Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin

Science

Volumn 307, Issue 5714, 2005, Pages 1468-1472

  Moqrich, Aziz ^a,b   Hwang, Sun Wook ^a   Earley, Taryn J ^a   Petrus, Matt J ^b   Murray, Amber N ^a   Spencer, Kathryn S R ^a   Andahazy, Mary ^b   Story, Gina M ^a   Patapoutian, Ardem ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATMOSPHERIC TEMPERATURE; KETONES; LIVING SYSTEMS STUDIES; NEUROLOGY; SENSORY PERCEPTION;

CAMPHOR; SENSORY NEURONS; THERMOSENSATION; TRANSIENT RECEPTOR POTENTIAL (TRP);

SKIN;

CAMPHOR; CELL PROTEIN; ION CHANNEL; PROTEIN TRPV3; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG;

NEUROLOGY; TEMPERATURE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; ENVIRONMENTAL TEMPERATURE; HEAT; HEAT SENSITIVITY; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSOR; SENSORY NERVE CELL; SKIN SENSATION; TEMPERATURE;

ANIMALS; BRADYKININ; CAMPHOR; CATION TRANSPORT PROTEINS; CELLS, CULTURED; CHO CELLS; CRICETINAE; DERMIS; EPIDERMIS; GANGLIA, SPINAL; HEAT; HUMANS; ION CHANNELS; KERATINOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS, AFFERENT; PATCH-CLAMP TECHNIQUES; TEMPERATURE; TEMPERATURE SENSE; THERMORECEPTORS; TIME FACTORS; TRPV CATION CHANNELS;

DRYOBALANOPS; MAMMALIA;

EID: 14644392188     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1108609     Document Type: Article

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25. We thank M. Bandell, B. Conti, H. Esendencia, P. Garrity, S. Kupriyanov, M. Mayford, A. Peier, L. Reijmers, M. Wood, and J. Watson for input and assistance; M. Caterina for sharing a detailed protocol on primary culture of keratinocytes; T. Bartfai for sharing the thermal gradient platform; and N. Hong, T. Jegla, U. Mueller, and L. Stowers for critical reading of the manuscript. Supported by National Institute of Neurological Disorders and Stroke grants R01NS046303 and R01NS42822. G.M.S. is a recipient of a National Research Service Award postdoctoral fellowship from NIH. A.P. is a Damon Runyon Scholar.