메뉴 건너뛰기




Volumn 63, Issue 13, 2006, Pages 1501-1509

Bitter taste receptors and human bitter taste perception

Author keywords

Bitter taste receptor; G protein coupled receptor; Gustatory system; Sensory physiology; Single nucleotide polymorphisms; Tongue

Indexed keywords

STRYCHNINE;

EID: 33746639193     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-006-6113-8     Document Type: Conference Paper
Times cited : (141)

References (81)
  • 1
    • 0002673542 scopus 로고
    • Anatomy of the peripheral taste system
    • Miller I. J. Jr (ed.), Doty R. L. (ed.), Dekker, New York
    • Miller I. J. Jr (ed.) (1995) Anatomy of the peripheral taste system. In: Handbook of Olfaction and Gustation, Doty R. L. (ed.), Dekker, New York
    • (1995) Handbook of Olfaction and Gustation
  • 2
    • 0013816757 scopus 로고
    • Renewal of cells within taste buds
    • Beidler L. M. and Smallman R. L. (1965) Renewal of cells within taste buds. J. Cell Biol. 27: 263-272
    • (1965) J. Cell Biol. , vol.27 , pp. 263-272
    • Beidler, L.M.1    Smallman, R.L.2
  • 3
    • 0018890254 scopus 로고
    • Renewal of taste bud cells in rat circumvallate papillae
    • Farbman A. I. (1980) Renewal of taste bud cells in rat circumvallate papillae. Cell Tissue Kinet. 13: 349-357
    • (1980) Cell Tissue Kinet. , vol.13 , pp. 349-357
    • Farbman, A.I.1
  • 4
    • 0022977463 scopus 로고
    • Ultrastructure of mouse vallate taste buds: II. Cell types and cell lineage
    • Delay R. J., Kinnamon J. C. and Roper S. D. (1986) Ultrastructure of mouse vallate taste buds: II. Cell types and cell lineage. J. Comp. Neurol. 253: 242-252
    • (1986) J. Comp. Neurol. , vol.253 , pp. 242-252
    • Delay, R.J.1    Kinnamon, J.C.2    Roper, S.D.3
  • 5
    • 18844384153 scopus 로고    scopus 로고
    • The taste cell-related diffuse chemosensory system
    • Sbarbati A. and Osculati F. (2005) The taste cell-related diffuse chemosensory system. Prog. Neurobiol. 75: 295-307
    • (2005) Prog. Neurobiol. , vol.75 , pp. 295-307
    • Sbarbati, A.1    Osculati, F.2
  • 6
    • 1642476838 scopus 로고    scopus 로고
    • Gustatory neural coding
    • Doty R. L. (ed.), 2nd edn., Marcel Dekker, New York
    • Smith D. V. and Scott T. R. (2003) Gustatory neural coding. In: Handbook of Olfaction and Gustation, pp. 731-758, Doty R. L. (ed.), 2nd edn., Marcel Dekker, New York
    • (2003) Handbook of Olfaction and Gustation , pp. 731-758
    • Smith, D.V.1    Scott, T.R.2
  • 7
    • 0033781033 scopus 로고    scopus 로고
    • Taste as a factor in the management of nutrition
    • Scott T. R. and Verhagen J. V. (2000) Taste as a factor in the management of nutrition. Nutrition 16: 874-885
    • (2000) Nutrition , vol.16 , pp. 874-885
    • Scott, T.R.1    Verhagen, J.V.2
  • 8
    • 0344837756 scopus 로고    scopus 로고
    • Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae
    • Hall J. M., Bell M. L. and Finger T. E. (2003) Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae. Dev. Biol. 255: 263-277
    • (2003) Dev. Biol. , vol.255 , pp. 263-277
    • Hall, J.M.1    Bell, M.L.2    Finger, T.E.3
  • 9
    • 0013570618 scopus 로고    scopus 로고
    • Amphibians provide new insights into taste-bud development
    • Northcutt R. G. and Barlow L. A. (1998) Amphibians provide new insights into taste-bud development. Trends Neurosci. 21: 38-43
    • (1998) Trends Neurosci. , vol.21 , pp. 38-43
    • Northcutt, R.G.1    Barlow, L.A.2
  • 10
    • 0033082393 scopus 로고    scopus 로고
    • A taste for development
    • Barlow L. A. (1999) A taste for development. Neuron 22: 209-212
    • (1999) Neuron , vol.22 , pp. 209-212
    • Barlow, L.A.1
  • 11
    • 0033909941 scopus 로고    scopus 로고
    • Role of saliva in the maintenance of taste sensitivity
    • Matsuo R. (2000) Role of saliva in the maintenance of taste sensitivity. Crit. Rev. Oral Biol. Med. 11: 216-229
    • (2000) Crit. Rev. Oral Biol. Med. , vol.11 , pp. 216-229
    • Matsuo, R.1
  • 12
    • 0021272299 scopus 로고
    • Human saliva and taste responses to acids varying in anions, titratable acidity, and pH
    • Norris M. B., Noble A. C. and Pangborn R. M. (1984) Human saliva and taste responses to acids varying in anions, titratable acidity, and pH. Physiol. Behav. 32: 237-244
    • (1984) Physiol. Behav. , vol.32 , pp. 237-244
    • Norris, M.B.1    Noble, A.C.2    Pangborn, R.M.3
  • 13
    • 0029920735 scopus 로고    scopus 로고
    • Changes in secreted salivary sodium are sufficient to alter salt taste sensitivity: Use of signal detection measures with continuous monitoring of the oral environment
    • Delwiche J. and O'Mahony M. (1996) Changes in secreted salivary sodium are sufficient to alter salt taste sensitivity: use of signal detection measures with continuous monitoring of the oral environment. Physiol. Behav. 59: 605-611
    • (1996) Physiol. Behav. , vol.59 , pp. 605-611
    • Delwiche, J.1    O'Mahony, M.2
  • 14
    • 0025176792 scopus 로고
    • Possible role for salivary gland protein in taste reception indicated by homology to lipophilic-ligand carrier proteins
    • Schmale H., Holtgreve-Grez H. and Christiansen H. (1990) Possible role for salivary gland protein in taste reception indicated by homology to lipophilic-ligand carrier proteins. Nature 343: 366-369
    • (1990) Nature , vol.343 , pp. 366-369
    • Schmale, H.1    Holtgreve-Grez, H.2    Christiansen, H.3
  • 15
    • 0027096822 scopus 로고
    • Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice
    • Capeless C. G., Whitney G. and Azen E. A. (1992) Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice. Behav. Genet. 22: 655-663
    • (1992) Behav. Genet. , vol.22 , pp. 655-663
    • Capeless, C.G.1    Whitney, G.2    Azen, E.A.3
  • 16
    • 0002729396 scopus 로고
    • The evolution of bitter and the acquisition of toxiphobia
    • Melbourne, Australia, Denton D. A. and Coghlan J. P. (eds.), Academic, New York
    • Garcia J. and Hankins W. G. (1975) The evolution of bitter and the acquisition of toxiphobia. In: Olfaction and Taste. Proceedings of the 5th International Symposium in Melbourne, Australia, vol. 5, p. 39, Denton D. A. and Coghlan J. P. (eds.), Academic, New York
    • (1975) Olfaction and Taste. Proceedings of the 5th International Symposium , vol.5 , pp. 39
    • Garcia, J.1    Hankins, W.G.2
  • 17
    • 27944434112 scopus 로고    scopus 로고
    • Elucidation of mammalian bitter taste
    • Jul. 20 [Epub ahead of print]
    • Meyerhof W. (2005) Elucidation of mammalian bitter taste. Rev. Physiol. Biochem. Pharmacol. Jul. 20 [Epub ahead of print]
    • (2005) Rev. Physiol. Biochem. Pharmacol.
    • Meyerhof, W.1
  • 18
    • 0042040501 scopus 로고    scopus 로고
    • Evolutionary relationships of the Tas2r receptor gene families in mouse and human
    • Conte C., Ebeling M., Marcuz A., Nef P. and Andres-Barquin P. J. (2003) Evolutionary relationships of the Tas2r receptor gene families in mouse and human. Physiol. Genomics 14: 73-82
    • (2003) Physiol. Genomics , vol.14 , pp. 73-82
    • Conte, C.1    Ebeling, M.2    Marcuz, A.3    Nef, P.4    Andres-Barquin, P.J.5
  • 19
    • 0038708520 scopus 로고    scopus 로고
    • Adaptive diversification of bitter taste receptor genes in Mammalian evolution
    • Shi P., Zhang J., Yang H. and Zhang Y. P. (2003) Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol. Biol. Evol. 20: 805-814
    • (2003) Mol. Biol. Evol. , vol.20 , pp. 805-814
    • Shi, P.1    Zhang, J.2    Yang, H.3    Zhang, Y.P.4
  • 20
    • 20444412707 scopus 로고    scopus 로고
    • Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates
    • Go Y., Satta Y., Takenaka O. and Takahata N. (2005) Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Genetics 170: 313-326
    • (2005) Genetics , vol.170 , pp. 313-326
    • Go, Y.1    Satta, Y.2    Takenaka, O.3    Takahata, N.4
  • 21
    • 14544295509 scopus 로고    scopus 로고
    • Evolution of bitter taste receptors in humans and apes
    • Fischer A., Gilad Y., Man O. and Paabo S. (2005) Evolution of bitter taste receptors in humans and apes. Mol. Biol. Evol. 22: 432-436
    • (2005) Mol. Biol. Evol. , vol.22 , pp. 432-436
    • Fischer, A.1    Gilad, Y.2    Man, O.3    Paabo, S.4
  • 22
    • 6944241419 scopus 로고    scopus 로고
    • Divergence of T2R chemosensory receptor families in humans, bonobos, and chimpanzees
    • USA
    • Parry C. M., Erkner A. and le Coutre J. (2004) Divergence of T2R chemosensory receptor families in humans, bonobos, and chimpanzees. Proc. Natl. Acad. Sci. USA 101: 14830-14834
    • (2004) Proc. Natl. Acad. Sci. , vol.101 , pp. 14830-14834
    • Parry, C.M.1    Erkner, A.2    Le Coutre, J.3
  • 23
    • 8444225000 scopus 로고    scopus 로고
    • Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes
    • Wang X., Thomas S. D. and Zhang J. (2004) Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes. Hum. Mol. Genet. 13: 2671-2678
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 2671-2678
    • Wang, X.1    Thomas, S.D.2    Zhang, J.3
  • 24
    • 22744443058 scopus 로고    scopus 로고
    • Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16
    • Soranzo N., Bufe B., Sabeti P. C., Wilson J. F., Weale M. E., Marguerie R. et al. (2005) Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Curr. Biol. 15: 1257-1265
    • (2005) Curr. Biol. , vol.15 , pp. 1257-1265
    • Soranzo, N.1    Bufe, B.2    Sabeti, P.C.3    Wilson, J.F.4    Weale, M.E.5    Marguerie, R.6
  • 25
    • 0028004195 scopus 로고
    • Is the bitter rejection response always adaptive?
    • Glendinning J. I. (1994) Is the bitter rejection response always adaptive? Physiol. Behav. 56: 1217-1227
    • (1994) Physiol. Behav. , vol.56 , pp. 1217-1227
    • Glendinning, J.I.1
  • 28
    • 0037133261 scopus 로고    scopus 로고
    • Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells
    • USA
    • Wu S. V., Rozengurt N., Yang M., Young S. H., Sinnett-Smith J. and Rozengurt E. (2002) Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc. Natl. Acad. Sci. USA 99: 2392-2397
    • (2002) Proc. Natl. Acad. Sci. , vol.99 , pp. 2392-2397
    • Wu, S.V.1    Rozengurt, N.2    Yang, M.3    Young, S.H.4    Sinnett-Smith, J.5    Rozengurt, E.6
  • 31
    • 0036844351 scopus 로고    scopus 로고
    • The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides
    • Bufe B., Hofmann T., Krautwurst D., Raguse J. D. and Meyerhof W (2002) The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat. Genet. 32: 397-401
    • (2002) Nat. Genet. , vol.32 , pp. 397-401
    • Bufe, B.1    Hofmann, T.2    Krautwurst, D.3    Raguse, J.D.4    Meyerhof, W.5
  • 32
    • 13944250257 scopus 로고    scopus 로고
    • The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception
    • Bufe B., Breslin P. A., Kuhn C., Reed D. R., Tharp C. D., Slack J. P. et al. (2005) The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr. Biol. 15: 322-327
    • (2005) Curr. Biol. , vol.15 , pp. 322-327
    • Bufe, B.1    Breslin, P.A.2    Kuhn, C.3    Reed, D.R.4    Tharp, C.D.5    Slack, J.P.6
  • 34
    • 0036522960 scopus 로고    scopus 로고
    • Rats fail to discriminate quinine from denatonium: Implications for the neural coding of bitter-tasting compounds
    • Spector A. C. and Kopka S. L. (2002) Rats fail to discriminate quinine from denatonium: implications for the neural coding of bitter-tasting compounds. J. Neurosci. 22: 1937-1941
    • (2002) J. Neurosci. , vol.22 , pp. 1937-1941
    • Spector, A.C.1    Kopka, S.L.2
  • 35
    • 0033007186 scopus 로고    scopus 로고
    • Training and characterization of a quinine taste discrimination in rhesus monkeys
    • Aspen J., Gatch M. B. and Woods J. H. (1999) Training and characterization of a quinine taste discrimination in rhesus monkeys. Psychopharmacology 141: 251-257
    • (1999) Psychopharmacology , vol.141 , pp. 251-257
    • Aspen, J.1    Gatch, M.B.2    Woods, J.H.3
  • 36
    • 0035936911 scopus 로고    scopus 로고
    • Taste receptor cells that discriminate between bitter stimuli
    • Caicedo A. and Roper S. D. (2001) Taste receptor cells that discriminate between bitter stimuli. Science 291: 1557-1560
    • (2001) Science , vol.291 , pp. 1557-1560
    • Caicedo, A.1    Roper, S.D.2
  • 37
    • 0030915416 scopus 로고    scopus 로고
    • Neural responses to bitter compounds in rats
    • Dahl M., Erickson R. P. and Simon S. A. (1997) Neural responses to bitter compounds in rats. Brain Res. 756: 22-34
    • (1997) Brain Res. , vol.756 , pp. 22-34
    • Dahl, M.1    Erickson, R.P.2    Simon, S.A.3
  • 38
    • 0026718951 scopus 로고
    • Gustducin is a taste-cell-specific G protein closely related to the transducins
    • McLaughlin S. K., McKinnon P. J. and Margolskee R. F. (1992) Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 357: 563-569
    • (1992) Nature , vol.357 , pp. 563-569
    • McLaughlin, S.K.1    McKinnon, P.J.2    Margolskee, R.F.3
  • 39
    • 0029957779 scopus 로고    scopus 로고
    • Transduction of bitter and sweet taste by gustducin
    • Wong G. T., Gannon K. S. and Margolskee R. F. (1996) Transduction of bitter and sweet taste by gustducin. Nature 381: 796-800
    • (1996) Nature , vol.381 , pp. 796-800
    • Wong, G.T.1    Gannon, K.S.2    Margolskee, R.F.3
  • 40
    • 0033565914 scopus 로고    scopus 로고
    • Directing gene expression to gustducin-positive taste receptor cells
    • Wong G. T., Ruiz-Avila L. and Margolskee R. F. (1999) Directing gene expression to gustducin-positive taste receptor cells. J. Neurosci. 19: 5802-5809
    • (1999) J. Neurosci. , vol.19 , pp. 5802-5809
    • Wong, G.T.1    Ruiz-Avila, L.2    Margolskee, R.F.3
  • 41
    • 0042739015 scopus 로고    scopus 로고
    • Functional interaction between T2R taste receptors and G protein alpha subunits expressed in taste receptor cells
    • Ueda T., Ugawa S., Yamamura H., Imaizumi Y. and Shimada S. (2003) Functional interaction between T2R taste receptors and G protein alpha subunits expressed in taste receptor cells. J. Neurosci. 23: 7376-7380
    • (2003) J. Neurosci. , vol.23 , pp. 7376-7380
    • Ueda, T.1    Ugawa, S.2    Yamamura, H.3    Imaizumi, Y.4    Shimada, S.5
  • 43
    • 0242440813 scopus 로고    scopus 로고
    • Role of the G protein subunit alpha-gustducin in taste cell responses to bitter stimuli
    • Caicedo A., Pereira E., Margolskee R. F. and Roper S. D. (2003) Role of the G protein subunit alpha-gustducin in taste cell responses to bitter stimuli. J. Neurosci. 23: 9947-9952
    • (2003) J. Neurosci. , vol.23 , pp. 9947-9952
    • Caicedo, A.1    Pereira, E.2    Margolskee, R.F.3    Roper, S.D.4
  • 44
    • 0029053161 scopus 로고
    • Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells
    • Ruiz-Avila L., McLaughlin S. K., Wildman D., McKinnon P. J., Robichon A., Spickofsky N. et al. (1995) Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells. Nature 376: 80-85
    • (1995) Nature , vol.376 , pp. 80-85
    • Ruiz-Avila, L.1    McLaughlin, S.K.2    Wildman, D.3    McKinnon, P.J.4    Robichon, A.5    Spickofsky, N.6
  • 45
    • 0036798864 scopus 로고    scopus 로고
    • Partial rescue of taste responses of alpha-gustducin null mice by transgenic expression of alpha-transducin
    • He W., Danilova V., Zou S., Hellekant G., Max M., Margolskee R. F. and Damak S. (2002) Partial rescue of taste responses of alpha-gustducin null mice by transgenic expression of alpha-transducin. Chem. Senses 27: 719-727
    • (2002) Chem. Senses , vol.27 , pp. 719-727
    • He, W.1    Danilova, V.2    Zou, S.3    Hellekant, G.4    Max, M.5    Margolskee, R.F.6    Damak, S.7
  • 46
    • 1942485954 scopus 로고    scopus 로고
    • Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways
    • Ozeck M., Brust P., Xu H. and Servant G. (2004) Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways. Eur. J. Pharmacol. 489: 139-149
    • (2004) Eur. J. Pharmacol. , vol.489 , pp. 139-149
    • Ozeck, M.1    Brust, P.2    Xu, H.3    Servant, G.4
  • 47
    • 0033233484 scopus 로고    scopus 로고
    • Ggamma13 colocalizes with gust-ducin in taste receptor cells and mediates IP3 responses to bitter denatonium
    • Huang L., Shanker Y. G., Dubauskaite J., Zheng J. Z., Yan W., Rosenzweig S. et al. (1999) Ggamma13 colocalizes with gust-ducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat. Neurosci. 2: 1055-1062
    • (1999) Nat. Neurosci. , vol.2 , pp. 1055-1062
    • Huang, L.1    Shanker, Y.G.2    Dubauskaite, J.3    Zheng, J.Z.4    Yan, W.5    Rosenzweig, S.6
  • 48
    • 0033624203 scopus 로고    scopus 로고
    • G protein betagamma complexes in circumvallate taste cells involved in bitter transduction
    • Rossler P., Boekhoff I., Tareilus E., Beck S., Breer H. and Freitag J. (2000) G protein betagamma complexes in circumvallate taste cells involved in bitter transduction. Chem. Senses 25: 413-421
    • (2000) Chem. Senses , vol.25 , pp. 413-421
    • Rossler, P.1    Boekhoff, I.2    Tareilus, E.3    Beck, S.4    Breer, H.5    Freitag, J.6
  • 50
    • 0031735630 scopus 로고    scopus 로고
    • Identification of a phospholipase C beta subtype in rat taste cells
    • Rossler P., Kroner C., Freitag J., Noe J. and Breer H. (1998) Identification of a phospholipase C beta subtype in rat taste cells. Eur J. Cell Biol. 77: 253-261
    • (1998) Eur J. Cell Biol. , vol.77 , pp. 253-261
    • Rossler, P.1    Kroner, C.2    Freitag, J.3    Noe, J.4    Breer, H.5
  • 51
    • 0034998556 scopus 로고    scopus 로고
    • Bitter taste transduced by PLC-beta(2)-dependent rise in IP(3) and alpha-gustducin-dependent fall in cyclic nucleotides
    • Yan W., Sunavala G., Rosenzweig S., Dasso M., Brand J. G. and Spielman A. I. (2001) Bitter taste transduced by PLC-beta(2)-dependent rise in IP(3) and alpha-gustducin-dependent fall in cyclic nucleotides. Am. J. Physiol. Cell Physiol. 280: C742-751
    • (2001) Am. J. Physiol. Cell Physiol. , vol.280
    • Yan, W.1    Sunavala, G.2    Rosenzweig, S.3    Dasso, M.4    Brand, J.G.5    Spielman, A.I.6
  • 52
    • 0030921657 scopus 로고    scopus 로고
    • Taste buds have a cyclic nucleotide-activated channel, CNGgust
    • Misaka T., Kusakabe Y., Emori Y., Gonoi T., Arai S. and Abe K. (1997) Taste buds have a cyclic nucleotide-activated channel, CNGgust. J. Biol. Chem. 272: 22623-22629
    • (1997) J. Biol. Chem. , vol.272 , pp. 22623-22629
    • Misaka, T.1    Kusakabe, Y.2    Emori, Y.3    Gonoi, T.4    Arai, S.5    Abe, K.6
  • 53
    • 0035789507 scopus 로고    scopus 로고
    • Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction
    • Clapp T. R., Stone L. M., Margolskee R. F. and Kinnamon S. C. (2001) Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction. BMC Neurosci. 2: 6
    • (2001) BMC Neurosci. , vol.2 , pp. 6
    • Clapp, T.R.1    Stone, L.M.2    Margolskee, R.F.3    Kinnamon, S.C.4
  • 54
    • 0031009293 scopus 로고    scopus 로고
    • Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus
    • Ogura T., Mackay-Sim A. and Kinnamon S. C. (1997) Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus. J. Neurosci. 17: 3580-3587
    • (1997) J. Neurosci. , vol.17 , pp. 3580-3587
    • Ogura, T.1    Mackay-Sim, A.2    Kinnamon, S.C.3
  • 55
    • 0037423367 scopus 로고    scopus 로고
    • Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways
    • Zhang Y., Hoon M. A., Chandrashekar J., Mueller K. L., Cook B., Wu D. et al. (2003) Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112: 293-301
    • (2003) Cell , vol.112 , pp. 293-301
    • Zhang, Y.1    Hoon, M.A.2    Chandrashekar, J.3    Mueller, K.L.4    Cook, B.5    Wu, D.6
  • 56
    • 24944469668 scopus 로고    scopus 로고
    • PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligands
    • Dotson C. D., Roper S. D. and Spector A. C. (2005) PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligands. Chem. Senses 30: 593-600
    • (2005) Chem. Senses , vol.30 , pp. 593-600
    • Dotson, C.D.1    Roper, S.D.2    Spector, A.C.3
  • 57
    • 0036830145 scopus 로고    scopus 로고
    • A transient receptor potential channel expressed in taste receptor cells
    • Perez C. A., Huang L., Rong M., Kozak J. A., Preuss A. K., Zhang H. et al. (2002) A transient receptor potential channel expressed in taste receptor cells. Nat. Neurosci. 5: 1169-1176
    • (2002) Nat. Neurosci. , vol.5 , pp. 1169-1176
    • Perez, C.A.1    Huang, L.2    Rong, M.3    Kozak, J.A.4    Preuss, A.K.5    Zhang, H.6
  • 58
    • 0037672155 scopus 로고    scopus 로고
    • TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel
    • Hofmann T., Chubanov V., Gudermann T. and Montell C. (2003) TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr. Biol. 13: 1153-1158
    • (2003) Curr. Biol. , vol.13 , pp. 1153-1158
    • Hofmann, T.1    Chubanov, V.2    Gudermann, T.3    Montell, C.4
  • 59
    • 0344149569 scopus 로고    scopus 로고
    • Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5
    • USA
    • Liu D. and Liman E. R. (2003) Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc. Natl. Acad. Sci. USA 100: 15160-15165
    • (2003) Proc. Natl. Acad. Sci. , vol.100 , pp. 15160-15165
    • Liu, D.1    Liman, E.R.2
  • 60
    • 0038650737 scopus 로고    scopus 로고
    • Making sense with TRP channels: Store-operated calcium entry and the ion channel Trpm5 in taste receptor cells
    • Perez C. A., Margolskee R. F., Kinnamon S. C. and Ogura T. (2003) Making sense with TRP channels: store-operated calcium entry and the ion channel Trpm5 in taste receptor cells. Cell Calcium. 33: 541-549
    • (2003) Cell Calcium. , vol.33 , pp. 541-549
    • Perez, C.A.1    Margolskee, R.F.2    Kinnamon, S.C.3    Ogura, T.4
  • 64
    • 0037458815 scopus 로고    scopus 로고
    • Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
    • Kim U. K., Jorgenson E., Coon H., Leppert M., Risch N. and Drayna D. (2003) Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299: 1221-1225
    • (2003) Science , vol.299 , pp. 1221-1225
    • Kim, U.K.1    Jorgenson, E.2    Coon, H.3    Leppert, M.4    Risch, N.5    Drayna, D.6
  • 65
    • 0001075372 scopus 로고
    • Taste thresholds of further eighteen compounds and their correlation with P.T.C thresholds
    • Barnicot N. A., Harris H. and Kalmus H. (1951) Taste thresholds of further eighteen compounds and their correlation with P.T.C thresholds. Ann. Eugen. 16: 119-128
    • (1951) Ann. Eugen. , vol.16 , pp. 119-128
    • Barnicot, N.A.1    Harris, H.2    Kalmus, H.3
  • 66
    • 8544242989 scopus 로고    scopus 로고
    • Identification of ligands for two human bitter T2R receptors
    • Pronin A. N., Tang H., Connor J. and Keung W. (2004) Identification of ligands for two human bitter T2R receptors. Chem. Senses 29: 583-593
    • (2004) Chem. Senses , vol.29 , pp. 583-593
    • Pronin, A.N.1    Tang, H.2    Connor, J.3    Keung, W.4
  • 68
    • 0034177929 scopus 로고    scopus 로고
    • Issues of gustatory neural coding: Where they stand today
    • Scott T. R. and Giza B. K. (2000) Issues of gustatory neural coding: where they stand today. Physiol. Behav. 69: 65-76
    • (2000) Physiol. Behav. , vol.69 , pp. 65-76
    • Scott, T.R.1    Giza, B.K.2
  • 69
    • 0033178521 scopus 로고    scopus 로고
    • Neural coding of gustatory information
    • Smith D. V. and St John S. J. (1999) Neural coding of gustatory information. Curr. Opin. Neurobiol. 9: 427-435
    • (1999) Curr. Opin. Neurobiol. , vol.9 , pp. 427-435
    • Smith, D.V.1    St John, S.J.2
  • 70
    • 0035399811 scopus 로고    scopus 로고
    • Distribution of gustatory sensitivities in rat taste cells: Whole-cell responses to apical chemical stimulation
    • Gilbertson T. A., Boughter J. D. Jr, Zhang H. and Smith D. V. (2001) Distribution of gustatory sensitivities in rat taste cells: whole-cell responses to apical chemical stimulation. J. Neurosci. 21: 4931-4941
    • (2001) J. Neurosci. , vol.21 , pp. 4931-4941
    • Gilbertson, T.A.1    Boughter Jr., J.D.2    Zhang, H.3    Smith, D.V.4
  • 71
    • 0037107438 scopus 로고    scopus 로고
    • Individual mouse taste cells respond to multiple chemical stimuli
    • Caicedo A., Kim K. N. and Roper S. D. (2002) Individual mouse taste cells respond to multiple chemical stimuli. J. Physiol. 544: 501-509
    • (2002) J. Physiol. , vol.544 , pp. 501-509
    • Caicedo, A.1    Kim, K.N.2    Roper, S.D.3
  • 74
    • 23044469366 scopus 로고    scopus 로고
    • Genetic tracing shows segregation of taste neuronal circuitries for bitter and sweet
    • Sugita M. and Shiba Y. (2005) Genetic tracing shows segregation of taste neuronal circuitries for bitter and sweet. Science 309: 781-785
    • (2005) Science , vol.309 , pp. 781-785
    • Sugita, M.1    Shiba, Y.2
  • 75
    • 16644365758 scopus 로고    scopus 로고
    • Diverse bitter stimuli elicit highly similar patterns of Fos-like immunoreactivity in the nucleus of the solitary tract
    • Chan C. Y., Yoo J. E. and Travers S. P. (2004) Diverse bitter stimuli elicit highly similar patterns of Fos-like immunoreactivity in the nucleus of the solitary tract. Chem. Senses 29: 573-581
    • (2004) Chem. Senses , vol.29 , pp. 573-581
    • Chan, C.Y.1    Yoo, J.E.2    Travers, S.P.3
  • 76
    • 0033870723 scopus 로고    scopus 로고
    • Comparing sensory experiences across individuals: Recent psychophysical advances illuminate genetic variation in taste perception
    • Bartoshuk L. M. (2000) Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception. Chem. Senses 25: 447-460
    • (2000) Chem. Senses , vol.25 , pp. 447-460
    • Bartoshuk, L.M.1
  • 77
    • 24344435450 scopus 로고    scopus 로고
    • Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci
    • Kim U., Wooding S., Ricci D., Jorde L. B. and Drayna D. (2005) Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum. Mutat. 26: 199-204
    • (2005) Hum. Mutat. , vol.26 , pp. 199-204
    • Kim, U.1    Wooding, S.2    Ricci, D.3    Jorde, L.B.4    Drayna, D.5
  • 79
    • 0038121048 scopus 로고    scopus 로고
    • Genetic analysis of a complex trait in the Utah Genetic Reference Project: A major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p
    • Drayna D., Coon H., Kim U. K., Elsner T., Cromer K., Otterud B. et al. (2003) Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p. Hum. Genet. 112: 567-572
    • (2003) Hum. Genet. , vol.112 , pp. 567-572
    • Drayna, D.1    Coon, H.2    Kim, U.K.3    Elsner, T.4    Cromer, K.5    Otterud, B.6
  • 81
    • 0030931522 scopus 로고    scopus 로고
    • Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
    • USA
    • Fahey J. W., Zhang Y. and Talalay P. (1997) Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. USA 94: 10367-10372
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 10367-10372
    • Fahey, J.W.1    Zhang, Y.2    Talalay, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.