High salt recruits aversive taste pathways

Nature

Volumn 494, Issue 7438, 2013, Pages 472-475

  Oka, Yuki ^a   Butnaru, Matthew ^a   Von Buchholtz, Lars ^b   Ryba, Nicholas J P ^b   Zuker, Charles S ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITHELIAL SODIUM CHANNEL; INORGANIC SALT; SODIUM; SODIUM CHLORIDE;

ANIMAL; BEHAVIORAL RESPONSE; CONCENTRATION (COMPOSITION); ELECTROLYTE; GENETIC ANALYSIS; MOLECULAR ANALYSIS; NEUROLOGY; SALT; SODIUM; TASTE;

ANIMAL EXPERIMENT; APPETITE; ARTICLE; BITTER TASTE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTROLYTE BALANCE; FLUID BALANCE; HOMEOSTASIS; MOUSE; NERVE TRACT; NONHUMAN; PRIORITY JOURNAL; SALT INTAKE; SWEETNESS; TASTE ACUITY; TASTE AVERSION; TASTE BUD;

ANIMALS; APPETITE; FEEDING BEHAVIOR; GENE SILENCING; MICE; MICE, KNOCKOUT; MUTATION; PHOSPHOLIPASE C BETA; SODIUM CHLORIDE, DIETARY; TASTE; TASTE BUDS; TRPM CATION CHANNELS;

ANIMALIA; MUS;

EID: 84874359134     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11905     Document Type: Article

References (30)

1. Chandrashekar, J., Hoon, M. A., Ryba, N. J. P. & Zuker, C. S. The receptors and cells for mammalian taste. Nature 444, 288-294 (2006).
2. Yarmolinsky, D. A., Zuker, C. S. & Ryba, N. J. P. Common sense about taste: from mammals to insects. Cell 139, 234-244 (2009).
3. Beauchamp, G. K., Bertino, M., Burke, D. & Engelman, K. Experimental sodium depletionandsalt taste in normalhumanvolunteers.Am. J. Clin.Nutr.51, 881-889 (1990).
4. Duncan, C. J. Salt preferences of birds and mammals. Physiologic. Zool. 35, 120-132 (1962).
5. Eylam, S. & Spector, A. C. Taste discrimination between NaCl and KCl is disrupted byamiloride in inbred mice withamiloride-insensitive chordatympani nerves.Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R1361-R1368 (2005).
6. Contreras, R. J. in Neural Mechanisms in Taste (ed. Cagan, R. H.) 119-145 (CRC, 1989).
7. Lindemann, B. Receptors and transduction in taste. Nature 413, 219-225 (2001).
8. Chandrashekar, J. et al. The cells and peripheral representation of sodiumtaste in mice. Nature 464, 297-301 (2010).
9. Doolin, R. E. & Gilbertson, T. A. Distribution and characterization of functional amiloride-sensitive sodium channels in rat tongue. J. Gen. Physiol. 107, 545-554 (1996).
10. Halpern, B. P. Amiloride and vertebrate gustatory responses to NaCl. Neurosci. Biobehav. Rev. 23, 5-47 (1998).
11. Heck, G. L., Mierson, S.& DeSimone, J. A. Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. Science 223, 403-405 (1984).
12. Hettinger, T. P. & Frank, M. E. Specificity of amiloride inhibition of hamster taste responses. Brain Res. 513, 24-34 (1990).
13. Spector, A. C., Guagliardo, N. A. & St John, S. J. Amiloride disrupts NaCl versus KCl discrimination performance: implications for salt taste coding in rats. J. Neurosci. 16, 8115-8122 (1996).
14. Mueller, K. L. et al. The receptors and coding logic for bitter taste. Nature 434, 225-229 (2005).
15. Zhang, Y. et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112, 293-301 (2003).
16. Huang, A. L. et al. The cells and logic for mammalian sour taste detection. Nature 442, 934-938 (2006).
17. Chandrashekar, J. et al. The taste of carbonation. Science 326, 443-445 (2009).
18. Yamamoto, M. et al.Reversible suppression of glutamatergic neurotransmissionof cerebellar granule cells in vivo by genetically manipulated expression of tetanus neurotoxin light chain. J. Neurosci. 23, 6759-6767 (2003).
19. Gao, Z. G., Jiang, Q., Jacobson, K. A. & Ijzerman, A. P. Site-directed mutagenesis studies of human A2A adenosine receptors: involvement of glu13 and his278 in ligand binding and sodium modulation. Biochem. Pharmacol. 60, 661-668 (2000).
20. Liu, W. et al. Structural basis for allosteric regulation of GPCRs by sodium ions. Science 337, 232-236 (2012).
21. Zhu, X. L. & Sly, W. S. Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney. J. Biol. Chem. 265, 8795-8801 (1990).
22. Baird, T. T., Jr, Waheed, A., Okuyama, T., Sly, W. S. & Fierke, C. A. Catalysis and inhibition of human carbonic anhydrase IV. Biochemistry 36, 2669-2678 (1997).
23. Hellekant, G., Ninomiya, Y. & Danilova, V. Taste in chimpanzees II: single chorda tympani fibers. Physiol. Behav. 61, 829-841 (1997).
24. Breslin, P. A. & Beauchamp, G. K. Suppression of bitterness by sodium: variation among bitter taste stimuli. Chem. Senses 20, 609-623 (1995).
25. Hallock, R. M., Tatangelo, M., Barrows, J. & Finger, T. E. Residual chemosensory capabilities in double P2X2/P2X3 purinergic receptor null mice: intraoral or postingestive detection? Chem. Senses 34, 799-808 (2009).
26. Ohkuri, T., Horio, N., Stratford, J. M., Finger, T. E. & Ninomiya, Y. Residual chemoresponsiveness to acids in the superior laryngeal nerve in "taste-blind" (P2X2/P2X3 double-KO) mice. Chem. Senses 37, 523-532 (2012).
27. Ugawa, S., Ueda, T., Yamamura, H., Nagao, M. & Shimada, S. Coexpression of vanilloid receptor subtype-1 and acid-sensing ion channel genes in the human trigeminal ganglion neurons. Chem. Senses 30 (suppl. 1), i195 (2005).
28. Tsien, R. Y. The green fluorescent protein. Annu. Rev. Biochem. 67, 509-544 (1998).
29. Nelson, G. et al. An amino-acid taste receptor. Nature 416, 199-202 (2002).
30. Oka, Y. et al. Odorant receptor map in the mouse olfactory bulb: in vivo sensitivity and specificity of receptor-defined glomeruli. Neuron 52, 857-869 (2006).