON; DNA; DNA, COMPLEMENTARY; FLUORESCENT ANTIBODY TECHNIQUE; GASTRIC MUCOSA; GLUCAGON-LIKE PEPTIDE 1; GTP-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROFILAMENT PROTEINS; PEPTIDE YY; PHENYLCARBAMATES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIOCARBAMATES; TRANSDUCIN;

EID: 33751100128     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00074.2006     Document Type: Article

References (60)

1. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJP, and Zuker CS. A novel family of mammalian taste receptors. Cell 100: 693-702, 2000.
2. Anini Y and Brubaker PL. Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells. Endocrinology 144: 3244-3250, 2003.
3. Anini Y and Brubaker PL. Role of leptin in the regulation of glucagon-like peptide-1 secretion. Diabetes 52: 252-259, 2003.
4. Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, and Bloom SR. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349: 941-948, 2003.
5. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, and Bloom SR. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418: 650-654, 2002.
6. Buchan AMJ. Nutrient tasting and signaling mechanisms in the gut. III. Endocrine cell recognition of luminal nutrients. Am J Physiol Gastrointest Liver Physiol 277: G1103-G1107, 1999.
7. Bufe B, Breslin PA, Kuhn C, Reed DR, Tharp CD, Slack JP, Kim UK, Drayna D, and Meyerhof W. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 15: 322-327, 2005.
8. Bufe B, Hofmann T, Krautwurst D, Raguse JD, and Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet 32: 397-401, 2002.
9. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, and Ryba NJP. T2Rs function as bitter taste receptors. Cell 100: 703-711, 2000.
10. Conte C, Ebeling M, Marcuz A, Nef P, and Andres-Barquin PJ. Evolutionary relationships of the Tas2r receptor gene families in mouse and human. Physiol Genomics 14: 73-82, 2003.
11. Degen L, Oesch S, Casanova M, Graf S, Ketterer S, Drewe J, and Beglinger C. Effect of peptide YY(3-36) on food intake in humans. Gastroenterology 129: 1430-1436, 2005.
12. Dockray GJ. Luminal sensing in the gut: an overview. J Physiol Pharmacol 54, Suppl 4: 9-17, 2003.
13. Dyer J, Salmon KS, Zibrik L, and Shirazi-Beechey SP. Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem Soc Trans 33: 302-305, 2005.
14. Eissele R, Goke R, Willemer S, Harthus HP, Vermeer H, Arnold R, and Goke B. Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur J Clin Invest 22: 283-291, 1992.
15. Ekblad E and Sundler F. Distribution of pancreatic polypeptide and peptide YY. Peptides 23: 251-261, 2002.
16. Facer P, Bishop AE, Lloyd RV, Wilson BS, Hennessy RJ, and Polak JM. Chromogranin: a newly recognized marker for endocrine cells of the human gastrointestinal tract. Gastroenterology 89: 1366-1373, 1985.
17. Furness JB, Kunze WAA, and Clerc N. Nutrient tasting and signaling mechanisms in the gut. II. The intestine as a sensory organ: neural, endocrine, and immune responses. Am J Physiol Gastrointest Liver Physiol 277: G922-G928, 1999.
18. Gautier JF, Fetita S, Sobngwi E, and Salaun-Martin C. Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes. Diabetes Metab 31: 233-242, 2005.
19. Glendinning JI, Tarre M, and Asaoka K. Contribution of different bitter-sensitive taste cells to feeding inhibition in a caterpillar (Manduca sexta). Behav Neurosci 113: 840-854, 1999.
20. Halatchev IG and Cone RD. Peripheral administration of PYY3-36 produces conditioned taste aversion in mice. Cell Metab 1: 159-168, 2005.
21. Hansotia T and Drucker DJ. GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice. Regul Pept 128: 125-134, 2005.
22. Herness MS and Gilbertson TA. Cellular mechanisms of taste transduction. Annu Rev Physiol 61: 873-900, 1999.
23. Hoefer D and Drenckhahn D. Identification of the taste cell G-protein, alpha-gustducin, in brush cells of the rat pancreatic duct system. Histochem Cell Biol 110: 303-309, 1998.
24. Hoefer D, Pueschel B, and Drenckhahn D. Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc Natl Acad Sci USA 93: 6631-6634, 1996.
25. Ji TH, Grossmann M, and Ji I. G protein-coupled receptors. I. Diversity of receptor-ligand interactions. J Biol Chem 273: 17299-17302, 1998.
26. Katz DB, Nicolelis MAL, and Simon SA. Nutrient tasting and signaling mechanisms in the gut. IV. There is more to taste than meets the tongue. Am J Physiol Gastrointest Liver Physiol 278: G6-G9, 2000.
27. Keire DA, Bowers CW, Solomon TE, and Reeve JR Jr. Structure and receptor binding of PYY analogs. Peptides 23: 305-321, 2002.
28. Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, and Drayna D. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299: 1221-1225, 2003.
29. Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, and Meyerhof W. Bitter taste receptors for saccharin and acesulfame K. J Neurosci 24: 10260-10265, 2004.
30. le Roux CW, Batterham RL, Aylwin SJB, Patterson M, Borg CM, Wynne KJ, Kent A, Vincent RP, Gardiner J, Ghatei MA, and Bloom SR. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 147: 3-8, 2006.
31. Lee LTO, Tan-Un KC, Pang RTK, Lam DTW, and Chow BKC. Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element. Mol Endocrinol 18: 1740-1755, 2004.
32. Li X, Staszewski L, Xu H, Durick K, Zoller M, and Adler E. Human receptors for sweet and umami taste. Proc Natl Acad Sci USA 99: 4692-4696, 2002.
33. Masuho I, Tateyama M, and Saitoh O. Characterization of bitter taste responses of intestinal STC-1 cells. Chem Senses 30: 281-290, 2005.
34. Matsunami H, Montmayeur JP, and Buck LB. A family of candidate taste receptors in human and mouse. Nature 404: 601-604, 2000.
35. Ming D, Ninomiya Y, and Margolskee RF. Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds. Proc Natl Acad Sci USA 96: 9903-9908, 1999.
36. Ming D, Ruiz-Avila L, and Margolskee RF. Characterization and solubilization of bitter-responsive receptors that couple to gustducin. Proc Natl Acad Sci USA 95: 8933-8938, 1998.
37. Mortensen K, Christensen LL, Holst JJ, and Orskov C. GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regul Pept 114: 189-196, 2003.
38. Nauck MA, Baller B, and Meier JJ. Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of Type 2 diabetes. Diabetes 53: S190-S196, 2004.
39. Neary NM, Small CJ, Druce MR, Park AJ, Ellis SM, Semjonous NM, Dakin CL, Filipsson K, Wang F, Kent AS, Frost GS, Ghatei MA, and Bloom SR. Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively. Endocrinology 146: 5120-5127, 2005.
40. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, and Zuker CS. An amino-acid taste receptor. Nature 416: 199-202, 2002.
41. Park JG, Oie HK, Sugarbaker PH, Henslee JG, Chen TR, Johnson BE, and Gazdar A. Characteristics of cell lines established from human colorectal carcinoma. Cancer Res 47: 6710-6718, 1987.
42. Portela-Gomes GM, Stridsberg M, Johansson H, and Grimelius L. Co-localization of synaptophysin with different neuroendocrine hormones in the human gastrointestinal tract. Histochem Cell Biol 111: 49-54, 1999.
43. Portela-Gomes GM, Stridsberg M, Johansson H, and Grimelius L. Complex co-localization of chromogranins and neurohormones in the human gastrointestinal tract. J Histochem Cytochem 45: 815-822, 1997.
44. Pronin AN, Tang H, Connor J, and Keung W. Identification of ligands for two human bitter T2R receptors. Chem Senses 29: 583-593, 2004.
45. Raybould HE. Does your gut taste? Sensory transduction in the gastrointestinal tract. News Physiol Sci 13: 275-280, 1998.
46. Rehfeld JF. The new biology of gastrointestinal hormones. Physiol Rev 78: 1087-1108, 1998.
47. Reid L, Meyrick B, Antony VB, Chang LY, Crapo JD, and Reynolds HY. The mysterious pulmonary brush cell: a cell in search of a function. Am J Respir Crit Care Med 172: 136-139, 2005.
48. Reimer RA, Darimont C, Gremlich S, Nicolas-Metral V, Ruegg UT, and Mace K. A human cellular model for studying the regulation of glucagon-like peptide-1 secretion. Endocrinology 142: 4522-4528, 2001.
49. Roth KA, Kim S, and Gordon JI. Immunocytochemical studies suggest two pathways for enteroendocrine cell differentiation in the colon. Am J Physiol Gastrointest Liver Physiol 263: G174-G180, 1992.
50. Ruiz-Avila L, McLaughlin SK, Wildman D, McKinnon PJ, Robichon A, Spickofsky N, and Margolskee RF. Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells. Nature 376: 80-85, 1995.
51. Ruiz-Avila L, Wong GT, Damak S, and Margolskee RF. Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in alpha-gustducin. Proc Natl Acad Sci USA 98: 8868-8873, 2001.
52. Schirra J and Goke B. The physiological role of GLP-1 in human: incretin, ileal brake or more? Regul Pept 128: 109-115, 2005.
53. Schonhoff SE, Giel-Moloney M, and Leiter AB. Minireview: development and differentiation of gut endocrine cells. Endocrinology 145: 2639-2644, 2004.
54. Scott TR and Verhagen JV. Taste as a factor in the management of nutrition. Nutrition 16: 874-885, 2000.
55. Shindler KS and Roth KA. Double immunofluorescent staining using two unconjugated primary antisera raised in the same species. J Histochem Cytochem 44: 1331-1335, 1996.
56. Talsania T, Anini Y, Siu S, Drucker DJ, and Brubaker PL. Peripheral exendin-4 and peptide YY3-36 synergistically reduce food intake through different mechanisms in mice. Endocrinology 146: 3748-3756, 2005.
57. Wong GT, Gannon KS, and Margolskee RF. Transduction of bitter and sweet taste by gustducin. Nature 381: 796-800, 1996.
58. Wooding S. Evolution: a study in bad taste? Curr Biol 15: R805-R807, 2005.
59. Wu SV, Chen MC, and Rozengurt E. Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat. Physiol Genomics 22: 139-149, 2005.
60. Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, and Rozengurt E. Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci USA 99: 2392-2397, 2002.